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Protein

ATP-dependent RNA helicase SUPV3L1, mitochondrial

Gene

Supv3l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi207 – 2148ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.4.13. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase SUPV3L1, mitochondrial (EC:3.6.4.13)
Alternative name(s):
Suppressor of var1 3-like protein 1
Short name:
SUV3-like protein 1
Gene namesi
Name:Supv3l1
Synonyms:Suv3l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:2441711. Supv3l1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid, Nucleus

Pathology & Biotechi

Disruption phenotypei

Die in utero before midgestation. Show elevated sister chromatid exchange (SCE).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4040MitochondrionSequence analysisAdd
BLAST
Chaini41 – 779739ATP-dependent RNA helicase SUPV3L1, mitochondrialPRO_0000310546Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei99 – 991N6-acetyllysineBy similarity
Modified residuei725 – 7251PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ80YD1.
MaxQBiQ80YD1.
PaxDbiQ80YD1.
PeptideAtlasiQ80YD1.
PRIDEiQ80YD1.

PTM databases

iPTMnetiQ80YD1.
PhosphoSiteiQ80YD1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020079.
CleanExiMM_SUPV3L1.
ExpressionAtlasiQ80YD1. baseline and differential.
GenevisibleiQ80YD1. MM.

Interactioni

Subunit structurei

Homodimer; in free form. Component of the mitochondrial degradosome (mtEXO) complex which is a heteropentamer containing 2 copies of SUPV3L1 and 3 copies of PNPT1. Interacts with LAMTOR5/HBXIP, WRN and BLM (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020273.

Structurei

3D structure databases

ProteinModelPortaliQ80YD1.
SMRiQ80YD1. Positions 59-688.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini194 – 334141Helicase ATP-bindingAdd
BLAST
Domaini353 – 521169Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni650 – 779130Interaction with LAMTOR5, important for protein stabilityBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the helicase family.Curated
Contains 1 helicase ATP-binding domain.Curated
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0953. Eukaryota.
ENOG410XSEY. LUCA.
GeneTreeiENSGT00390000003100.
HOGENOMiHOG000175283.
HOVERGENiHBG108522.
InParanoidiQ80YD1.
KOiK17675.
OMAiADMIQHI.
OrthoDBiEOG091G02NO.
PhylomeDBiQ80YD1.
TreeFamiTF106432.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR022192. SUV3_C.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF12513. SUV3_C. 1 hit.
[Graphical view]
SMARTiSM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80YD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPRCTLLW ARLPAGRGAG PRAAPCSALR ALVGSFPGAS GRVPCLAASS
60 70 80 90 100
SASGGSKAPN TSLFVPLTVK PQGPSADGDV GAELTRPLDK NEVKKILDKF
110 120 130 140 150
YKRQEIQKLS ADYGLDARLF HQAFISFRNY IMQSHSLDVD IHIVLNDICF
160 170 180 190 200
SAAHVDDLFP FFLRHAKQIF PVLECKDDLR KISDLRIPPN WYPEARARQR
210 220 230 240 250
KIIFHSGPTN SGKTYHAIQR YLSATSGVYC GPLKLLAHEI FEKSNAAGVP
260 270 280 290 300
CDLVTGEERL TVEPEGKQAT HVSCTVEMCN VATPYEVAVI DEIQMIRDPA
310 320 330 340 350
RGWAWTRALL GLCAEEVHLC GESAAINLVS ELLYTTGEEV EVQKYERLTP
360 370 380 390 400
ISVLDHALES LDNLQPGDCI VCFSKNDIYS VSRQIEIRGL ESAVIYGSLP
410 420 430 440 450
PGTKLAQARK FNDPNDPCKI LVATDAIGMG LNLSIRRIIF YSLIKPSINE
460 470 480 490 500
KGEKELEPIT TSQALQIAGR AGRFSSHFKE GQVTTMHRDD LALLKDILNR
510 520 530 540 550
PVDPIQAAGL HPTAEQIEMF AYHLPETTLS NLIDIFVDFA QVDGQYFVCN
560 570 580 590 600
MDDFKFSAEL IQHIPLSLRV RYVFCTAPIN KKQPFVCSSL LQFARQYSRN
610 620 630 640 650
EPLTFAWLRR YIKWPLLPPK NIKDLMDLEA VHDVFDLYLW LSYRFIDMFP
660 670 680 690 700
DSSLVRSLQK ELDAIIQEGV HNITKLIKIS ESRKLLNLES LPSGDQSRLS
710 720 730 740 750
GASKSPARRT RGTKSAGNKA TEPLSPSDKE LPLASRLVQQ GLLTADMLRQ
760 770
LQKEWLTQQP EHSREKVGTR RKKKDPDSD
Length:779
Mass (Da):87,005
Last modified:June 1, 2003 - v1
Checksum:i877F2B611FEEE1A9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti109 – 1091L → R in CAI92124 (Ref. 1) Curated
Sequence conflicti157 – 1571D → G in CAI92124 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ968954 mRNA. Translation: CAI92124.1.
BC049796 mRNA. Translation: AAH49796.1.
CCDSiCCDS35920.1.
RefSeqiNP_852088.1. NM_181423.2.
UniGeneiMm.235898.

Genome annotation databases

EnsembliENSMUST00000020273; ENSMUSP00000020273; ENSMUSG00000020079.
GeneIDi338359.
KEGGimmu:338359.
UCSCiuc007fhd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ968954 mRNA. Translation: CAI92124.1.
BC049796 mRNA. Translation: AAH49796.1.
CCDSiCCDS35920.1.
RefSeqiNP_852088.1. NM_181423.2.
UniGeneiMm.235898.

3D structure databases

ProteinModelPortaliQ80YD1.
SMRiQ80YD1. Positions 59-688.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020273.

PTM databases

iPTMnetiQ80YD1.
PhosphoSiteiQ80YD1.

Proteomic databases

EPDiQ80YD1.
MaxQBiQ80YD1.
PaxDbiQ80YD1.
PeptideAtlasiQ80YD1.
PRIDEiQ80YD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020273; ENSMUSP00000020273; ENSMUSG00000020079.
GeneIDi338359.
KEGGimmu:338359.
UCSCiuc007fhd.1. mouse.

Organism-specific databases

CTDi6832.
MGIiMGI:2441711. Supv3l1.

Phylogenomic databases

eggNOGiKOG0953. Eukaryota.
ENOG410XSEY. LUCA.
GeneTreeiENSGT00390000003100.
HOGENOMiHOG000175283.
HOVERGENiHBG108522.
InParanoidiQ80YD1.
KOiK17675.
OMAiADMIQHI.
OrthoDBiEOG091G02NO.
PhylomeDBiQ80YD1.
TreeFamiTF106432.

Enzyme and pathway databases

BRENDAi3.6.4.13. 3474.

Miscellaneous databases

PROiQ80YD1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020079.
CleanExiMM_SUPV3L1.
ExpressionAtlasiQ80YD1. baseline and differential.
GenevisibleiQ80YD1. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR022192. SUV3_C.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF12513. SUV3_C. 1 hit.
[Graphical view]
SMARTiSM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUV3_MOUSE
AccessioniPrimary (citable) accession number: Q80YD1
Secondary accession number(s): Q50HX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.