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Protein

Calcium-transporting ATPase type 2C member 1

Gene

Atp2c1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.By similarity1 Publication

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3494-aspartylphosphate intermediateBy similarity1
Metal bindingi643MagnesiumBy similarity1
Metal bindingi647MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCalcium transport, Ion transport, Transport
LigandATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase type 2C member 1 (EC:3.6.3.8)
Short name:
ATPase 2C1
Alternative name(s):
ATP-dependent Ca(2+) pump PMR1
Gene namesi
Name:Atp2c1
Synonyms:Pmr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1889008 Atp2c1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 78CytoplasmicSequence analysisAdd BLAST78
Transmembranei79 – 95HelicalSequence analysisAdd BLAST17
Topological domaini96 – 99ExtracellularSequence analysis4
Transmembranei100 – 121HelicalSequence analysisAdd BLAST22
Topological domaini122 – 262CytoplasmicSequence analysisAdd BLAST141
Transmembranei263 – 282HelicalSequence analysisAdd BLAST20
Topological domaini283 – 294ExtracellularSequence analysisAdd BLAST12
Transmembranei295 – 316HelicalSequence analysisAdd BLAST22
Topological domaini317 – 699CytoplasmicSequence analysisAdd BLAST383
Transmembranei700 – 722HelicalSequence analysisAdd BLAST23
Topological domaini723 – 727ExtracellularSequence analysis5
Transmembranei728 – 751HelicalSequence analysisAdd BLAST24
Topological domaini752 – 775CytoplasmicSequence analysisAdd BLAST24
Transmembranei776 – 794HelicalSequence analysisAdd BLAST19
Topological domaini795 – 801ExtracellularSequence analysis7
Transmembranei802 – 827HelicalSequence analysisAdd BLAST26
Topological domaini828 – 842CytoplasmicSequence analysisAdd BLAST15
Transmembranei843 – 862HelicalSequence analysisAdd BLAST20
Topological domaini863 – 875ExtracellularSequence analysisAdd BLAST13
Transmembranei876 – 892HelicalSequence analysisAdd BLAST17
Topological domaini893 – 918CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462241 – 918Calcium-transporting ATPase type 2C member 1Add BLAST918

Proteomic databases

EPDiQ80XR2
MaxQBiQ80XR2
PaxDbiQ80XR2
PRIDEiQ80XR2

PTM databases

iPTMnetiQ80XR2
PhosphoSitePlusiQ80XR2
SwissPalmiQ80XR2

Expressioni

Gene expression databases

BgeeiENSMUSG00000032570
CleanExiMM_ATP2C1
ExpressionAtlasiQ80XR2 baseline and differential
GenevisibleiQ80XR2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082220

Structurei

3D structure databases

ProteinModelPortaliQ80XR2
SMRiQ80XR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0202 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00890000139334
HOGENOMiHOG000265621
HOVERGENiHBG106478
InParanoidiQ80XR2
KOiK01537
TreeFamiTF354251

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR030336 ATP2C1
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006413 P-type_ATPase_IIA_PMR1
IPR001757 P_typ_ATPase
PANTHERiPTHR42861:SF2 PTHR42861:SF2, 1 hit
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
PRINTSiPR00120 HATPASE
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01522 ATPase-IIA2_Ca, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

Q80XR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVARFQKIP NVENETMIPV LTSKRASELA VSEVAGLLQA DLQNGLNKSE
60 70 80 90 100
VSHRRAFHGW NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISILMRQF
110 120 130 140 150
DDAVSITVAI VIVVTVAFVQ EYRSEKSLEE LSKLVPPECH CVREGKLEHT
160 170 180 190 200
LARDLVPGDT VCLSVGDRVP ADLRLFEAVD LSVDESSLTG ETAPCSKVTA
210 220 230 240 250
PQPAANGDLA SRSNIAFMGT LVRCGKAKGI VIGTGENSEF GEVFKMMQAE
260 270 280 290 300
EAPKTPLQKS MDLLGKQLSF YSFGIIGIIM LVGWLLGKDI LEMFTISVSL
310 320 330 340 350
AVAAIPEGLP IVVTVTLALG VMRMVKKRAI VKKLPIVETL GCCNVICSDK
360 370 380 390 400
TGTLTKNEMT VTHILTSDGL HAEVTGVGYN QFGEVIVDGD VVHGFYNPAV
410 420 430 440 450
SRIVEAGCVC NDAVIRNNTL MGKPTEGALI ALAMKMGLDG LQQDYIRKAE
460 470 480 490 500
YPFSSEQKWM AVKCVHRTQQ DRPEICFMKG AYEQVIKYCT TYNSKGQTLA
510 520 530 540 550
LTQQQRDLYQ QEKARMGSAG LRVLALASGP ELGQLTFLGL VGIIDPPRTG
560 570 580 590 600
VKEAVTTLIA SGVSIKMITG DSQETAIAIA SRLGLYSKTS QSVSGEEVDT
610 620 630 640 650
MEVQHLSQIV PKVAVFYRAS PRHKMKIIKS LQKNGAVVAM TGDGVNDAVA
660 670 680 690 700
LKAADIGVAM GQTGTDVCKE AADMILVDDD FQTIMSAIEE GKGIYNNIKN
710 720 730 740 750
FVRFQLSTSI AALTLISLAT LMNFPNPLNA MQILWINIIM DGPPAQSLGV
760 770 780 790 800
EPVDKDVIRK PPRNWKDSIL TKNLILKILV SSIIIVCGTL FVFWRELRDN
810 820 830 840 850
VITPRDTTMT FTCFVFFDMF NALSSRSQTK SVFEIGLCSN KMFCYAVLGS
860 870 880 890 900
IMGQLLVIYF PPLQKVFQTE SLSILDLLFL LGLTSSVCIV SEIIKKVERS
910
REKVQKNAGS ASSSFLEV
Length:918
Mass (Da):100,299
Last modified:July 27, 2011 - v2
Checksum:i8C57096C69AA7C15
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156V → A in CAD82864 (PubMed:14747290).Curated1
Sequence conflicti189T → I in AAH43091 (PubMed:15489334).Curated1
Sequence conflicti217F → S in CAD82864 (PubMed:14747290).Curated1
Sequence conflicti280M → T in CAD82864 (PubMed:14747290).Curated1
Sequence conflicti743P → S in AAH43091 (PubMed:15489334).Curated1
Sequence conflicti813C → R in CAD82864 (PubMed:14747290).Curated1
Sequence conflicti902E → G in CAD82864 (PubMed:14747290).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ551270 mRNA Translation: CAD82864.1
AC113016 Genomic DNA No translation available.
AC117679 Genomic DNA No translation available.
BC043091 mRNA Translation: AAH43091.1
CCDSiCCDS40752.1
RefSeqiNP_001240760.1, NM_001253831.1
NP_001240763.1, NM_001253834.1
NP_778190.3, NM_175025.4
UniGeneiMm.326247
Mm.489853

Genome annotation databases

EnsembliENSMUST00000038118; ENSMUSP00000039103; ENSMUSG00000032570
ENSMUST00000112558; ENSMUSP00000108177; ENSMUSG00000032570
GeneIDi235574
KEGGimmu:235574
UCSCiuc009rif.3 mouse

Similar proteinsi

Entry informationi

Entry nameiAT2C1_MOUSE
AccessioniPrimary (citable) accession number: Q80XR2
Secondary accession number(s): E9QMB9, Q80YZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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