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Q80Y44

- DDX10_MOUSE

UniProt

Q80Y44 - DDX10_MOUSE

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Protein
Probable ATP-dependent RNA helicase DDX10
Gene
Ddx10
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Putative ATP-dependent RNA helicase By similarity.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei96 – 961ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi89 – 913ATP By similarity
Nucleotide bindingi113 – 1208ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent helicase activity Source: InterPro
  3. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX10 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 10
Gene namesi
Name:Ddx10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1924841. Ddx10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 875875Probable ATP-dependent RNA helicase DDX10
PRO_0000055084Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4 – 41Phosphothreonine By similarity
Modified residuei540 – 5401Phosphoserine By similarity
Modified residuei556 – 5561N6-acetyllysine1 Publication
Modified residuei587 – 5871Phosphothreonine2 Publications
Modified residuei783 – 7831Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ80Y44.
PRIDEiQ80Y44.

PTM databases

PhosphoSiteiQ80Y44.

Expressioni

Gene expression databases

ArrayExpressiQ80Y44.
BgeeiQ80Y44.
CleanExiMM_DDX10.
GenevestigatoriQ80Y44.

Interactioni

Protein-protein interaction databases

BioGridi218780. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ80Y44.
SMRiQ80Y44. Positions 47-476.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini100 – 274175Helicase ATP-binding
Add
BLAST
Domaini300 – 449150Helicase C-terminal
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi69 – 9729Q motif
Add
BLAST
Motifi222 – 2254DEAD box

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0513.
GeneTreeiENSGT00550000074980.
HOGENOMiHOG000268801.
HOVERGENiHBG102756.
InParanoidiQ80Y44.
KOiK14776.
OMAiCCKEVQY.
OrthoDBiEOG7GFB4K.
PhylomeDBiQ80Y44.
TreeFamiTF315215.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR025313. DUF4217.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF13959. DUF4217. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80Y44-1 [UniParc]FASTAAdd to Basket

« Hide

MGKTVASLGQ GTRPDPVRSF NRWKKKHSHR QHQKKERRKQ LKKPEWQVER    50
EGISRLMQNY EKINVNEITR FSDFPLSKKT LKGLQEAQYR LVTEIQKQTI 100
GLALQGKDVL GAAKTGSGKT LAFLVPVLEA LYRLQWTSTD GLGVLIISPT 150
RELAYQTFEV LRKVGKNHDF SAGLIIGGKD LKHEAERINN INILVCTPGR 200
LLQHMDETIC FHATNLQMLV LDEADRILDM GFADTMNAII ENLPKKRQTL 250
LFSATQTKSV KDLARLSLKD PEYVWVHEKA KYSTPATLEQ NYIICELHQK 300
ISVLFSFLRS HLKKKSIVFF SSCKEVQYLY RVFCRLRPGI SILALHGRQQ 350
QMRRMEVYNE FVRKRAAVLF ATDIAARGLD FPAVNWVLQF DCPEDANTYI 400
HRAGRTARYK EDGEALLILL PSEEQGMVQQ LLQKKVPVKE IKINPEKLID 450
VQKKLESFLA QDQDLKERAQ RCFVSYIRSV YLMKDKEVFN VSKLPITEYA 500
LSLGLAVAPR IRFLQKLEKQ PSTELVKNPV TEAVPPRAPS LPNDEADESP 550
AYVSEKMSVL HKSGERLEET EHRLASGDGD EEQDEETEDE ETEDHLGKAR 600
EPHTESVVSI EEAQKVKEVS VQFLNRDDDD EDGPDADFLT VKRRDVFGLD 650
LKENEALSKK EPSKSSVKKK LTKVAEAKKV MKRSFKVNKK ITFTDEGELV 700
QQWPQIQKCA IKDVEEEDDT GGINLDKAKE RLQEEDKFDK EEYRKKIKAK 750
HRERRLKERE ARREANKRQA KARDEEEAFL DWSDEDDGGF DPSTLPDPDK 800
HRSSEESESE DTNHKMSDTK KKQETRKRNN TEDDDVRPRS RHGKKAKWET 850
VEPLDTGLSL AEDEELVLHL LKSQN 875
Length:875
Mass (Da):100,739
Last modified:September 27, 2005 - v2
Checksum:i07D6574185AC3646
GO

Sequence cautioni

The sequence AAH49261.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC049261 mRNA. Translation: AAH49261.1. Different initiation.
CCDSiCCDS52796.1.
RefSeqiNP_084212.2. NM_029936.2.
UniGeneiMm.133560.

Genome annotation databases

EnsembliENSMUST00000065630; ENSMUSP00000065198; ENSMUSG00000053289.
GeneIDi77591.
KEGGimmu:77591.
UCSCiuc009plz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC049261 mRNA. Translation: AAH49261.1 . Different initiation.
CCDSi CCDS52796.1.
RefSeqi NP_084212.2. NM_029936.2.
UniGenei Mm.133560.

3D structure databases

ProteinModelPortali Q80Y44.
SMRi Q80Y44. Positions 47-476.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 218780. 1 interaction.

PTM databases

PhosphoSitei Q80Y44.

Proteomic databases

PaxDbi Q80Y44.
PRIDEi Q80Y44.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000065630 ; ENSMUSP00000065198 ; ENSMUSG00000053289 .
GeneIDi 77591.
KEGGi mmu:77591.
UCSCi uc009plz.2. mouse.

Organism-specific databases

CTDi 1662.
MGIi MGI:1924841. Ddx10.

Phylogenomic databases

eggNOGi COG0513.
GeneTreei ENSGT00550000074980.
HOGENOMi HOG000268801.
HOVERGENi HBG102756.
InParanoidi Q80Y44.
KOi K14776.
OMAi CCKEVQY.
OrthoDBi EOG7GFB4K.
PhylomeDBi Q80Y44.
TreeFami TF315215.

Miscellaneous databases

ChiTaRSi DDX10. mouse.
NextBioi 347162.
PROi Q80Y44.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q80Y44.
Bgeei Q80Y44.
CleanExi MM_DDX10.
Genevestigatori Q80Y44.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR025313. DUF4217.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF13959. DUF4217. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-587, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  3. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-587, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiDDX10_MOUSE
AccessioniPrimary (citable) accession number: Q80Y44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi