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Protein

Probable ATP-dependent RNA helicase DDX10

Gene

Ddx10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative ATP-dependent RNA helicase.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei96ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi89 – 91ATPPROSITE-ProRule annotation3
Nucleotide bindingi113 – 120ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • anterior head development Source: MGI
  • RNA secondary structure unwinding Source: GO_Central

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX10 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 10
Gene namesi
Name:Ddx10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1924841 Ddx10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550841 – 875Probable ATP-dependent RNA helicase DDX10Add BLAST875

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphothreonineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei540PhosphoserineBy similarity1
Modified residuei556N6-acetyllysineCombined sources1
Modified residuei587PhosphothreonineCombined sources1
Cross-linki652Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei783PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ80Y44
MaxQBiQ80Y44
PaxDbiQ80Y44
PeptideAtlasiQ80Y44
PRIDEiQ80Y44

PTM databases

iPTMnetiQ80Y44
PhosphoSitePlusiQ80Y44

Expressioni

Gene expression databases

BgeeiENSMUSG00000053289
CleanExiMM_DDX10
GenevisibleiQ80Y44 MM

Interactioni

Protein-protein interaction databases

BioGridi2187802 interactors.
STRINGi10090.ENSMUSP00000065198

Structurei

3D structure databases

ProteinModelPortaliQ80Y44
SMRiQ80Y44
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 274Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST175
Domaini300 – 449Helicase C-terminalPROSITE-ProRule annotationAdd BLAST150

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi69 – 97Q motifAdd BLAST29
Motifi222 – 225DEAD box4

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0342 Eukaryota
COG0513 LUCA
GeneTreeiENSGT00550000074980
HOGENOMiHOG000268801
HOVERGENiHBG102756
InParanoidiQ80Y44
KOiK14776
OMAiYGTLHQD
OrthoDBiEOG091G06N7
PhylomeDBiQ80Y44
TreeFamiTF315215

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR025313 DUF4217
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF13959 DUF4217, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM01178 DUF4217, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

Q80Y44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKTVASLGQ GTRPDPVRSF NRWKKKHSHR QHQKKERRKQ LKKPEWQVER
60 70 80 90 100
EGISRLMQNY EKINVNEITR FSDFPLSKKT LKGLQEAQYR LVTEIQKQTI
110 120 130 140 150
GLALQGKDVL GAAKTGSGKT LAFLVPVLEA LYRLQWTSTD GLGVLIISPT
160 170 180 190 200
RELAYQTFEV LRKVGKNHDF SAGLIIGGKD LKHEAERINN INILVCTPGR
210 220 230 240 250
LLQHMDETIC FHATNLQMLV LDEADRILDM GFADTMNAII ENLPKKRQTL
260 270 280 290 300
LFSATQTKSV KDLARLSLKD PEYVWVHEKA KYSTPATLEQ NYIICELHQK
310 320 330 340 350
ISVLFSFLRS HLKKKSIVFF SSCKEVQYLY RVFCRLRPGI SILALHGRQQ
360 370 380 390 400
QMRRMEVYNE FVRKRAAVLF ATDIAARGLD FPAVNWVLQF DCPEDANTYI
410 420 430 440 450
HRAGRTARYK EDGEALLILL PSEEQGMVQQ LLQKKVPVKE IKINPEKLID
460 470 480 490 500
VQKKLESFLA QDQDLKERAQ RCFVSYIRSV YLMKDKEVFN VSKLPITEYA
510 520 530 540 550
LSLGLAVAPR IRFLQKLEKQ PSTELVKNPV TEAVPPRAPS LPNDEADESP
560 570 580 590 600
AYVSEKMSVL HKSGERLEET EHRLASGDGD EEQDEETEDE ETEDHLGKAR
610 620 630 640 650
EPHTESVVSI EEAQKVKEVS VQFLNRDDDD EDGPDADFLT VKRRDVFGLD
660 670 680 690 700
LKENEALSKK EPSKSSVKKK LTKVAEAKKV MKRSFKVNKK ITFTDEGELV
710 720 730 740 750
QQWPQIQKCA IKDVEEEDDT GGINLDKAKE RLQEEDKFDK EEYRKKIKAK
760 770 780 790 800
HRERRLKERE ARREANKRQA KARDEEEAFL DWSDEDDGGF DPSTLPDPDK
810 820 830 840 850
HRSSEESESE DTNHKMSDTK KKQETRKRNN TEDDDVRPRS RHGKKAKWET
860 870
VEPLDTGLSL AEDEELVLHL LKSQN
Length:875
Mass (Da):100,739
Last modified:September 27, 2005 - v2
Checksum:i07D6574185AC3646
GO

Sequence cautioni

The sequence AAH49261 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC049261 mRNA Translation: AAH49261.1 Different initiation.
CCDSiCCDS52796.1
RefSeqiNP_084212.2, NM_029936.2
UniGeneiMm.133560

Genome annotation databases

EnsembliENSMUST00000065630; ENSMUSP00000065198; ENSMUSG00000053289
GeneIDi77591
KEGGimmu:77591
UCSCiuc009plz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDDX10_MOUSE
AccessioniPrimary (citable) accession number: Q80Y44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: March 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome