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Protein

Mitogen-activated protein kinase 15

Gene

Mapk15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Constitutively active kinase which may function as a negative regulator of cell growth.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases, such as DUSP1 (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431ATPPROSITE-ProRule annotation
Active sitei138 – 1381Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 289ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 15 (EC:2.7.11.24)
Short name:
MAP kinase 15
Short name:
MAPK 15
Alternative name(s):
Extracellular signal-regulated kinase 7
Short name:
ERK-7
Gene namesi
Name:Mapk15
Synonyms:Erk7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2652894. Mapk15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Mitogen-activated protein kinase 15PRO_0000232638Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei176 – 1761PhosphothreonineBy similarity
Modified residuei178 – 1781PhosphotyrosineBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-176 and Tyr-178, which activates the enzyme.By similarity
Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ80Y86.
PaxDbiQ80Y86.
PRIDEiQ80Y86.

PTM databases

PhosphoSiteiQ80Y86.

Expressioni

Gene expression databases

BgeeiQ80Y86.
CleanExiMM_MAPK15.
GenevisibleiQ80Y86. MM.

Interactioni

Subunit structurei

Interacts with TGFB1I1.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087098.

Structurei

3D structure databases

ProteinModelPortaliQ80Y86.
SMRiQ80Y86. Positions 6-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 305292Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2020Ubiquitin-conjugatingAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi176 – 1783TXY

Domaini

The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteasomal degradation.By similarity
The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00800000124204.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ80Y86.
KOiK08293.
OMAiIRGDWNR.
OrthoDBiEOG7VDXPC.
PhylomeDBiQ80Y86.
TreeFamiTF105101.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80Y86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCAAEVDRHV AQRYLIKRRL GKGAYGIVWK AMDRRTGEVV AIKKIFDAFR
60 70 80 90 100
DQIDAQRTFR EIMLLKEFGG HPNIIRLLDV IPAKNDRDIY LVFESMDTDL
110 120 130 140 150
NAVIQKGRLL KDIHKRCIFY QLLRATKFIH SGRVIHRDQK PANVLLDSAC
160 170 180 190 200
RVKLCDFGLA RSLGDLPEGP GGQALTEYVA TRWYRAPEVL LSSRWYTPGV
210 220 230 240 250
DMWSLGCILG EMLRGQPLFP GTSTFHQLEL ILKTIPLPSM EELQDLGSDY
260 270 280 290 300
SALILQNLGS RPQQTLDALL PPDTPPEALD LLKRLLAFAP DKRLSAEQAL
310 320 330 340 350
QHPYVQRFHC PDREWARESD VRLPVHEGDQ LSAPEYRKRL YQIILEQSGN
360 370 380 390 400
SRSPREEGLG VVASRAELRA SPARTQSLKS GVLPQVPAET PARKRGPKPP
410 420 430 440 450
RSPGHDPEHV EVRRQSSDPL FQLPPPGRGE RPPGATGQPP SAPSGVKTQV
460 470 480 490 500
RAMAPSLTSQ AEAQAANQAL IRSDPARGGG PRAVGARRVP SRLPREAPEP
510 520 530 540
RPGRRMFGIS VSQGAQGAAR AALGGYSQAY GTVCRSALGR LPLLPGPRA
Length:549
Mass (Da):60,679
Last modified:June 1, 2003 - v1
Checksum:iA42181A1EC40C1A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC048082 mRNA. Translation: AAH48082.1.
CCDSiCCDS27558.1.
RefSeqiNP_808590.1. NM_177922.2.
UniGeneiMm.40843.

Genome annotation databases

EnsembliENSMUST00000089669; ENSMUSP00000087098; ENSMUSG00000063704.
GeneIDi332110.
KEGGimmu:332110.
UCSCiuc007whz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC048082 mRNA. Translation: AAH48082.1.
CCDSiCCDS27558.1.
RefSeqiNP_808590.1. NM_177922.2.
UniGeneiMm.40843.

3D structure databases

ProteinModelPortaliQ80Y86.
SMRiQ80Y86. Positions 6-356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000087098.

PTM databases

PhosphoSiteiQ80Y86.

Proteomic databases

MaxQBiQ80Y86.
PaxDbiQ80Y86.
PRIDEiQ80Y86.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089669; ENSMUSP00000087098; ENSMUSG00000063704.
GeneIDi332110.
KEGGimmu:332110.
UCSCiuc007whz.1. mouse.

Organism-specific databases

CTDi225689.
MGIiMGI:2652894. Mapk15.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00800000124204.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ80Y86.
KOiK08293.
OMAiIRGDWNR.
OrthoDBiEOG7VDXPC.
PhylomeDBiQ80Y86.
TreeFamiTF105101.

Miscellaneous databases

NextBioi399846.
PROiQ80Y86.
SOURCEiSearch...

Gene expression databases

BgeeiQ80Y86.
CleanExiMM_MAPK15.
GenevisibleiQ80Y86. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  2. "ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5."
    Saelzler M.P., Spackman C.C., Liu Y., Martinez L.C., Harris J.P., Abe M.K.
    J. Biol. Chem. 281:16821-16832(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TGFB1I1.

Entry informationi

Entry nameiMK15_MOUSE
AccessioniPrimary (citable) accession number: Q80Y86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.