Calcium-transporting ATPase type 2C member 1

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Q80XR2 (AT2C1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 91. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Calcium-transporting ATPase type 2C member 1
Short name=ATPase 2C1
EC=3.6.3.8

Alternative name(s):
ATP-dependent Ca(2+) pump PMR1

Gene names

Name:	Atp2c1
Synonyms:	Pmr1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	918 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium By similarity. Ref.1
Catalytic activity	ATP + H₂O + Ca²⁺(Side 1) = ADP + phosphate + Ca²⁺(Side 2).
Subcellular location	Golgi apparatus › Golgi stack membrane; Multi-pass membrane protein By similarity Ref.1.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Golgi apparatus Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Calcium Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	Golgi calcium ion homeostasis Inferred from sequence or structural similarity. Source: UniProtKB Golgi calcium ion transport Inferred from sequence or structural similarity. Source: UniProtKB actin cytoskeleton reorganization Inferred from sequence or structural similarity. Source: UniProtKB calcium-dependent cell-cell adhesion Inferred from sequence or structural similarity. Source: UniProtKB cellular manganese ion homeostasis Inferred from sequence or structural similarity. Source: UniProtKB epidermis development Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	Golgi cisterna membrane Inferred from electronic annotation. Source: UniProtKB-SubCell Golgi membrane Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW trans-Golgi network Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Inferred from sequence or structural similarity. Source: UniProtKB calcium ion binding Inferred from sequence or structural similarity. Source: UniProtKB calcium-transporting ATPase activity Inferred from sequence or structural similarity. Source: UniProtKB manganese ion binding Inferred from sequence or structural similarity. Source: UniProtKB manganese-transporting ATPase activity Inferred from sequence or structural similarity. Source: UniProtKB signal transducer activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 918

918

Calcium-transporting ATPase type 2C member 1

PRO_0000046224

Regions

Topological domain

1 – 78

Cytoplasmic Potential

Transmembrane

79 – 95

Helical; Potential

Topological domain

96 – 99

Extracellular Potential

Transmembrane

100 – 121

Helical; Potential

Topological domain

122 – 262

141

Cytoplasmic Potential

Transmembrane

263 – 282

Helical; Potential

Topological domain

283 – 294

Extracellular Potential

Transmembrane

295 – 316

Helical; Potential

Topological domain

317 – 699

383

Cytoplasmic Potential

Transmembrane

700 – 722

Helical; Potential

Topological domain

723 – 727

Extracellular Potential

Transmembrane

728 – 751

Helical; Potential

Topological domain

752 – 775

Cytoplasmic Potential

Transmembrane

776 – 794

Helical; Potential

Topological domain

795 – 801

Extracellular Potential

Transmembrane

802 – 827

Helical; Potential

Topological domain

828 – 842

Cytoplasmic Potential

Transmembrane

843 – 862

Helical; Potential

Topological domain

863 – 875

Extracellular Potential

Transmembrane

876 – 892

Helical; Potential

Topological domain

893 – 918

Cytoplasmic Potential

Sites

Active site

349

4-aspartylphosphate intermediate By similarity

Metal binding

643

Magnesium By similarity

Metal binding

647

Magnesium By similarity

Experimental info

Sequence conflict

156

V → A in CAD82864. Ref.1

Sequence conflict

189

T → I in AAH43091. Ref.3

Sequence conflict

217

F → S in CAD82864. Ref.1

Sequence conflict

280

M → T in CAD82864. Ref.1

Sequence conflict

743

P → S in AAH43091. Ref.3

Sequence conflict

813

C → R in CAD82864. Ref.1

Sequence conflict

902

E → G in CAD82864. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q80XR2 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 8C57096C69AA7C15
Show »

FASTA

918

100,299

        10         20         30         40         50         60 
MKVARFQKIP NVENETMIPV LTSKRASELA VSEVAGLLQA DLQNGLNKSE VSHRRAFHGW 

        70         80         90        100        110        120 
NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISILMRQF DDAVSITVAI VIVVTVAFVQ 

       130        140        150        160        170        180 
EYRSEKSLEE LSKLVPPECH CVREGKLEHT LARDLVPGDT VCLSVGDRVP ADLRLFEAVD 

       190        200        210        220        230        240 
LSVDESSLTG ETAPCSKVTA PQPAANGDLA SRSNIAFMGT LVRCGKAKGI VIGTGENSEF 

       250        260        270        280        290        300 
GEVFKMMQAE EAPKTPLQKS MDLLGKQLSF YSFGIIGIIM LVGWLLGKDI LEMFTISVSL 

