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Q80YA7

- DPP8_MOUSE

UniProt

Q80YA7 - DPP8_MOUSE

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Protein
Dipeptidyl peptidase 8
Gene
Dpp8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Enzyme regulationi

Inhibited by zinc. Inhibited by the serine proteinase inhibitor 4-(2-aminoethyl)benzenesulphonyl fluoride (AEBSF), and by di-isopropylfuorophosphate. Specifically inhibited by isoindoline derivatives By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei749 – 7491Charge relay system By similarity
Active sitei827 – 8271Charge relay system By similarity
Active sitei859 – 8591Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.018.

Names & Taxonomyi

Protein namesi
Recommended name:
Dipeptidyl peptidase 8 (EC:3.4.14.5)
Short name:
DP8
Alternative name(s):
Dipeptidyl peptidase VIII
Short name:
DPP VIII
Gene namesi
Name:Dpp8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1921638. Dpp8.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. membrane Source: InterPro
  3. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 892892Dipeptidyl peptidase 8
PRO_0000122414Add
BLAST

Proteomic databases

MaxQBiQ80YA7.
PaxDbiQ80YA7.
PRIDEiQ80YA7.

PTM databases

PhosphoSiteiQ80YA7.

Expressioni

Gene expression databases

ArrayExpressiQ80YA7.
BgeeiQ80YA7.
CleanExiMM_DPP8.
GenevestigatoriQ80YA7.

Interactioni

Protein-protein interaction databases

IntActiQ80YA7. 1 interaction.
MINTiMINT-4127022.
STRINGi10090.ENSMUSP00000034960.

Structurei

3D structure databases

ProteinModelPortaliQ80YA7.
SMRiQ80YA7. Positions 130-872.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1506.
GeneTreeiENSGT00740000115073.
HOGENOMiHOG000006870.
HOVERGENiHBG061620.
InParanoidiQ80YA7.
KOiK08655.
OMAiSRHCDFF.
OrthoDBiEOG7XWPN8.
PhylomeDBiQ80YA7.
TreeFamiTF313309.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80YA7-1 [UniParc]FASTAAdd to Basket

« Hide

MKIPSGRCNM AAAMETEQLG VEIFETAECE EGNGESQDRP KLEPFYVERY    50
SWSQLKKLLA DTRKYHGYMM AKAPHDFMFV KRTDPDGPHS DRVYYLAMSG 100
ENRENTLFYS EIPKTINRAA VLMLSWKPLL DLFQATLDYG MYSREEELLR 150
ERKRIGTVGI AAYDYHPGSG TFLFQAGSGI YHIKDGGPHG FTQQPLRPNL 200
VETSCPNIRM DPKLCPADPD WIAFIHSNDI WISNLVTREE RRITYVHNEL 250
ANMEEDPRSA GVATFVLQEE FDRYSGYWWC PQAERTPSGG KILRILYEEN 300
DESEVEIIHV TSPMLETRRA DSFRYPKTGT ANPKVTFKMS EIVVDAAGGI 350
IDVIDKELVQ PFEILFEGVE YIARAGWTPE GKHAWSILLD RSQTHLQIVL 400
ISPELFIPVE DDAMDRQRLI ESVPDSVTPL IIYEETTDIW INIHDIFHVF 450
PQTHEDEIEF IFASECKTGF RHLYKITSIL KESKYKRSSG GLPAPSDFKC 500
PIKEEITITS GEWEVLGRHG SNIWVDEARK LVYFEGTKDS PLEHHLYVTS 550
YANPGEVVRL TDRGYSHSCC LSRHCDFFIS KYSNQKNPHC VSLYKLSSPE 600
DDPVHKTKEF WATILDSAGP LPDYTPPEIF SFESTTGFTL YGMLYKPHDL 650
QPGKKYPTVL FIYGGPQVQL VNNRFKGVKY FRLNTLASLG YVVVVIDNRG 700
SCHRGLKFEG AFKYKMGQIE IDDQVEGLQY LASQYDFIDL DRVGIHGWSY 750
GGYLSLMALM QRSDIFRVAI AGAPVTLWIF YDTGYTERYM GHPDQNEQGY 800
YLGSVAMQAE KFPSEPNRLL LLHGFLDENV HFAHTSILLS FLVRAGKPYD 850
LQIYPQERHS IRVPESGEHY ELHLLHYLQE NLGSRIAALK VI 892
Length:892
Mass (Da):102,186
Last modified:June 1, 2003 - v1
Checksum:i59081CD9792E03ED
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871G → R in BAB30295. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK016546 mRNA. Translation: BAB30295.2.
BC043124 mRNA. Translation: AAH43124.1.
BC059222 mRNA. Translation: AAH59222.1.
CCDSiCCDS23285.1.
RefSeqiNP_083182.2. NM_028906.2.
UniGeneiMm.202749.
Mm.391842.

Genome annotation databases

EnsembliENSMUST00000034960; ENSMUSP00000034960; ENSMUSG00000032393.
ENSMUST00000167773; ENSMUSP00000126065; ENSMUSG00000032393.
GeneIDi74388.
KEGGimmu:74388.
UCSCiuc009qcq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK016546 mRNA. Translation: BAB30295.2 .
BC043124 mRNA. Translation: AAH43124.1 .
BC059222 mRNA. Translation: AAH59222.1 .
CCDSi CCDS23285.1.
RefSeqi NP_083182.2. NM_028906.2.
UniGenei Mm.202749.
Mm.391842.

3D structure databases

ProteinModelPortali Q80YA7.
SMRi Q80YA7. Positions 130-872.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q80YA7. 1 interaction.
MINTi MINT-4127022.
STRINGi 10090.ENSMUSP00000034960.

Protein family/group databases

MEROPSi S09.018.

PTM databases

PhosphoSitei Q80YA7.

Proteomic databases

MaxQBi Q80YA7.
PaxDbi Q80YA7.
PRIDEi Q80YA7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034960 ; ENSMUSP00000034960 ; ENSMUSG00000032393 .
ENSMUST00000167773 ; ENSMUSP00000126065 ; ENSMUSG00000032393 .
GeneIDi 74388.
KEGGi mmu:74388.
UCSCi uc009qcq.1. mouse.

Organism-specific databases

CTDi 54878.
MGIi MGI:1921638. Dpp8.

Phylogenomic databases

eggNOGi COG1506.
GeneTreei ENSGT00740000115073.
HOGENOMi HOG000006870.
HOVERGENi HBG061620.
InParanoidi Q80YA7.
KOi K08655.
OMAi SRHCDFF.
OrthoDBi EOG7XWPN8.
PhylomeDBi Q80YA7.
TreeFami TF313309.

Miscellaneous databases

ChiTaRSi DPP8. mouse.
NextBioi 340625.
PROi Q80YA7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q80YA7.
Bgeei Q80YA7.
CleanExi MM_DPP8.
Genevestigatori Q80YA7.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiDPP8_MOUSE
AccessioniPrimary (citable) accession number: Q80YA7
Secondary accession number(s): Q9D4G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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