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Protein

Glutaredoxin-related protein 5, mitochondrial

Gene

Glrx5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (By similarity). Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase (By similarity). Required for normal iron homeostasis (By similarity). Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (By similarity). May protect cells against apoptosis due to reactive oxygen species and oxidative stress (PubMed:19442627).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei55GlutathioneBy similarity1
Metal bindingi63Iron-sulfur (2Fe-2S); shared with dimeric partnerBy similarity1
Binding sitei105Glutathione; via amide nitrogen and carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin-related protein 5, mitochondrial
Alternative name(s):
Monothiol glutaredoxin-5
Gene namesi
Name:Glrx5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1920296. Glrx5.

Subcellular locationi

  • Mitochondrion matrix By similarity

GO - Cellular componenti

  • dendrite Source: Ensembl
  • mitochondrial matrix Source: MGI
  • mitochondrion Source: UniProtKB
  • neuronal cell body Source: Ensembl
  • nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 31MitochondrionSequence analysisAdd BLAST31
ChainiPRO_000014165132 – 152Glutaredoxin-related protein 5, mitochondrialAdd BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55N6-succinyllysineCombined sources1
Modified residuei151PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80Y14.
MaxQBiQ80Y14.
PaxDbiQ80Y14.
PeptideAtlasiQ80Y14.
PRIDEiQ80Y14.

PTM databases

iPTMnetiQ80Y14.
PhosphoSitePlusiQ80Y14.
SwissPalmiQ80Y14.

Expressioni

Tissue specificityi

Detected in bone, liver, muscle and kidney.1 Publication

Developmental stagei

Ubiquitously expressed at 7.5 dpc. At 8.5 dpc, preferential expression in yolk sac blood islands. Progressive down-regulation in maturing primitive red cells between 10.5 and 12.5 dpc. High expression in fetal liver at 12.5 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000021102.
CleanExiMM_GLRX5.
GenevisibleiQ80Y14. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with ISCU.By similarity

Protein-protein interaction databases

IntActiQ80Y14. 4 interactors.
MINTiMINT-1753495.
STRINGi10090.ENSMUSP00000021522.

Structurei

3D structure databases

ProteinModelPortaliQ80Y14.
SMRiQ80Y14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 141GlutaredoxinPROSITE-ProRule annotationAdd BLAST104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni93 – 97Glutathione bindingBy similarity5
Regioni118 – 119Glutathione bindingBy similarity2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 11Poly-Ala4
Compositional biasi20 – 23Poly-Gly4

Sequence similaritiesi

Contains 1 glutaredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

eggNOGiKOG0911. Eukaryota.
COG0278. LUCA.
GeneTreeiENSGT00550000075082.
HOGENOMiHOG000095211.
InParanoidiQ80Y14.
KOiK07390.
OMAiVDKATMD.
OrthoDBiEOG091G0YN0.
PhylomeDBiQ80Y14.
TreeFamiTF318988.

Family and domain databases

CDDicd03028. GRX_PICOT_like. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR002109. Glutaredoxin.
IPR033658. GRX_PICOT-like.
IPR004480. Monothiol_GRX-rel.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR10293. PTHR10293. 1 hit.
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00365. TIGR00365. 1 hit.
PROSITEiPS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80Y14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASLSRAAA ALLRWGRSAG GGGLPGAGVR AASSGGQAEQ LDALVKKDKV
60 70 80 90 100
VVFLKGTPEQ PQCGFSNAVV QILRLHGVRD YAAYNVLDDP ELRQGIKDYS
110 120 130 140 150
NWPTIPQVYL NGEFVGGCDI LLQMHQNGDL VEELKKLGIR SALVDEKDQD

SK
Length:152
Mass (Da):16,292
Last modified:February 1, 2005 - v2
Checksum:i76EBEAA30F482825
GO

Sequence cautioni

The sequence AAH50937 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ083330 mRNA. Translation: AAZ30730.1.
AK013761 mRNA. Translation: BAB28985.1.
AK050883 mRNA. Translation: BAC34443.1.
BC050937 mRNA. Translation: AAH50937.1. Different initiation.
BC058371 mRNA. Translation: AAH58371.1.
CCDSiCCDS26154.1.
RefSeqiNP_082695.1. NM_028419.3.
UniGeneiMm.29128.
Mm.490286.

Genome annotation databases

EnsembliENSMUST00000021522; ENSMUSP00000021522; ENSMUSG00000021102.
GeneIDi73046.
KEGGimmu:73046.
UCSCiuc007oxu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ083330 mRNA. Translation: AAZ30730.1.
AK013761 mRNA. Translation: BAB28985.1.
AK050883 mRNA. Translation: BAC34443.1.
BC050937 mRNA. Translation: AAH50937.1. Different initiation.
BC058371 mRNA. Translation: AAH58371.1.
CCDSiCCDS26154.1.
RefSeqiNP_082695.1. NM_028419.3.
UniGeneiMm.29128.
Mm.490286.

3D structure databases

ProteinModelPortaliQ80Y14.
SMRiQ80Y14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80Y14. 4 interactors.
MINTiMINT-1753495.
STRINGi10090.ENSMUSP00000021522.

PTM databases

iPTMnetiQ80Y14.
PhosphoSitePlusiQ80Y14.
SwissPalmiQ80Y14.

Proteomic databases

EPDiQ80Y14.
MaxQBiQ80Y14.
PaxDbiQ80Y14.
PeptideAtlasiQ80Y14.
PRIDEiQ80Y14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021522; ENSMUSP00000021522; ENSMUSG00000021102.
GeneIDi73046.
KEGGimmu:73046.
UCSCiuc007oxu.1. mouse.

Organism-specific databases

CTDi51218.
MGIiMGI:1920296. Glrx5.

Phylogenomic databases

eggNOGiKOG0911. Eukaryota.
COG0278. LUCA.
GeneTreeiENSGT00550000075082.
HOGENOMiHOG000095211.
InParanoidiQ80Y14.
KOiK07390.
OMAiVDKATMD.
OrthoDBiEOG091G0YN0.
PhylomeDBiQ80Y14.
TreeFamiTF318988.

Miscellaneous databases

ChiTaRSiGlrx5. mouse.
PROiQ80Y14.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021102.
CleanExiMM_GLRX5.
GenevisibleiQ80Y14. MM.

Family and domain databases

CDDicd03028. GRX_PICOT_like. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR002109. Glutaredoxin.
IPR033658. GRX_PICOT-like.
IPR004480. Monothiol_GRX-rel.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR10293. PTHR10293. 1 hit.
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00365. TIGR00365. 1 hit.
PROSITEiPS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLRX5_MOUSE
AccessioniPrimary (citable) accession number: Q80Y14
Secondary accession number(s): Q3YML1, Q9D6E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: November 30, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.