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Q80Y14

- GLRX5_MOUSE

UniProt

Q80Y14 - GLRX5_MOUSE

Protein

Glutaredoxin-related protein 5, mitochondrial

Gene

Glrx5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1. May protect cells against apoptosis due to reactive oxygen species and oxidative stress.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei55 – 551GlutathioneBy similarity
    Metal bindingi63 – 631Iron-sulfur (2Fe-2S); shared with dimeric partnerBy similarity
    Binding sitei105 – 1051Glutathione; via amide nitrogen and carbonyl oxygenBy similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. electron carrier activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW
    4. protein disulfide oxidoreductase activity Source: InterPro

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. hemopoiesis Source: UniProtKB

    Keywords - Ligandi

    2Fe-2S, Iron, Iron-sulfur, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutaredoxin-related protein 5, mitochondrial
    Alternative name(s):
    Monothiol glutaredoxin-5
    Gene namesi
    Name:Glrx5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1920296. Glrx5.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB
    2. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3131MitochondrionSequence AnalysisAdd
    BLAST
    Chaini32 – 152121Glutaredoxin-related protein 5, mitochondrialPRO_0000141651Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei55 – 551N6-succinyllysine1 Publication

    Proteomic databases

    MaxQBiQ80Y14.
    PaxDbiQ80Y14.
    PRIDEiQ80Y14.

    PTM databases

    PhosphoSiteiQ80Y14.

    Expressioni

    Tissue specificityi

    Detected in bone, liver, muscle and kidney.1 Publication

    Developmental stagei

    Ubiquitously expressed at 7.5 dpc. At 8.5 dpc, preferential expression in yolk sac blood islands. Progressive down-regulation in maturing primitive red cells between 10.5 and 12.5 dpc. High expression in fetal liver at 12.5 dpc.1 Publication

    Gene expression databases

    BgeeiQ80Y14.
    CleanExiMM_GLRX5.
    GenevestigatoriQ80Y14.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiQ80Y14. 1 interaction.
    MINTiMINT-1753495.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80Y14.
    SMRiQ80Y14. Positions 38-145.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 141104GlutaredoxinPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni93 – 975Glutathione bindingBy similarity
    Regioni118 – 1192Glutathione bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi8 – 114Poly-Ala
    Compositional biasi20 – 234Poly-Gly

    Sequence similaritiesi

    Contains 1 glutaredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Transit peptide

    Phylogenomic databases

    eggNOGiCOG0278.
    GeneTreeiENSGT00550000075082.
    HOGENOMiHOG000095211.
    InParanoidiQ80Y14.
    KOiK07390.
    OMAiQMHQNGE.
    OrthoDBiEOG7B5WX3.
    PhylomeDBiQ80Y14.
    TreeFamiTF318988.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR002109. Glutaredoxin.
    IPR004480. Monothiol_GRX-rel.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PANTHERiPTHR10293. PTHR10293. 1 hit.
    PfamiPF00462. Glutaredoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR00365. TIGR00365. 1 hit.
    PROSITEiPS51354. GLUTAREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q80Y14-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSASLSRAAA ALLRWGRSAG GGGLPGAGVR AASSGGQAEQ LDALVKKDKV    50
    VVFLKGTPEQ PQCGFSNAVV QILRLHGVRD YAAYNVLDDP ELRQGIKDYS 100
    NWPTIPQVYL NGEFVGGCDI LLQMHQNGDL VEELKKLGIR SALVDEKDQD 150
    SK 152
    Length:152
    Mass (Da):16,292
    Last modified:February 1, 2005 - v2
    Checksum:i76EBEAA30F482825
    GO

    Sequence cautioni

    The sequence AAH50937.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ083330 mRNA. Translation: AAZ30730.1.
    AK013761 mRNA. Translation: BAB28985.1.
    AK050883 mRNA. Translation: BAC34443.1.
    BC050937 mRNA. Translation: AAH50937.1. Different initiation.
    BC058371 mRNA. Translation: AAH58371.1.
    CCDSiCCDS26154.1.
    RefSeqiNP_082695.1. NM_028419.2.
    UniGeneiMm.29128.
    Mm.490286.

    Genome annotation databases

    EnsembliENSMUST00000021522; ENSMUSP00000021522; ENSMUSG00000021102.
    GeneIDi73046.
    KEGGimmu:73046.
    UCSCiuc007oxu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ083330 mRNA. Translation: AAZ30730.1 .
    AK013761 mRNA. Translation: BAB28985.1 .
    AK050883 mRNA. Translation: BAC34443.1 .
    BC050937 mRNA. Translation: AAH50937.1 . Different initiation.
    BC058371 mRNA. Translation: AAH58371.1 .
    CCDSi CCDS26154.1.
    RefSeqi NP_082695.1. NM_028419.2.
    UniGenei Mm.29128.
    Mm.490286.

    3D structure databases

    ProteinModelPortali Q80Y14.
    SMRi Q80Y14. Positions 38-145.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q80Y14. 1 interaction.
    MINTi MINT-1753495.

    PTM databases

    PhosphoSitei Q80Y14.

    Proteomic databases

    MaxQBi Q80Y14.
    PaxDbi Q80Y14.
    PRIDEi Q80Y14.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021522 ; ENSMUSP00000021522 ; ENSMUSG00000021102 .
    GeneIDi 73046.
    KEGGi mmu:73046.
    UCSCi uc007oxu.1. mouse.

    Organism-specific databases

    CTDi 51218.
    MGIi MGI:1920296. Glrx5.

    Phylogenomic databases

    eggNOGi COG0278.
    GeneTreei ENSGT00550000075082.
    HOGENOMi HOG000095211.
    InParanoidi Q80Y14.
    KOi K07390.
    OMAi QMHQNGE.
    OrthoDBi EOG7B5WX3.
    PhylomeDBi Q80Y14.
    TreeFami TF318988.

    Miscellaneous databases

    ChiTaRSi GLRX5. mouse.
    NextBioi 337371.
    PROi Q80Y14.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q80Y14.
    CleanExi MM_GLRX5.
    Genevestigatori Q80Y14.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR002109. Glutaredoxin.
    IPR004480. Monothiol_GRX-rel.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    PANTHERi PTHR10293. PTHR10293. 1 hit.
    Pfami PF00462. Glutaredoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR00365. TIGR00365. 1 hit.
    PROSITEi PS51354. GLUTAREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hippocampus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Glutaredoxin 5 regulates osteoblast apoptosis by protecting against oxidative stress."
      Linares G.R., Xing W., Govoni K.E., Chen S.T., Mohan S.
      Bone 44:795-804(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-55, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiGLRX5_MOUSE
    AccessioniPrimary (citable) accession number: Q80Y14
    Secondary accession number(s): Q3YML1, Q9D6E9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3