Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q80Y44 (DDX10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ATP-dependent RNA helicase DDX10

EC=3.6.4.13
Alternative name(s):
DEAD box protein 10
Gene names
Name:Ddx10
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length875 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Putative ATP-dependent RNA helicase By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Domain

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similarities

Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Sequence caution

The sequence AAH49261.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 875875Probable ATP-dependent RNA helicase DDX10
PRO_0000055084

Regions

Domain100 – 274175Helicase ATP-binding
Domain300 – 449150Helicase C-terminal
Nucleotide binding89 – 913ATP By similarity
Nucleotide binding113 – 1208ATP By similarity
Motif69 – 9729Q motif
Motif222 – 2254DEAD box

Sites

Binding site961ATP By similarity

Amino acid modifications

Modified residue41Phosphothreonine By similarity
Modified residue5401Phosphoserine By similarity
Modified residue5561N6-acetyllysine Ref.4
Modified residue5871Phosphothreonine Ref.2 Ref.3
Modified residue7831Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q80Y44 [UniParc].

Last modified September 27, 2005. Version 2.
Checksum: 07D6574185AC3646

FASTA875100,739
        10         20         30         40         50         60 
MGKTVASLGQ GTRPDPVRSF NRWKKKHSHR QHQKKERRKQ LKKPEWQVER EGISRLMQNY 

        70         80         90        100        110        120 
EKINVNEITR FSDFPLSKKT LKGLQEAQYR LVTEIQKQTI GLALQGKDVL GAAKTGSGKT 

       130        140        150        160        170        180 
LAFLVPVLEA LYRLQWTSTD GLGVLIISPT RELAYQTFEV LRKVGKNHDF SAGLIIGGKD 

       190        200        210        220        230        240 
LKHEAERINN INILVCTPGR LLQHMDETIC FHATNLQMLV LDEADRILDM GFADTMNAII 

       250        260        270        280        290        300 
ENLPKKRQTL LFSATQTKSV KDLARLSLKD PEYVWVHEKA KYSTPATLEQ NYIICELHQK 

       310        320        330        340        350        360 
ISVLFSFLRS HLKKKSIVFF SSCKEVQYLY RVFCRLRPGI SILALHGRQQ QMRRMEVYNE 

       370        380        390        400        410        420 
FVRKRAAVLF ATDIAARGLD FPAVNWVLQF DCPEDANTYI HRAGRTARYK EDGEALLILL 

       430        440        450        460        470        480 
PSEEQGMVQQ LLQKKVPVKE IKINPEKLID VQKKLESFLA QDQDLKERAQ RCFVSYIRSV 

       490        500        510        520        530        540 
YLMKDKEVFN VSKLPITEYA LSLGLAVAPR IRFLQKLEKQ PSTELVKNPV TEAVPPRAPS 

       550        560        570        580        590        600 
LPNDEADESP AYVSEKMSVL HKSGERLEET EHRLASGDGD EEQDEETEDE ETEDHLGKAR 

       610        620        630        640        650        660 
EPHTESVVSI EEAQKVKEVS VQFLNRDDDD EDGPDADFLT VKRRDVFGLD LKENEALSKK 

       670        680        690        700        710        720 
EPSKSSVKKK LTKVAEAKKV MKRSFKVNKK ITFTDEGELV QQWPQIQKCA IKDVEEEDDT 

       730        740        750        760        770        780 
GGINLDKAKE RLQEEDKFDK EEYRKKIKAK HRERRLKERE ARREANKRQA KARDEEEAFL 

       790        800        810        820        830        840 
DWSDEDDGGF DPSTLPDPDK HRSSEESESE DTNHKMSDTK KKQETRKRNN TEDDDVRPRS 

       850        860        870 
RHGKKAKWET VEPLDTGLSL AEDEELVLHL LKSQN 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[2]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-587, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[3]"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-587, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
[4]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-556, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC049261 mRNA. Translation: AAH49261.1. Different initiation.
CCDSCCDS52796.1.
RefSeqNP_084212.2. NM_029936.2.
UniGeneMm.133560.

3D structure databases

ProteinModelPortalQ80Y44.
SMRQ80Y44. Positions 47-476.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid218780. 1 interaction.

PTM databases

PhosphoSiteQ80Y44.

Proteomic databases

PaxDbQ80Y44.
PRIDEQ80Y44.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000065630; ENSMUSP00000065198; ENSMUSG00000053289.
GeneID77591.
KEGGmmu:77591.
UCSCuc009plz.2. mouse.

Organism-specific databases

CTD1662.
MGIMGI:1924841. Ddx10.

Phylogenomic databases

eggNOGCOG0513.
GeneTreeENSGT00550000074980.
HOGENOMHOG000268801.
HOVERGENHBG102756.
InParanoidQ80Y44.
KOK14776.
OMACCKEVQY.
OrthoDBEOG7GFB4K.
PhylomeDBQ80Y44.
TreeFamTF315215.

Gene expression databases

ArrayExpressQ80Y44.
BgeeQ80Y44.
CleanExMM_DDX10.
GenevestigatorQ80Y44.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR025313. DUF4217.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamPF00270. DEAD. 1 hit.
PF13959. DUF4217. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDDX10. mouse.
NextBio347162.
PROQ80Y44.
SOURCESearch...

Entry information

Entry nameDDX10_MOUSE
AccessionPrimary (citable) accession number: Q80Y44
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot