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Q80YA7

- DPP8_MOUSE

UniProt

Q80YA7 - DPP8_MOUSE

Protein

Dipeptidyl peptidase 8

Gene

Dpp8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Enzyme regulationi

    Inhibited by zinc. Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di-isopropylfuorophosphate. Specifically inhibited by isoindoline derivatives By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei749 – 7491Charge relay systemBy similarity
    Active sitei827 – 8271Charge relay systemBy similarity
    Active sitei859 – 8591Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS09.018.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dipeptidyl peptidase 8 (EC:3.4.14.5)
    Short name:
    DP8
    Alternative name(s):
    Dipeptidyl peptidase VIII
    Short name:
    DPP VIII
    Gene namesi
    Name:Dpp8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1921638. Dpp8.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane Source: InterPro
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 892892Dipeptidyl peptidase 8PRO_0000122414Add
    BLAST

    Proteomic databases

    MaxQBiQ80YA7.
    PaxDbiQ80YA7.
    PRIDEiQ80YA7.

    PTM databases

    PhosphoSiteiQ80YA7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ80YA7.
    BgeeiQ80YA7.
    CleanExiMM_DPP8.
    GenevestigatoriQ80YA7.

    Interactioni

    Protein-protein interaction databases

    IntActiQ80YA7. 1 interaction.
    MINTiMINT-4127022.
    STRINGi10090.ENSMUSP00000034960.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80YA7.
    SMRiQ80YA7. Positions 130-872.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family. DPPIV subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG1506.
    GeneTreeiENSGT00740000115073.
    HOGENOMiHOG000006870.
    HOVERGENiHBG061620.
    InParanoidiQ80YA7.
    KOiK08655.
    OMAiSRHCDFF.
    OrthoDBiEOG7XWPN8.
    PhylomeDBiQ80YA7.
    TreeFamiTF313309.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q80YA7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIPSGRCNM AAAMETEQLG VEIFETAECE EGNGESQDRP KLEPFYVERY    50
    SWSQLKKLLA DTRKYHGYMM AKAPHDFMFV KRTDPDGPHS DRVYYLAMSG 100
    ENRENTLFYS EIPKTINRAA VLMLSWKPLL DLFQATLDYG MYSREEELLR 150
    ERKRIGTVGI AAYDYHPGSG TFLFQAGSGI YHIKDGGPHG FTQQPLRPNL 200
    VETSCPNIRM DPKLCPADPD WIAFIHSNDI WISNLVTREE RRITYVHNEL 250
    ANMEEDPRSA GVATFVLQEE FDRYSGYWWC PQAERTPSGG KILRILYEEN 300
    DESEVEIIHV TSPMLETRRA DSFRYPKTGT ANPKVTFKMS EIVVDAAGGI 350
    IDVIDKELVQ PFEILFEGVE YIARAGWTPE GKHAWSILLD RSQTHLQIVL 400
    ISPELFIPVE DDAMDRQRLI ESVPDSVTPL IIYEETTDIW INIHDIFHVF 450
    PQTHEDEIEF IFASECKTGF RHLYKITSIL KESKYKRSSG GLPAPSDFKC 500
    PIKEEITITS GEWEVLGRHG SNIWVDEARK LVYFEGTKDS PLEHHLYVTS 550
    YANPGEVVRL TDRGYSHSCC LSRHCDFFIS KYSNQKNPHC VSLYKLSSPE 600
    DDPVHKTKEF WATILDSAGP LPDYTPPEIF SFESTTGFTL YGMLYKPHDL 650
    QPGKKYPTVL FIYGGPQVQL VNNRFKGVKY FRLNTLASLG YVVVVIDNRG 700
    SCHRGLKFEG AFKYKMGQIE IDDQVEGLQY LASQYDFIDL DRVGIHGWSY 750
    GGYLSLMALM QRSDIFRVAI AGAPVTLWIF YDTGYTERYM GHPDQNEQGY 800
    YLGSVAMQAE KFPSEPNRLL LLHGFLDENV HFAHTSILLS FLVRAGKPYD 850
    LQIYPQERHS IRVPESGEHY ELHLLHYLQE NLGSRIAALK VI 892
    Length:892
    Mass (Da):102,186
    Last modified:June 1, 2003 - v1
    Checksum:i59081CD9792E03ED
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti87 – 871G → R in BAB30295. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK016546 mRNA. Translation: BAB30295.2.
    BC043124 mRNA. Translation: AAH43124.1.
    BC059222 mRNA. Translation: AAH59222.1.
    CCDSiCCDS23285.1.
    RefSeqiNP_083182.2. NM_028906.2.
    UniGeneiMm.202749.
    Mm.391842.

    Genome annotation databases

    EnsembliENSMUST00000034960; ENSMUSP00000034960; ENSMUSG00000032393.
    ENSMUST00000167773; ENSMUSP00000126065; ENSMUSG00000032393.
    GeneIDi74388.
    KEGGimmu:74388.
    UCSCiuc009qcq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK016546 mRNA. Translation: BAB30295.2 .
    BC043124 mRNA. Translation: AAH43124.1 .
    BC059222 mRNA. Translation: AAH59222.1 .
    CCDSi CCDS23285.1.
    RefSeqi NP_083182.2. NM_028906.2.
    UniGenei Mm.202749.
    Mm.391842.

    3D structure databases

    ProteinModelPortali Q80YA7.
    SMRi Q80YA7. Positions 130-872.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q80YA7. 1 interaction.
    MINTi MINT-4127022.
    STRINGi 10090.ENSMUSP00000034960.

    Protein family/group databases

    MEROPSi S09.018.

    PTM databases

    PhosphoSitei Q80YA7.

    Proteomic databases

    MaxQBi Q80YA7.
    PaxDbi Q80YA7.
    PRIDEi Q80YA7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034960 ; ENSMUSP00000034960 ; ENSMUSG00000032393 .
    ENSMUST00000167773 ; ENSMUSP00000126065 ; ENSMUSG00000032393 .
    GeneIDi 74388.
    KEGGi mmu:74388.
    UCSCi uc009qcq.1. mouse.

    Organism-specific databases

    CTDi 54878.
    MGIi MGI:1921638. Dpp8.

    Phylogenomic databases

    eggNOGi COG1506.
    GeneTreei ENSGT00740000115073.
    HOGENOMi HOG000006870.
    HOVERGENi HBG061620.
    InParanoidi Q80YA7.
    KOi K08655.
    OMAi SRHCDFF.
    OrthoDBi EOG7XWPN8.
    PhylomeDBi Q80YA7.
    TreeFami TF313309.

    Miscellaneous databases

    ChiTaRSi DPP8. mouse.
    NextBioi 340625.
    PROi Q80YA7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q80YA7.
    Bgeei Q80YA7.
    CleanExi MM_DPP8.
    Genevestigatori Q80YA7.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiDPP8_MOUSE
    AccessioniPrimary (citable) accession number: Q80YA7
    Secondary accession number(s): Q9D4G6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3