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Q80Y86

- MK15_MOUSE

UniProt

Q80Y86 - MK15_MOUSE

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Protein

Mitogen-activated protein kinase 15

Gene

Mapk15

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Constitutively active kinase which may function as a negative regulator of cell growth.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases, such as DUSP1 (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431ATPPROSITE-ProRule annotation
Active sitei138 – 1381Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 289ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB

GO - Biological processi

  1. MAPK cascade Source: GOC
  2. negative regulation of DNA replication Source: Ensembl
  3. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. positive regulation of protein catabolic process Source: Ensembl
  5. positive regulation of protein phosphorylation Source: Ensembl
  6. positive regulation of protein ubiquitination Source: Ensembl
  7. protein autophosphorylation Source: UniProtKB
  8. response to estradiol Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 15 (EC:2.7.11.24)
Short name:
MAP kinase 15
Short name:
MAPK 15
Alternative name(s):
Extracellular signal-regulated kinase 7
Short name:
ERK-7
Gene namesi
Name:Mapk15
Synonyms:Erk7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:2652894. Mapk15.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Mitogen-activated protein kinase 15PRO_0000232638Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei176 – 1761PhosphothreonineBy similarity
Modified residuei178 – 1781PhosphotyrosineBy similarity
Modified residuei417 – 4171PhosphoserineBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-176 and Tyr-178, which activates the enzyme.By similarity
Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ80Y86.
PaxDbiQ80Y86.
PRIDEiQ80Y86.

PTM databases

PhosphoSiteiQ80Y86.

Expressioni

Gene expression databases

BgeeiQ80Y86.
CleanExiMM_MAPK15.
GenevestigatoriQ80Y86.

Interactioni

Subunit structurei

Interacts with TGFB1I1.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087098.

Structurei

3D structure databases

ProteinModelPortaliQ80Y86.
SMRiQ80Y86. Positions 6-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 305292Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2020Ubiquitin-conjugatingAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi176 – 1783TXY

Domaini

The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteasomal degradation.By similarity
The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00770000120669.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ80Y86.
KOiK08293.
OMAiCTVKLCD.
OrthoDBiEOG7VDXPC.
PhylomeDBiQ80Y86.
TreeFamiTF105101.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80Y86-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCAAEVDRHV AQRYLIKRRL GKGAYGIVWK AMDRRTGEVV AIKKIFDAFR
60 70 80 90 100
DQIDAQRTFR EIMLLKEFGG HPNIIRLLDV IPAKNDRDIY LVFESMDTDL
110 120 130 140 150
NAVIQKGRLL KDIHKRCIFY QLLRATKFIH SGRVIHRDQK PANVLLDSAC
160 170 180 190 200
RVKLCDFGLA RSLGDLPEGP GGQALTEYVA TRWYRAPEVL LSSRWYTPGV
210 220 230 240 250
DMWSLGCILG EMLRGQPLFP GTSTFHQLEL ILKTIPLPSM EELQDLGSDY
260 270 280 290 300
SALILQNLGS RPQQTLDALL PPDTPPEALD LLKRLLAFAP DKRLSAEQAL
310 320 330 340 350
QHPYVQRFHC PDREWARESD VRLPVHEGDQ LSAPEYRKRL YQIILEQSGN
360 370 380 390 400
SRSPREEGLG VVASRAELRA SPARTQSLKS GVLPQVPAET PARKRGPKPP
410 420 430 440 450
RSPGHDPEHV EVRRQSSDPL FQLPPPGRGE RPPGATGQPP SAPSGVKTQV
460 470 480 490 500
RAMAPSLTSQ AEAQAANQAL IRSDPARGGG PRAVGARRVP SRLPREAPEP
510 520 530 540
RPGRRMFGIS VSQGAQGAAR AALGGYSQAY GTVCRSALGR LPLLPGPRA
Length:549
Mass (Da):60,679
Last modified:June 1, 2003 - v1
Checksum:iA42181A1EC40C1A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC048082 mRNA. Translation: AAH48082.1.
CCDSiCCDS27558.1.
RefSeqiNP_808590.1. NM_177922.2.
UniGeneiMm.40843.

Genome annotation databases

EnsembliENSMUST00000089669; ENSMUSP00000087098; ENSMUSG00000063704.
GeneIDi332110.
KEGGimmu:332110.
UCSCiuc007whz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC048082 mRNA. Translation: AAH48082.1 .
CCDSi CCDS27558.1.
RefSeqi NP_808590.1. NM_177922.2.
UniGenei Mm.40843.

3D structure databases

ProteinModelPortali Q80Y86.
SMRi Q80Y86. Positions 6-356.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000087098.

PTM databases

PhosphoSitei Q80Y86.

Proteomic databases

MaxQBi Q80Y86.
PaxDbi Q80Y86.
PRIDEi Q80Y86.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000089669 ; ENSMUSP00000087098 ; ENSMUSG00000063704 .
GeneIDi 332110.
KEGGi mmu:332110.
UCSCi uc007whz.1. mouse.

Organism-specific databases

CTDi 225689.
MGIi MGI:2652894. Mapk15.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00770000120669.
HOGENOMi HOG000233024.
HOVERGENi HBG014652.
InParanoidi Q80Y86.
KOi K08293.
OMAi CTVKLCD.
OrthoDBi EOG7VDXPC.
PhylomeDBi Q80Y86.
TreeFami TF105101.

Miscellaneous databases

NextBioi 399846.
PROi Q80Y86.
SOURCEi Search...

Gene expression databases

Bgeei Q80Y86.
CleanExi MM_MAPK15.
Genevestigatori Q80Y86.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  2. "ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5."
    Saelzler M.P., Spackman C.C., Liu Y., Martinez L.C., Harris J.P., Abe M.K.
    J. Biol. Chem. 281:16821-16832(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TGFB1I1.

Entry informationi

Entry nameiMK15_MOUSE
AccessioniPrimary (citable) accession number: Q80Y86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3