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Protein

Secretion-regulating guanine nucleotide exchange factor

Gene

Sergef

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Secretion-regulating guanine nucleotide exchange factor
Alternative name(s):
Deafness locus-associated putative guanine nucleotide exchange factor
Short name:
DelGEF
Guanine nucleotide exchange factor-related protein
Gene namesi
Name:Sergef
Synonyms:Delgef, Gnefr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1351630. Sergef.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002066501 – 464Secretion-regulating guanine nucleotide exchange factorAdd BLAST464

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei429PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80YD6.
MaxQBiQ80YD6.
PaxDbiQ80YD6.
PRIDEiQ80YD6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030839.
ExpressionAtlasiQ80YD6. baseline and differential.
GenevisibleiQ80YD6. MM.

Interactioni

Subunit structurei

Interacts with SEC5. The interaction occurs only in the presence of magnesium or manganese and is stimulated by dCTP or GTP (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033127.

Structurei

3D structure databases

ProteinModelPortaliQ80YD6.
SMRiQ80YD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati15 – 67RCC1 1Add BLAST53
Repeati68 – 119RCC1 2Add BLAST52
Repeati120 – 171RCC1 3Add BLAST52
Repeati172 – 230RCC1 4Add BLAST59
Repeati231 – 283RCC1 5Add BLAST53
Repeati284 – 351RCC1 6Add BLAST68
Repeati352 – 402RCC1 7Add BLAST51

Sequence similaritiesi

Contains 7 RCC1 repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1426. Eukaryota.
COG5184. LUCA.
GeneTreeiENSGT00860000133726.
HOGENOMiHOG000154414.
HOVERGENiHBG051746.
InParanoidiQ80YD6.
KOiK15421.
OMAiMDKERNW.
OrthoDBiEOG091G0BU1.
PhylomeDBiQ80YD6.
TreeFamiTF330842.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR027048. DelGEF.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PANTHERiPTHR22870:SF208. PTHR22870:SF208. 2 hits.
PfamiPF00415. RCC1. 5 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SUPFAMiSSF50985. SSF50985. 1 hit.
PROSITEiPS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80YD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARESCASET VSAAAVLFAW GANSYGQLGL GHKEDVFLPQ QLSDFCQAGC
60 70 80 90 100
IKSVTGGGGH SAVVTDGGDL FVCGLNKDGQ LGLGHTEEVL RFTICKPLRG
110 120 130 140 150
CPIRQVACGW DFTIMLTEKG QVLSCGSNAF GQLGVPHGPR KCVVPQAIEC
160 170 180 190 200
LREKVVCVAA GLRHALATTA TGSVFQWGTG LASSGRRLCP GQNLPLFLTA
210 220 230 240 250
KEPSRVTGLE NSTAVCAVAG SDHSASLTDT GELYVWGRNK HGQLASRAVF
260 270 280 290 300
LPLPQRIEAH YFQDEKVTAV WSGWTHLVAK TETGKVFTWG RADYGQLGRR
310 320 330 340 350
LEPPEAQKPV EQDSSLAFQG PQNSVPSPLH CLTGATEISC GSEHNLAVIR
360 370 380 390 400
DKCCSWGWNE HGMCGDGTES NVWTPTPVQA LPPSPSRLLL VGCGAGHSLA
410 420 430 440 450
VCQLPAHPVP CQDLKVTCPL PDDTENTESQ GAVDRDRLEG ETISDLNPDR
460
TRNGGGGCES ETVQ
Length:464
Mass (Da):49,226
Last modified:October 31, 2003 - v2
Checksum:i2090CEEA0C914046
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti448P → Q in BAE26671 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243952 mRNA. Translation: CAB60840.1.
AK145819 mRNA. Translation: BAE26671.1.
AK147848 mRNA. Translation: BAE28179.1.
BC049603 mRNA. Translation: AAH49603.2.
BC119533 mRNA. Translation: AAI19534.1.
BC119534 mRNA. Translation: AAI19535.1.
CCDSiCCDS21279.1.
RefSeqiNP_038817.1. NM_013789.2.
UniGeneiMm.76659.

Genome annotation databases

EnsembliENSMUST00000033127; ENSMUSP00000033127; ENSMUSG00000030839.
GeneIDi27414.
KEGGimmu:27414.
UCSCiuc009gyp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243952 mRNA. Translation: CAB60840.1.
AK145819 mRNA. Translation: BAE26671.1.
AK147848 mRNA. Translation: BAE28179.1.
BC049603 mRNA. Translation: AAH49603.2.
BC119533 mRNA. Translation: AAI19534.1.
BC119534 mRNA. Translation: AAI19535.1.
CCDSiCCDS21279.1.
RefSeqiNP_038817.1. NM_013789.2.
UniGeneiMm.76659.

3D structure databases

ProteinModelPortaliQ80YD6.
SMRiQ80YD6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033127.

Proteomic databases

EPDiQ80YD6.
MaxQBiQ80YD6.
PaxDbiQ80YD6.
PRIDEiQ80YD6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033127; ENSMUSP00000033127; ENSMUSG00000030839.
GeneIDi27414.
KEGGimmu:27414.
UCSCiuc009gyp.2. mouse.

Organism-specific databases

CTDi26297.
MGIiMGI:1351630. Sergef.

Phylogenomic databases

eggNOGiKOG1426. Eukaryota.
COG5184. LUCA.
GeneTreeiENSGT00860000133726.
HOGENOMiHOG000154414.
HOVERGENiHBG051746.
InParanoidiQ80YD6.
KOiK15421.
OMAiMDKERNW.
OrthoDBiEOG091G0BU1.
PhylomeDBiQ80YD6.
TreeFamiTF330842.

Miscellaneous databases

PROiQ80YD6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030839.
ExpressionAtlasiQ80YD6. baseline and differential.
GenevisibleiQ80YD6. MM.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR027048. DelGEF.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PANTHERiPTHR22870:SF208. PTHR22870:SF208. 2 hits.
PfamiPF00415. RCC1. 5 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SUPFAMiSSF50985. SSF50985. 1 hit.
PROSITEiPS00626. RCC1_2. 2 hits.
PS50012. RCC1_3. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRGEF_MOUSE
AccessioniPrimary (citable) accession number: Q80YD6
Secondary accession number(s): Q0VDT0
, Q3UGM8, Q3UKY0, Q9QXB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: November 30, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.