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Protein

Dixin

Gene

Dixdc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.2 Publications

GO - Molecular functioni

  • gamma-tubulin binding Source: UniProtKB
  • protein domain specific binding Source: MGI

GO - Biological processi

  • canonical Wnt signaling pathway Source: DFLAT
  • cell cycle Source: DFLAT
  • cell proliferation in forebrain Source: DFLAT
  • cerebral cortex cell migration Source: DFLAT
  • cerebral cortex radially oriented cell migration Source: DFLAT
  • forebrain ventricular zone progenitor cell division Source: DFLAT
  • negative regulation of neuron differentiation Source: DFLAT
  • positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  • positive regulation of Wnt signaling pathway Source: DFLAT
  • regulation of actin cytoskeleton organization Source: DFLAT
  • regulation of microtubule cytoskeleton organization Source: DFLAT
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dixin
Alternative name(s):
Coiled-coil protein DIX1
Short name:
Coiled-coil-DIX1
DIX domain-containing protein 1
Gene namesi
Name:Dixdc1
Synonyms:Ccd1, Kiaa1735
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2679721. Dixdc1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 711711DixinPRO_0000287224Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei212 – 2121PhosphoserineCombined sources
Modified residuei257 – 2571PhosphoserineCombined sources
Modified residuei618 – 6181PhosphoserineBy similarity
Isoform 4 (identifier: Q80Y83-4)
Lipidationi2 – 21N-myristoyl glycineBy similarity
Isoform 11 (identifier: Q80Y83-11)
Modified residuei13 – 131PhosphoserineCombined sources
Isoform 12 (identifier: Q80Y83-12)
Modified residuei13 – 131PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated on tyrosine and serine residues.By similarity
Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ80Y83.
PaxDbiQ80Y83.
PRIDEiQ80Y83.

PTM databases

iPTMnetiQ80Y83.
PhosphoSiteiQ80Y83.

Expressioni

Tissue specificityi

Abundantly expressed in brain and testis and to a lower extent in lung, kidney, colon, ovary and urinary bladder. Expressed in brain, liver, testis and spleen (at protein level). Expressed throughout the brain with strong expression in main and accessory olfactory bulbs, cerebral cortex, piriform cortex, hippocampus, habenular nucleus, dorsal thalamus, superior and inferior colliculi and cerebellum.1 Publication

Developmental stagei

Expressed in embryonic brain, liver and spleen (at protein level). First detected at E7.5 in the node. Expressed in the cephalic mesenchyme and tail bud at E8.5, and in the branchial arch and forelimb bud at E9.5. In the central nervous system, expression begins and persists in the regions where the neurons differentiate. Expression is also strong in the peripheral nervous system, including sensory cranial ganglia, dorsal root ganglia, and autonomic ganglia, and in the sensory organs, such as the inner nuclear layer of the neural retina, saccule and cochlea of the inner ear, and nasal epithelium. Outside the nervous system, expression is detected in the cartilage, tongue, lung bud, stomach, and gonad from E12.5 to E14.5, and in the tooth bud, bronchial epithelium, and kidney at E17.5.2 Publications

Gene expression databases

BgeeiQ80Y83.
CleanExiMM_DIXDC1.
ExpressionAtlasiQ80Y83. baseline and differential.
GenevisibleiQ80Y83. MM.

Interactioni

Subunit structurei

May bind filamentous actin. Directly interacts (via DIX domain) with DVL2 (via DIX domain). Interacts with gamma-tubulin (By similarity). Interacts with the complex composed of DVL2 and Rac. Interacts with AXIN1; competes with MAP3K1. Interacts with MAP3K4 preventing MAP3K4 interaction with AXIN1.By similarity1 Publication

GO - Molecular functioni

  • gamma-tubulin binding Source: UniProtKB
  • protein domain specific binding Source: MGI

Protein-protein interaction databases

BioGridi237048. 1 interaction.
STRINGi10090.ENSMUSP00000034566.

Structurei

3D structure databases

ProteinModelPortaliQ80Y83.
SMRiQ80Y83. Positions 20-151, 622-707.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 127108CHPROSITE-ProRule annotationAdd
BLAST
Domaini600 – 68081DIXPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni153 – 326174Actin-bindingBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili279 – 452174Sequence analysisAdd
BLAST

Domaini

The coiled-coil domain mediates interaction with MAP3K4 and inhibition of AXIN1-mediated JNK activation through MAP3K4.By similarity
The DIX domain mediates interaction with AXIN1 and inhibition of AXIN1-mediated JNK activation through MAP3K1. Mediates interaction with DVL2; this interaction is required for activation of Wnt signaling (By similarity).By similarity

Sequence similaritiesi

Belongs to the DIXDC1 family.Curated
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 1 DIX domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFNC. Eukaryota.
ENOG410XPPR. LUCA.
GeneTreeiENSGT00390000013552.
HOVERGENiHBG107812.
InParanoidiQ80Y83.
OMAiETSWEEQ.
OrthoDBiEOG7X0VGJ.
PhylomeDBiQ80Y83.
TreeFamiTF318198.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 2 hits.
PfamiPF00307. CH. 1 hit.
PF00778. DIX. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00021. DAX. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS50841. DIX. 1 hit.
[Graphical view]

Sequences (16)i

Sequence statusi: Complete.

This entry describes 16 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80Y83-1) [UniParc]FASTAAdd to basket

Also known as: Abeta1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLACLTRGNL LDVLQEGFNE QQLQAYVAWV NAQLKKRPSV KPVQDLRQDL
60 70 80 90 100
RDGVILAYLI EIVGQLALDS DASVDERTDF FLLHSPFKAA GEKLTGVQLS
110 120 130 140 150
PSNQQEMKSN VERVLQFVAS KKIRMHQTSA KDIVEGNLKS IMRLVLALAA
160 170 180 190 200
HFKPGSSRTV SQGRDSKAPV QSHQPHCATA VAQGAAAALA DVCHDVSRSG
210 220 230 240 250
RDVFRYRQRN ASVDGEIENP YWSVRALVQQ YEGQQKSPSE SSCSSLTSPS
260 270 280 290 300
PIHSAKSESI ITQAEEKADF VIIPSEGIEN RTDEPDSPSS RDWRPGSRGT
310 320 330 340 350
YLEATWEEQL LEQQEHLEKE MEEAKKMISG LQALLLNGSL PEDEQERPVA
360 370 380 390 400
LCEPGVNPEE QLIIIRSRLD QSVEENQDLK KELLKCKQEA RNLQGIKDAL
410 420 430 440 450
QQRLTQQDTS VLQLKQELLR ANMDKDELHN QNVDLQRKLE ERNRLLGEYK
460 470 480 490 500
KELGQKDRLF QQQQAKLEEA LRKLSDASYQ QVDLERELEQ KDVLLAHCMK
510 520 530 540 550
GETDEVTNYN SHSSQRNGFV LPVAGRGATT VTHRGPQTSD LQLVRDALRS
560 570 580 590 600
LRNSFSGHDP QHHTIDSLEQ GISSLMERLH VVETQKKQER KVGGRSPRNQ
610 620 630 640 650
ASSEYRASWP PNSTLPHSQS SPAVSSTCTK VLYFTDRSLT PFMVNIPKRL
660 670 680 690 700
GEVTLKDFKA AIDREGNHRY HFKALDPEFG TVKEEVFHDD DAIPGWEGKI
710
VAWVEEDHRE N
Length:711
Mass (Da):80,215
Last modified:June 1, 2003 - v1
Checksum:i153063F1B995EB8C
GO
Isoform 2 (identifier: Q80Y83-2) [UniParc]FASTAAdd to basket

Also known as: Abeta1S

The sequence of this isoform differs from the canonical sequence as follows:
     506-535: Missing.

Show »
Length:681
Mass (Da):77,048
Checksum:i644FC11062E8C3AE
GO
Isoform 3 (identifier: Q80Y83-3) [UniParc]FASTAAdd to basket

Also known as: Aalpha1L

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MLACLTRGNLLDVLQEGFNE → MGTQVVMRVCNSSMPGAPS

Show »
Length:710
Mass (Da):79,931
Checksum:i313D5838DE1B658A
GO
Isoform 4 (identifier: Q80Y83-4) [UniParc]FASTAAdd to basket

Also known as: Aalpha1S

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MLACLTRGNLLDVLQEGFNE → MGTQVVMRVCNSSMPGAPS
     506-535: Missing.

Show »
Length:680
Mass (Da):76,764
Checksum:i66D1643B1903D044
GO
Isoform 5 (identifier: Q80Y83-5) [UniParc]FASTAAdd to basket

Also known as: Abeta2L

The sequence of this isoform differs from the canonical sequence as follows:
     64-89: Missing.

Note: Major isoform.
Show »
Length:685
Mass (Da):77,353
Checksum:iC49B303441826CE6
GO
Isoform 6 (identifier: Q80Y83-6) [UniParc]FASTAAdd to basket

Also known as: Abeta2S

The sequence of this isoform differs from the canonical sequence as follows:
     64-89: Missing.
     506-535: Missing.