       310        320        330        340        350        360 
AVAAIPEGLP IVVTVTLALG VMRMVKKRAI VKKLPIVETL GCCNVICSDK TGTLTKNEMT 

       370        380        390        400        410        420 
VTHILTSDGL HAEVTGVGYN QFGEVIVDGD VVHGFYNPAV SRIVEAGCVC NDAVIRNNTL 

       430        440        450        460        470        480 
MGKPTEGALI ALAMKMGLDG LQQDYIRKAE YPFSSEQKWM AVKCVHRTQQ DRPEICFMKG 

       490        500        510        520        530        540 
AYEQVIKYCT TYNSKGQTLA LTQQQRDLYQ QEKARMGSAG LRVLALASGP ELGQLTFLGL 

       550        560        570        580        590        600 
VGIIDPPRTG VKEAVTTLIA SGVSIKMITG DSQETAIAIA SRLGLYSKTS QSVSGEEVDT 

       610        620        630        640        650        660 
MEVQHLSQIV PKVAVFYRAS PRHKMKIIKS LQKNGAVVAM TGDGVNDAVA LKAADIGVAM 

       670        680        690        700        710        720 
GQTGTDVCKE AADMILVDDD FQTIMSAIEE GKGIYNNIKN FVRFQLSTSI AALTLISLAT 

       730        740        750        760        770        780 
LMNFPNPLNA MQILWINIIM DGPPAQSLGV EPVDKDVIRK PPRNWKDSIL TKNLILKILV 

       790        800        810        820        830        840 
SSIIIVCGTL FVFWRELRDN VITPRDTTMT FTCFVFFDMF NALSSRSQTK SVFEIGLCSN 

       850        860        870        880        890        900 
KMFCYAVLGS IMGQLLVIYF PPLQKVFQTE SLSILDLLFL LGLTSSVCIV SEIIKKVERS 

       910 
REKVQKNAGS ASSSFLEV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Role for plasma membrane-related Ca2+-ATPase-1 (ATP2C1) in pancreatic beta-cell Ca2+ homeostasis revealed by RNA silencing." Mitchell K.J., Tsuboi T., Rutter G.A. Diabetes 53:393-400(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
[4]	Lubec G., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 127-133, MASS SPECTROMETRY. Strain: OF1. Tissue: Hippocampus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ551270 mRNA. Translation: CAD82864.1. AC113016 Genomic DNA. No translation available. AC117679 Genomic DNA. No translation available. BC043091 mRNA. Translation: AAH43091.1.
IPI	IPI00336323.
RefSeq	NP_001240760.1. NM_001253831.1. NP_001240763.1. NM_001253834.1. NP_778190.3. NM_175025.4.
UniGene	Mm.326247. Mm.489853.
3D structure databases
ProteinModelPortal	Q80XR2.
SMR	Q80XR2. Positions 45-900.
ModBase	Search...
PTM databases
PhosphoSite	Q80XR2.
Proteomic databases
PaxDb	Q80XR2.
PRIDE	Q80XR2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000038118; ENSMUSP00000039103; ENSMUSG00000032570. ENSMUST00000112558; ENSMUSP00000108177; ENSMUSG00000032570.
GeneID	235574.
KEGG	mmu:235574.
Organism-specific databases
CTD	27032.
MGI	MGI:1889008. Atp2c1.
Phylogenomic databases
eggNOG	COG0474.
GeneTree	ENSGT00560000076887.
HOGENOM	HOG000265621.
HOVERGEN	HBG106478.
KO	K01537.
Gene expression databases
ArrayExpress	Q80XR2.
Bgee	Q80XR2.
CleanEx	MM_ATP2C1.
Genevestigator	Q80XR2.
GermOnline	ENSMUSG00000032570. Mus musculus.
Family and domain databases
Gene3D	1.20.1110.10. 3 hits.
InterPro	IPR006413. ATPase_P-typ_Ca-transp_PMR1. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023299. ATPase_P-typ_cyto_domN. IPR018303. ATPase_P-typ_P_site. IPR023298. ATPase_P-typ_TM_dom. IPR008250. ATPase_P-typ_transduc_dom_A. IPR001757. Cation_transp_P_typ_ATPase. IPR023214. HAD-like_dom. [Graphical view]
PANTHER	PTHR24093. PTHR24093. 1 hit.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00120. HATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01522. ATPase-IIA2_Ca. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ATP2C1. mouse.
NextBio	382755.
SOURCE	Search...

Entry information

Entry name

AT2C1_MOUSE

Accession

Primary (citable) accession number: Q80XR2
Secondary accession number(s): E9QMB9, Q80YZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents