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Protein

Interleukin-22 receptor subunit alpha-1

Gene

Il22ra1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.1 Publication

GO - Molecular functioni

  • cytokine receptor activity Source: GO_Central
  • interleukin-20 binding Source: MGI

GO - Biological processi

  • cytokine-mediated signaling pathway Source: GO_Central
  • defense response to Gram-negative bacterium Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-8854691. Interleukin-19, 20, 22, 24.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-22 receptor subunit alpha-1
Short name:
IL-22 receptor subunit alpha-1
Short name:
IL-22R-alpha-1
Short name:
IL-22RA1
Gene namesi
Name:Il22ra1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2663588. Il22ra1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini16 – 230ExtracellularSequence analysisAdd BLAST215
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Topological domaini252 – 581CytoplasmicSequence analysisAdd BLAST330

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000032432116 – 581Interleukin-22 receptor subunit alpha-1Add BLAST566

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi71 ↔ 79By similarity
Glycosylationi80N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi128 ↔ 217By similarity
Glycosylationi172N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ80XZ4.
PRIDEiQ80XZ4.

PTM databases

iPTMnetiQ80XZ4.
PhosphoSitePlusiQ80XZ4.

Expressioni

Tissue specificityi

Expressed in kidney, liver and lung.1 Publication

Inductioni

By LPS stimulation in the liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000037157.
CleanExiMM_IL22RA1.

Interactioni

Subunit structurei

Heterodimer with IL10RB and with IL20RB.By similarity

GO - Molecular functioni

  • interleukin-20 binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099605.

Structurei

3D structure databases

ProteinModelPortaliQ80XZ4.
SMRiQ80XZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 115Fibronectin type-III 1Add BLAST98
Domaini141 – 221Fibronectin type-III 2Add BLAST81

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated
Contains 2 fibronectin type-III domains.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF2U. Eukaryota.
ENOG4111CQU. LUCA.
GeneTreeiENSGT00530000063352.
HOGENOMiHOG000060223.
HOVERGENiHBG104189.
InParanoidiQ80XZ4.
KOiK05138.
OMAiSVQIEGH.
OrthoDBiEOG091G068P.
PhylomeDBiQ80XZ4.
TreeFamiTF334107.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80XZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLLTILTV GSLAAHTTVD TSGLLQHVKF QSSNFENILT WDGGPASTSD
60 70 80 90 100
TVYSVEYKKY GERKWLAKAG CQRITQKFCN LTMETRNHTE FYYAKVTAVS
110 120 130 140 150
AGGPPVTKMT DRFSSLQHTT IKPPDVTCIP KVRSIQMLVH PTLTPVLSED
160 170 180 190 200
GHQLTLEEIF HDLFYRLELH VNHTYQMHLE GKQREYEFLG LTPDTEFLGS
210 220 230 240 250
ITILTPILSK ESAPYVCRVK TLPDRTWAYS FSGAVLFSMG FLVGLLCYLG
260 270 280 290 300
YKYITKPPVP PNSLNVQRVL TFQPLRFIQE HVLIPVLDLS GPSSLPQPIQ
310 320 330 340 350
YSQVVVSGPR EPPGAVWRQS LSDLTYVGQS DVSILQPTNV PAQQTLSPPS
360 370 380 390 400
YAPKAVPEVQ PPSYAPQVAS DAKALFYSPQ QGMKTRPATY DPQDILDSCP
410 420 430 440 450
ASYAVCVEDS GKDSTPGILS TPKYLKTKGQ LQEDTLVRSC LPGDLSLQKV
460 470 480 490 500
TSLGEGETQR PKSLPSPLGF CTDRGPDLHT LRSEEPETPR YLKGALSLLS
510 520 530 540 550
SVQIEGHPVS LPLHVHSVSC SPSDEGPSPW GLLDSLVCPK DEGPAVETEA
560 570 580
MCPSAAASEL EQSTELDSLF KGLALTVQWE S
Length:581
Mass (Da):63,795
Last modified:June 1, 2003 - v1
Checksum:iA2BF8692BB8AA93B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti335L → M in BAE24639 (PubMed:16141072).Curated1
Sequence conflicti535S → Y in BAE24639 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY103454 mRNA. Translation: AAM52222.1.
AK141289 mRNA. Translation: BAE24639.1.
AL662911 Genomic DNA. Translation: CAM13650.1.
BC140972 mRNA. Translation: AAI40973.1.
BC140973 mRNA. Translation: AAI40974.1.
CCDSiCCDS18789.1.
RefSeqiNP_839988.1. NM_178257.2.
UniGeneiMm.261647.

Genome annotation databases

EnsembliENSMUST00000102546; ENSMUSP00000099605; ENSMUSG00000037157.
GeneIDi230828.
KEGGimmu:230828.
UCSCiuc008vgx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY103454 mRNA. Translation: AAM52222.1.
AK141289 mRNA. Translation: BAE24639.1.
AL662911 Genomic DNA. Translation: CAM13650.1.
BC140972 mRNA. Translation: AAI40973.1.
BC140973 mRNA. Translation: AAI40974.1.
CCDSiCCDS18789.1.
RefSeqiNP_839988.1. NM_178257.2.
UniGeneiMm.261647.

3D structure databases

ProteinModelPortaliQ80XZ4.
SMRiQ80XZ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099605.

PTM databases

iPTMnetiQ80XZ4.
PhosphoSitePlusiQ80XZ4.

Proteomic databases

PaxDbiQ80XZ4.
PRIDEiQ80XZ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102546; ENSMUSP00000099605; ENSMUSG00000037157.
GeneIDi230828.
KEGGimmu:230828.
UCSCiuc008vgx.2. mouse.

Organism-specific databases

CTDi58985.
MGIiMGI:2663588. Il22ra1.

Phylogenomic databases

eggNOGiENOG410IF2U. Eukaryota.
ENOG4111CQU. LUCA.
GeneTreeiENSGT00530000063352.
HOGENOMiHOG000060223.
HOVERGENiHBG104189.
InParanoidiQ80XZ4.
KOiK05138.
OMAiSVQIEGH.
OrthoDBiEOG091G068P.
PhylomeDBiQ80XZ4.
TreeFamiTF334107.

Enzyme and pathway databases

ReactomeiR-MMU-8854691. Interleukin-19, 20, 22, 24.

Miscellaneous databases

PROiQ80XZ4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037157.
CleanExiMM_IL22RA1.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR015373. Interferon/interleukin_rcp_dom.
[Graphical view]
PfamiPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiI22R1_MOUSE
AccessioniPrimary (citable) accession number: Q80XZ4
Secondary accession number(s): B2RU51, Q3URP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.