Unreviewed, UniProtKB/TrEMBL Q80Y89 (Q80Y89_MOUSE)

Names and origin

Protein names

Submitted name:
    Erbb2 protein EMBL AAH46811.1

Gene names

Name:

Erbb2 EMBL AAH46811.1

Organism

Mus musculus (Mouse) EMBL AAH46811.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	711 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

Ontologies

Gene Ontology (GO)
Biological process	estrus Inferred from electronic annotation. Source: Compara glial cell differentiation Inferred from electronic annotation. Source: Compara liver development Inferred from electronic annotation. Source: Compara mammary gland involution Inferred from electronic annotation. Source: Compara negative regulation of apoptosis Inferred from electronic annotation. Source: Compara peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: InterPro peripheral nervous system development Inferred from electronic annotation. Source: Compara phosphoinositide 3-kinase cascade Inferred from electronic annotation. Source: Compara positive regulation of MAP kinase activity Inferred from electronic annotation. Source: Compara positive regulation of MAPKKK cascade Inferred from electronic annotation. Source: Compara positive regulation of Ras protein signal transduction Inferred from electronic annotation. Source: Compara positive regulation of cell adhesion Inferred from electronic annotation. Source: Compara positive regulation of epithelial cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of phosphoinositide 3-kinase cascade Inferred from electronic annotation. Source: Compara protein amino acid autophosphorylation Inferred from electronic annotation. Source: Compara response to axon injury Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to progesterone stimulus Inferred from electronic annotation. Source: Compara skeletal muscle tissue development Inferred from electronic annotation. Source: Compara sympathetic nervous system development Inferred from electronic annotation. Source: Compara tongue development Inferred from electronic annotation. Source: Compara transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro wound healing Inferred from electronic annotation. Source: Compara
Cellular component	apical plasma membrane Inferred from electronic annotation. Source: Compara basal plasma membrane Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: InterPro lateral loop Inferred from electronic annotation. Source: Compara membrane raft Inferred from electronic annotation. Source: Compara microvillus Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara perinuclear region of cytoplasm Inferred from electronic annotation. Source: Compara postsynaptic membrane Inferred from electronic annotation. Source: Compara
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro Hsp90 protein binding Inferred from electronic annotation. Source: Compara glycoprotein binding Inferred from electronic annotation. Source: Compara growth factor binding Inferred from electronic annotation. Source: Compara identical protein binding Inferred from electronic annotation. Source: Compara protein C-terminus binding Inferred from electronic annotation. Source: Compara protein heterodimerization activity Inferred from electronic annotation. Source: Compara protein phosphatase binding Inferred from electronic annotation. Source: Compara transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro ubiquitin protein ligase binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q80Y89-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 682B188EB0E71318	FASTA	711	78,707
	10 20 30 40 50 60 MELAAWCRWG FLLALLSPGA AGTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL 70 80 90 100 110 120 ELTYLPANAS LSFLQDIQEV QGYMLIAHNR VKHVPLQRLR IVRGTQLFED KYALAVLDNR 130 140 150 160 170 180 DPLDNVTTAA PGRTPEGLRE LQLRSLTEIL KGGVLIRGNP QLCYQDMVLW KDVLRKNNQL 190 200 210 220 230 240 APVDMDTNRS RACPPCAPTC KDNHCWGESP EDCQILTGTI CTSGCARCKG RLPTDCCHEQ 250 260 270 280 290 300 CAAGCTGPKH SDCLACLHFN HSGICELHCP ALITYNTDTF ESMLNPEGRY TFGASCVTTC 310 320 330 340 350 360 PYNYLSTEVG SCTLVCPPNN QEVTAEDGTQ RCEKCSKPCA GVCYGLGMEH LRGARAITSD 370 380 390 400 410 420 NIQEFAGCKK IFGSLAFLPE SFDGNPSSGV APLKPEHLQV FETLEEITGY LYISAWPESF 430 440 450 460 470 480 QDLSVFQNLR VIRGRILHDG AYSLTLQGLG IHSLGLRSLR ELGSGLALIH RNTHLCFVNT 490 500 510 520 530 540 VPWDQLFRNP HQALLHSGNR PEEACGLEGL VCNSLCARGH CWGPGPTQCV NCSQFLRGQE 550 560 570 580 590 600 CVEECRVWKG LPREYVRGKH CLPCHPECQP QNSSETCYGS EADQCEACAH YKDSSSCVAR 610 620 630 640 650 660 CPSGVKPDLS YMPIWKYPDE EGICQPCPIN CTHSCVDLDE RGCPAEQRAS PVTFIIATVV 670 680 690 700 710 GVLLFLIIVV VIGILIKRRR QKIRKYTMRR LLQETEVRRA EGLLAPPWLC S

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6 EMBL AAH46811.1. Tissue: Brain EMBL AAH46811.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC046811 mRNA. Translation: AAH46811.1. BC053078 mRNA. Translation: AAH53078.1.
IPI	IPI00626433.
UniGene	Mm.290822 Mm.406337
3D structure databases
HSSP	HSSP built from PDB template 1N8Y based on UniProtKB P06494.
SMR	Q80Y89. Positions 23-630, 642-685.
ModBase	Search...
Protein-protein interaction databases
STRING	Q80Y89.
Genome annotation databases
Ensembl	ENSMUST00000058295; ENSMUSP00000053897; ENSMUSG00000062312; Mus musculus. [Genome view]
Organism-specific databases
MGI	MGI:95410. Erbb2.
Phylogenomic databases
HOVERGEN	Q80Y89.
InParanoid	Q80Y89.
Gene expression databases
ArrayExpress	Q80Y89.
Bgee	Q80Y89.
Genevestigator	Q80Y89.
Family and domain databases
InterPro	IPR000494. EGF_rcpt_L. IPR006211. Furin-like_Cys-rich_dom. IPR006212. Furin_repeat. IPR009030. Growth_fac_rcpt. IPR020685. Tyr_prot_kinase. [Graphical view]
PANTHER	PTHR23256. Tyr_prot_kinase. 1 hit.
Pfam	PF00757. Furin-like. 1 hit. PF01030. Recep_L_domain. 2 hits. [Graphical view]
SMART	SM00261. FU. 4 hits. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

Q80Y89_MOUSE

Accession

Primary (citable) accession number: Q80Y89

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	January 19, 2010
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)