Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rho GTPase-activating protein 33

Gene

Arhgap33

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking (By similarity). Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport.By similarity

GO - Molecular functioni

  • GTPase activator activity Source: MGI
  • phosphatidylinositol binding Source: InterPro
  • protein kinase binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionGTPase activation
Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 33
Alternative name(s):
Rho-type GTPase-activating protein 33
Sorting nexin-26
Tc10/CDC42 GTPase-activating protein
Gene namesi
Name:Arhgap33
Synonyms:Snx26, Tcgap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2673998 Arhgap33

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567221 – 1305Rho GTPase-activating protein 33Add BLAST1305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineCombined sources1
Modified residuei594PhosphoserineCombined sources1
Modified residuei660PhosphoserineCombined sources1
Modified residuei749PhosphoserineCombined sources1
Modified residuei1188PhosphotyrosineCombined sources1
Modified residuei1263Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ80YF9
MaxQBiQ80YF9
PaxDbiQ80YF9
PRIDEiQ80YF9

PTM databases

iPTMnetiQ80YF9
PhosphoSitePlusiQ80YF9

Expressioni

Tissue specificityi

Highly expressed in brain and testis. Also expressed in white adipose tissue (WAT) and muscle at a low level.1 Publication

Inductioni

Dramatically induced during adipocyte differentiation.1 Publication

Gene expression databases

BgeeiENSMUSG00000036882
CleanExiMM_SNX26
ExpressionAtlasiQ80YF9 baseline and differential
GenevisibleiQ80YF9 MM

Interactioni

Subunit structurei

Specifically interacts with CDC42 and RHOQ/TC10 through its Rho-GAP domain. Interacts with NEK6 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231366, 4 interactors
IntActiQ80YF9, 1 interactor
STRINGi10090.ENSMUSP00000038412

Structurei

3D structure databases

ProteinModelPortaliQ80YF9
SMRiQ80YF9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 192PX; atypicalAdd BLAST110
Domaini210 – 272SH3PROSITE-ProRule annotationAdd BLAST63
Domaini339 – 534Rho-GAPPROSITE-ProRule annotationAdd BLAST196

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi150 – 153Poly-Pro4
Compositional biasi701 – 721Poly-SerAdd BLAST21
Compositional biasi909 – 913Poly-Pro5
Compositional biasi1158 – 1161Poly-Pro4
Compositional biasi1202 – 1207Poly-Ser6
Compositional biasi1284 – 1291Poly-Pro8

Domaini

The N-terminal PX domain interacts specifically with phosphatidylinositol 4,5-bisphosphate.

Sequence similaritiesi

Belongs to the PX domain-containing GAP family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG1449 Eukaryota
ENOG410Y1FN LUCA
GeneTreeiENSGT00910000143995
HOVERGENiHBG079688
InParanoidiQ80YF9
KOiK17933
OMAiDPLTFRC
OrthoDBiEOG091G02IN
PhylomeDBiQ80YF9
TreeFamiTF351451

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR035510 ARHGAP33
IPR036871 PX_dom_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR15729:SF11 PTHR15729:SF11, 1 hit
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q80YF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQAQKQSDP ILPWGASWAG RGQTLRARST DSLDGPGEGS VQPVPTTGGP
60 70 80 90 100
GTKGKPGKRL SAPRGPFPRL ADCAHFHYEN VDFGHIQLLL SPEREGPSLS
110 120 130 140 150
GENELVFGVQ VTCQGRSWPV LRSYDDFRSL DAHLHRCIFD RRFSCLPELP
160 170 180 190 200
PPPEGTRAAQ MLVPLLLQYL ETLSGLVDSN LNCGPVLTWM ELDNHGRRLL
210 220 230 240 250
LSEEASLNIP AVAAAHVVKR YTAQAPDELS FEVGDIVSVI DMPPTEDRSW
260 270 280 290 300
WRGKRGFQVG FFPSECVELF TERPGPGLKA DADSPLCGIP APQGISSLTS
310 320 330 340 350
AVPRPRGKLA GLLRTFMRSR PSRQRLRQRG ILRQRVFGCD LGEHLSNSGQ
360 370 380 390 400
DVPQVLRCCS EFIEAHGVVD GIYRLSGVSS NIQRLRHEFD SERIPELSGP
410 420 430 440 450
AFLQDIHSVS SLCKLYFREL PNPLLTYQLY GKFSEAMSVP GEEERLVRVH
460 470 480 490 500
DVIQQLPPPH YRTLEYLLRH LARMARHSAN TSMHARNLAI VWAPNLLRSM
510 520 530 540 550
ELESVGLGGA AAFREVRVQS VVVEFLLTHV EVLFSDTFTS AGLDPAGRCL
560 570 580 590 600
LPRPKSLAGS SPSTRLLTLE EAQARTQGRL GTPTEPTTPK TPASPVERRK
610 620 630 640 650
RERAEKQRKP GGSSWKTFFA LGRGPSIPRK KPLPWLGGSR APPQPSGSRP
660 670 680 690 700
DTVTLRSAKS EESLSSQASG AGLQRLHRLR RPHSSSDAFP VGPAPAGSCE
710 720 730 740 750
SLSSSSSSSS SSSSSSSSES SAGGLGPLSG SPSHRTSAWL DDGDDLDFSP
760 770 780 790 800
PRCLEGLRGL DFDPLTFRCS SPTPGDPAPP ASPAPPASAS AFPPRATPQA
810 820 830 840 850
LSPHGPTKPA SPTALDISEP LAVSVPPAVL ELLGAGGTPA SATPTPALSP
860 870 880 890 900
HLIPLLLRGA EAQLSDTCQQ EISSKLAPTR GAPGQQSPGG MDSPLLPPPL
910 920 930 940 950
PLLRPGGAPP PPPKNPARLM ALALAERAQQ VAEQQSQQEQ GGTPPAPHSP
960 970 980 990 1000
FRRSLSLEVG GEPVGTSGSG IHPPSLAHPG AWAPGPPPYL PRQQSDGSLV
1010 1020 1030 1040 1050
RSQRPLGTSR RSPRGPSQVS AHLRASGAYR DAPEMAAQSP CSVPSQGSNP
1060 1070 1080 1090 1100
SFFSTPRECL PPFLGVPKQG LYSLGPPSFP PSSPAPVWRN SLGAPSALDR
1110 1120 1130 1140 1150
GENLYYEIGV GEGTSYSGPS RSWSPFRSMP PDRHNASYGM LGQSPPLHRS
1160 1170 1180 1190 1200
PDFLLSYPPP PSCFPPEHLT HSVSQRLARR PTRPEPLYVN LALGPRGPSP
1210 1220 1230 1240 1250
ASSSSSSPPA HPRSRSDPGP PVPRLPQKQR APWGPHTPHR VPGPWGSPEP
1260 1270 1280 1290 1300
FLLYRPAPPS YGRGGEVRGS LYRNGGHRGE GAGPPPPYPT PSWSLHSEGQ

TRSYC
Length:1,305
Mass (Da):139,801
Last modified:June 1, 2003 - v1
Checksum:iAA8723BDF4A3CBB6
GO

Sequence cautioni

The sequence AAH61471 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti357R → C in AAH61471 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY217764 mRNA Translation: AAO89073.1
BC065086 mRNA Translation: AAH65086.1
BC065166 mRNA Translation: AAH65166.1
BC066047 mRNA Translation: AAH66047.1
BC061471 mRNA Translation: AAH61471.1 Different initiation.
CCDSiCCDS21095.1
RefSeqiNP_001276599.1, NM_001289670.1
NP_001276611.1, NM_001289682.1
NP_839983.1, NM_178252.3
XP_006539951.1, XM_006539888.3
UniGeneiMm.190704

Genome annotation databases

EnsembliENSMUST00000044338; ENSMUSP00000038412; ENSMUSG00000036882
ENSMUST00000207860; ENSMUSP00000146602; ENSMUSG00000036882
ENSMUST00000208538; ENSMUSP00000146767; ENSMUSG00000036882
GeneIDi233071
KEGGimmu:233071
UCSCiuc009geq.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRHG33_MOUSE
AccessioniPrimary (citable) accession number: Q80YF9
Secondary accession number(s): Q6P7W6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health