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Protein

Secretion-regulating guanine nucleotide exchange factor

Gene

Sergef

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Secretion-regulating guanine nucleotide exchange factor
Alternative name(s):
Deafness locus-associated putative guanine nucleotide exchange factor
Short name:
DelGEF
Guanine nucleotide exchange factor-related protein
Gene namesi
Name:Sergef
Synonyms:Delgef, Gnefr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1351630. Sergef.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 464464Secretion-regulating guanine nucleotide exchange factorPRO_0000206650Add
BLAST

Proteomic databases

EPDiQ80YD6.
MaxQBiQ80YD6.
PaxDbiQ80YD6.
PRIDEiQ80YD6.

Expressioni

Gene expression databases

BgeeiQ80YD6.
ExpressionAtlasiQ80YD6. baseline and differential.
GenevisibleiQ80YD6. MM.

Interactioni

Subunit structurei

Interacts with SEC5. The interaction occurs only in the presence of magnesium or manganese and is stimulated by dCTP or GTP (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033127.

Structurei

3D structure databases

ProteinModelPortaliQ80YD6.
SMRiQ80YD6. Positions 5-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati15 – 6753RCC1 1Add
BLAST
Repeati68 – 11952RCC1 2Add
BLAST
Repeati120 – 17152RCC1 3Add
BLAST
Repeati172 – 23059RCC1 4Add
BLAST
Repeati231 – 28353RCC1 5Add
BLAST
Repeati284 – 35168RCC1 6Add
BLAST
Repeati352 – 40251RCC1 7Add
BLAST

Sequence similaritiesi

Contains 7 RCC1 repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1426. Eukaryota.
COG5184. LUCA.
GeneTreeiENSGT00840000129719.
HOGENOMiHOG000154414.
HOVERGENiHBG051746.
InParanoidiQ80YD6.
KOiK15421.
OMAiSGMVFQW.
OrthoDBiEOG7DJSMT.
PhylomeDBiQ80YD6.
TreeFamiTF330842.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR027048. DelGEF.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PANTHERiPTHR22870:SF208. PTHR22870:SF208. 2 hits.
PfamiPF00415. RCC1. 5 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SUPFAMiSSF50985. SSF50985. 1 hit.
PROSITEiPS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80YD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARESCASET VSAAAVLFAW GANSYGQLGL GHKEDVFLPQ QLSDFCQAGC
60 70 80 90 100
IKSVTGGGGH SAVVTDGGDL FVCGLNKDGQ LGLGHTEEVL RFTICKPLRG
110 120 130 140 150
CPIRQVACGW DFTIMLTEKG QVLSCGSNAF GQLGVPHGPR KCVVPQAIEC
160 170 180 190 200
LREKVVCVAA GLRHALATTA TGSVFQWGTG LASSGRRLCP GQNLPLFLTA
210 220 230 240 250
KEPSRVTGLE NSTAVCAVAG SDHSASLTDT GELYVWGRNK HGQLASRAVF
260 270 280 290 300
LPLPQRIEAH YFQDEKVTAV WSGWTHLVAK TETGKVFTWG RADYGQLGRR
310 320 330 340 350
LEPPEAQKPV EQDSSLAFQG PQNSVPSPLH CLTGATEISC GSEHNLAVIR
360 370 380 390 400
DKCCSWGWNE HGMCGDGTES NVWTPTPVQA LPPSPSRLLL VGCGAGHSLA
410 420 430 440 450
VCQLPAHPVP CQDLKVTCPL PDDTENTESQ GAVDRDRLEG ETISDLNPDR
460
TRNGGGGCES ETVQ
Length:464
Mass (Da):49,226
Last modified:October 31, 2003 - v2
Checksum:i2090CEEA0C914046
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti448 – 4481P → Q in BAE26671 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243952 mRNA. Translation: CAB60840.1.
AK145819 mRNA. Translation: BAE26671.1.
AK147848 mRNA. Translation: BAE28179.1.
BC049603 mRNA. Translation: AAH49603.2.
BC119533 mRNA. Translation: AAI19534.1.
BC119534 mRNA. Translation: AAI19535.1.
CCDSiCCDS21279.1.
RefSeqiNP_038817.1. NM_013789.2.
UniGeneiMm.76659.

Genome annotation databases

EnsembliENSMUST00000033127; ENSMUSP00000033127; ENSMUSG00000030839.
GeneIDi27414.
KEGGimmu:27414.
UCSCiuc009gyp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243952 mRNA. Translation: CAB60840.1.
AK145819 mRNA. Translation: BAE26671.1.
AK147848 mRNA. Translation: BAE28179.1.
BC049603 mRNA. Translation: AAH49603.2.
BC119533 mRNA. Translation: AAI19534.1.
BC119534 mRNA. Translation: AAI19535.1.
CCDSiCCDS21279.1.
RefSeqiNP_038817.1. NM_013789.2.
UniGeneiMm.76659.

3D structure databases

ProteinModelPortaliQ80YD6.
SMRiQ80YD6. Positions 5-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033127.

Proteomic databases

EPDiQ80YD6.
MaxQBiQ80YD6.
PaxDbiQ80YD6.
PRIDEiQ80YD6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033127; ENSMUSP00000033127; ENSMUSG00000030839.
GeneIDi27414.
KEGGimmu:27414.
UCSCiuc009gyp.2. mouse.

Organism-specific databases

CTDi26297.
MGIiMGI:1351630. Sergef.

Phylogenomic databases

eggNOGiKOG1426. Eukaryota.
COG5184. LUCA.
GeneTreeiENSGT00840000129719.
HOGENOMiHOG000154414.
HOVERGENiHBG051746.
InParanoidiQ80YD6.
KOiK15421.
OMAiSGMVFQW.
OrthoDBiEOG7DJSMT.
PhylomeDBiQ80YD6.
TreeFamiTF330842.

Miscellaneous databases

PROiQ80YD6.
SOURCEiSearch...

Gene expression databases

BgeeiQ80YD6.
ExpressionAtlasiQ80YD6. baseline and differential.
GenevisibleiQ80YD6. MM.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR027048. DelGEF.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PANTHERiPTHR22870:SF208. PTHR22870:SF208. 2 hits.
PfamiPF00415. RCC1. 5 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SUPFAMiSSF50985. SSF50985. 1 hit.
PROSITEiPS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DelGEF, an RCC1-related protein encoded by a gene on chromosome 11p14 critical for two forms of hereditary deafness."
    Uhlmann J., Wiemann S., Ponstingl H.
    FEBS Lett. 460:153-160(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Melanocyte and Placenta.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiSRGEF_MOUSE
AccessioniPrimary (citable) accession number: Q80YD6
Secondary accession number(s): Q0VDT0
, Q3UGM8, Q3UKY0, Q9QXB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: June 8, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.