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Q80YE4 (LMTK1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase LMTK1

EC=2.7.11.1
Alternative name(s):
Apoptosis-associated tyrosine kinase
Short name=AATYK
Brain apoptosis-associated tyrosine kinase
Lemur tyrosine kinase 1
Gene names
Name:Aatk
Synonyms:Aatyk, Kiaa0641, Lmr1, Lmtk1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1365 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in neuronal differentiation By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Interacts with CDK5 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein. Cytoplasm. Cytoplasmperinuclear region By similarity. Cell projectiondendrite. Cell projectionaxon. Cell projectiongrowth cone. Note: Predominantly perinuclear By similarity. Ref.3

Isoform 2: Membrane. Note: Peripheral membrane protein. Ref.3

Isoform 3: Membrane; Single-pass type I membrane protein Ref.3.

Tissue specificity

Expressed in brain, and, to a lower extent, in kidney, heart, lung and skeletal muscle. In the brain, expressed in the olfactory bulb, cerebellum, striatum, hippocampal formation, thalamus, hypothalamus, and pontine nuclei (at protein level). Ref.1 Ref.2 Ref.3 Ref.8

Developmental stage

Isoform 2 is predominantly expressed in adult stage. Isoform 3 is up-regulated during postnatal development. Ref.3

Induction

Up-regulated during the apoptotic death of myeloid cells induced by cytokine withdrawal, such as IL3, and during G-CSF-induced terminal differentiation of myeloblasts to granulocytes. Ref.1 Ref.2

Post-translational modification

Autophosphorylated. Phosphorylated by CDK5 By similarity. Ref.3 Ref.8

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 1 protein kinase domain.

Sequence caution

The sequence BAC41437.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Cellular componentCell projection
Cytoplasm
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRab protein signal transduction

Inferred from genetic interaction PubMed 22573681. Source: MGI

apoptotic process

Inferred from direct assay Ref.1. Source: MGI

brain development

Inferred from mutant phenotype PubMed 22573681. Source: MGI

negative regulation of axon extension

Inferred from mutant phenotype PubMed 22573681. Source: MGI

neuron apoptotic process

Inferred from direct assay Ref.8. Source: MGI

peptidyl-tyrosine autophosphorylation

Inferred from direct assay Ref.8. Source: MGI

protein autophosphorylation

Inferred from direct assay Ref.3. Source: MGI

   Cellular_componentaxonal growth cone

Inferred from direct assay PubMed 22573681. Source: MGI

dendrite

Inferred from electronic annotation. Source: UniProtKB-SubCell

endoplasmic reticulum

Inferred from direct assay PubMed 18691334. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

perinuclear region of cytoplasm

Inferred from direct assay PubMed 22573681. Source: MGI

recycling endosome

Inferred from direct assay PubMed 18691334PubMed 22573681. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction PubMed 18691334. Source: MGI

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

protein tyrosine kinase activity

Inferred from direct assay Ref.8. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q80YE4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q80YE4-2)

Also known as: AATYK1A;

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
Isoform 3 (identifier: Q80YE4-3)

Also known as: AATYK1B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLIALLALAM
Isoform 4 (identifier: Q80YE4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-168: Missing.
     1354-1365: PAAGAGGRYTEA → MSVVGAEVEQRDTTNGDL
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13651365Serine/threonine-protein kinase LMTK1
PRO_0000248301

Regions

Transmembrane32 – 5221Helical; Potential
Domain126 – 396271Protein kinase
Nucleotide binding132 – 1409ATP By similarity
Compositional bias84 – 874Poly-Ala

Sites

Active site2541Proton acceptor By similarity
Binding site1571ATP By similarity

Natural variations

Alternative sequence1 – 168168Missing in isoform 4.
VSP_020229
Alternative sequence1 – 4848Missing in isoform 2.
VSP_020230
Alternative sequence11M → MLIALLALAM in isoform 3.
VSP_020231
Alternative sequence1354 – 136512PAAGA…RYTEA → MSVVGAEVEQRDTTNGDL in isoform 4.
VSP_020232

Experimental info

Mutagenesis2541D → V: Significant decrease in autophosphorylation. Ref.3 Ref.8
Sequence conflict2701V → D in BAC29541. Ref.6
Sequence conflict3451R → G in BAC29541. Ref.6
Sequence conflict3451R → G in BAE27789. Ref.6
Sequence conflict3451R → G in BAE33045. Ref.6
Sequence conflict3451R → G in AAH80846. Ref.7
Sequence conflict7731T → K in BAE33045. Ref.6
Sequence conflict9881G → S in BAE27789. Ref.6
Sequence conflict13171A → S in BAC29541. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 051A53505EDAF502

FASTA1,365144,607
        10         20         30         40         50         60 
MSSSFFNPSF AFSSHFDPDG APLSELSWSS SLAVVAVSFS GIFTVVILML ACLCCKKGGI 

        70         80         90        100        110        120 
GFKEFENAEG DEYVADFSEQ GSPAAAAQTG PDVYVLPLTE VSLPMAKQPG RSVQLLKSTD 

       130        140        150        160        170        180 
LGRHSLLYLK EIGHGWFGKV FLGEVHSGVS GTQVVVKELK VSASVQEQMQ FLEEAQPYRA 

       190        200        210        220        230        240 
LQHSNLLQCL AQCAEVTPYL LVMEFCPLGD LKGYLRSCRV TESMAPDPLT LQRMACEVAC 

       250        260        270        280        290        300 
GVLHLHRHNY VHSDLALRNC LLTADLTVKV GDYGLSHCKY REDYLVTADQ LWVPLRWIAP 

       310        320        330        340        350        360 
ELVDEVHGNL LVVDQTKSSN VWSLGVTIWE LFELGAQPYP QHSDRQVLAY AVREQQLKLP 

       370        380        390        400        410        420 
KPQLQLALSD RWYEVMQFCW LQPEQRPTAE EVHLLLSYLC AKGTTELEEE FERRWRSLRP 

       430        440        450        460        470        480 
GGSTGLGSGS AAPAAATAAS AELTAASSFP LLERFTSDGF HVDSDDVLTV TETSHGLNFE 

       490        500        510        520        530        540 
YKWEAGCGAE EYPPSGAASS PGSAARLQEL CAPDSSPPGV VPVLSAHSPS VGSEYFIRLE 

       550        560        570        580        590        600 
GAVPAAGHDP DCAGCAPSPQ AVTDQDNNSE ESTVASLAME PLLGHAPPTE GLWGPCDHHS 

       610        620        630        640        650        660 
HRRQGSPCPS RSPSPGTPML PAEDIDWGVA TFCPPFFDDP LGASPSGSPG AQPSPSDEEP 

       670        680        690        700        710        720 
EEGKVGLAAQ CGHWSSNMSA NNNSASRDPE SWDPGYVSSF TDSYRDDCSS LEQTPRASPE 

       730        740        750        760        770        780 
VGHLLSQEDP RDFLPGLVAV SPGQEPSRPF NLLPLCPAKG LAPAACLITS PWTEGAVGGA 

       790        800        810        820        830        840 
ENPIVEPKLA QEAEGSAEPQ LPLPSVPSPS CEGASLPSEE ASAPDILPAS PTPAAGSWVT 

       850        860        870        880        890        900 
VPEPAPTLES SGSSLGQEAP SSEDEDTTEA TSGVFTDLSS DGPHTEKSGI VPALRSLQKQ 

       910        920        930        940        950        960 
VGTPDSLDSL DIPSSASDGG CEVLSPSAAG PPGGQPRAVD SGYDTENYES PEFVLKEAHE 

       970        980        990       1000       1010       1020 
SSEPEAFGEP ASEGESPGPD PLLSVSLGGL SKKSPYRDSA YFSDLDAESE PTFGPEKHSG 

      1030       1040       1050       1060       1070       1080 
IQDSQKEQDL RSPPSPGHQS VQAFPRSAVS SEVLSPPQQS EEPLPEVPRP EPLGAQGPVG 

      1090       1100       1110       1120       1130       1140 
VQPVPGPSHS KCFPLTSVPL ISEGSGTEPQ GPSGQLSGRA QQGQMGNPST PRSPLCLALP 

      1150       1160       1170       1180       1190       1200 
GHPGALEGRP EEDEDTEDSE ESDEELRCYS VQEPSEDSEE EPPAVPVVVA ESQSARNLRS 

      1210       1220       1230       1240       1250       1260 
LLKMPSLLSE AFCDDLERKK KAVSFFDDVT VYLFDQESPT RETGEPFPST KESLPTFLEG 

      1270       1280       1290       1300       1310       1320 
GPSSPSATGL PLRAGHSPDS SAPEPGSRFE WDGDFPLVPG KAALVTELDP ADPVLAAPPT 

      1330       1340       1350       1360 
PAAPFSRFTV SPTPASRFSI THISDSDAQS VGGPAAGAGG RYTEA 

« Hide

Isoform 2 (AATYK1A) [UniParc].

Checksum: 578C9F925CCF9408
Show »

FASTA1,317139,551
Isoform 3 (AATYK1B) [UniParc].

Checksum: C1292D7311141628
Show »

FASTA1,374145,517
Isoform 4 [UniParc].

Checksum: 747436FFC8A3B4BF
Show »

FASTA1,203127,544

References

« Hide 'large scale' references
[1]"AATYK: a novel tyrosine kinase induced during growth arrest and apoptosis of myeloid cells."
Gaozza E., Baker S.J., Vora R.K., Reddy E.P.
Oncogene 15:3127-3135(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), INDUCTION, TISSUE SPECIFICITY.
Tissue: Bone marrow.
[2]"Characterization of an alternatively spliced AATYK mRNA: expression pattern of AATYK in the brain and neuronal cells."
Baker S.J., Sumerson R., Reddy C.D., Berrebi A.S., Flynn D.C., Reddy E.P.
Oncogene 20:1015-1021(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), INDUCTION, TISSUE SPECIFICITY.
Strain: 129/SvJ.
Tissue: Brain.
[3]"Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family."
Tomomura M., Morita N., Yoshikawa F., Konishi A., Akiyama H., Furuichi T., Kamiguchi H.
Neuroscience 148:510-521(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), ALTERNATIVE SPLICING (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, PHOSPHORYLATION, MUTAGENESIS OF ASP-254.
Tissue: Brain.
[4]"Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[5]Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H.
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[6]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
Strain: C57BL/6J and NOD.
Tissue: Bone.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6.
Tissue: Brain.
[8]"Characterization of the apoptosis-associated tyrosine kinase (AATYK) expressed in the CNS."
Tomomura M., Fernandez-Gonzales A., Yano R., Yuzaki M.
Oncogene 20:1022-1032(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, PHOSPHORYLATION, MUTAGENESIS OF ASP-254.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF011908 mRNA. Translation: AAB71837.1.
AY236858 mRNA. Translation: AAO92350.1.
AY236859 mRNA. Translation: AAO92351.1.
AB288871 mRNA. Translation: BAF64832.1.
AB093253 mRNA. Translation: BAC41437.2. Different initiation.
AK036705 mRNA. Translation: BAC29541.1.
AK147239 mRNA. Translation: BAE27789.1.
AK155100 mRNA. Translation: BAE33045.1.
BC080846 mRNA. Translation: AAH80846.1.
CCDSCCDS25725.1. [Q80YE4-2]
CCDS56826.1. [Q80YE4-3]
PIRT03748.
RefSeqNP_001185714.1. NM_001198785.1.
NP_001185716.1. NM_001198787.1.
NP_031403.2. NM_007377.4.
UniGeneMm.6826.

3D structure databases

ProteinModelPortalQ80YE4.
SMRQ80YE4. Positions 98-396.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ80YE4. 1 interaction.

PTM databases

PhosphoSiteQ80YE4.

Proteomic databases

PaxDbQ80YE4.
PRIDEQ80YE4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID11302.
KEGGmmu:11302.
UCSCuc007mrn.3. mouse. [Q80YE4-4]

Organism-specific databases

CTD9625.
MGIMGI:1197518. Aatk.
RougeSearch...

Phylogenomic databases

eggNOGCOG0515.
HOVERGENHBG080533.
InParanoidQ80YE4.
KOK17480.

Gene expression databases

CleanExMM_AATK.
GenevestigatorQ80YE4.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR00109. TYRKINASE.
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio278582.
PROQ80YE4.
SOURCESearch...

Entry information

Entry nameLMTK1_MOUSE
AccessionPrimary (citable) accession number: Q80YE4
Secondary accession number(s): A6BLY8 expand/collapse secondary AC list , O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot