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Protein

Calmodulin-binding transcription activator 2

Gene

Camta2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription activator. May act as tumor suppressor (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi30 – 160CG-1PROSITE-ProRule annotationAdd BLAST131

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-binding transcription activator 2
Gene namesi
Name:Camta2
Synonyms:Kiaa0909
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2135957 Camta2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002358221 – 1208Calmodulin-binding transcription activator 2Add BLAST1208

Proteomic databases

PaxDbiQ80Y50
PRIDEiQ80Y50

PTM databases

iPTMnetiQ80Y50
PhosphoSitePlusiQ80Y50

Expressioni

Gene expression databases

BgeeiENSMUSG00000040712
CleanExiMM_CAMTA2
ExpressionAtlasiQ80Y50 baseline and differential
GenevisibleiQ80Y50 MM

Interactioni

Subunit structurei

May interact with calmodulin.Curated

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043792

Structurei

3D structure databases

ProteinModelPortaliQ80Y50
SMRiQ80Y50
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini540 – 622IPT/TIGAdd BLAST83
Repeati717 – 750ANK 1Add BLAST34
Repeati762 – 792ANK 2Add BLAST31
Repeati796 – 826ANK 3Add BLAST31
Domaini1054 – 1083IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini1107 – 1136IQ 2PROSITE-ProRule annotationAdd BLAST30

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi78 – 86Nuclear localization signalPROSITE-ProRule annotation9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi294 – 305Ser-richAdd BLAST12

Sequence similaritiesi

Belongs to the CAMTA family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0520 Eukaryota
ENOG410XS5M LUCA
GeneTreeiENSGT00390000001446
HOVERGENiHBG058078
InParanoidiQ80Y50
KOiK21596
OMAiHGIKWSC
OrthoDBiEOG091G01MB
PhylomeDBiQ80Y50
TreeFamiTF323452

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005559 CG-1_dom
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR000048 IQ_motif_EF-hand-BS
PfamiView protein in Pfam
PF03859 CG-1, 1 hit
PF01833 TIG, 1 hit
SMARTiView protein in SMART
SM01076 CG-1, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS51437 CG_1, 1 hit
PS50096 IQ, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80Y50-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNTKDTTEVA ENSHHLKIFL PKKLLECLPR CPLLPPERLR WNTNEEIASY
60 70 80 90 100
LITFEKHDEW LSCAPKTRPQ NGSIILYNRK KVKYRKDGYL WKKRKDGKTT
110 120 130 140 150
REDHMKLKVQ GMEPVSWQCL YGCYVHSSIV PTFHRRCYWL LQNPDIVLVH
160 170 180 190 200
YLNVPALEDC GKGCSPIFCS ISSDRREWLK WSREELLGQL KPMFHGIKWS
210 220 230 240 250
CGNGAEEFSV EQLVQQILDT HPTKPAPRTH ACLCSGGLGS GSLTHKCSST
260 270 280 290 300
KHRIISPKVE PRALALASIS HSKPPEPPPL IAPLPPELPK AHTSPSSSSS
310 320 330 340 350
SSSSSGFAEP LEIRPSPPTS RGGSSRGGTA ILLLTGLEQR AGGLTPTRHL
360 370 380 390 400
APQAEPRPPV SLAVVVGSEP SAPPAPPSPA FDPDRFLNSP QRGQTYGGGQ
410 420 430 440 450
GVNPDFPEAE GTHTPCPALE PAAALEPQAA ARGLAPQLGA NGRRGNKFFI
460 470 480 490 500
QDDDSGEELK GPGTVPPVPS SPPSSPSSPT ALPPSGRATR GEALFGGSAG
510 520 530 540 550
SSSELEPFSL SSFPDLMGEL ISDEAPGVPA PAPQLSPALN AITDFSPEWS
560 570 580 590 600
YPEGGVKVLI TGPWTEAAEH YSCVFDHIAV PASLVQPGVL RCYCPAHEVG
610 620 630 640 650
LVSLQVAGRE GPLSASVLFE YRARRFLSLP STQLDWLSLD DSQFRMSILE
660 670 680 690 700
RLEQMEKRMA EIAAAGQAPG QGPEAPPIQD EGQGPGFEAR VVVLVESMIP
710 720 730 740 750
RSTWRGPERL IHGSPFRGMS LLHLAAAQGY ARLIETLSQW RSVETGSLDL
760 770 780 790 800
EQEVDPLNVD HFSCTPLMWA CALGHLEAAV LLFCWNRQAL SIPDSLGRLP
810 820 830 840 850
LSVAHSRGHV RLARCLEELQ RQELSVEHPL ALSPPSSSPD TGLSSASSPS
860 870 880 890 900
ELSDGTFSVT SAYSSAPDGS PPPAPPLASD ISMEMIPGQL SCGAPETPLL
910 920 930 940 950
LMDYEATNSK EPAPSPCGPP LAQDNGAAPE DADSPPAVDV IPVDMISLAK
960 970 980 990 1000
QIIDATPERI KREDFSEFPD AGASPREHTG TVGLSETMSW LASYLENVDH
1010 1020 1030 1040 1050
FPSSAPPSEL PFERGRLAIP PAPSWAEFLS ASTSGKMESD FALLTLSDHE
1060 1070 1080 1090 1100
QRELYEAARV IQTAFRKYKG RRLKEQQEVA AAVIQRCYRK YKQLTWIALK
1110 1120 1130 1140 1150
FALYKKMTQA AILIQSKFRS YYEQKRFQQS RRAAVLIQQH YRSYRRRPGP
1160 1170 1180 1190 1200
PHRPSGPLPA RNKGTFLTKK QDQAARKIMR FLRRCRHRMR ELKQNQELEG

LPQPGLAT
Length:1,208
Mass (Da):132,010
Last modified:June 1, 2003 - v1
Checksum:iF32D05F8C5A3590C
GO
Isoform 2 (identifier: Q80Y50-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-118: Missing.

Show »
Length:1,203
Mass (Da):131,412
Checksum:iB3F0DB6909322F70
GO
Isoform 3 (identifier: Q80Y50-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MNTKDTTEVA → MAAAAVTRGTPG
     114-118: Missing.
     1094-1100: Missing.

Show »
Length:1,198
Mass (Da):130,579
Checksum:i1CF2720DAE9455C2
GO
Isoform 4 (identifier: Q80Y50-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-142: Missing.
     1094-1100: Missing.

Show »
Length:1,172
Mass (Da):127,659
Checksum:i09D06F1D2E68BD94
GO
Isoform 5 (identifier: Q80Y50-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     913-1001: APSPCGPPLA...ASYLENVDHF → PPPGLTRFLP...FAARALVFQG
     1002-1208: Missing.

Show »
Length:1,001
Mass (Da):107,857
Checksum:i29903B372A6F0751
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti235S → G in BAE40898 (PubMed:16141072).Curated1
Sequence conflicti545F → L in BAE40898 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0184941 – 10MNTKDTTEVA → MAAAAVTRGTPG in isoform 3. 1 Publication10
Alternative sequenceiVSP_018495114 – 142Missing in isoform 4. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_018496114 – 118Missing in isoform 2 and isoform 3. 3 Publications5
Alternative sequenceiVSP_018497913 – 1001APSPC…NVDHF → PPPGLTRFLPSGCASSFGLR LQKTHAPHICIFSCDLRSPA CTFSISPFLPAPDSDLPDLP YLFVRESLMNVSASVPTAAF AARALVFQG in isoform 5. 1 PublicationAdd BLAST89
Alternative sequenceiVSP_0184981002 – 1208Missing in isoform 5. 1 PublicationAdd BLAST207
Alternative sequenceiVSP_0184991094 – 1100Missing in isoform 3 and isoform 4. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK169118 mRNA Translation: BAE40898.1
AL596117 Genomic DNA Translation: CAI25176.1
AL596117 Genomic DNA Translation: CAI25177.2
AL596117 Genomic DNA Translation: CAI25178.1
AL596117 Genomic DNA Translation: CAQ12359.1
CR933736, CR933735 Genomic DNA Translation: CAM28112.1
CR933735, CR933736 Genomic DNA Translation: CAM28144.1
BC027039 mRNA Translation: AAH27039.1
BC027385 mRNA Translation: AAH27385.1
BC049133 mRNA Translation: AAH49133.1
BC056395 mRNA Translation: AAH56395.1
AK122400 mRNA Translation: BAC65682.1
CCDSiCCDS24963.1 [Q80Y50-1]
CCDS56786.1 [Q80Y50-4]
CCDS56788.1 [Q80Y50-2]
RefSeqiNP_001177305.1, NM_001190376.1 [Q80Y50-2]
NP_001177308.1, NM_001190379.1 [Q80Y50-4]
NP_835217.1, NM_178116.4 [Q80Y50-1]
UniGeneiMm.473726

Genome annotation databases

EnsembliENSMUST00000036299; ENSMUSP00000043792; ENSMUSG00000040712 [Q80Y50-1]
ENSMUST00000100933; ENSMUSP00000098493; ENSMUSG00000040712 [Q80Y50-3]
ENSMUST00000108544; ENSMUSP00000104184; ENSMUSG00000040712 [Q80Y50-2]
ENSMUST00000108545; ENSMUSP00000104185; ENSMUSG00000040712 [Q80Y50-4]
GeneIDi216874
KEGGimmu:216874
UCSCiuc007jwa.2 mouse [Q80Y50-4]
uc007jwc.2 mouse [Q80Y50-1]
uc007jwd.2 mouse [Q80Y50-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCMTA2_MOUSE
AccessioniPrimary (citable) accession number: Q80Y50
Secondary accession number(s): B0QZH5
, Q3TFK0, Q5SX54, Q5SX68, Q6PHS5, Q80TP1, Q8R0D9, Q8R2N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health