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Q80XZ4 (I22R1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-22 receptor subunit alpha-1

Short name=IL-22 receptor subunit alpha-1
Short name=IL-22R-alpha-1
Short name=IL-22RA1
Gene names
Name:Il22ra1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length581 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. Ref.1

Subunit structure

Heterodimer with IL10RB and with IL20RB By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed in kidney, liver and lung. Ref.1

Induction

By LPS stimulation in the liver. Ref.1

Sequence similarities

Belongs to the type II cytokine receptor family.

Contains 2 fibronectin type-III domains.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 581566Interleukin-22 receptor subunit alpha-1
PRO_0000324321

Regions

Topological domain16 – 230215Extracellular Potential
Transmembrane231 – 25121Helical; Potential
Topological domain252 – 581330Cytoplasmic Potential
Domain18 – 11598Fibronectin type-III 1
Domain141 – 22181Fibronectin type-III 2

Amino acid modifications

Glycosylation801N-linked (GlcNAc...) Potential
Glycosylation1721N-linked (GlcNAc...) Potential
Disulfide bond71 ↔ 79 By similarity
Disulfide bond128 ↔ 217 By similarity

Experimental info

Sequence conflict3351L → M in BAE24639. Ref.2
Sequence conflict5351S → Y in BAE24639. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q80XZ4 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: A2BF8692BB8AA93B

FASTA58163,795
        10         20         30         40         50         60 
MKTLLTILTV GSLAAHTTVD TSGLLQHVKF QSSNFENILT WDGGPASTSD TVYSVEYKKY 

        70         80         90        100        110        120 
GERKWLAKAG CQRITQKFCN LTMETRNHTE FYYAKVTAVS AGGPPVTKMT DRFSSLQHTT 

       130        140        150        160        170        180 
IKPPDVTCIP KVRSIQMLVH PTLTPVLSED GHQLTLEEIF HDLFYRLELH VNHTYQMHLE 

       190        200        210        220        230        240 
GKQREYEFLG LTPDTEFLGS ITILTPILSK ESAPYVCRVK TLPDRTWAYS FSGAVLFSMG 

       250        260        270        280        290        300 
FLVGLLCYLG YKYITKPPVP PNSLNVQRVL TFQPLRFIQE HVLIPVLDLS GPSSLPQPIQ 

       310        320        330        340        350        360 
YSQVVVSGPR EPPGAVWRQS LSDLTYVGQS DVSILQPTNV PAQQTLSPPS YAPKAVPEVQ 

       370        380        390        400        410        420 
PPSYAPQVAS DAKALFYSPQ QGMKTRPATY DPQDILDSCP ASYAVCVEDS GKDSTPGILS 

       430        440        450        460        470        480 
TPKYLKTKGQ LQEDTLVRSC LPGDLSLQKV TSLGEGETQR PKSLPSPLGF CTDRGPDLHT 

       490        500        510        520        530        540 
LRSEEPETPR YLKGALSLLS SVQIEGHPVS LPLHVHSVSC SPSDEGPSPW GLLDSLVCPK 

       550        560        570        580 
DEGPAVETEA MCPSAAASEL EQSTELDSLF KGLALTVQWE S 

« Hide

References

« Hide 'large scale' references
[1]"Genomic structure and inducible expression of the IL-22 receptor alpha chain in mice."
Tachiiri A., Imamura R., Wang Y., Fukui M., Umemura M., Suda T.
Genes Immun. 4:153-159(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION.
Strain: BALB/c.
Tissue: Liver.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY103454 mRNA. Translation: AAM52222.1.
AK141289 mRNA. Translation: BAE24639.1.
AL662911 Genomic DNA. Translation: CAM13650.1.
BC140972 mRNA. Translation: AAI40973.1.
BC140973 mRNA. Translation: AAI40974.1.
CCDSCCDS18789.1.
RefSeqNP_839988.1. NM_178257.2.
UniGeneMm.261647.

3D structure databases

ProteinModelPortalQ80XZ4.
SMRQ80XZ4. Positions 20-225.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ80XZ4.

Proteomic databases

PRIDEQ80XZ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000102546; ENSMUSP00000099605; ENSMUSG00000037157.
GeneID230828.
KEGGmmu:230828.
UCSCuc008vgx.2. mouse.

Organism-specific databases

CTD58985.
MGIMGI:2663588. Il22ra1.

Phylogenomic databases

eggNOGNOG26150.
GeneTreeENSGT00530000063352.
HOGENOMHOG000060223.
HOVERGENHBG104189.
InParanoidB2RU51.
KOK05138.
OMALTVQWES.
OrthoDBEOG7NPFVK.
PhylomeDBQ80XZ4.
TreeFamTF334107.

Gene expression databases

BgeeQ80XZ4.
CleanExMM_IL22RA1.
GenevestigatorQ80XZ4.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR015373. Interferon_alpha/beta_rcpt_bsu.
[Graphical view]
PfamPF09294. Interfer-bind. 1 hit.
PF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
ProtoNetSearch...

Other

NextBio380202.
PROQ80XZ4.
SOURCESearch...

Entry information

Entry nameI22R1_MOUSE
AccessionPrimary (citable) accession number: Q80XZ4
Secondary accession number(s): B2RU51, Q3URP9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot