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Q80YC5

- FA12_MOUSE

UniProt

Q80YC5 - FA12_MOUSE

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Protein
Coagulation factor XII
Gene
F12
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa By similarity.

Catalytic activityi

Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei394 – 3941Charge relay system By similarity
Active sitei443 – 4431Charge relay system By similarity
Active sitei545 – 5451Charge relay system By similarity

GO - Molecular functioni

  1. peptidase activity Source: MGI
  2. serine-type aminopeptidase activity Source: Ensembl
  3. serine-type endopeptidase activity Source: Ensembl

GO - Biological processi

  1. Factor XII activation Source: Ensembl
  2. blood coagulation Source: MGI
  3. fibrinolysis Source: UniProtKB-KW
  4. positive regulation of blood coagulation Source: Ensembl
  5. positive regulation of fibrinolysis Source: Ensembl
  6. positive regulation of plasminogen activation Source: Ensembl
  7. protein autoprocessing Source: Ensembl
  8. regulation of blood coagulation Source: MGI
  9. response to misfolded protein Source: Ensembl
  10. zymogen activation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Blood coagulation, Fibrinolysis, Hemostasis

Protein family/group databases

MEROPSiS01.211.

Names & Taxonomyi

Protein namesi
Recommended name:
Coagulation factor XII (EC:3.4.21.38)
Alternative name(s):
Hageman factor
Short name:
HAF
Cleaved into the following 2 chains:
Gene namesi
Name:F12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1891012. F12.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 By similarity
Add
BLAST
Chaini20 – 354335Coagulation factor XIIa heavy chain
PRO_0000394555Add
BLAST
Chaini355 – 597243Coagulation factor XIIa light chain
PRO_0000394556Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 73 By similarity
Disulfide bondi61 ↔ 88 By similarity
Disulfide bondi98 ↔ 110 By similarity
Disulfide bondi104 ↔ 119 By similarity
Glycosylationi109 – 1091O-linked (Fuc) By similarity
Disulfide bondi121 ↔ 130 By similarity
Disulfide bondi135 ↔ 163 By similarity
Disulfide bondi161 ↔ 170 By similarity
Disulfide bondi178 ↔ 189 By similarity
Disulfide bondi183 ↔ 198 By similarity
Disulfide bondi200 ↔ 209 By similarity
Disulfide bondi217 ↔ 295 By similarity
Disulfide bondi238 ↔ 277 By similarity
Glycosylationi249 – 2491N-linked (GlcNAc...) By similarity
Disulfide bondi266 ↔ 290 By similarity
Glycosylationi299 – 2991O-linked (GalNAc...) By similarity
Glycosylationi308 – 3081O-linked (GalNAc...) By similarity
Glycosylationi327 – 3271O-linked (GalNAc...) By similarity
Disulfide bondi341 ↔ 468 By similarity
Disulfide bondi379 ↔ 395 By similarity
Disulfide bondi387 ↔ 457 By similarity
Glycosylationi415 – 4151N-linked (GlcNAc...) By similarity
Disulfide bondi418 ↔ 421 By similarity
Disulfide bondi482 ↔ 551 By similarity
Disulfide bondi514 ↔ 530 By similarity
Disulfide bondi541 ↔ 572 By similarity

Post-translational modificationi

O- and N-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ80YC5.
PRIDEiQ80YC5.

Expressioni

Gene expression databases

BgeeiQ80YC5.
GenevestigatoriQ80YC5.

Interactioni

Subunit structurei

Interacts with HRG; the interaction, which is enhanced in the presence of zinc ions and inhibited by heparin-binding, inhibits factor XII autoactivation and contact-initiated coagulation By similarity.

Protein-protein interaction databases

IntActiQ80YC5. 2 interactions.
MINTiMINT-4104823.
STRINGi10090.ENSMUSP00000021948.

Structurei

3D structure databases

ProteinModelPortaliQ80YC5.
SMRiQ80YC5. Positions 44-88, 96-597.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 9049Fibronectin type-II
Add
BLAST
Domaini94 – 13138EGF-like 1
Add
BLAST
Domaini133 – 17341Fibronectin type-I
Add
BLAST
Domaini174 – 21037EGF-like 2
Add
BLAST
Domaini216 – 29580Kringle
Add
BLAST
Domaini355 – 596242Peptidase S1
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi296 – 33136Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 kringle domain.

Keywords - Domaini

EGF-like domain, Kringle, Repeat, Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00740000115235.
HOGENOMiHOG000237314.
HOVERGENiHBG004345.
InParanoidiQ6PER0.
KOiK01328.
OMAiPKKVKDH.
OrthoDBiEOG75B84T.
PhylomeDBiQ80YC5.
TreeFamiTF329901.

Family and domain databases

Gene3Di2.10.10.10. 1 hit.
2.40.20.10. 1 hit.
InterProiIPR014394. Coagulation_fac_XIIa/HGFA.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000083. Fibronectin_type1.
IPR000562. FN_type2_col-bd.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00008. EGF. 2 hits.
PF00039. fn1. 1 hit.
PF00040. fn2. 1 hit.
PF00051. Kringle. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PIRSFiPIRSF001146. Factor_XII_HGFA. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00181. EGF. 2 hits.
SM00058. FN1. 1 hit.
SM00059. FN2. 1 hit.
SM00130. KR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 2 hits.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01253. FN1_1. 1 hit.
PS51091. FN1_2. 1 hit.
PS00023. FN2_1. 1 hit.
PS51092. FN2_2. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80YC5-1 [UniParc]FASTAAdd to Basket

« Hide

MTALLFLGSL LMSLDLTLSA PPWKDSKKFK DAPDGPTVVL TVDGRLCHFP    50
FQYHRQLHHK CIHKRRPGSR PWCATTPNFD EDQQWGYCLE PKKVKDHCSK 100
HNPCHKGGTC INTPNGPHCL CPEHLTGKHC QKEKCFEPQL LKFFHENELW 150
FRTGPGGVAR CECKGSEAHC KPVASQACSI NPCLNGGSCL LVEDHPLCRC 200
PTGYTGYFCD LDLWATCYEG RGLSYRGQAG TTQSGAPCQR WTVEATYRNM 250
TEKQALSWGL GHHAFCRNPD NDTRPWCFVW SGDRLSWDYC GLEQCQTPTF 300
APLVVPESQE ESPSQAPSLS HAPNDSTDHQ TSLSKTNTMG CGQRFRKGLS 350
SFMRVVGGLV ALPGSHPYIA ALYWGNNFCA GSLIAPCWVL TAAHCLQNRP 400
APEELTVVLG QDRHNQSCEW CQTLAVRSYR LHEGFSSITY QHDLALLRLQ 450
ESKTNSCAIL SPHVQPVCLP SGAAPPSETV LCEVAGWGHQ FEGAEEYSTF 500
LQEAQVPFIA LDRCSNSNVH GDAILPGMLC AGFLEGGTDA CQGDSGGPLV 550
CEEGTAEHQL TLRGVISWGS GCGDRNKPGV YTDVANYLAW IQKHIAS 597
Length:597
Mass (Da):65,701
Last modified:June 15, 2010 - v2
Checksum:i342FB7E764957E03
GO

Sequence cautioni

The sequence AAH49867.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821D → N in CAA67891. 1 Publication
Sequence conflicti152 – 1521R → K in CAA67891. 1 Publication
Sequence conflicti491 – 4911F → L in CAA67891. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99571 mRNA. Translation: CAA67891.1.
BC057921 mRNA. Translation: AAH57921.1.
BC049867 mRNA. Translation: AAH49867.1. Different initiation.
CCDSiCCDS36675.1.
RefSeqiNP_067464.2. NM_021489.2.
UniGeneiMm.42224.

Genome annotation databases

EnsembliENSMUST00000021948; ENSMUSP00000021948; ENSMUSG00000021492.
GeneIDi58992.
KEGGimmu:58992.
UCSCiuc007qqv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99571 mRNA. Translation: CAA67891.1 .
BC057921 mRNA. Translation: AAH57921.1 .
BC049867 mRNA. Translation: AAH49867.1 . Different initiation.
CCDSi CCDS36675.1.
RefSeqi NP_067464.2. NM_021489.2.
UniGenei Mm.42224.

3D structure databases

ProteinModelPortali Q80YC5.
SMRi Q80YC5. Positions 44-88, 96-597.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q80YC5. 2 interactions.
MINTi MINT-4104823.
STRINGi 10090.ENSMUSP00000021948.

Protein family/group databases

MEROPSi S01.211.

Proteomic databases

PaxDbi Q80YC5.
PRIDEi Q80YC5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021948 ; ENSMUSP00000021948 ; ENSMUSG00000021492 .
GeneIDi 58992.
KEGGi mmu:58992.
UCSCi uc007qqv.2. mouse.

Organism-specific databases

CTDi 2161.
MGIi MGI:1891012. F12.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00740000115235.
HOGENOMi HOG000237314.
HOVERGENi HBG004345.
InParanoidi Q6PER0.
KOi K01328.
OMAi PKKVKDH.
OrthoDBi EOG75B84T.
PhylomeDBi Q80YC5.
TreeFami TF329901.

Miscellaneous databases

NextBioi 314494.
PROi Q80YC5.
SOURCEi Search...

Gene expression databases

Bgeei Q80YC5.
Genevestigatori Q80YC5.

Family and domain databases

Gene3Di 2.10.10.10. 1 hit.
2.40.20.10. 1 hit.
InterProi IPR014394. Coagulation_fac_XIIa/HGFA.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR000083. Fibronectin_type1.
IPR000562. FN_type2_col-bd.
IPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00008. EGF. 2 hits.
PF00039. fn1. 1 hit.
PF00040. fn2. 1 hit.
PF00051. Kringle. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view ]
PIRSFi PIRSF001146. Factor_XII_HGFA. 1 hit.
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00181. EGF. 2 hits.
SM00058. FN1. 1 hit.
SM00059. FN2. 1 hit.
SM00130. KR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
SSF57440. SSF57440. 2 hits.
PROSITEi PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS01253. FN1_1. 1 hit.
PS51091. FN1_2. 1 hit.
PS00023. FN2_1. 1 hit.
PS51092. FN2_2. 1 hit.
PS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Schloesser M., Schwager S., Engel W.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiFA12_MOUSE
AccessioniPrimary (citable) accession number: Q80YC5
Secondary accession number(s): O35727, Q6PER0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi