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Q80Y86

- MK15_MOUSE

UniProt

Q80Y86 - MK15_MOUSE

Protein

Mitogen-activated protein kinase 15

Gene

Mapk15

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Constitutively active kinase which may function as a negative regulator of cell growth.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases, such as DUSP1 By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431ATPPROSITE-ProRule annotation
    Active sitei138 – 1381Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi20 – 289ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of DNA replication Source: Ensembl
    2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    3. positive regulation of protein catabolic process Source: Ensembl
    4. positive regulation of protein phosphorylation Source: Ensembl
    5. positive regulation of protein ubiquitination Source: Ensembl
    6. protein autophosphorylation Source: UniProtKB
    7. response to estradiol Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase 15 (EC:2.7.11.24)
    Short name:
    MAP kinase 15
    Short name:
    MAPK 15
    Alternative name(s):
    Extracellular signal-regulated kinase 7
    Short name:
    ERK-7
    Gene namesi
    Name:Mapk15
    Synonyms:Erk7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:2652894. Mapk15.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 549549Mitogen-activated protein kinase 15PRO_0000232638Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei176 – 1761PhosphothreonineBy similarity
    Modified residuei178 – 1781PhosphotyrosineBy similarity
    Modified residuei417 – 4171PhosphoserineBy similarity

    Post-translational modificationi

    Dually phosphorylated on Thr-176 and Tyr-178, which activates the enzyme.By similarity
    Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ80Y86.
    PRIDEiQ80Y86.

    PTM databases

    PhosphoSiteiQ80Y86.

    Expressioni

    Gene expression databases

    BgeeiQ80Y86.
    CleanExiMM_MAPK15.
    GenevestigatoriQ80Y86.

    Interactioni

    Subunit structurei

    Interacts with TGFB1I1.1 Publication

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000087098.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80Y86.
    SMRiQ80Y86. Positions 6-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 305292Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2020Ubiquitin-conjugatingAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi176 – 1783TXY

    Domaini

    The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteasomal degradation.By similarity
    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00730000110881.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    InParanoidiQ80Y86.
    KOiK08293.
    OMAiCTVKLCD.
    OrthoDBiEOG7VDXPC.
    PhylomeDBiQ80Y86.
    TreeFamiTF105101.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q80Y86-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCAAEVDRHV AQRYLIKRRL GKGAYGIVWK AMDRRTGEVV AIKKIFDAFR    50
    DQIDAQRTFR EIMLLKEFGG HPNIIRLLDV IPAKNDRDIY LVFESMDTDL 100
    NAVIQKGRLL KDIHKRCIFY QLLRATKFIH SGRVIHRDQK PANVLLDSAC 150
    RVKLCDFGLA RSLGDLPEGP GGQALTEYVA TRWYRAPEVL LSSRWYTPGV 200
    DMWSLGCILG EMLRGQPLFP GTSTFHQLEL ILKTIPLPSM EELQDLGSDY 250
    SALILQNLGS RPQQTLDALL PPDTPPEALD LLKRLLAFAP DKRLSAEQAL 300
    QHPYVQRFHC PDREWARESD VRLPVHEGDQ LSAPEYRKRL YQIILEQSGN 350
    SRSPREEGLG VVASRAELRA SPARTQSLKS GVLPQVPAET PARKRGPKPP 400
    RSPGHDPEHV EVRRQSSDPL FQLPPPGRGE RPPGATGQPP SAPSGVKTQV 450
    RAMAPSLTSQ AEAQAANQAL IRSDPARGGG PRAVGARRVP SRLPREAPEP 500
    RPGRRMFGIS VSQGAQGAAR AALGGYSQAY GTVCRSALGR LPLLPGPRA 549
    Length:549
    Mass (Da):60,679
    Last modified:June 1, 2003 - v1
    Checksum:iA42181A1EC40C1A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC048082 mRNA. Translation: AAH48082.1.
    CCDSiCCDS27558.1.
    RefSeqiNP_808590.1. NM_177922.2.
    UniGeneiMm.40843.

    Genome annotation databases

    EnsembliENSMUST00000089669; ENSMUSP00000087098; ENSMUSG00000063704.
    GeneIDi332110.
    KEGGimmu:332110.
    UCSCiuc007whz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC048082 mRNA. Translation: AAH48082.1 .
    CCDSi CCDS27558.1.
    RefSeqi NP_808590.1. NM_177922.2.
    UniGenei Mm.40843.

    3D structure databases

    ProteinModelPortali Q80Y86.
    SMRi Q80Y86. Positions 6-356.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000087098.

    PTM databases

    PhosphoSitei Q80Y86.

    Proteomic databases

    PaxDbi Q80Y86.
    PRIDEi Q80Y86.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000089669 ; ENSMUSP00000087098 ; ENSMUSG00000063704 .
    GeneIDi 332110.
    KEGGi mmu:332110.
    UCSCi uc007whz.1. mouse.

    Organism-specific databases

    CTDi 225689.
    MGIi MGI:2652894. Mapk15.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00730000110881.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    InParanoidi Q80Y86.
    KOi K08293.
    OMAi CTVKLCD.
    OrthoDBi EOG7VDXPC.
    PhylomeDBi Q80Y86.
    TreeFami TF105101.

    Miscellaneous databases

    NextBioi 399846.
    PROi Q80Y86.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q80Y86.
    CleanExi MM_MAPK15.
    Genevestigatori Q80Y86.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.
    2. "ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5."
      Saelzler M.P., Spackman C.C., Liu Y., Martinez L.C., Harris J.P., Abe M.K.
      J. Biol. Chem. 281:16821-16832(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TGFB1I1.

    Entry informationi

    Entry nameiMK15_MOUSE
    AccessioniPrimary (citable) accession number: Q80Y86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3