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Q80XZ4

- I22R1_MOUSE

UniProt

Q80XZ4 - I22R1_MOUSE

Protein

Interleukin-22 receptor subunit alpha-1

Gene

Il22ra1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.1 Publication

    GO - Molecular functioni

    1. interleukin-20 binding Source: MGI

    GO - Biological processi

    1. defense response to Gram-negative bacterium Source: MGI

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-22 receptor subunit alpha-1
    Short name:
    IL-22 receptor subunit alpha-1
    Short name:
    IL-22R-alpha-1
    Short name:
    IL-22RA1
    Gene namesi
    Name:Il22ra1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:2663588. Il22ra1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 581566Interleukin-22 receptor subunit alpha-1PRO_0000324321Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi71 ↔ 79By similarity
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi128 ↔ 217By similarity
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ80XZ4.

    PTM databases

    PhosphoSiteiQ80XZ4.

    Expressioni

    Tissue specificityi

    Expressed in kidney, liver and lung.1 Publication

    Inductioni

    By LPS stimulation in the liver.1 Publication

    Gene expression databases

    BgeeiQ80XZ4.
    CleanExiMM_IL22RA1.
    GenevestigatoriQ80XZ4.

    Interactioni

    Subunit structurei

    Heterodimer with IL10RB and with IL20RB.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ80XZ4.
    SMRiQ80XZ4. Positions 20-225.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini16 – 230215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini252 – 581330CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei231 – 25121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 11598Fibronectin type-III 1Add
    BLAST
    Domaini141 – 22181Fibronectin type-III 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the type II cytokine receptor family.Curated
    Contains 2 fibronectin type-III domains.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG26150.
    GeneTreeiENSGT00530000063352.
    HOGENOMiHOG000060223.
    HOVERGENiHBG104189.
    InParanoidiB2RU51.
    KOiK05138.
    OMAiLTVQWES.
    OrthoDBiEOG7NPFVK.
    PhylomeDBiQ80XZ4.
    TreeFamiTF334107.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015373. Interferon_alpha/beta_rcpt_bsu.
    [Graphical view]
    PfamiPF09294. Interfer-bind. 1 hit.
    PF01108. Tissue_fac. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q80XZ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTLLTILTV GSLAAHTTVD TSGLLQHVKF QSSNFENILT WDGGPASTSD    50
    TVYSVEYKKY GERKWLAKAG CQRITQKFCN LTMETRNHTE FYYAKVTAVS 100
    AGGPPVTKMT DRFSSLQHTT IKPPDVTCIP KVRSIQMLVH PTLTPVLSED 150
    GHQLTLEEIF HDLFYRLELH VNHTYQMHLE GKQREYEFLG LTPDTEFLGS 200
    ITILTPILSK ESAPYVCRVK TLPDRTWAYS FSGAVLFSMG FLVGLLCYLG 250
    YKYITKPPVP PNSLNVQRVL TFQPLRFIQE HVLIPVLDLS GPSSLPQPIQ 300
    YSQVVVSGPR EPPGAVWRQS LSDLTYVGQS DVSILQPTNV PAQQTLSPPS 350
    YAPKAVPEVQ PPSYAPQVAS DAKALFYSPQ QGMKTRPATY DPQDILDSCP 400
    ASYAVCVEDS GKDSTPGILS TPKYLKTKGQ LQEDTLVRSC LPGDLSLQKV 450
    TSLGEGETQR PKSLPSPLGF CTDRGPDLHT LRSEEPETPR YLKGALSLLS 500
    SVQIEGHPVS LPLHVHSVSC SPSDEGPSPW GLLDSLVCPK DEGPAVETEA 550
    MCPSAAASEL EQSTELDSLF KGLALTVQWE S 581
    Length:581
    Mass (Da):63,795
    Last modified:June 1, 2003 - v1
    Checksum:iA2BF8692BB8AA93B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti335 – 3351L → M in BAE24639. (PubMed:16141072)Curated
    Sequence conflicti535 – 5351S → Y in BAE24639. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY103454 mRNA. Translation: AAM52222.1.
    AK141289 mRNA. Translation: BAE24639.1.
    AL662911 Genomic DNA. Translation: CAM13650.1.
    BC140972 mRNA. Translation: AAI40973.1.
    BC140973 mRNA. Translation: AAI40974.1.
    CCDSiCCDS18789.1.
    RefSeqiNP_839988.1. NM_178257.2.
    UniGeneiMm.261647.

    Genome annotation databases

    EnsembliENSMUST00000102546; ENSMUSP00000099605; ENSMUSG00000037157.
    GeneIDi230828.
    KEGGimmu:230828.
    UCSCiuc008vgx.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY103454 mRNA. Translation: AAM52222.1 .
    AK141289 mRNA. Translation: BAE24639.1 .
    AL662911 Genomic DNA. Translation: CAM13650.1 .
    BC140972 mRNA. Translation: AAI40973.1 .
    BC140973 mRNA. Translation: AAI40974.1 .
    CCDSi CCDS18789.1.
    RefSeqi NP_839988.1. NM_178257.2.
    UniGenei Mm.261647.

    3D structure databases

    ProteinModelPortali Q80XZ4.
    SMRi Q80XZ4. Positions 20-225.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q80XZ4.

    Proteomic databases

    PRIDEi Q80XZ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102546 ; ENSMUSP00000099605 ; ENSMUSG00000037157 .
    GeneIDi 230828.
    KEGGi mmu:230828.
    UCSCi uc008vgx.2. mouse.

    Organism-specific databases

    CTDi 58985.
    MGIi MGI:2663588. Il22ra1.

    Phylogenomic databases

    eggNOGi NOG26150.
    GeneTreei ENSGT00530000063352.
    HOGENOMi HOG000060223.
    HOVERGENi HBG104189.
    InParanoidi B2RU51.
    KOi K05138.
    OMAi LTVQWES.
    OrthoDBi EOG7NPFVK.
    PhylomeDBi Q80XZ4.
    TreeFami TF334107.

    Miscellaneous databases

    NextBioi 380202.
    PROi Q80XZ4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q80XZ4.
    CleanExi MM_IL22RA1.
    Genevestigatori Q80XZ4.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR015373. Interferon_alpha/beta_rcpt_bsu.
    [Graphical view ]
    Pfami PF09294. Interfer-bind. 1 hit.
    PF01108. Tissue_fac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic structure and inducible expression of the IL-22 receptor alpha chain in mice."
      Tachiiri A., Imamura R., Wang Y., Fukui M., Umemura M., Suda T.
      Genes Immun. 4:153-159(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION.
      Strain: BALB/c.
      Tissue: Liver.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiI22R1_MOUSE
    AccessioniPrimary (citable) accession number: Q80XZ4
    Secondary accession number(s): B2RU51, Q3URP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3