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Protein

Tumor protein p53-inducible nuclear protein 1

Gene

Trp53inp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Antioxidant

Keywords - Biological processi

Apoptosis, Autophagy, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein p53-inducible nuclear protein 1
Alternative name(s):
Stress-induced protein
Thymus-expressed acidic protein
Short name:
TEAP
p53-dependent damage-inducible nuclear protein 1
Short name:
p53DINP1
Gene namesi
Name:Trp53inp1
Synonyms:Sip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi631423. Trp53inp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Tumor protein p53-inducible nuclear protein 1PRO_0000072408Add
BLAST

Proteomic databases

PaxDbiQ80YE2.

Expressioni

Tissue specificityi

Specifically expressed by acinar cells of chronic pancreatitis tissue.1 Publication

Inductioni

In chronic pancreatitis tissue, expression is suppressed by camostat mesilate, a serine protease inhibitor, and by Saiko-keishi-to, a herbal medicine.1 Publication

Interactioni

Subunit structurei

Interacts with p53/TP53 and HIPK2. Interacts with PRKCG, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010591.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi25 – 3713LIRAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi46 – 527Poly-Glu

Domaini

The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.By similarity

Phylogenomic databases

eggNOGiENOG410IJ9V. Eukaryota.
ENOG4111S9D. LUCA.
HOGENOMiHOG000010288.
HOVERGENiHBG055647.
InParanoidiQ80YE2.
KOiK15310.
PhylomeDBiQ80YE2.

Family and domain databases

InterProiIPR029431. TP53INP.
IPR029556. TP53INP1.
[Graphical view]
PANTHERiPTHR31671. PTHR31671. 1 hit.
PTHR31671:SF0. PTHR31671:SF0. 1 hit.
PfamiPF14839. DOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80YE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQRLNKMFV GEVTTSSSHE PEFSEKEDDE WILVDFIDTC TGFSAEEEEE
60 70 80 90 100
DEDIGEESSA EHTSVFSCLP TSLECLADTS DSCFLQFESC PMEESWFITP
110 120 130 140 150
PPCFTAGGLT TIKVETSPME NLLIEHPSMS VYAVHNSCPG LSEASCGNDD
160 170 180 190 200
YNSSGPRMEA QSELGTHIHC CVAALAAQAT FLEQPKSFRP SQWIKGHSER
210 220 230
QSLNRNGLRR QNLTRDCHTR QMKHRCWAVH QPCPRQYNY
Length:239
Mass (Da):26,976
Last modified:June 1, 2003 - v1
Checksum:i593502B9798B55B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB107917 mRNA. Translation: BAC75468.1.
RefSeqiNP_851598.1. NM_181084.2.
UniGeneiRn.48267.

Genome annotation databases

GeneIDi297822.
KEGGirno:297822.
UCSCiRGD:631423. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB107917 mRNA. Translation: BAC75468.1.
RefSeqiNP_851598.1. NM_181084.2.
UniGeneiRn.48267.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010591.

Proteomic databases

PaxDbiQ80YE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi297822.
KEGGirno:297822.
UCSCiRGD:631423. rat.

Organism-specific databases

CTDi94241.
RGDi631423. Trp53inp1.

Phylogenomic databases

eggNOGiENOG410IJ9V. Eukaryota.
ENOG4111S9D. LUCA.
HOGENOMiHOG000010288.
HOVERGENiHBG055647.
InParanoidiQ80YE2.
KOiK15310.
PhylomeDBiQ80YE2.

Miscellaneous databases

NextBioi642714.
PROiQ80YE2.

Family and domain databases

InterProiIPR029431. TP53INP.
IPR029556. TP53INP1.
[Graphical view]
PANTHERiPTHR31671. PTHR31671. 1 hit.
PTHR31671:SF0. PTHR31671:SF0. 1 hit.
PfamiPF14839. DOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of rat SIP protein."
    Wakizono T., Suzuki G., Nibuya M., Nomura S.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Tumor protein p53-induced nuclear protein 1 (TP53INP1) in spontaneous chronic pancreatitis in the WBN/Kob rat: drug effects on its expression in the pancreas."
    Jiang P.-H., Motoo Y., Iovanna J.L., Pebusque M.-J., Xie M.-J., Okada G., Sawabu N.
    J. Pancreas 5:205-216(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiT53I1_RAT
AccessioniPrimary (citable) accession number: Q80YE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2003
Last modified: May 11, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.