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Q80XZ4

- I22R1_MOUSE

UniProt

Q80XZ4 - I22R1_MOUSE

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Protein

Interleukin-22 receptor subunit alpha-1

Gene

Il22ra1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.1 Publication

GO - Molecular functioni

  1. interleukin-20 binding Source: MGI

GO - Biological processi

  1. defense response to Gram-negative bacterium Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-22 receptor subunit alpha-1
Short name:
IL-22 receptor subunit alpha-1
Short name:
IL-22R-alpha-1
Short name:
IL-22RA1
Gene namesi
Name:Il22ra1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2663588. Il22ra1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini16 – 230215ExtracellularSequence AnalysisAdd
BLAST
Transmembranei231 – 25121HelicalSequence AnalysisAdd
BLAST
Topological domaini252 – 581330CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence AnalysisAdd
BLAST
Chaini16 – 581566Interleukin-22 receptor subunit alpha-1PRO_0000324321Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 79By similarity
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi128 ↔ 217By similarity
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ80XZ4.

PTM databases

PhosphoSiteiQ80XZ4.

Expressioni

Tissue specificityi

Expressed in kidney, liver and lung.1 Publication

Inductioni

By LPS stimulation in the liver.1 Publication

Gene expression databases

BgeeiQ80XZ4.
CleanExiMM_IL22RA1.
GenevestigatoriQ80XZ4.

Interactioni

Subunit structurei

Heterodimer with IL10RB and with IL20RB.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ80XZ4.
SMRiQ80XZ4. Positions 20-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 11598Fibronectin type-III 1Add
BLAST
Domaini141 – 22181Fibronectin type-III 2Add
BLAST

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated
Contains 2 fibronectin type-III domains.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26150.
GeneTreeiENSGT00530000063352.
HOGENOMiHOG000060223.
HOVERGENiHBG104189.
InParanoidiQ80XZ4.
KOiK05138.
OMAiLTVQWES.
OrthoDBiEOG7NPFVK.
PhylomeDBiQ80XZ4.
TreeFamiTF334107.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80XZ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTLLTILTV GSLAAHTTVD TSGLLQHVKF QSSNFENILT WDGGPASTSD
60 70 80 90 100
TVYSVEYKKY GERKWLAKAG CQRITQKFCN LTMETRNHTE FYYAKVTAVS
110 120 130 140 150
AGGPPVTKMT DRFSSLQHTT IKPPDVTCIP KVRSIQMLVH PTLTPVLSED
160 170 180 190 200
GHQLTLEEIF HDLFYRLELH VNHTYQMHLE GKQREYEFLG LTPDTEFLGS
210 220 230 240 250
ITILTPILSK ESAPYVCRVK TLPDRTWAYS FSGAVLFSMG FLVGLLCYLG
260 270 280 290 300
YKYITKPPVP PNSLNVQRVL TFQPLRFIQE HVLIPVLDLS GPSSLPQPIQ
310 320 330 340 350
YSQVVVSGPR EPPGAVWRQS LSDLTYVGQS DVSILQPTNV PAQQTLSPPS
360 370 380 390 400
YAPKAVPEVQ PPSYAPQVAS DAKALFYSPQ QGMKTRPATY DPQDILDSCP
410 420 430 440 450
ASYAVCVEDS GKDSTPGILS TPKYLKTKGQ LQEDTLVRSC LPGDLSLQKV
460 470 480 490 500
TSLGEGETQR PKSLPSPLGF CTDRGPDLHT LRSEEPETPR YLKGALSLLS
510 520 530 540 550
SVQIEGHPVS LPLHVHSVSC SPSDEGPSPW GLLDSLVCPK DEGPAVETEA
560 570 580
MCPSAAASEL EQSTELDSLF KGLALTVQWE S
Length:581
Mass (Da):63,795
Last modified:June 1, 2003 - v1
Checksum:iA2BF8692BB8AA93B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti335 – 3351L → M in BAE24639. (PubMed:16141072)Curated
Sequence conflicti535 – 5351S → Y in BAE24639. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY103454 mRNA. Translation: AAM52222.1.
AK141289 mRNA. Translation: BAE24639.1.
AL662911 Genomic DNA. Translation: CAM13650.1.
BC140972 mRNA. Translation: AAI40973.1.
BC140973 mRNA. Translation: AAI40974.1.
CCDSiCCDS18789.1.
RefSeqiNP_839988.1. NM_178257.2.
UniGeneiMm.261647.

Genome annotation databases

EnsembliENSMUST00000102546; ENSMUSP00000099605; ENSMUSG00000037157.
GeneIDi230828.
KEGGimmu:230828.
UCSCiuc008vgx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY103454 mRNA. Translation: AAM52222.1 .
AK141289 mRNA. Translation: BAE24639.1 .
AL662911 Genomic DNA. Translation: CAM13650.1 .
BC140972 mRNA. Translation: AAI40973.1 .
BC140973 mRNA. Translation: AAI40974.1 .
CCDSi CCDS18789.1.
RefSeqi NP_839988.1. NM_178257.2.
UniGenei Mm.261647.

3D structure databases

ProteinModelPortali Q80XZ4.
SMRi Q80XZ4. Positions 20-225.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q80XZ4.

Proteomic databases

PRIDEi Q80XZ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102546 ; ENSMUSP00000099605 ; ENSMUSG00000037157 .
GeneIDi 230828.
KEGGi mmu:230828.
UCSCi uc008vgx.2. mouse.

Organism-specific databases

CTDi 58985.
MGIi MGI:2663588. Il22ra1.

Phylogenomic databases

eggNOGi NOG26150.
GeneTreei ENSGT00530000063352.
HOGENOMi HOG000060223.
HOVERGENi HBG104189.
InParanoidi Q80XZ4.
KOi K05138.
OMAi LTVQWES.
OrthoDBi EOG7NPFVK.
PhylomeDBi Q80XZ4.
TreeFami TF334107.

Miscellaneous databases

NextBioi 380202.
PROi Q80XZ4.
SOURCEi Search...

Gene expression databases

Bgeei Q80XZ4.
CleanExi MM_IL22RA1.
Genevestigatori Q80XZ4.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view ]
Pfami PF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic structure and inducible expression of the IL-22 receptor alpha chain in mice."
    Tachiiri A., Imamura R., Wang Y., Fukui M., Umemura M., Suda T.
    Genes Immun. 4:153-159(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION.
    Strain: BALB/c.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiI22R1_MOUSE
AccessioniPrimary (citable) accession number: Q80XZ4
Secondary accession number(s): B2RU51, Q3URP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3