Show »
Length:655
Mass (Da):74,186
Checksum:iF21678E676FB57D4
GO
Isoform 7 (identifier: Q80Y83-7) [UniParc]FASTAAdd to basket

Also known as: Aalpha2L

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MLACLTRGNLLDVLQEGFNE → MGTQVVMRVCNSSMPGAPS
     64-89: Missing.

Note: Major isoform.
Show »
Length:684
Mass (Da):77,068
Checksum:i8A467968A31CC9CD
GO
Isoform 8 (identifier: Q80Y83-8) [UniParc]FASTAAdd to basket

Also known as: Aalpha2S

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MLACLTRGNLLDVLQEGFNE → MGTQVVMRVCNSSMPGAPS
     64-89: Missing.
     506-535: Missing.

Show »
Length:654
Mass (Da):73,902
Checksum:i0753993D739AFC84
GO
Isoform 9 (identifier: Q80Y83-9) [UniParc]FASTAAdd to basket

Also known as: BbetaL

The sequence of this isoform differs from the canonical sequence as follows:
     1-234: Missing.
     235-245: QKSPSESSCSS → MMIILQSKLIT

Show »
Length:477
Mass (Da):54,487
Checksum:iA4C5B03A794D05F6
GO
Isoform 10 (identifier: Q80Y83-10) [UniParc]FASTAAdd to basket

Also known as: BbetaS

The sequence of this isoform differs from the canonical sequence as follows:
     1-234: Missing.
     235-245: QKSPSESSCSS → MMIILQSKLIT
     506-535: Missing.

Show »
Length:447
Mass (Da):51,321
Checksum:i51567F8E0072EAD9
GO
Isoform 11 (identifier: Q80Y83-11) [UniParc]FASTAAdd to basket

Also known as: BalphaL

The sequence of this isoform differs from the canonical sequence as follows:
     1-237: Missing.
     238-245: PSESSCSS → MGGTQVKC

Note: Major isoform.Combined sources
Show »
Length:474
Mass (Da):54,019
Checksum:iC196BF5788A0CEED
GO
Isoform 12 (identifier: Q80Y83-12) [UniParc]FASTAAdd to basket

Also known as: BalphaS

The sequence of this isoform differs from the canonical sequence as follows:
     1-237: Missing.
     238-245: PSESSCSS → MGGTQVKC
     506-535: Missing.

Show »
Length:444
Mass (Da):50,853
Checksum:i83FE9CCFC405E81F
GO
Isoform 13 (identifier: Q80Y83-13) [UniParc]FASTAAdd to basket

Also known as: CL

The sequence of this isoform differs from the canonical sequence as follows:
     1-320: Missing.

Show »
Length:391
Mass (Da):44,724
Checksum:iB6C49B325B438E2F
GO
Isoform 14 (identifier: Q80Y83-14) [UniParc]FASTAAdd to basket

Also known as: CS

The sequence of this isoform differs from the canonical sequence as follows:
     1-320: Missing.
     506-535: Missing.

Show »
Length:361
Mass (Da):41,558
Checksum:i4EFD96029308CE46
GO
Isoform 15 (identifier: Q80Y83-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-272: Missing.
     273-282: IPSEGIENRT → MNYGSTFHLA
     614-615: TL → KA
     616-711: Missing.

Note: No experimental confirmation available.
Show »
Length:343
Mass (Da):39,375
Checksum:i5441871A12784754
GO
Isoform 16 (identifier: Q80Y83-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MLACLTRGNLLDVLQEGFNE → MGTQVVMRVCNSSMPGAPS
     90-117: AGEKLTGVQLSPSNQQEMKSNVERVLQF → GCSFFRMHGNSVGKYLKVLALVNLRVGQ
     118-711: Missing.

Show »
Length:116
Mass (Da):12,850
Checksum:iBD7F6FF410958217
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti278 – 2781I → T in BAC98242 (PubMed:14621295).Curated
Sequence conflicti474 – 4741L → F in BAC98242 (PubMed:14621295).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 320320Missing in isoform 13 and isoform 14. 1 PublicationVSP_025383Add
BLAST
Alternative sequencei1 – 272272Missing in isoform 15. 1 PublicationVSP_025384Add
BLAST
Alternative sequencei1 – 237237Missing in isoform 11 and isoform 12. 1 PublicationVSP_025385Add
BLAST
Alternative sequencei1 – 234234Missing in isoform 9 and isoform 10. 1 PublicationVSP_025386Add
BLAST
Alternative sequencei1 – 2020MLACL…EGFNE → MGTQVVMRVCNSSMPGAPS in isoform 3, isoform 4, isoform 7, isoform 8 and isoform 16. 2 PublicationsVSP_025387Add
BLAST
Alternative sequencei64 – 8926Missing in isoform 5, isoform 6, isoform 7 and isoform 8. 1 PublicationVSP_025388Add
BLAST
Alternative sequencei90 – 11728AGEKL…RVLQF → GCSFFRMHGNSVGKYLKVLA LVNLRVGQ in isoform 16. 1 PublicationVSP_025389Add
BLAST
Alternative sequencei118 – 711594Missing in isoform 16. 1 PublicationVSP_025390Add
BLAST
Alternative sequencei235 – 24511QKSPSESSCSS → MMIILQSKLIT in isoform 9 and isoform 10. 1 PublicationVSP_025391Add
BLAST
Alternative sequencei238 – 2458PSESSCSS → MGGTQVKC in isoform 11 and isoform 12. 1 PublicationVSP_025392
Alternative sequencei273 – 28210IPSEGIENRT → MNYGSTFHLA in isoform 15. 1 PublicationVSP_025393
Alternative sequencei506 – 53530Missing in isoform 2, isoform 4, isoform 6, isoform 8, isoform 10, isoform 12 and isoform 14. CuratedVSP_025394Add
BLAST
Alternative sequencei614 – 6152TL → KA in isoform 15. 1 PublicationVSP_025395
Alternative sequencei616 – 71196Missing in isoform 15. 1 PublicationVSP_025396Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY549883 mRNA. Translation: AAT41660.1.
AY549884 mRNA. Translation: AAT41661.1.
AY549885 mRNA. Translation: AAT41662.1.
AY549886 mRNA. Translation: AAT41663.1.
AY549887 mRNA. Translation: AAT41664.1.
AK082960 mRNA. Translation: BAC38711.1.
AK142668 mRNA. Translation: BAE25153.1.
AK164424 mRNA. Translation: BAE37782.1.
BC024834 mRNA. Translation: AAH24834.1.
BC048182 mRNA. Translation: AAH48182.1.
BC063085 mRNA. Translation: AAH63085.1.
AK129432 mRNA. Translation: BAC98242.1.
CCDSiCCDS23169.1. [Q80Y83-1]
CCDS80995.1. [Q80Y83-3]
RefSeqiNP_001297998.1. NM_001311069.1. [Q80Y83-3]
NP_835219.1. NM_178118.2. [Q80Y83-1]
XP_006510517.1. XM_006510454.2. [Q80Y83-5]
XP_006510518.1. XM_006510455.2. [Q80Y83-2]
XP_006510519.1. XM_006510456.2. [Q80Y83-11]
XP_006510520.1. XM_006510457.2. [Q80Y83-13]
UniGeneiMm.82598.

Genome annotation databases

EnsembliENSMUST00000034566; ENSMUSP00000034566; ENSMUSG00000032064. [Q80Y83-1]
ENSMUST00000117093; ENSMUSP00000112654; ENSMUSG00000032064. [Q80Y83-16]
ENSMUST00000117646; ENSMUSP00000112431; ENSMUSG00000032064. [Q80Y83-5]
ENSMUST00000120622; ENSMUSP00000113934; ENSMUSG00000032064. [Q80Y83-15]
ENSMUST00000121634; ENSMUSP00000113089; ENSMUSG00000032064. [Q80Y83-3]
GeneIDi330938.
KEGGimmu:330938.
UCSCiuc009pkb.1. mouse. [Q80Y83-11]
uc009pkc.2. mouse. [Q80Y83-1]
uc009pkd.1. mouse. [Q80Y83-3]
uc009pke.1. mouse. [Q80Y83-15]
uc009pkh.1. mouse. [Q80Y83-16]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY549883 mRNA. Translation: AAT41660.1.
AY549884 mRNA. Translation: AAT41661.1.
AY549885 mRNA. Translation: AAT41662.1.
AY549886 mRNA. Translation: AAT41663.1.
AY549887 mRNA. Translation: AAT41664.1.
AK082960 mRNA. Translation: BAC38711.1.
AK142668 mRNA. Translation: BAE25153.1.
AK164424 mRNA. Translation: BAE37782.1.
BC024834 mRNA. Translation: AAH24834.1.
BC048182 mRNA. Translation: AAH48182.1.
BC063085 mRNA. Translation: AAH63085.1.
AK129432 mRNA. Translation: BAC98242.1.
CCDSiCCDS23169.1. [Q80Y83-1]
CCDS80995.1. [Q80Y83-3]
RefSeqiNP_001297998.1. NM_001311069.1. [Q80Y83-3]
NP_835219.1. NM_178118.2. [Q80Y83-1]
XP_006510517.1. XM_006510454.2. [Q80Y83-5]
XP_006510518.1. XM_006510455.2. [Q80Y83-2]
XP_006510519.1. XM_006510456.2. [Q80Y83-11]
XP_006510520.1. XM_006510457.2. [Q80Y83-13]
UniGeneiMm.82598.

3D structure databases

ProteinModelPortaliQ80Y83.
SMRiQ80Y83. Positions 20-151, 622-707.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi237048. 1 interaction.
STRINGi10090.ENSMUSP00000034566.

PTM databases

iPTMnetiQ80Y83.
PhosphoSiteiQ80Y83.

Proteomic databases

MaxQBiQ80Y83.
PaxDbiQ80Y83.
PRIDEiQ80Y83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034566; ENSMUSP00000034566; ENSMUSG00000032064. [Q80Y83-1]
ENSMUST00000117093; ENSMUSP00000112654; ENSMUSG00000032064. [Q80Y83-16]
ENSMUST00000117646; ENSMUSP00000112431; ENSMUSG00000032064. [Q80Y83-5]
ENSMUST00000120622; ENSMUSP00000113934; ENSMUSG00000032064. [Q80Y83-15]
ENSMUST00000121634; ENSMUSP00000113089; ENSMUSG00000032064. [Q80Y83-3]
GeneIDi330938.
KEGGimmu:330938.
UCSCiuc009pkb.1. mouse. [Q80Y83-11]
uc009pkc.2. mouse. [Q80Y83-1]
uc009pkd.1. mouse. [Q80Y83-3]
uc009pke.1. mouse. [Q80Y83-15]
uc009pkh.1. mouse. [Q80Y83-16]

Organism-specific databases

CTDi85458.
MGIiMGI:2679721. Dixdc1.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IFNC. Eukaryota.
ENOG410XPPR. LUCA.
GeneTreeiENSGT00390000013552.
HOVERGENiHBG107812.
InParanoidiQ80Y83.
OMAiETSWEEQ.
OrthoDBiEOG7X0VGJ.
PhylomeDBiQ80Y83.
TreeFamiTF318198.

Miscellaneous databases

PROiQ80Y83.
SOURCEiSearch...

Gene expression databases

BgeeiQ80Y83.
CleanExiMM_DIXDC1.
ExpressionAtlasiQ80Y83. baseline and differential.
GenevisibleiQ80Y83. MM.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 2 hits.
PfamiPF00307. CH. 1 hit.
PF00778. DIX. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00021. DAX. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS50841. DIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and differential expression of multiple isoforms of mouse coiled-coil-DIX1 (Ccd1), a positive regulator of Wnt signaling."
    Shiomi K., Kanemoto M., Keino-Masu K., Yoshida S., Soma K., Masu M.
    Brain Res. Mol. Brain Res. 135:169-180(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 9; 11 AND 13), ALTERNATIVE SPLICING (ISOFORMS 2; 4; 5; 6; 7; 8; 10; 12 AND 14), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 15), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-316 (ISOFORM 5), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 612-711 (ISOFORMS 1/2/3/4/5).
    Strain: C57BL/6J.
    Tissue: Embryonic eye, Embryonic spinal cord and Mammary gland.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 16).
    Strain: C57BL/6J.
    Tissue: Embryonic brain and Eye.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 228-711 (ISOFORMS 1/2).
    Tissue: Embryonic tail.
  5. "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms."
    Wong C.K., Luo W., Deng Y., Zou H., Ye Z., Lin S.-C.
    J. Biol. Chem. 279:39366-39373(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH AXIN1; DVL2; MAP3K4 AND RAC.
  6. "Expression of mouse Coiled-coil-DIX1 (Ccd1), a positive regulator of Wnt signaling, during embryonic development."
    Soma K., Shiomi K., Keino-Masu K., Masu M.
    Gene Expr. Patterns 6:325-330(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212 AND SER-257, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13 (ISOFORMS 11 AND 12), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Kidney.

Entry informationi

Entry nameiDIXC1_MOUSE
AccessioniPrimary (citable) accession number: Q80Y83
Secondary accession number(s): Q3TPF4
, Q3UQ90, Q5DPZ2, Q5DPZ3, Q5DPZ4, Q5DPZ6, Q6ZPJ2, Q8C467, Q8R1C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.