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Protein

Breast carcinoma-amplified sequence 1 homolog

Gene

Bcas1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. protein homodimerization activity Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Breast carcinoma-amplified sequence 1 homolog
Alternative name(s):
Novel amplified in breast cancer 1 homolog
Gene namesi
Name:Bcas1
Synonyms:Nabc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1924210. Bcas1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: MGI
  2. extracellular vesicular exosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 633633Breast carcinoma-amplified sequence 1 homologPRO_0000235984Add
BLAST

Proteomic databases

MaxQBiQ80YN3.
PaxDbiQ80YN3.
PRIDEiQ80YN3.

PTM databases

PhosphoSiteiQ80YN3.

Expressioni

Gene expression databases

BgeeiQ80YN3.
CleanExiMM_BCAS1.
ExpressionAtlasiQ80YN3. baseline and differential.
GenevestigatoriQ80YN3.

Interactioni

Subunit structurei

Homodimer. May interact with DYNLL1 and DYNLL2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi218429. 2 interactions.
IntActiQ80YN3. 2 interactions.
MINTiMINT-4125396.

Structurei

3D structure databases

ProteinModelPortaliQ80YN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG40594.
GeneTreeiENSGT00390000003167.
HOGENOMiHOG000232037.
HOVERGENiHBG082347.
InParanoidiQ80YN3.
OMAiTQGAAKN.
TreeFamiTF335555.

Family and domain databases

InterProiIPR026115. NABC1.
[Graphical view]
PANTHERiPTHR15016. PTHR15016. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80YN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNQMSVPLR PGDQEHDPGA DTCKVTSDNE CVQNGNPVVL STRVIQHYEE
60 70 80 90 100
VDLGISSSKD NVATSSPKTM EAQAVGDASG KNLGKEAKTK APAARSHFFL
110 120 130 140 150
TLSRPVPGRP GDQGTDSSAA SGRFDVSPSA APENKDPSEH GALPVAAAPG
160 170 180 190 200
QAPDKTPGCP EAKQQTLPAT GPLAPSPPES QAEAPAQDKD FGFLNRFFKL
210 220 230 240 250
DKGRESAPVN SQPKEAKGSE DPEQATEAPA VPGNPHGVSA GEDIVDSEQR
260 270 280 290 300
GQDVDTLSYS VPGDPEVPGT TKEDPQVVDT TENSSSIMSF FKTLVSPNKT
310 320 330 340 350
ETKKDPEDTK ATKADSVCDG HAAGQKMSET QAKSKKKRLD SPRLGLSFRK
360 370 380 390 400
LFRHKDTENS PTTSANLKSD KANFTPQETR GKTKATKSCS PPPPPPEPTS
410 420 430 440 450
EGRDSGKEKA GPTSLPLGKL FWKKSVKEDT LSTGAEENAV CESPVETVRL
460 470 480 490 500
EEVESSLQTV DLSEETQPEP TDVKVKEESK PRKTPLMAFL RQMSVRSSEG
510 520 530 540 550
IPRSEESNVK DSSCQTSNSV EKTPSPPEPE PAGTAQKNKE TSSSKDKKSV
560 570 580 590 600
DKKSATENSK QKNGKQEVRE PAPCVQPPTV EANAMQTGDK TPKKSEKRRQ
610 620 630
SLGGFLKGLG PKRMSDAQVQ TDPVSIGPVG KSK
Length:633
Mass (Da):67,378
Last modified:July 26, 2011 - v3
Checksum:i53DBECB3581A245D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221G → E in AAO88011 (PubMed:14567997).Curated
Sequence conflicti164 – 1641Q → E in BAB25989 (PubMed:16141072).Curated
Sequence conflicti354 – 3541H → R in AAO88011 (PubMed:14567997).Curated
Sequence conflicti396 – 3961P → S in AAO88011 (PubMed:14567997).Curated
Sequence conflicti414 – 4141S → L in AAO88011 (PubMed:14567997).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY219233 mRNA. Translation: AAO88011.1.
AL928812, AL935134 Genomic DNA. Translation: CAM20736.1.
AL935134, AL928812 Genomic DNA. Translation: CAM20748.1.
AK008957 mRNA. Translation: BAB25989.1.
CCDSiCCDS17121.1.
RefSeqiNP_084091.2. NM_029815.2.
UniGeneiMm.240850.

Genome annotation databases

EnsembliENSMUST00000013667; ENSMUSP00000013667; ENSMUSG00000013523.
GeneIDi76960.
KEGGimmu:76960.
UCSCiuc008obx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY219233 mRNA. Translation: AAO88011.1.
AL928812, AL935134 Genomic DNA. Translation: CAM20736.1.
AL935134, AL928812 Genomic DNA. Translation: CAM20748.1.
AK008957 mRNA. Translation: BAB25989.1.
CCDSiCCDS17121.1.
RefSeqiNP_084091.2. NM_029815.2.
UniGeneiMm.240850.

3D structure databases

ProteinModelPortaliQ80YN3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218429. 2 interactions.
IntActiQ80YN3. 2 interactions.
MINTiMINT-4125396.

PTM databases

PhosphoSiteiQ80YN3.

Proteomic databases

MaxQBiQ80YN3.
PaxDbiQ80YN3.
PRIDEiQ80YN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000013667; ENSMUSP00000013667; ENSMUSG00000013523.
GeneIDi76960.
KEGGimmu:76960.
UCSCiuc008obx.2. mouse.

Organism-specific databases

CTDi8537.
MGIiMGI:1924210. Bcas1.

Phylogenomic databases

eggNOGiNOG40594.
GeneTreeiENSGT00390000003167.
HOGENOMiHOG000232037.
HOVERGENiHBG082347.
InParanoidiQ80YN3.
OMAiTQGAAKN.
TreeFamiTF335555.

Miscellaneous databases

NextBioi346183.
PROiQ80YN3.
SOURCEiSearch...

Gene expression databases

BgeeiQ80YN3.
CleanExiMM_BCAS1.
ExpressionAtlasiQ80YN3. baseline and differential.
GenevestigatoriQ80YN3.

Family and domain databases

InterProiIPR026115. NABC1.
[Graphical view]
PANTHERiPTHR15016. PTHR15016. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the novel amplified in breast cancer-1 (NABC1) gene product."
    Beardsley D.I., Kowbel D., Lataxes T.A., Mannino J.M., Xin H., Kim W.-J., Collins C., Brown K.D.
    Exp. Cell Res. 290:402-413(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 164-633.
    Strain: C57BL/6J.
    Tissue: Stomach.

Entry informationi

Entry nameiBCAS1_MOUSE
AccessioniPrimary (citable) accession number: Q80YN3
Secondary accession number(s): A2AVX2, Q9CVA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2006
Last sequence update: July 26, 2011
Last modified: February 3, 2015
This is version 74 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.