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Protein

Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

Gene

Nucks1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
Alternative name(s):
JC7
Gene namesi
Name:Nucks1
Synonyms:Nucks
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1934811. Nucks1.

Subcellular locationi

GO - Cellular componenti

  • chromatin Source: ParkinsonsUK-UCL
  • cytoplasm Source: ParkinsonsUK-UCL
  • nuclear chromatin Source: MGI
  • nucleus Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000579791 – 234Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphotyrosineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei26PhosphotyrosineBy similarity1
Modified residuei54PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei61PhosphoserineCombined sources1
Modified residuei73PhosphoserineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei79PhosphoserineBy similarity1
Modified residuei113PhosphoserineCombined sources1
Modified residuei130PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei144PhosphoserineBy similarity1
Modified residuei179PhosphothreonineCombined sources1
Modified residuei181PhosphoserineCombined sources1
Modified residuei202PhosphothreonineBy similarity1
Modified residuei204PhosphoserineBy similarity1
Modified residuei214PhosphoserineCombined sources1
Modified residuei225PhosphoserineBy similarity1
Modified residuei231PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by CDK1 and casein kinase.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80XU3.
MaxQBiQ80XU3.
PaxDbiQ80XU3.
PeptideAtlasiQ80XU3.
PRIDEiQ80XU3.
TopDownProteomicsiQ80XU3.

PTM databases

iPTMnetiQ80XU3.
PhosphoSitePlusiQ80XU3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026434.
ExpressionAtlasiQ80XU3. baseline and differential.
GenevisibleiQ80XU3. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ80XU3. 2 interactors.
STRINGi10090.ENSMUSP00000062576.

Structurei

3D structure databases

ProteinModelPortaliQ80XU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi140 – 145Poly-Asp6
Compositional biasi150 – 206Lys-richAdd BLAST57

Phylogenomic databases

eggNOGiENOG410IH23. Eukaryota.
ENOG410XQNM. LUCA.
GeneTreeiENSGT00730000111108.
HOGENOMiHOG000113884.
HOVERGENiHBG052687.
InParanoidiQ80XU3.
OMAiEDGGSDY.
OrthoDBiEOG091G13RX.
PhylomeDBiQ80XU3.

Sequencei

Sequence statusi: Complete.

Q80XU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPVRNRKV VDYSQFQESD DADEDYGRDS GPPAKKIRSS PREAKNKRRS
60 70 80 90 100
GKNSQEDSED SEEKDVKTKK DDSHSAEDSE DEKDDHKNVR QQRQAASKAA
110 120 130 140 150
SKQREMLLED VGSEEEPEED DEAPFQEKDS GSDEDFLMED DDDSDYGSSK
160 170 180 190 200
KKNKKMVKKS KPERKEKKMP KPRLKATVTP SPVKGKAKVG RPTASKKSKE
210 220 230
KTPSPKEEDE EAESPPEKKS GDEGSEDEAS SGED
Length:234
Mass (Da):26,313
Last modified:June 1, 2003 - v1
Checksum:iCB2075863AA0E87A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128 – 129KD → N in BAC37408 (PubMed:16141072).Curated2
Sequence conflicti154K → Q in BAC37408 (PubMed:16141072).Curated1
Sequence conflicti161K → Q in BAC37408 (PubMed:16141072).Curated1
Sequence conflicti168K → E in BAC37408 (PubMed:16141072).Curated1
Sequence conflicti171K → Q in BAC37408 (PubMed:16141072).Curated1
Sequence conflicti174L → V in BAC37408 (PubMed:16141072).Curated1
Sequence conflicti186K → Q in BAC37408 (PubMed:16141072).Curated1
Sequence conflicti206K → Q in BAC37408 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049825 mRNA. Translation: BAC06821.1.
AK078816 mRNA. Translation: BAC37408.1.
BC039951 mRNA. Translation: AAH39951.1.
CCDSiCCDS48356.1.
RefSeqiNP_001139276.1. NM_001145804.1.
NP_780503.2. NM_175294.3.
UniGeneiMm.246869.
Mm.392848.

Genome annotation databases

EnsembliENSMUST00000062264; ENSMUSP00000062576; ENSMUSG00000026434.
GeneIDi98415.
KEGGimmu:98415.
UCSCiuc007cny.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049825 mRNA. Translation: BAC06821.1.
AK078816 mRNA. Translation: BAC37408.1.
BC039951 mRNA. Translation: AAH39951.1.
CCDSiCCDS48356.1.
RefSeqiNP_001139276.1. NM_001145804.1.
NP_780503.2. NM_175294.3.
UniGeneiMm.246869.
Mm.392848.

3D structure databases

ProteinModelPortaliQ80XU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80XU3. 2 interactors.
STRINGi10090.ENSMUSP00000062576.

PTM databases

iPTMnetiQ80XU3.
PhosphoSitePlusiQ80XU3.

Proteomic databases

EPDiQ80XU3.
MaxQBiQ80XU3.
PaxDbiQ80XU3.
PeptideAtlasiQ80XU3.
PRIDEiQ80XU3.
TopDownProteomicsiQ80XU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062264; ENSMUSP00000062576; ENSMUSG00000026434.
GeneIDi98415.
KEGGimmu:98415.
UCSCiuc007cny.2. mouse.

Organism-specific databases

CTDi64710.
MGIiMGI:1934811. Nucks1.

Phylogenomic databases

eggNOGiENOG410IH23. Eukaryota.
ENOG410XQNM. LUCA.
GeneTreeiENSGT00730000111108.
HOGENOMiHOG000113884.
HOVERGENiHBG052687.
InParanoidiQ80XU3.
OMAiEDGGSDY.
OrthoDBiEOG091G13RX.
PhylomeDBiQ80XU3.

Miscellaneous databases

ChiTaRSiNucks1. mouse.
PROiQ80XU3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026434.
ExpressionAtlasiQ80XU3. baseline and differential.
GenevisibleiQ80XU3. MM.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiNUCKS_MOUSE
AccessioniPrimary (citable) accession number: Q80XU3
Secondary accession number(s): Q8BVD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.