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Q80YF9

- RHG33_MOUSE

UniProt

Q80YF9 - RHG33_MOUSE

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Protein
Rho GTPase-activating protein 33
Gene
Arhgap33, Snx26, Tcgap
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking By similarity. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport.1 Publication

GO - Molecular functioni

  1. Rac GTPase activator activity Source: MGI
  2. Rho GTPase activator activity Source: MGI
  3. phosphatidylinositol binding Source: InterPro
  4. protein binding Source: MGI

GO - Biological processi

  1. positive regulation of Rac GTPase activity Source: GOC
  2. positive regulation of Rho GTPase activity Source: GOC
  3. protein transport Source: UniProtKB-KW
  4. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_210090. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 33
Alternative name(s):
Rho-type GTPase-activating protein 33
Sorting nexin-26
Tc10/CDC42 GTPase-activating protein
Gene namesi
Name:Arhgap33
Synonyms:Snx26, Tcgap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2673998. Arhgap33.

Subcellular locationi

Cell membrane
Note: Translocates to the plasma membrane in response to insulin in adipocytes.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13051305Rho GTPase-activating protein 33
PRO_0000056722Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei594 – 5941Phosphoserine1 Publication
Modified residuei660 – 6601Phosphoserine By similarity
Modified residuei1188 – 11881Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80YF9.
PRIDEiQ80YF9.

PTM databases

PhosphoSiteiQ80YF9.

Expressioni

Tissue specificityi

Highly expressed in brain and testis. Also expressed in white adipose tissue (WAT) and muscle at a low level.1 Publication

Inductioni

Dramatically induced during adipocyte differentiation.1 Publication

Gene expression databases

BgeeiQ80YF9.
CleanExiMM_SNX26.
GenevestigatoriQ80YF9.

Interactioni

Subunit structurei

Specifically interacts with CDC42 and RHOQ/TC10 through its Rho-GAP domain. Interacts with NEK6 By similarity.1 Publication

Protein-protein interaction databases

BioGridi231366. 4 interactions.
IntActiQ80YF9. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ80YF9.
SMRiQ80YF9. Positions 221-272, 335-535.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 192110PX; atypical
Add
BLAST
Domaini210 – 27263SH3
Add
BLAST
Domaini339 – 534196Rho-GAP
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi150 – 1534Poly-Pro
Compositional biasi701 – 72121Poly-Ser
Add
BLAST
Compositional biasi909 – 9135Poly-Pro
Compositional biasi1158 – 11614Poly-Pro
Compositional biasi1202 – 12076Poly-Ser
Compositional biasi1284 – 12918Poly-Pro

Domaini

The N-terminal PX domain interacts specifically with phosphatidylinositol 4,5-bisphosphate.

Sequence similaritiesi

Contains 1 Rho-GAP domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG311367.
GeneTreeiENSGT00720000108475.
HOVERGENiHBG079688.
InParanoidiQ80YF9.
KOiK17933.
OMAiCFPPDHL.
OrthoDBiEOG7WMCHV.
PhylomeDBiQ80YF9.
TreeFamiTF351451.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR001683. Phox.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80YF9-1 [UniParc]FASTAAdd to Basket

« Hide

MLQAQKQSDP ILPWGASWAG RGQTLRARST DSLDGPGEGS VQPVPTTGGP     50
GTKGKPGKRL SAPRGPFPRL ADCAHFHYEN VDFGHIQLLL SPEREGPSLS 100
GENELVFGVQ VTCQGRSWPV LRSYDDFRSL DAHLHRCIFD RRFSCLPELP 150
PPPEGTRAAQ MLVPLLLQYL ETLSGLVDSN LNCGPVLTWM ELDNHGRRLL 200
LSEEASLNIP AVAAAHVVKR YTAQAPDELS FEVGDIVSVI DMPPTEDRSW 250
WRGKRGFQVG FFPSECVELF TERPGPGLKA DADSPLCGIP APQGISSLTS 300
AVPRPRGKLA GLLRTFMRSR PSRQRLRQRG ILRQRVFGCD LGEHLSNSGQ 350
DVPQVLRCCS EFIEAHGVVD GIYRLSGVSS NIQRLRHEFD SERIPELSGP 400
AFLQDIHSVS SLCKLYFREL PNPLLTYQLY GKFSEAMSVP GEEERLVRVH 450
DVIQQLPPPH YRTLEYLLRH LARMARHSAN TSMHARNLAI VWAPNLLRSM 500
ELESVGLGGA AAFREVRVQS VVVEFLLTHV EVLFSDTFTS AGLDPAGRCL 550
LPRPKSLAGS SPSTRLLTLE EAQARTQGRL GTPTEPTTPK TPASPVERRK 600
RERAEKQRKP GGSSWKTFFA LGRGPSIPRK KPLPWLGGSR APPQPSGSRP 650
DTVTLRSAKS EESLSSQASG AGLQRLHRLR RPHSSSDAFP VGPAPAGSCE 700
SLSSSSSSSS SSSSSSSSES SAGGLGPLSG SPSHRTSAWL DDGDDLDFSP 750
PRCLEGLRGL DFDPLTFRCS SPTPGDPAPP ASPAPPASAS AFPPRATPQA 800
LSPHGPTKPA SPTALDISEP LAVSVPPAVL ELLGAGGTPA SATPTPALSP 850
HLIPLLLRGA EAQLSDTCQQ EISSKLAPTR GAPGQQSPGG MDSPLLPPPL 900
PLLRPGGAPP PPPKNPARLM ALALAERAQQ VAEQQSQQEQ GGTPPAPHSP 950
FRRSLSLEVG GEPVGTSGSG IHPPSLAHPG AWAPGPPPYL PRQQSDGSLV 1000
RSQRPLGTSR RSPRGPSQVS AHLRASGAYR DAPEMAAQSP CSVPSQGSNP 1050
SFFSTPRECL PPFLGVPKQG LYSLGPPSFP PSSPAPVWRN SLGAPSALDR 1100
GENLYYEIGV GEGTSYSGPS RSWSPFRSMP PDRHNASYGM LGQSPPLHRS 1150
PDFLLSYPPP PSCFPPEHLT HSVSQRLARR PTRPEPLYVN LALGPRGPSP 1200
ASSSSSSPPA HPRSRSDPGP PVPRLPQKQR APWGPHTPHR VPGPWGSPEP 1250
FLLYRPAPPS YGRGGEVRGS LYRNGGHRGE GAGPPPPYPT PSWSLHSEGQ 1300
TRSYC 1305
Length:1,305
Mass (Da):139,801
Last modified:June 1, 2003 - v1
Checksum:iAA8723BDF4A3CBB6
GO

