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Protein

Rho GTPase-activating protein 11A

Gene

Arhgap11a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 11A
Alternative name(s):
Rho-type GTPase-activating protein 11A
Gene namesi
Name:Arhgap11a
Synonyms:Kiaa0013
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2444300. Arhgap11a.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 987987Rho GTPase-activating protein 11APRO_0000267214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei284 – 2841PhosphoserineCombined sources
Modified residuei305 – 3051PhosphothreonineBy similarity
Modified residuei315 – 3151PhosphoserineBy similarity
Modified residuei317 – 3171PhosphoserineCombined sources
Modified residuei322 – 3221PhosphothreonineCombined sources
Modified residuei338 – 3381PhosphoserineBy similarity
Modified residuei339 – 3391PhosphoserineBy similarity
Modified residuei481 – 4811PhosphoserineBy similarity
Modified residuei505 – 5051PhosphothreonineBy similarity
Modified residuei581 – 5811PhosphoserineBy similarity
Modified residuei655 – 6551PhosphoserineBy similarity
Modified residuei819 – 8191PhosphoserineBy similarity
Modified residuei840 – 8401PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80Y19.
MaxQBiQ80Y19.
PaxDbiQ80Y19.
PeptideAtlasiQ80Y19.
PRIDEiQ80Y19.

PTM databases

iPTMnetiQ80Y19.
PhosphoSiteiQ80Y19.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041219.
CleanExiMM_ARHGAP11A.
ExpressionAtlasiQ80Y19. baseline and differential.
GenevisibleiQ80Y19. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099604.

Structurei

3D structure databases

ProteinModelPortaliQ80Y19.
SMRiQ80Y19. Positions 1-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 239188Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2710. Eukaryota.
ENOG410YVI5. LUCA.
GeneTreeiENSGT00760000119123.
HOGENOMiHOG000231616.
HOVERGENiHBG062938.
InParanoidiQ80Y19.
OMAiSYRMSWT.
OrthoDBiEOG091G0F5G.
TreeFamiTF332212.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80Y19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWDQRLVRLA LLQQLRAVYG IKVKGGRGQC DRRRHETAAT EIKGKVFGVP
60 70 80 90 100
FNSLPHSVVP EFGHIPSFLV DACASLKEHI HTEGLFRKSG SVVRLKALKS
110 120 130 140 150
KLDQGEACLS SALPCDVAGL LKQFFRELPE PVLPADLHEA LFKAQQLGAE
160 170 180 190 200
ERNKATLLLS CLMANPTVDI LRYFFNFLKS VSLRASENKM DSSNLAVIFA
210 220 230 240 250
PNLLQTSEGH EKMSANTEKK LRLQAAVVQT FIDCASDIGR VPDFILEKIP
260 270 280 290 300
AMLGIDGLCT TPSLEGFEGD FETPGECKRK RRQSVGDFVN GALNKLKSSR
310 320 330 340 350
TPSITPQQDR TAQASASPLI LTPSVKRKLP GESSHAFSSK KRKSIKHNLN
360 370 380 390 400
FELLPSHFFS SNSTPVSVHL DTSPDGSSQT SLSPIAMSGN HLVSTELRRS
410 420 430 440 450
KRIASKKVYR VESGKAGCFS PKVSRKEKTR RSLRLKFSLG KNRDSDGCSV
460 470 480 490 500
INRYENVGRR LANQQNLKSR IDSVKTGLLF SPDIDERLLK KGSEKISKSE
510 520 530 540 550
EHLLTPDQLD GTGYRMSWTE PSNSSFQDMS ANGTSPIMQN LEVKSFSLEP
560 570 580 590 600
DITVEKSPVV SCELRPSTFH SQPDSSVLSL SGDEGNLASE TLQKIQKAFS
610 620 630 640 650
ESGSDLHMVI NHEQSSVTNT GEEVEFRDVT VTESKGHDGS CAGEEENCPS
660 670 680 690 700
ERNFSPDQSP EFAREADEEC YSTQMKVECE GLHSETPKAD PLILQAFPGE
710 720 730 740 750
EPAEEPQSPR NQLSTPSRGN ENGGESAGAS GAPGEDESTC SVAVLSKPRP
760 770 780 790 800
QRLSRQQSLV EKCDSVAPGA LQVTEHGKVS DHIQWFNKLS LNEPNRGKVK
810 820 830 840 850
SPLKFQRTPV RQSVRRINSL LEYGRQPVRQ KLAIFGDAAS PLVKSVSCDS
860 870 880 890 900
ALPSCVQNTS KGPTAPLITS GLEAQKSTSC NKSSVELTSK SFTKMKRHPD
910 920 930 940 950
PLSASLGTPR LCKQENKSNG HIKFPLDDLT NHERLKFVVN NNVAFSPGMK
960 970 980
NRVVRKPSEK ERVWYKGSPK NPIGKTQLLP TSKPVDL
Length:987
Mass (Da):108,436
Last modified:July 27, 2011 - v2
Checksum:iE7566F732548997D
GO

Sequence cautioni

The sequence BAC97844 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti723 – 7231G → V in BAC97844 (PubMed:14621295).Curated
Sequence conflicti723 – 7231G → V in AAH50875 (PubMed:15489334).Curated
Sequence conflicti867 – 8671L → H in BAC97844 (PubMed:14621295).Curated
Sequence conflicti867 – 8671L → H in AAH50875 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129034 mRNA. Translation: BAC97844.1. Different initiation.
AL772405 Genomic DNA. Translation: CAM16570.1.
BC050875 mRNA. Translation: AAH50875.1.
CCDSiCCDS16562.1.
RefSeqiNP_852081.2. NM_181416.3.
UniGeneiMm.45753.
Mm.491249.

Genome annotation databases

EnsembliENSMUST00000102545; ENSMUSP00000099604; ENSMUSG00000041219.
ENSMUST00000110949; ENSMUSP00000106574; ENSMUSG00000041219.
GeneIDi228482.
KEGGimmu:228482.
UCSCiuc008lpr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129034 mRNA. Translation: BAC97844.1. Different initiation.
AL772405 Genomic DNA. Translation: CAM16570.1.
BC050875 mRNA. Translation: AAH50875.1.
CCDSiCCDS16562.1.
RefSeqiNP_852081.2. NM_181416.3.
UniGeneiMm.45753.
Mm.491249.

3D structure databases

ProteinModelPortaliQ80Y19.
SMRiQ80Y19. Positions 1-252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099604.

PTM databases

iPTMnetiQ80Y19.
PhosphoSiteiQ80Y19.

Proteomic databases

EPDiQ80Y19.
MaxQBiQ80Y19.
PaxDbiQ80Y19.
PeptideAtlasiQ80Y19.
PRIDEiQ80Y19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102545; ENSMUSP00000099604; ENSMUSG00000041219.
ENSMUST00000110949; ENSMUSP00000106574; ENSMUSG00000041219.
GeneIDi228482.
KEGGimmu:228482.
UCSCiuc008lpr.2. mouse.

Organism-specific databases

CTDi9824.
MGIiMGI:2444300. Arhgap11a.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2710. Eukaryota.
ENOG410YVI5. LUCA.
GeneTreeiENSGT00760000119123.
HOGENOMiHOG000231616.
HOVERGENiHBG062938.
InParanoidiQ80Y19.
OMAiSYRMSWT.
OrthoDBiEOG091G0F5G.
TreeFamiTF332212.

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSiArhgap11a. mouse.
PROiQ80Y19.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041219.
CleanExiMM_ARHGAP11A.
ExpressionAtlasiQ80Y19. baseline and differential.
GenevisibleiQ80Y19. MM.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHGBA_MOUSE
AccessioniPrimary (citable) accession number: Q80Y19
Secondary accession number(s): A2AL17, Q6ZQL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.