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Q80Y44

- DDX10_MOUSE

UniProt

Q80Y44 - DDX10_MOUSE

Protein

Probable ATP-dependent RNA helicase DDX10

Gene

Ddx10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (27 Sep 2005)
      Previous versions | rss
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    Functioni

    Putative ATP-dependent RNA helicase.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei96 – 961ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi89 – 913ATPPROSITE-ProRule annotation
    Nucleotide bindingi113 – 1208ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP-dependent helicase activity Source: InterPro
    3. RNA binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ATP-dependent RNA helicase DDX10 (EC:3.6.4.13)
    Alternative name(s):
    DEAD box protein 10
    Gene namesi
    Name:Ddx10
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1924841. Ddx10.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 875875Probable ATP-dependent RNA helicase DDX10PRO_0000055084Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei4 – 41PhosphothreonineBy similarity
    Modified residuei540 – 5401PhosphoserineBy similarity
    Modified residuei556 – 5561N6-acetyllysine1 Publication
    Modified residuei587 – 5871Phosphothreonine2 Publications
    Modified residuei783 – 7831PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ80Y44.
    PRIDEiQ80Y44.

    PTM databases

    PhosphoSiteiQ80Y44.

    Expressioni

    Gene expression databases

    ArrayExpressiQ80Y44.
    BgeeiQ80Y44.
    CleanExiMM_DDX10.
    GenevestigatoriQ80Y44.

    Interactioni

    Protein-protein interaction databases

    BioGridi218780. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80Y44.
    SMRiQ80Y44. Positions 47-476.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini100 – 274175Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini300 – 449150Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi69 – 9729Q motifAdd
    BLAST
    Motifi222 – 2254DEAD box

    Domaini

    The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

    Sequence similaritiesi

    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0513.
    GeneTreeiENSGT00550000074980.
    HOGENOMiHOG000268801.
    HOVERGENiHBG102756.
    InParanoidiQ80Y44.
    KOiK14776.
    OMAiCCKEVQY.
    OrthoDBiEOG7GFB4K.
    PhylomeDBiQ80Y44.
    TreeFamiTF315215.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR025313. DUF4217.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000629. RNA-helicase_DEAD-box_CS.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    [Graphical view]
    PfamiPF00270. DEAD. 1 hit.
    PF13959. DUF4217. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q80Y44-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKTVASLGQ GTRPDPVRSF NRWKKKHSHR QHQKKERRKQ LKKPEWQVER    50
    EGISRLMQNY EKINVNEITR FSDFPLSKKT LKGLQEAQYR LVTEIQKQTI 100
    GLALQGKDVL GAAKTGSGKT LAFLVPVLEA LYRLQWTSTD GLGVLIISPT 150
    RELAYQTFEV LRKVGKNHDF SAGLIIGGKD LKHEAERINN INILVCTPGR 200
    LLQHMDETIC FHATNLQMLV LDEADRILDM GFADTMNAII ENLPKKRQTL 250
    LFSATQTKSV KDLARLSLKD PEYVWVHEKA KYSTPATLEQ NYIICELHQK 300
    ISVLFSFLRS HLKKKSIVFF SSCKEVQYLY RVFCRLRPGI SILALHGRQQ 350
    QMRRMEVYNE FVRKRAAVLF ATDIAARGLD FPAVNWVLQF DCPEDANTYI 400
    HRAGRTARYK EDGEALLILL PSEEQGMVQQ LLQKKVPVKE IKINPEKLID 450
    VQKKLESFLA QDQDLKERAQ RCFVSYIRSV YLMKDKEVFN VSKLPITEYA 500
    LSLGLAVAPR IRFLQKLEKQ PSTELVKNPV TEAVPPRAPS LPNDEADESP 550
    AYVSEKMSVL HKSGERLEET EHRLASGDGD EEQDEETEDE ETEDHLGKAR 600
    EPHTESVVSI EEAQKVKEVS VQFLNRDDDD EDGPDADFLT VKRRDVFGLD 650
    LKENEALSKK EPSKSSVKKK LTKVAEAKKV MKRSFKVNKK ITFTDEGELV 700
    QQWPQIQKCA IKDVEEEDDT GGINLDKAKE RLQEEDKFDK EEYRKKIKAK 750
    HRERRLKERE ARREANKRQA KARDEEEAFL DWSDEDDGGF DPSTLPDPDK 800
    HRSSEESESE DTNHKMSDTK KKQETRKRNN TEDDDVRPRS RHGKKAKWET 850
    VEPLDTGLSL AEDEELVLHL LKSQN 875
    Length:875
    Mass (Da):100,739
    Last modified:September 27, 2005 - v2
    Checksum:i07D6574185AC3646
    GO

    Sequence cautioni

    The sequence AAH49261.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC049261 mRNA. Translation: AAH49261.1. Different initiation.
    CCDSiCCDS52796.1.
    RefSeqiNP_084212.2. NM_029936.2.
    UniGeneiMm.133560.

    Genome annotation databases

    EnsembliENSMUST00000065630; ENSMUSP00000065198; ENSMUSG00000053289.
    GeneIDi77591.
    KEGGimmu:77591.
    UCSCiuc009plz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC049261 mRNA. Translation: AAH49261.1 . Different initiation.
    CCDSi CCDS52796.1.
    RefSeqi NP_084212.2. NM_029936.2.
    UniGenei Mm.133560.

    3D structure databases

    ProteinModelPortali Q80Y44.
    SMRi Q80Y44. Positions 47-476.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 218780. 1 interaction.

    PTM databases

    PhosphoSitei Q80Y44.

    Proteomic databases

    PaxDbi Q80Y44.
    PRIDEi Q80Y44.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000065630 ; ENSMUSP00000065198 ; ENSMUSG00000053289 .
    GeneIDi 77591.
    KEGGi mmu:77591.
    UCSCi uc009plz.2. mouse.

    Organism-specific databases

    CTDi 1662.
    MGIi MGI:1924841. Ddx10.

    Phylogenomic databases

    eggNOGi COG0513.
    GeneTreei ENSGT00550000074980.
    HOGENOMi HOG000268801.
    HOVERGENi HBG102756.
    InParanoidi Q80Y44.
    KOi K14776.
    OMAi CCKEVQY.
    OrthoDBi EOG7GFB4K.
    PhylomeDBi Q80Y44.
    TreeFami TF315215.

    Miscellaneous databases

    ChiTaRSi DDX10. mouse.
    NextBioi 347162.
    PROi Q80Y44.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q80Y44.
    Bgeei Q80Y44.
    CleanExi MM_DDX10.
    Genevestigatori Q80Y44.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR025313. DUF4217.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000629. RNA-helicase_DEAD-box_CS.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    [Graphical view ]
    Pfami PF00270. DEAD. 1 hit.
    PF13959. DUF4217. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00039. DEAD_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-587, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    3. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-587, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiDDX10_MOUSE
    AccessioniPrimary (citable) accession number: Q80Y44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: September 27, 2005
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3