Sequence cautioni

The sequence AAH61471.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti357 – 3571R → C in AAH61471. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY217764 mRNA. Translation: AAO89073.1.
BC065086 mRNA. Translation: AAH65086.1.
BC065166 mRNA. Translation: AAH65166.1.
BC066047 mRNA. Translation: AAH66047.1.
BC061471 mRNA. Translation: AAH61471.1. Different initiation.
CCDSiCCDS21095.1.
RefSeqiNP_001276599.1. NM_001289670.1.
NP_001276611.1. NM_001289682.1.
NP_839983.1. NM_178252.3.
XP_006539951.1. XM_006539888.1.
UniGeneiMm.190704.

Genome annotation databases

EnsembliENSMUST00000044338; ENSMUSP00000038412; ENSMUSG00000036882.
GeneIDi233071.
KEGGimmu:233071.
UCSCiuc009geq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY217764 mRNA. Translation: AAO89073.1 .
BC065086 mRNA. Translation: AAH65086.1 .
BC065166 mRNA. Translation: AAH65166.1 .
BC066047 mRNA. Translation: AAH66047.1 .
BC061471 mRNA. Translation: AAH61471.1 . Different initiation.
CCDSi CCDS21095.1.
RefSeqi NP_001276599.1. NM_001289670.1.
NP_001276611.1. NM_001289682.1.
NP_839983.1. NM_178252.3.
XP_006539951.1. XM_006539888.1.
UniGenei Mm.190704.

3D structure databases

ProteinModelPortali Q80YF9.
SMRi Q80YF9. Positions 221-272, 335-535.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 231366. 4 interactions.
IntActi Q80YF9. 1 interaction.

PTM databases

PhosphoSitei Q80YF9.

Proteomic databases

PaxDbi Q80YF9.
PRIDEi Q80YF9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044338 ; ENSMUSP00000038412 ; ENSMUSG00000036882 .
GeneIDi 233071.
KEGGi mmu:233071.
UCSCi uc009geq.1. mouse.

Organism-specific databases

CTDi 115703.
MGIi MGI:2673998. Arhgap33.

Phylogenomic databases

eggNOGi NOG311367.
GeneTreei ENSGT00720000108475.
HOVERGENi HBG079688.
InParanoidi Q80YF9.
KOi K17933.
OMAi CFPPDHL.
OrthoDBi EOG7WMCHV.
PhylomeDBi Q80YF9.
TreeFami TF351451.

Enzyme and pathway databases

Reactomei REACT_210090. Rho GTPase cycle.

Miscellaneous databases

NextBioi 381531.
PROi Q80YF9.
SOURCEi Search...

Gene expression databases

Bgeei Q80YF9.
CleanExi MM_SNX26.
Genevestigatori Q80YF9.

Family and domain databases

Gene3Di 1.10.555.10. 1 hit.
InterProi IPR001683. Phox.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
SMARTi SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEi PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport."
    Chiang S.-H., Hwang J., Legendre M., Zhang M., Kimura A., Saltiel A.R.
    EMBO J. 22:2679-2691(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INDUCTION, INTERACTION WITH CDC42 AND RHOQ, POSSIBLE FUNCTION.
    Tissue: Adipocyte.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 220-1305.
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-594, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  4. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1188, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiRHG33_MOUSE
AccessioniPrimary (citable) accession number: Q80YF9
Secondary accession number(s): Q6P7W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi