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Q80Y14

- GLRX5_MOUSE

UniProt

Q80Y14 - GLRX5_MOUSE

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Protein
Glutaredoxin-related protein 5, mitochondrial
Gene
Glrx5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1. May protect cells against apoptosis due to reactive oxygen species and oxidative stress.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei55 – 551Glutathione By similarity
Metal bindingi63 – 631Iron-sulfur (2Fe-2S); shared with dimeric partner By similarity
Binding sitei105 – 1051Glutathione; via amide nitrogen and carbonyl oxygen By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. electron carrier activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. protein disulfide oxidoreductase activity Source: InterPro

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. hemopoiesis Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin-related protein 5, mitochondrial
Alternative name(s):
Monothiol glutaredoxin-5
Gene namesi
Name:Glrx5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1920296. Glrx5.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB
  2. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3131Mitochondrion Reviewed prediction
Add
BLAST
Chaini32 – 152121Glutaredoxin-related protein 5, mitochondrial
PRO_0000141651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei55 – 551N6-succinyllysine1 Publication

Proteomic databases

MaxQBiQ80Y14.
PaxDbiQ80Y14.
PRIDEiQ80Y14.

PTM databases

PhosphoSiteiQ80Y14.

Expressioni

Tissue specificityi

Detected in bone, liver, muscle and kidney.1 Publication

Developmental stagei

Ubiquitously expressed at 7.5 dpc. At 8.5 dpc, preferential expression in yolk sac blood islands. Progressive down-regulation in maturing primitive red cells between 10.5 and 12.5 dpc. High expression in fetal liver at 12.5 dpc.1 Publication

Gene expression databases

BgeeiQ80Y14.
CleanExiMM_GLRX5.
GenevestigatoriQ80Y14.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

IntActiQ80Y14. 1 interaction.
MINTiMINT-1753495.

Structurei

3D structure databases

ProteinModelPortaliQ80Y14.
SMRiQ80Y14. Positions 38-145.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 141104Glutaredoxin
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 975Glutathione binding By similarity
Regioni118 – 1192Glutathione binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi8 – 114Poly-Ala
Compositional biasi20 – 234Poly-Gly

Sequence similaritiesi

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

eggNOGiCOG0278.
GeneTreeiENSGT00550000075082.
HOGENOMiHOG000095211.
InParanoidiQ80Y14.
KOiK07390.
OMAiQMHQNGE.
OrthoDBiEOG7B5WX3.
PhylomeDBiQ80Y14.
TreeFamiTF318988.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR002109. Glutaredoxin.
IPR004480. Monothiol_GRX-rel.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR10293. PTHR10293. 1 hit.
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00365. TIGR00365. 1 hit.
PROSITEiPS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80Y14-1 [UniParc]FASTAAdd to Basket

« Hide

MSASLSRAAA ALLRWGRSAG GGGLPGAGVR AASSGGQAEQ LDALVKKDKV    50
VVFLKGTPEQ PQCGFSNAVV QILRLHGVRD YAAYNVLDDP ELRQGIKDYS 100
NWPTIPQVYL NGEFVGGCDI LLQMHQNGDL VEELKKLGIR SALVDEKDQD 150
SK 152
Length:152
Mass (Da):16,292
Last modified:February 1, 2005 - v2
Checksum:i76EBEAA30F482825
GO

Sequence cautioni

The sequence AAH50937.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ083330 mRNA. Translation: AAZ30730.1.
AK013761 mRNA. Translation: BAB28985.1.
AK050883 mRNA. Translation: BAC34443.1.
BC050937 mRNA. Translation: AAH50937.1. Different initiation.
BC058371 mRNA. Translation: AAH58371.1.
CCDSiCCDS26154.1.
RefSeqiNP_082695.1. NM_028419.2.
UniGeneiMm.29128.
Mm.490286.

Genome annotation databases

EnsembliENSMUST00000021522; ENSMUSP00000021522; ENSMUSG00000021102.
GeneIDi73046.
KEGGimmu:73046.
UCSCiuc007oxu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ083330 mRNA. Translation: AAZ30730.1 .
AK013761 mRNA. Translation: BAB28985.1 .
AK050883 mRNA. Translation: BAC34443.1 .
BC050937 mRNA. Translation: AAH50937.1 . Different initiation.
BC058371 mRNA. Translation: AAH58371.1 .
CCDSi CCDS26154.1.
RefSeqi NP_082695.1. NM_028419.2.
UniGenei Mm.29128.
Mm.490286.

3D structure databases

ProteinModelPortali Q80Y14.
SMRi Q80Y14. Positions 38-145.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q80Y14. 1 interaction.
MINTi MINT-1753495.

PTM databases

PhosphoSitei Q80Y14.

Proteomic databases

MaxQBi Q80Y14.
PaxDbi Q80Y14.
PRIDEi Q80Y14.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021522 ; ENSMUSP00000021522 ; ENSMUSG00000021102 .
GeneIDi 73046.
KEGGi mmu:73046.
UCSCi uc007oxu.1. mouse.

Organism-specific databases

CTDi 51218.
MGIi MGI:1920296. Glrx5.

Phylogenomic databases

eggNOGi COG0278.
GeneTreei ENSGT00550000075082.
HOGENOMi HOG000095211.
InParanoidi Q80Y14.
KOi K07390.
OMAi QMHQNGE.
OrthoDBi EOG7B5WX3.
PhylomeDBi Q80Y14.
TreeFami TF318988.

Miscellaneous databases

ChiTaRSi GLRX5. mouse.
NextBioi 337371.
PROi Q80Y14.
SOURCEi Search...

Gene expression databases

Bgeei Q80Y14.
CleanExi MM_GLRX5.
Genevestigatori Q80Y14.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR002109. Glutaredoxin.
IPR004480. Monothiol_GRX-rel.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR10293. PTHR10293. 1 hit.
Pfami PF00462. Glutaredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR00365. TIGR00365. 1 hit.
PROSITEi PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hippocampus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Glutaredoxin 5 regulates osteoblast apoptosis by protecting against oxidative stress."
    Linares G.R., Xing W., Govoni K.E., Chen S.T., Mohan S.
    Bone 44:795-804(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-55, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiGLRX5_MOUSE
AccessioniPrimary (citable) accession number: Q80Y14
Secondary accession number(s): Q3YML1, Q9D6E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi