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Protein

Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

Gene

Nucks1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • glucose homeostasis Source: MGI
  • positive regulation of insulin receptor signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
Alternative name(s):
JC7
Gene namesi
Name:Nucks1
Synonyms:Nucks
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1934811. Nucks1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1PRO_0000057979Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphotyrosineCombined sources
Modified residuei14 – 141PhosphoserineCombined sources
Modified residuei19 – 191PhosphoserineCombined sources
Modified residuei26 – 261PhosphotyrosineBy similarity
Modified residuei54 – 541PhosphoserineCombined sources
Modified residuei58 – 581PhosphoserineCombined sources
Modified residuei61 – 611PhosphoserineCombined sources
Modified residuei73 – 731PhosphoserineBy similarity
Modified residuei75 – 751PhosphoserineBy similarity
Modified residuei79 – 791PhosphoserineBy similarity
Modified residuei113 – 1131PhosphoserineCombined sources
Modified residuei130 – 1301PhosphoserineCombined sources
Modified residuei132 – 1321PhosphoserineCombined sources
Modified residuei144 – 1441PhosphoserineBy similarity
Modified residuei179 – 1791PhosphothreonineCombined sources
Modified residuei181 – 1811PhosphoserineCombined sources
Modified residuei202 – 2021PhosphothreonineBy similarity
Modified residuei204 – 2041PhosphoserineBy similarity
Modified residuei214 – 2141PhosphoserineCombined sources
Modified residuei225 – 2251PhosphoserineBy similarity
Modified residuei231 – 2311PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated by CDK1 and casein kinase.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80XU3.
MaxQBiQ80XU3.
PaxDbiQ80XU3.
PeptideAtlasiQ80XU3.
PRIDEiQ80XU3.
TopDownProteomicsiQ80XU3.

PTM databases

iPTMnetiQ80XU3.
PhosphoSiteiQ80XU3.

Expressioni

Gene expression databases

BgeeiQ80XU3.
ExpressionAtlasiQ80XU3. baseline and differential.
GenevisibleiQ80XU3. MM.

Interactioni

Protein-protein interaction databases

IntActiQ80XU3. 2 interactions.
STRINGi10090.ENSMUSP00000062576.

Structurei

3D structure databases

ProteinModelPortaliQ80XU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi140 – 1456Poly-Asp
Compositional biasi150 – 20657Lys-richAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IH23. Eukaryota.
ENOG410XQNM. LUCA.
GeneTreeiENSGT00730000111108.
HOGENOMiHOG000113884.
HOVERGENiHBG052687.
InParanoidiQ80XU3.
OMAiEDGGSDY.
OrthoDBiEOG7PVWS0.
PhylomeDBiQ80XU3.

Sequencei

Sequence statusi: Complete.

Q80XU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPVRNRKV VDYSQFQESD DADEDYGRDS GPPAKKIRSS PREAKNKRRS
60 70 80 90 100
GKNSQEDSED SEEKDVKTKK DDSHSAEDSE DEKDDHKNVR QQRQAASKAA
110 120 130 140 150
SKQREMLLED VGSEEEPEED DEAPFQEKDS GSDEDFLMED DDDSDYGSSK
160 170 180 190 200
KKNKKMVKKS KPERKEKKMP KPRLKATVTP SPVKGKAKVG RPTASKKSKE
210 220 230
KTPSPKEEDE EAESPPEKKS GDEGSEDEAS SGED
Length:234
Mass (Da):26,313
Last modified:June 1, 2003 - v1
Checksum:iCB2075863AA0E87A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1292KD → N in BAC37408 (PubMed:16141072).Curated
Sequence conflicti154 – 1541K → Q in BAC37408 (PubMed:16141072).Curated
Sequence conflicti161 – 1611K → Q in BAC37408 (PubMed:16141072).Curated
Sequence conflicti168 – 1681K → E in BAC37408 (PubMed:16141072).Curated
Sequence conflicti171 – 1711K → Q in BAC37408 (PubMed:16141072).Curated
Sequence conflicti174 – 1741L → V in BAC37408 (PubMed:16141072).Curated
Sequence conflicti186 – 1861K → Q in BAC37408 (PubMed:16141072).Curated
Sequence conflicti206 – 2061K → Q in BAC37408 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049825 mRNA. Translation: BAC06821.1.
AK078816 mRNA. Translation: BAC37408.1.
BC039951 mRNA. Translation: AAH39951.1.
CCDSiCCDS48356.1.
RefSeqiNP_001139276.1. NM_001145804.1.
NP_780503.2. NM_175294.3.
UniGeneiMm.246869.
Mm.392848.

Genome annotation databases

EnsembliENSMUST00000062264; ENSMUSP00000062576; ENSMUSG00000026434.
GeneIDi98415.
KEGGimmu:98415.
UCSCiuc007cny.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049825 mRNA. Translation: BAC06821.1.
AK078816 mRNA. Translation: BAC37408.1.
BC039951 mRNA. Translation: AAH39951.1.
CCDSiCCDS48356.1.
RefSeqiNP_001139276.1. NM_001145804.1.
NP_780503.2. NM_175294.3.
UniGeneiMm.246869.
Mm.392848.

3D structure databases

ProteinModelPortaliQ80XU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80XU3. 2 interactions.
STRINGi10090.ENSMUSP00000062576.

PTM databases

iPTMnetiQ80XU3.
PhosphoSiteiQ80XU3.

Proteomic databases

EPDiQ80XU3.
MaxQBiQ80XU3.
PaxDbiQ80XU3.
PeptideAtlasiQ80XU3.
PRIDEiQ80XU3.
TopDownProteomicsiQ80XU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062264; ENSMUSP00000062576; ENSMUSG00000026434.
GeneIDi98415.
KEGGimmu:98415.
UCSCiuc007cny.2. mouse.

Organism-specific databases

CTDi64710.
MGIiMGI:1934811. Nucks1.

Phylogenomic databases

eggNOGiENOG410IH23. Eukaryota.
ENOG410XQNM. LUCA.
GeneTreeiENSGT00730000111108.
HOGENOMiHOG000113884.
HOVERGENiHBG052687.
InParanoidiQ80XU3.
OMAiEDGGSDY.
OrthoDBiEOG7PVWS0.
PhylomeDBiQ80XU3.

Miscellaneous databases

ChiTaRSiNucks1. mouse.
PROiQ80XU3.
SOURCEiSearch...

Gene expression databases

BgeeiQ80XU3.
ExpressionAtlasiQ80XU3. baseline and differential.
GenevisibleiQ80XU3. MM.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A search for cell proliferation related new genes."
    Yoshitaka T.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19 AND SER-113, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  5. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19; SER-58; SER-61; THR-179 AND SER-181, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19; SER-58; SER-61; SER-130 AND SER-132, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19 AND SER-181, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-13; SER-14; SER-19; SER-54; SER-58; SER-61; SER-113; THR-179; SER-181 AND SER-214, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiNUCKS_MOUSE
AccessioniPrimary (citable) accession number: Q80XU3
Secondary accession number(s): Q8BVD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2003
Last modified: July 6, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.