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Protein

Probable ATP-dependent RNA helicase DDX10

Gene

Ddx10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative ATP-dependent RNA helicase.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei96ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi89 – 91ATPPROSITE-ProRule annotation3
Nucleotide bindingi113 – 120ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX10 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 10
Gene namesi
Name:Ddx10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1924841. Ddx10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550841 – 875Probable ATP-dependent RNA helicase DDX10Add BLAST875

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphothreonineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei540PhosphoserineBy similarity1
Modified residuei556N6-acetyllysineCombined sources1
Modified residuei587PhosphothreonineCombined sources1
Modified residuei783PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ80Y44.
MaxQBiQ80Y44.
PaxDbiQ80Y44.
PeptideAtlasiQ80Y44.
PRIDEiQ80Y44.

PTM databases

iPTMnetiQ80Y44.
PhosphoSitePlusiQ80Y44.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053289.
CleanExiMM_DDX10.
GenevisibleiQ80Y44. MM.

Interactioni

Protein-protein interaction databases

BioGridi218780. 1 interactor.
STRINGi10090.ENSMUSP00000065198.

Structurei

3D structure databases

ProteinModelPortaliQ80Y44.
SMRiQ80Y44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 274Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST175
Domaini300 – 449Helicase C-terminalPROSITE-ProRule annotationAdd BLAST150

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi69 – 97Q motifAdd BLAST29
Motifi222 – 225DEAD box4

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0342. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00550000074980.
HOGENOMiHOG000268801.
HOVERGENiHBG102756.
InParanoidiQ80Y44.
KOiK14776.
OMAiDIRCVQI.
OrthoDBiEOG091G06N7.
PhylomeDBiQ80Y44.
TreeFamiTF315215.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR025313. DUF4217.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF13959. DUF4217. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM01178. DUF4217. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80Y44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKTVASLGQ GTRPDPVRSF NRWKKKHSHR QHQKKERRKQ LKKPEWQVER
60 70 80 90 100
EGISRLMQNY EKINVNEITR FSDFPLSKKT LKGLQEAQYR LVTEIQKQTI
110 120 130 140 150
GLALQGKDVL GAAKTGSGKT LAFLVPVLEA LYRLQWTSTD GLGVLIISPT
160 170 180 190 200
RELAYQTFEV LRKVGKNHDF SAGLIIGGKD LKHEAERINN INILVCTPGR
210 220 230 240 250
LLQHMDETIC FHATNLQMLV LDEADRILDM GFADTMNAII ENLPKKRQTL
260 270 280 290 300
LFSATQTKSV KDLARLSLKD PEYVWVHEKA KYSTPATLEQ NYIICELHQK
310 320 330 340 350
ISVLFSFLRS HLKKKSIVFF SSCKEVQYLY RVFCRLRPGI SILALHGRQQ
360 370 380 390 400
QMRRMEVYNE FVRKRAAVLF ATDIAARGLD FPAVNWVLQF DCPEDANTYI
410 420 430 440 450
HRAGRTARYK EDGEALLILL PSEEQGMVQQ LLQKKVPVKE IKINPEKLID
460 470 480 490 500
VQKKLESFLA QDQDLKERAQ RCFVSYIRSV YLMKDKEVFN VSKLPITEYA
510 520 530 540 550
LSLGLAVAPR IRFLQKLEKQ PSTELVKNPV TEAVPPRAPS LPNDEADESP
560 570 580 590 600
AYVSEKMSVL HKSGERLEET EHRLASGDGD EEQDEETEDE ETEDHLGKAR
610 620 630 640 650
EPHTESVVSI EEAQKVKEVS VQFLNRDDDD EDGPDADFLT VKRRDVFGLD
660 670 680 690 700
LKENEALSKK EPSKSSVKKK LTKVAEAKKV MKRSFKVNKK ITFTDEGELV
710 720 730 740 750
QQWPQIQKCA IKDVEEEDDT GGINLDKAKE RLQEEDKFDK EEYRKKIKAK
760 770 780 790 800
HRERRLKERE ARREANKRQA KARDEEEAFL DWSDEDDGGF DPSTLPDPDK
810 820 830 840 850
HRSSEESESE DTNHKMSDTK KKQETRKRNN TEDDDVRPRS RHGKKAKWET
860 870
VEPLDTGLSL AEDEELVLHL LKSQN
Length:875
Mass (Da):100,739
Last modified:September 27, 2005 - v2
Checksum:i07D6574185AC3646
GO

Sequence cautioni

The sequence AAH49261 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049261 mRNA. Translation: AAH49261.1. Different initiation.
CCDSiCCDS52796.1.
RefSeqiNP_084212.2. NM_029936.2.
UniGeneiMm.133560.

Genome annotation databases

EnsembliENSMUST00000065630; ENSMUSP00000065198; ENSMUSG00000053289.
GeneIDi77591.
KEGGimmu:77591.
UCSCiuc009plz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049261 mRNA. Translation: AAH49261.1. Different initiation.
CCDSiCCDS52796.1.
RefSeqiNP_084212.2. NM_029936.2.
UniGeneiMm.133560.

3D structure databases

ProteinModelPortaliQ80Y44.
SMRiQ80Y44.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218780. 1 interactor.
STRINGi10090.ENSMUSP00000065198.

PTM databases

iPTMnetiQ80Y44.
PhosphoSitePlusiQ80Y44.

Proteomic databases

EPDiQ80Y44.
MaxQBiQ80Y44.
PaxDbiQ80Y44.
PeptideAtlasiQ80Y44.
PRIDEiQ80Y44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065630; ENSMUSP00000065198; ENSMUSG00000053289.
GeneIDi77591.
KEGGimmu:77591.
UCSCiuc009plz.2. mouse.

Organism-specific databases

CTDi1662.
MGIiMGI:1924841. Ddx10.

Phylogenomic databases

eggNOGiKOG0342. Eukaryota.
COG0513. LUCA.
GeneTreeiENSGT00550000074980.
HOGENOMiHOG000268801.
HOVERGENiHBG102756.
InParanoidiQ80Y44.
KOiK14776.
OMAiDIRCVQI.
OrthoDBiEOG091G06N7.
PhylomeDBiQ80Y44.
TreeFamiTF315215.

Miscellaneous databases

ChiTaRSiDdx10. mouse.
PROiQ80Y44.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053289.
CleanExiMM_DDX10.
GenevisibleiQ80Y44. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR025313. DUF4217.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF13959. DUF4217. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM01178. DUF4217. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDX10_MOUSE
AccessioniPrimary (citable) accession number: Q80Y44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: November 2, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.