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Q80YA7 (DPP8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dipeptidyl peptidase 8

Short name=DP8
EC=3.4.14.5
Alternative name(s):
Dipeptidyl peptidase VIII
Short name=DPP VIII
Gene names
Name:Dpp8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length892 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Enzyme regulation

Inhibited by zinc. Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di-isopropylfuorophosphate. Specifically inhibited by isoindoline derivatives By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the peptidase S9B family. DPPIV subfamily.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionAminopeptidase
Hydrolase
Protease
Serine protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: InterPro

nucleus

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionaminopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 892892Dipeptidyl peptidase 8
PRO_0000122414

Sites

Active site7491Charge relay system By similarity
Active site8271Charge relay system By similarity
Active site8591Charge relay system By similarity

Experimental info

Sequence conflict871G → R in BAB30295. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q80YA7 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 59081CD9792E03ED

FASTA892102,186
        10         20         30         40         50         60 
MKIPSGRCNM AAAMETEQLG VEIFETAECE EGNGESQDRP KLEPFYVERY SWSQLKKLLA 

        70         80         90        100        110        120 
DTRKYHGYMM AKAPHDFMFV KRTDPDGPHS DRVYYLAMSG ENRENTLFYS EIPKTINRAA 

       130        140        150        160        170        180 
VLMLSWKPLL DLFQATLDYG MYSREEELLR ERKRIGTVGI AAYDYHPGSG TFLFQAGSGI 

       190        200        210        220        230        240 
YHIKDGGPHG FTQQPLRPNL VETSCPNIRM DPKLCPADPD WIAFIHSNDI WISNLVTREE 

       250        260        270        280        290        300 
RRITYVHNEL ANMEEDPRSA GVATFVLQEE FDRYSGYWWC PQAERTPSGG KILRILYEEN 

       310        320        330        340        350        360 
DESEVEIIHV TSPMLETRRA DSFRYPKTGT ANPKVTFKMS EIVVDAAGGI IDVIDKELVQ 

       370        380        390        400        410        420 
PFEILFEGVE YIARAGWTPE GKHAWSILLD RSQTHLQIVL ISPELFIPVE DDAMDRQRLI 

       430        440        450        460        470        480 
ESVPDSVTPL IIYEETTDIW INIHDIFHVF PQTHEDEIEF IFASECKTGF RHLYKITSIL 

       490        500        510        520        530        540 
KESKYKRSSG GLPAPSDFKC PIKEEITITS GEWEVLGRHG SNIWVDEARK LVYFEGTKDS 

       550        560        570        580        590        600 
PLEHHLYVTS YANPGEVVRL TDRGYSHSCC LSRHCDFFIS KYSNQKNPHC VSLYKLSSPE 

       610        620        630        640        650        660 
DDPVHKTKEF WATILDSAGP LPDYTPPEIF SFESTTGFTL YGMLYKPHDL QPGKKYPTVL 

       670        680        690        700        710        720 
FIYGGPQVQL VNNRFKGVKY FRLNTLASLG YVVVVIDNRG SCHRGLKFEG AFKYKMGQIE 

       730        740        750        760        770        780 
IDDQVEGLQY LASQYDFIDL DRVGIHGWSY GGYLSLMALM QRSDIFRVAI AGAPVTLWIF 

       790        800        810        820        830        840 
YDTGYTERYM GHPDQNEQGY YLGSVAMQAE KFPSEPNRLL LLHGFLDENV HFAHTSILLS 

       850        860        870        880        890 
FLVRAGKPYD LQIYPQERHS IRVPESGEHY ELHLLHYLQE NLGSRIAALK VI 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK016546 mRNA. Translation: BAB30295.2.
BC043124 mRNA. Translation: AAH43124.1.
BC059222 mRNA. Translation: AAH59222.1.
CCDSCCDS23285.1.
RefSeqNP_083182.2. NM_028906.2.
UniGeneMm.202749.
Mm.391842.

3D structure databases

ProteinModelPortalQ80YA7.
SMRQ80YA7. Positions 130-872.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ80YA7. 1 interaction.
MINTMINT-4127022.
STRING10090.ENSMUSP00000034960.

Protein family/group databases

MEROPSS09.018.

PTM databases

PhosphoSiteQ80YA7.

Proteomic databases

MaxQBQ80YA7.
PaxDbQ80YA7.
PRIDEQ80YA7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034960; ENSMUSP00000034960; ENSMUSG00000032393.
ENSMUST00000167773; ENSMUSP00000126065; ENSMUSG00000032393.
GeneID74388.
KEGGmmu:74388.
UCSCuc009qcq.1. mouse.

Organism-specific databases

CTD54878.
MGIMGI:1921638. Dpp8.

Phylogenomic databases

eggNOGCOG1506.
GeneTreeENSGT00740000115073.
HOGENOMHOG000006870.
HOVERGENHBG061620.
InParanoidQ80YA7.
KOK08655.
OMASRHCDFF.
OrthoDBEOG7XWPN8.
PhylomeDBQ80YA7.
TreeFamTF313309.

Gene expression databases

ArrayExpressQ80YA7.
BgeeQ80YA7.
CleanExMM_DPP8.
GenevestigatorQ80YA7.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Other

ChiTaRSDPP8. mouse.
NextBio340625.
PROQ80YA7.
SOURCESearch...

Entry information

Entry nameDPP8_MOUSE
AccessionPrimary (citable) accession number: Q80YA7
Secondary accession number(s): Q9D4G6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot