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Q80Y86 (MK15_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase 15

Short name=MAP kinase 15
Short name=MAPK 15
EC=2.7.11.24
Alternative name(s):
Extracellular signal-regulated kinase 7
Short name=ERK-7
Gene names
Name:Mapk15
Synonyms:Erk7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length549 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Constitutively active kinase which may function as a negative regulator of cell growth By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases, such as DUSP1 By similarity.

Subunit structure

Interacts with TGFB1I1. Ref.2

Domain

The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteasomal degradation By similarity.

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-176 and Tyr-178, which activates the enzyme By similarity.

Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 549549Mitogen-activated protein kinase 15
PRO_0000232638

Regions

Domain14 – 305292Protein kinase
Nucleotide binding20 – 289ATP By similarity
Region1 – 2020Ubiquitin-conjugating
Motif176 – 1783TXY

Sites

Active site1381Proton acceptor By similarity
Binding site431ATP By similarity

Amino acid modifications

Modified residue1761Phosphothreonine By similarity
Modified residue1781Phosphotyrosine By similarity
Modified residue4171Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q80Y86 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: A42181A1EC40C1A6

FASTA54960,679
        10         20         30         40         50         60 
MCAAEVDRHV AQRYLIKRRL GKGAYGIVWK AMDRRTGEVV AIKKIFDAFR DQIDAQRTFR 

        70         80         90        100        110        120 
EIMLLKEFGG HPNIIRLLDV IPAKNDRDIY LVFESMDTDL NAVIQKGRLL KDIHKRCIFY 

       130        140        150        160        170        180 
QLLRATKFIH SGRVIHRDQK PANVLLDSAC RVKLCDFGLA RSLGDLPEGP GGQALTEYVA 

       190        200        210        220        230        240 
TRWYRAPEVL LSSRWYTPGV DMWSLGCILG EMLRGQPLFP GTSTFHQLEL ILKTIPLPSM 

       250        260        270        280        290        300 
EELQDLGSDY SALILQNLGS RPQQTLDALL PPDTPPEALD LLKRLLAFAP DKRLSAEQAL 

       310        320        330        340        350        360 
QHPYVQRFHC PDREWARESD VRLPVHEGDQ LSAPEYRKRL YQIILEQSGN SRSPREEGLG 

       370        380        390        400        410        420 
VVASRAELRA SPARTQSLKS GVLPQVPAET PARKRGPKPP RSPGHDPEHV EVRRQSSDPL 

       430        440        450        460        470        480 
FQLPPPGRGE RPPGATGQPP SAPSGVKTQV RAMAPSLTSQ AEAQAANQAL IRSDPARGGG 

       490        500        510        520        530        540 
PRAVGARRVP SRLPREAPEP RPGRRMFGIS VSQGAQGAAR AALGGYSQAY GTVCRSALGR 


LPLLPGPRA 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
[2]"ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5."
Saelzler M.P., Spackman C.C., Liu Y., Martinez L.C., Harris J.P., Abe M.K.
J. Biol. Chem. 281:16821-16832(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TGFB1I1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC048082 mRNA. Translation: AAH48082.1.
RefSeqNP_808590.1. NM_177922.2.
UniGeneMm.40843.

3D structure databases

ProteinModelPortalQ80Y86.
SMRQ80Y86. Positions 6-356.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000087098.

PTM databases

PhosphoSiteQ80Y86.

Proteomic databases

PaxDbQ80Y86.
PRIDEQ80Y86.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000089669; ENSMUSP00000087098; ENSMUSG00000063704.
GeneID332110.
KEGGmmu:332110.
UCSCuc007whz.1. mouse.

Organism-specific databases

CTD225689.
MGIMGI:2652894. Mapk15.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00730000110881.
HOGENOMHOG000233024.
HOVERGENHBG014652.
InParanoidQ80Y86.
KOK08293.
OMACTVKLCD.
OrthoDBEOG7VDXPC.
PhylomeDBQ80Y86.
TreeFamTF105101.

Gene expression databases

BgeeQ80Y86.
CleanExMM_MAPK15.
GenevestigatorQ80Y86.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio399846.
PROQ80Y86.
SOURCESearch...

Entry information

Entry nameMK15_MOUSE
AccessionPrimary (citable) accession number: Q80Y86
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot