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Protein

Zinc phosphodiesterase ELAC protein 2

Gene

Elac2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.

Cofactori

Zn2+Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc phosphodiesterase ELAC protein 2 (EC:3.1.26.11)
Alternative name(s):
ElaC homolog protein 2
Ribonuclease Z 2
Short name:
RNase Z 2
tRNA 3 endonuclease 2
tRNase Z 2
Gene namesi
Name:Elac2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1890496. Elac2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial nucleoid Source: MGI
  • mitochondrion Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 16MitochondrionSequence analysisAdd BLAST16
ChainiPRO_000015583017 – 831Zinc phosphodiesterase ELAC protein 2Add BLAST815

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei191PhosphoserineCombined sources1
Modified residuei195PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei204PhosphoserineBy similarity1
Modified residuei732PhosphoserineBy similarity1
Modified residuei792PhosphothreonineCombined sources1
Modified residuei797PhosphoserineCombined sources1
Modified residuei815PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80Y81.
PRIDEiQ80Y81.

PTM databases

iPTMnetiQ80Y81.
PhosphoSitePlusiQ80Y81.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020549.
CleanExiMM_ELAC2.
ExpressionAtlasiQ80Y81. baseline and differential.
GenevisibleiQ80Y81. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with PTCD1.By similarity

Protein-protein interaction databases

IntActiQ80Y81. 1 interactor.
MINTiMINT-4132795.
STRINGi10090.ENSMUSP00000071788.

Structurei

3D structure databases

ProteinModelPortaliQ80Y81.
SMRiQ80Y81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2121. Eukaryota.
COG1234. LUCA.
GeneTreeiENSGT00730000111191.
HOVERGENiHBG050042.
InParanoidiQ80Y81.
KOiK00784.
OMAiHNQCQEV.
OrthoDBiEOG091G028A.
PhylomeDBiQ80Y81.
TreeFamiTF105797.

Family and domain databases

Gene3Di3.60.15.10. 3 hits.
InterProiIPR001279. Metallo-B-lactamas.
IPR027794. tRNase_Z_dom.
[Graphical view]
PfamiPF12706. Lactamase_B_2. 1 hit.
PF13691. Lactamase_B_4. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80Y81-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWALRSLLRP LGLRTMSQGS ARRPRPSKDP LRHLRTREKR GPGPGGPNTV
60 70 80 90 100
YLQVVAAGGR DAGAALYVFS EYNRYLFNCG EGVQRLMQEH KLKVARLDNI
110 120 130 140 150
FLTRMHWSNV GGLCGMILTL KETGLPKCVL SGPPQLEKYL EAIKIFSGPL
160 170 180 190 200
KGIELAVRPH SAPEYKDETM TVYQVPIHSE RRCGKQQPSQ SPRTSPNRLS
210 220 230 240 250
PKQSSDSGSA ENGQCPPEDS SAGANRKAWG RDPSLVVAFV CKLHLRKGNF
260 270 280 290 300
LVLKAKELGL PVGTAAIAPI IAAVKDGKSI TYEGREIAAE ELCTPPDPGL
310 320 330 340 350
VFIVVECPDE GFILPICEND TFKRYQAEAD APVALVVHIA PESVLIDSRY
360 370 380 390 400
QQWMERFGPD TQHLILNENC PSVHNLRSHK IQTQLSLIHP DIFPQLTSFY
410 420 430 440 450
SKEEGSTLSV PTVRGECLLK YQLRPKREWQ RDTTLDCNTD EFIAEALELP
460 470 480 490 500
SFQESVEEYR KNVQENPAPA EKRSQYPEIV FLGTGSAIPM KIRNVSSTLV
510 520 530 540 550
NLSPDKSVLL DCGEGTFGQL CRHYGQQIDR VLCSLTAVFV SHLHADHHTG
560 570 580 590 600
LLNILLQREH ALASLGKPFQ PLLVVAPTQL RAWLQQYHNH CQEILHHVSM
610 620 630 640 650
IPAKCLQKGA EVSNTTLERL ISLLLETCDL EEFQTCLVRH CKHAFGCALV
660 670 680 690 700
HSSGWKVVYS GDTMPCEALV QMGKDATLLI HEATLEDGLE EEAVEKTHST
710 720 730 740 750
TSQAINVGMR MNAEFIMLNH FSQRYAKIPL FSPDFNEKVG IAFDHMKVCF
760 770 780 790 800
GDFPTVPKLI PPLKALFAGD IEEMVERREK RELRLVRAAL LTQQADSPED
810 820 830
REPQQKRAHT DEPHSPQSKK ESVANTLGAR V
Length:831
Mass (Da):92,719
Last modified:June 1, 2003 - v1
Checksum:i77E3876AE2862224
GO
Isoform 2 (identifier: Q80Y81-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     821-831: ESVANTLGARV → VRAQ

Note: No experimental confirmation available.
Show »
Length:824
Mass (Da):92,076
Checksum:iFF19EBED86228B8A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27S → P in AAK29420 (PubMed:11175785).Curated1
Sequence conflicti27S → P in AAK29421 (PubMed:11175785).Curated1
Sequence conflicti397T → S in BAB23185 (PubMed:16141072).Curated1
Sequence conflicti435L → P in AAG24918 (PubMed:11175785).Curated1
Sequence conflicti714E → G in AAG24918 (PubMed:11175785).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009173821 – 831ESVANTLGARV → VRAQ in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF308696 mRNA. Translation: AAG24918.2.
AF348157 Genomic DNA. Translation: AAK29420.1.
AF348157 Genomic DNA. Translation: AAK29421.1.
AL663045 Genomic DNA. Translation: CAI24609.1.
BC048235 mRNA. Translation: AAH48235.1.
AK003759 mRNA. Translation: BAB22981.2.
AK004136 mRNA. Translation: BAB23185.1.
CCDSiCCDS24841.1. [Q80Y81-1]
RefSeqiNP_075968.2. NM_023479.2. [Q80Y81-1]
UniGeneiMm.157711.

Genome annotation databases

EnsembliENSMUST00000071891; ENSMUSP00000071788; ENSMUSG00000020549. [Q80Y81-1]
ENSMUST00000101049; ENSMUSP00000098610; ENSMUSG00000020549. [Q80Y81-2]
GeneIDi68626.
KEGGimmu:68626.
UCSCiuc007jks.2. mouse. [Q80Y81-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF308696 mRNA. Translation: AAG24918.2.
AF348157 Genomic DNA. Translation: AAK29420.1.
AF348157 Genomic DNA. Translation: AAK29421.1.
AL663045 Genomic DNA. Translation: CAI24609.1.
BC048235 mRNA. Translation: AAH48235.1.
AK003759 mRNA. Translation: BAB22981.2.
AK004136 mRNA. Translation: BAB23185.1.
CCDSiCCDS24841.1. [Q80Y81-1]
RefSeqiNP_075968.2. NM_023479.2. [Q80Y81-1]
UniGeneiMm.157711.

3D structure databases

ProteinModelPortaliQ80Y81.
SMRiQ80Y81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80Y81. 1 interactor.
MINTiMINT-4132795.
STRINGi10090.ENSMUSP00000071788.

PTM databases

iPTMnetiQ80Y81.
PhosphoSitePlusiQ80Y81.

Proteomic databases

PaxDbiQ80Y81.
PRIDEiQ80Y81.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071891; ENSMUSP00000071788; ENSMUSG00000020549. [Q80Y81-1]
ENSMUST00000101049; ENSMUSP00000098610; ENSMUSG00000020549. [Q80Y81-2]
GeneIDi68626.
KEGGimmu:68626.
UCSCiuc007jks.2. mouse. [Q80Y81-1]

Organism-specific databases

CTDi60528.
MGIiMGI:1890496. Elac2.

Phylogenomic databases

eggNOGiKOG2121. Eukaryota.
COG1234. LUCA.
GeneTreeiENSGT00730000111191.
HOVERGENiHBG050042.
InParanoidiQ80Y81.
KOiK00784.
OMAiHNQCQEV.
OrthoDBiEOG091G028A.
PhylomeDBiQ80Y81.
TreeFamiTF105797.

Miscellaneous databases

PROiQ80Y81.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020549.
CleanExiMM_ELAC2.
ExpressionAtlasiQ80Y81. baseline and differential.
GenevisibleiQ80Y81. MM.

Family and domain databases

Gene3Di3.60.15.10. 3 hits.
InterProiIPR001279. Metallo-B-lactamas.
IPR027794. tRNase_Z_dom.
[Graphical view]
PfamiPF12706. Lactamase_B_2. 1 hit.
PF13691. Lactamase_B_4. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiRNZ2_MOUSE
AccessioniPrimary (citable) accession number: Q80Y81
Secondary accession number(s): B1ATP6
, Q99MF0, Q99MF1, Q9CTA2, Q9D1A8, Q9EPZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.