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Protein

Serine/threonine-protein kinase LMTK1

Gene

Aatk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in neuronal differentiation.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei157ATPPROSITE-ProRule annotation1
Active sitei254Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi132 – 140ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: MGI
  • brain development Source: MGI
  • negative regulation of axon extension Source: MGI
  • neuron apoptotic process Source: MGI
  • peptidyl-tyrosine autophosphorylation Source: MGI
  • protein autophosphorylation Source: MGI
  • Rab protein signal transduction Source: MGI

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase LMTK1 (EC:2.7.11.1)
Alternative name(s):
Apoptosis-associated tyrosine kinase
Short name:
AATYK
Brain apoptosis-associated tyrosine kinase
Lemur tyrosine kinase 1
Gene namesi
Name:Aatk
Synonyms:Aatyk, Kiaa0641, Lmr1, Lmtk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1197518 Aatk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi254D → V: Significant decrease in autophosphorylation. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002483011 – 1365Serine/threonine-protein kinase LMTK1Add BLAST1365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei500PhosphoserineBy similarity1
Modified residuei1035PhosphoserineCombined sources1
Modified residuei1156PhosphothreonineCombined sources1
Modified residuei1159PhosphoserineCombined sources1
Modified residuei1162PhosphoserineCombined sources1
Modified residuei1175PhosphoserineCombined sources1
Modified residuei1178PhosphoserineCombined sources1
Modified residuei1253PhosphoserineBy similarity1

Post-translational modificationi

Autophosphorylated. Phosphorylated by CDK5 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80YE4
PeptideAtlasiQ80YE4
PRIDEiQ80YE4

PTM databases

iPTMnetiQ80YE4
PhosphoSitePlusiQ80YE4
SwissPalmiQ80YE4

Expressioni

Tissue specificityi

Expressed in brain, and, to a lower extent, in kidney, heart, lung and skeletal muscle. In the brain, expressed in the olfactory bulb, cerebellum, striatum, hippocampal formation, thalamus, hypothalamus, and pontine nuclei (at protein level).4 Publications

Developmental stagei

Isoform 2 is predominantly expressed in adult stage. Isoform 3 is up-regulated during postnatal development.1 Publication

Inductioni

Up-regulated during the apoptotic death of myeloid cells induced by cytokine withdrawal, such as IL3, and during G-CSF-induced terminal differentiation of myeloblasts to granulocytes.2 Publications

Gene expression databases

CleanExiMM_AATK

Interactioni

Subunit structurei

Interacts with CDK5.By similarity

Protein-protein interaction databases

IntActiQ80YE4, 1 interactor
STRINGi10090.ENSMUSP00000067181

Structurei

3D structure databases

ProteinModelPortaliQ80YE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 396Protein kinasePROSITE-ProRule annotationAdd BLAST271

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi84 – 87Poly-Ala4

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGQE Eukaryota
ENOG410XQFM LUCA
HOGENOMiHOG000049266
HOVERGENiHBG080533
InParanoidiQ80YE4
KOiK17480

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80YE4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSFFNPSF AFSSHFDPDG APLSELSWSS SLAVVAVSFS GIFTVVILML
60 70 80 90 100
ACLCCKKGGI GFKEFENAEG DEYVADFSEQ GSPAAAAQTG PDVYVLPLTE
110 120 130 140 150
VSLPMAKQPG RSVQLLKSTD LGRHSLLYLK EIGHGWFGKV FLGEVHSGVS
160 170 180 190 200
GTQVVVKELK VSASVQEQMQ FLEEAQPYRA LQHSNLLQCL AQCAEVTPYL
210 220 230 240 250
LVMEFCPLGD LKGYLRSCRV TESMAPDPLT LQRMACEVAC GVLHLHRHNY
260 270 280 290 300
VHSDLALRNC LLTADLTVKV GDYGLSHCKY REDYLVTADQ LWVPLRWIAP
310 320 330 340 350
ELVDEVHGNL LVVDQTKSSN VWSLGVTIWE LFELGAQPYP QHSDRQVLAY
360 370 380 390 400
AVREQQLKLP KPQLQLALSD RWYEVMQFCW LQPEQRPTAE EVHLLLSYLC
410 420 430 440 450
AKGTTELEEE FERRWRSLRP GGSTGLGSGS AAPAAATAAS AELTAASSFP
460 470 480 490 500
LLERFTSDGF HVDSDDVLTV TETSHGLNFE YKWEAGCGAE EYPPSGAASS
510 520 530 540 550
PGSAARLQEL CAPDSSPPGV VPVLSAHSPS VGSEYFIRLE GAVPAAGHDP
560 570 580 590 600
DCAGCAPSPQ AVTDQDNNSE ESTVASLAME PLLGHAPPTE GLWGPCDHHS
610 620 630 640 650
HRRQGSPCPS RSPSPGTPML PAEDIDWGVA TFCPPFFDDP LGASPSGSPG
660 670 680 690 700
AQPSPSDEEP EEGKVGLAAQ CGHWSSNMSA NNNSASRDPE SWDPGYVSSF
710 720 730 740 750
TDSYRDDCSS LEQTPRASPE VGHLLSQEDP RDFLPGLVAV SPGQEPSRPF
760 770 780 790 800
NLLPLCPAKG LAPAACLITS PWTEGAVGGA ENPIVEPKLA QEAEGSAEPQ
810 820 830 840 850
LPLPSVPSPS CEGASLPSEE ASAPDILPAS PTPAAGSWVT VPEPAPTLES
860 870 880 890 900
SGSSLGQEAP SSEDEDTTEA TSGVFTDLSS DGPHTEKSGI VPALRSLQKQ
910 920 930 940 950
VGTPDSLDSL DIPSSASDGG CEVLSPSAAG PPGGQPRAVD SGYDTENYES
960 970 980 990 1000
PEFVLKEAHE SSEPEAFGEP ASEGESPGPD PLLSVSLGGL SKKSPYRDSA
1010 1020 1030 1040 1050
YFSDLDAESE PTFGPEKHSG IQDSQKEQDL RSPPSPGHQS VQAFPRSAVS
1060 1070 1080 1090 1100
SEVLSPPQQS EEPLPEVPRP EPLGAQGPVG VQPVPGPSHS KCFPLTSVPL
1110 1120 1130 1140 1150
ISEGSGTEPQ GPSGQLSGRA QQGQMGNPST PRSPLCLALP GHPGALEGRP
1160 1170 1180 1190 1200
EEDEDTEDSE ESDEELRCYS VQEPSEDSEE EPPAVPVVVA ESQSARNLRS
1210 1220 1230 1240 1250
LLKMPSLLSE AFCDDLERKK KAVSFFDDVT VYLFDQESPT RETGEPFPST
1260 1270 1280 1290 1300
KESLPTFLEG GPSSPSATGL PLRAGHSPDS SAPEPGSRFE WDGDFPLVPG
1310 1320 1330 1340 1350
KAALVTELDP ADPVLAAPPT PAAPFSRFTV SPTPASRFSI THISDSDAQS
1360
VGGPAAGAGG RYTEA
Length:1,365
Mass (Da):144,607
Last modified:June 1, 2003 - v1
Checksum:i051A53505EDAF502
GO
Isoform 2 (identifier: Q80YE4-2) [UniParc]FASTAAdd to basket
Also known as: AATYK1A

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.

Show »
Length:1,317
Mass (Da):139,551
Checksum:i578C9F925CCF9408
GO
Isoform 3 (identifier: Q80YE4-3) [UniParc]FASTAAdd to basket
Also known as: AATYK1B

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLIALLALAM

Show »
Length:1,374
Mass (Da):145,517
Checksum:iC1292D7311141628
GO
Isoform 4 (identifier: Q80YE4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-168: Missing.
     1354-1365: PAAGAGGRYTEA → MSVVGAEVEQRDTTNGDL

Note: No experimental confirmation available.
Show »
Length:1,203
Mass (Da):127,544
Checksum:i747436FFC8A3B4BF
GO

Sequence cautioni

The sequence BAC41437 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti270V → D in BAC29541 (PubMed:16141072).Curated1
Sequence conflicti345R → G in BAC29541 (PubMed:16141072).Curated1
Sequence conflicti345R → G in BAE27789 (PubMed:16141072).Curated1
Sequence conflicti345R → G in BAE33045 (PubMed:16141072).Curated1
Sequence conflicti345R → G in AAH80846 (PubMed:15489334).Curated1
Sequence conflicti773T → K in BAE33045 (PubMed:16141072).Curated1
Sequence conflicti988G → S in BAE27789 (PubMed:16141072).Curated1
Sequence conflicti1317A → S in BAC29541 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0202291 – 168Missing in isoform 4. 1 PublicationAdd BLAST168
Alternative sequenceiVSP_0202301 – 48Missing in isoform 2. 4 PublicationsAdd BLAST48
Alternative sequenceiVSP_0202311M → MLIALLALAM in isoform 3. 2 Publications1
Alternative sequenceiVSP_0202321354 – 1365PAAGA…RYTEA → MSVVGAEVEQRDTTNGDL in isoform 4. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF011908 mRNA Translation: AAB71837.1
AY236858 mRNA Translation: AAO92350.1
AY236859 mRNA Translation: AAO92351.1
AB288871 mRNA Translation: BAF64832.1
AB093253 mRNA Translation: BAC41437.2 Different initiation.
AK036705 mRNA Translation: BAC29541.1
AK147239 mRNA Translation: BAE27789.1
AK155100 mRNA Translation: BAE33045.1
BC080846 mRNA Translation: AAH80846.1
CCDSiCCDS25725.1 [Q80YE4-2]
CCDS56826.1 [Q80YE4-3]
PIRiT03748
RefSeqiNP_001185714.1, NM_001198785.1
NP_001185716.1, NM_001198787.1
NP_031403.2, NM_007377.4
UniGeneiMm.6826

Genome annotation databases

GeneIDi11302
KEGGimmu:11302
UCSCiuc007mrn.3 mouse [Q80YE4-4]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLMTK1_MOUSE
AccessioniPrimary (citable) accession number: Q80YE4
Secondary accession number(s): A6BLY8
, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health