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Protein

Zinc finger protein interacting with ribonucleoprotein K

Gene

Zik1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be a transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri215 – 23723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein interacting with ribonucleoprotein K
Gene namesi
Name:Zik1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:108070. Zik1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Zinc finger protein interacting with ribonucleoprotein KPRO_0000286794Add
BLAST

Proteomic databases

MaxQBiQ80YP6.
PaxDbiQ80YP6.
PRIDEiQ80YP6.

PTM databases

PhosphoSiteiQ80YP6.

Expressioni

Tissue specificityi

Expressed in ovary and liver, and at lower levels in brain and muscle.1 Publication

Gene expression databases

BgeeiQ80YP6.
CleanExiMM_ZIK1.
GenevisibleiQ80YP6. MM.

Interactioni

Subunit structurei

Interacts with HNRPK.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032551.

Structurei

3D structure databases

ProteinModelPortaliQ80YP6.
SMRiQ80YP6. Positions 191-461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8976KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri215 – 23723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri243 – 26523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ80YP6.
KOiK09228.
OMAiCGKASRH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ80YP6.
TreeFamiTF339848.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80YP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAEMDMALM QGCVTFQDVA ICFSHEEWRL LDETQRLLYL SVMLQNFALI
60 70 80 90 100
NSQGCGHKTE DEERRVSTRA SKGLRSETTP KTNLCEKCVP ILQDILCLPG
110 120 130 140 150
LPGQKHSTEA SSKVDQHQDH NSTGKPLEKN ADRSSYLFYL SAKSFPSWDV
160 170 180 190 200
EKDLPDILSL LKSQVCPKTK KYRKSTEGRK ETSHESDKSE ECQSLSSQKQ
210 220 230 240 250
TLAHHPKTSN GKKLYECSKC GKTFRGKYSL DQHQRVHTGE RPWECRDCGK
260 270 280 290 300
FFSQTSHLND HRRIHTGERP YECSECGKLF RQNSSLVDHQ KTHTGARPYE
310 320 330 340 350
CSQCGKSFSQ KATLVKHKRV HTGERPYKCS ECGNSFSQSA ILNQHRRIHT
360 370 380 390 400
GVKPYECREC GKSFSQKATL IKHQRVHTGE RPYKCSECGK SFSQSSILIQ
410 420 430 440 450
HRRIHTGARP YECSQCGKSF SQKSGLIQHQ VVHTGERPYE CDTCGNSFSQ
460
CSSLIHHQKC HNA
Length:463
Mass (Da):52,727
Last modified:June 1, 2003 - v1
Checksum:i019059C0D27F5365
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti211 – 2111G → E in AAC52877 (PubMed:8910362).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69133 mRNA. Translation: AAC52877.1.
AK146692 mRNA. Translation: BAE27363.1.
AK159077 mRNA. Translation: BAE34796.1.
BC050942 mRNA. Translation: AAH50942.1.
BC067196 mRNA. Translation: AAH67196.1.
CCDSiCCDS20792.1.
RefSeqiNP_033603.2. NM_009577.3.
UniGeneiMm.49441.

Genome annotation databases

EnsembliENSMUST00000032551; ENSMUSP00000032551; ENSMUSG00000030393.
GeneIDi22775.
KEGGimmu:22775.
UCSCiuc009fdf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69133 mRNA. Translation: AAC52877.1.
AK146692 mRNA. Translation: BAE27363.1.
AK159077 mRNA. Translation: BAE34796.1.
BC050942 mRNA. Translation: AAH50942.1.
BC067196 mRNA. Translation: AAH67196.1.
CCDSiCCDS20792.1.
RefSeqiNP_033603.2. NM_009577.3.
UniGeneiMm.49441.

3D structure databases

ProteinModelPortaliQ80YP6.
SMRiQ80YP6. Positions 191-461.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032551.

PTM databases

PhosphoSiteiQ80YP6.

Proteomic databases

MaxQBiQ80YP6.
PaxDbiQ80YP6.
PRIDEiQ80YP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032551; ENSMUSP00000032551; ENSMUSG00000030393.
GeneIDi22775.
KEGGimmu:22775.
UCSCiuc009fdf.1. mouse.

Organism-specific databases

CTDi284307.
MGIiMGI:108070. Zik1.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ80YP6.
KOiK09228.
OMAiCGKASRH.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ80YP6.
TreeFamiTF339848.

Miscellaneous databases

ChiTaRSiZik1. mouse.
PROiQ80YP6.
SOURCEiSearch...

Gene expression databases

BgeeiQ80YP6.
CleanExiMM_ZIK1.
GenevisibleiQ80YP6. MM.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 9 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Zik1, a transcriptional repressor that interacts with the heterogeneous nuclear ribonucleoprotein particle K protein."
    Denisenko O.N., O'Neill B., Ostrowski J., Van Seuningen I., Bomsztyk K.
    J. Biol. Chem. 271:27701-27706(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH HNRPK, FUNCTION.
    Tissue: B-cell.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Rathke gland.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiZIK1_MOUSE
AccessioniPrimary (citable) accession number: Q80YP6
Secondary accession number(s): P70405
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2003
Last modified: July 6, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.