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Protein

Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

Gene

Nucks1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular glucose homeostasis Source: ParkinsonsUK-UCL
  • cellular response to X-ray Source: MGI
  • chromatin organization Source: ParkinsonsUK-UCL
  • double-strand break repair via homologous recombination Source: MGI
  • glucose homeostasis Source: MGI
  • interstrand cross-link repair Source: MGI
  • modulation by host of RNA binding by virus Source: MGI
  • modulation by host of viral RNA-binding transcription factor activity Source: MGI
  • positive regulation by host of viral genome replication Source: MGI
  • positive regulation by host of viral transcription Source: MGI
  • positive regulation of insulin receptor signaling pathway Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: ParkinsonsUK-UCL
  • regulation of DNA replication Source: MGI
  • regulation of DNA strand elongation Source: MGI
  • regulation of insulin receptor signaling pathway Source: ParkinsonsUK-UCL
  • regulation of transcription by RNA polymerase II Source: ParkinsonsUK-UCL
  • release from viral latency Source: MGI
  • replication fork processing Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
Alternative name(s):
JC7
Gene namesi
Name:Nucks1
Synonyms:Nucks
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1934811 Nucks1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000579791 – 234Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphotyrosineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei26PhosphotyrosineBy similarity1
Modified residuei54PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei61PhosphoserineCombined sources1
Modified residuei73PhosphoserineBy similarity1
Modified residuei75PhosphoserineBy similarity1
Modified residuei79PhosphoserineBy similarity1
Modified residuei113PhosphoserineCombined sources1
Modified residuei130PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei144PhosphoserineBy similarity1
Modified residuei179PhosphothreonineCombined sources1
Modified residuei181PhosphoserineCombined sources1
Modified residuei202PhosphothreonineBy similarity1
Modified residuei204PhosphoserineBy similarity1
Modified residuei214PhosphoserineCombined sources1
Modified residuei225PhosphoserineBy similarity1
Modified residuei231PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by CDK1 and casein kinase.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80XU3
MaxQBiQ80XU3
PaxDbiQ80XU3
PeptideAtlasiQ80XU3
PRIDEiQ80XU3
TopDownProteomicsiQ80XU3

PTM databases

iPTMnetiQ80XU3
PhosphoSitePlusiQ80XU3

Expressioni

Gene expression databases

BgeeiENSMUSG00000026434
ExpressionAtlasiQ80XU3 baseline and differential
GenevisibleiQ80XU3 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ80XU3, 2 interactors
STRINGi10090.ENSMUSP00000062576

Structurei

3D structure databases

ProteinModelPortaliQ80XU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi140 – 145Poly-Asp6
Compositional biasi150 – 206Lys-richAdd BLAST57

Phylogenomic databases

eggNOGiENOG410IH23 Eukaryota
ENOG410XQNM LUCA
GeneTreeiENSGT00730000111108
HOGENOMiHOG000113884
HOVERGENiHBG052687
InParanoidiQ80XU3
OMAiSYMDPDE
OrthoDBiEOG091G13RX
PhylomeDBiQ80XU3

Family and domain databases

InterProiView protein in InterPro
IPR026633 NUCKS1
PANTHERiPTHR15361:SF1 PTHR15361:SF1, 2 hits

Sequencei

Sequence statusi: Complete.

Q80XU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPVRNRKV VDYSQFQESD DADEDYGRDS GPPAKKIRSS PREAKNKRRS
60 70 80 90 100
GKNSQEDSED SEEKDVKTKK DDSHSAEDSE DEKDDHKNVR QQRQAASKAA
110 120 130 140 150
SKQREMLLED VGSEEEPEED DEAPFQEKDS GSDEDFLMED DDDSDYGSSK
160 170 180 190 200
KKNKKMVKKS KPERKEKKMP KPRLKATVTP SPVKGKAKVG RPTASKKSKE
210 220 230
KTPSPKEEDE EAESPPEKKS GDEGSEDEAS SGED
Length:234
Mass (Da):26,313
Last modified:June 1, 2003 - v1
Checksum:iCB2075863AA0E87A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128 – 129KD → N in BAC37408 (PubMed:16141072).Curated2
Sequence conflicti154K → Q in BAC37408 (PubMed:16141072).Curated1
Sequence conflicti161K → Q in BAC37408 (PubMed:16141072).Curated1
Sequence conflicti168K → E in BAC37408 (PubMed:16141072).Curated1
Sequence conflicti171K → Q in BAC37408 (PubMed:16141072).Curated1
Sequence conflicti174L → V in BAC37408 (PubMed:16141072).Curated1
Sequence conflicti186K → Q in BAC37408 (PubMed:16141072).Curated1
Sequence conflicti206K → Q in BAC37408 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049825 mRNA Translation: BAC06821.1
AK078816 mRNA Translation: BAC37408.1
BC039951 mRNA Translation: AAH39951.1
CCDSiCCDS48356.1
RefSeqiNP_001139276.1, NM_001145804.1
NP_780503.2, NM_175294.3
UniGeneiMm.246869
Mm.392848

Genome annotation databases

EnsembliENSMUST00000062264; ENSMUSP00000062576; ENSMUSG00000026434
GeneIDi98415
KEGGimmu:98415
UCSCiuc007cny.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNUCKS_MOUSE
AccessioniPrimary (citable) accession number: Q80XU3
Secondary accession number(s): Q8BVD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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