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Q80XR2

- AT2C1_MOUSE

UniProt

Q80XR2 - AT2C1_MOUSE

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Protein

Calcium-transporting ATPase type 2C member 1

Gene

Atp2c1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.By similarity

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei349 – 34914-aspartylphosphate intermediateBy similarity
Metal bindingi643 – 6431MagnesiumBy similarity
Metal bindingi647 – 6471MagnesiumBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. calcium ion binding Source: UniProtKB
  3. calcium-transporting ATPase activity Source: UniProtKB
  4. manganese ion binding Source: UniProtKB
  5. manganese-transporting ATPase activity Source: UniProtKB
  6. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. actin cytoskeleton reorganization Source: UniProtKB
  2. calcium-dependent cell-cell adhesion Source: UniProtKB
  3. calcium ion transmembrane transport Source: GOC
  4. calcium ion transport Source: UniProtKB
  5. cellular calcium ion homeostasis Source: UniProtKB
  6. cellular manganese ion homeostasis Source: UniProtKB
  7. epidermis development Source: UniProtKB
  8. Golgi calcium ion homeostasis Source: UniProtKB
  9. Golgi calcium ion transport Source: UniProtKB
  10. manganese ion transport Source: UniProtKB
  11. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase type 2C member 1 (EC:3.6.3.8)
Short name:
ATPase 2C1
Alternative name(s):
ATP-dependent Ca(2+) pump PMR1
Gene namesi
Name:Atp2c1
Synonyms:Pmr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1889008. Atp2c1.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. Golgi membrane Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane Source: MGI
  5. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 918918Calcium-transporting ATPase type 2C member 1PRO_0000046224Add
BLAST

Proteomic databases

MaxQBiQ80XR2.
PaxDbiQ80XR2.
PRIDEiQ80XR2.

PTM databases

PhosphoSiteiQ80XR2.

Expressioni

Gene expression databases

BgeeiQ80XR2.
CleanExiMM_ATP2C1.
ExpressionAtlasiQ80XR2. baseline and differential.
GenevestigatoriQ80XR2.

Structurei

3D structure databases

ProteinModelPortaliQ80XR2.
SMRiQ80XR2. Positions 45-900.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7878CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini96 – 994ExtracellularSequence Analysis
Topological domaini122 – 262141CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini283 – 29412ExtracellularSequence AnalysisAdd
BLAST
Topological domaini317 – 699383CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini723 – 7275ExtracellularSequence Analysis
Topological domaini752 – 77524CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini795 – 8017ExtracellularSequence Analysis
Topological domaini828 – 84215CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini863 – 87513ExtracellularSequence AnalysisAdd
BLAST
Topological domaini893 – 91826CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei79 – 9517HelicalSequence AnalysisAdd
BLAST
Transmembranei100 – 12122HelicalSequence AnalysisAdd
BLAST
Transmembranei263 – 28220HelicalSequence AnalysisAdd
BLAST
Transmembranei295 – 31622HelicalSequence AnalysisAdd
BLAST
Transmembranei700 – 72223HelicalSequence AnalysisAdd
BLAST
Transmembranei728 – 75124HelicalSequence AnalysisAdd
BLAST
Transmembranei776 – 79419HelicalSequence AnalysisAdd
BLAST
Transmembranei802 – 82726HelicalSequence AnalysisAdd
BLAST
Transmembranei843 – 86220HelicalSequence AnalysisAdd
BLAST
Transmembranei876 – 89217HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
GeneTreeiENSGT00760000119003.
HOGENOMiHOG000265621.
HOVERGENiHBG106478.
InParanoidiQ80XR2.
KOiK01537.
TreeFamiTF354251.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR006413. ATPase_P-typ_Ca-transp_PMR1.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
PR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80XR2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVARFQKIP NVENETMIPV LTSKRASELA VSEVAGLLQA DLQNGLNKSE
60 70 80 90 100
VSHRRAFHGW NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISILMRQF
110 120 130 140 150
DDAVSITVAI VIVVTVAFVQ EYRSEKSLEE LSKLVPPECH CVREGKLEHT
160 170 180 190 200
LARDLVPGDT VCLSVGDRVP ADLRLFEAVD LSVDESSLTG ETAPCSKVTA
210 220 230 240 250
PQPAANGDLA SRSNIAFMGT LVRCGKAKGI VIGTGENSEF GEVFKMMQAE
260 270 280 290 300
EAPKTPLQKS MDLLGKQLSF YSFGIIGIIM LVGWLLGKDI LEMFTISVSL
310 320 330 340 350
AVAAIPEGLP IVVTVTLALG VMRMVKKRAI VKKLPIVETL GCCNVICSDK
360 370 380 390 400
TGTLTKNEMT VTHILTSDGL HAEVTGVGYN QFGEVIVDGD VVHGFYNPAV
410 420 430 440 450
SRIVEAGCVC NDAVIRNNTL MGKPTEGALI ALAMKMGLDG LQQDYIRKAE
460 470 480 490 500
YPFSSEQKWM AVKCVHRTQQ DRPEICFMKG AYEQVIKYCT TYNSKGQTLA
510 520 530 540 550
LTQQQRDLYQ QEKARMGSAG LRVLALASGP ELGQLTFLGL VGIIDPPRTG
560 570 580 590 600
VKEAVTTLIA SGVSIKMITG DSQETAIAIA SRLGLYSKTS QSVSGEEVDT
610 620 630 640 650
MEVQHLSQIV PKVAVFYRAS PRHKMKIIKS LQKNGAVVAM TGDGVNDAVA
660 670 680 690 700
LKAADIGVAM GQTGTDVCKE AADMILVDDD FQTIMSAIEE GKGIYNNIKN
710 720 730 740 750
FVRFQLSTSI AALTLISLAT LMNFPNPLNA MQILWINIIM DGPPAQSLGV
760 770 780 790 800
EPVDKDVIRK PPRNWKDSIL TKNLILKILV SSIIIVCGTL FVFWRELRDN
810 820 830 840 850
VITPRDTTMT FTCFVFFDMF NALSSRSQTK SVFEIGLCSN KMFCYAVLGS
860 870 880 890 900
IMGQLLVIYF PPLQKVFQTE SLSILDLLFL LGLTSSVCIV SEIIKKVERS
910
REKVQKNAGS ASSSFLEV
Length:918
Mass (Da):100,299
Last modified:July 27, 2011 - v2
Checksum:i8C57096C69AA7C15
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561V → A in CAD82864. (PubMed:14747290)Curated
Sequence conflicti189 – 1891T → I in AAH43091. (PubMed:15489334)Curated
Sequence conflicti217 – 2171F → S in CAD82864. (PubMed:14747290)Curated
Sequence conflicti280 – 2801M → T in CAD82864. (PubMed:14747290)Curated
Sequence conflicti743 – 7431P → S in AAH43091. (PubMed:15489334)Curated
Sequence conflicti813 – 8131C → R in CAD82864. (PubMed:14747290)Curated
Sequence conflicti902 – 9021E → G in CAD82864. (PubMed:14747290)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ551270 mRNA. Translation: CAD82864.1.
AC113016 Genomic DNA. No translation available.
AC117679 Genomic DNA. No translation available.
BC043091 mRNA. Translation: AAH43091.1.
CCDSiCCDS40752.1.
RefSeqiNP_001240760.1. NM_001253831.1.
NP_001240763.1. NM_001253834.1.
NP_778190.3. NM_175025.4.
UniGeneiMm.326247.
Mm.489853.

Genome annotation databases

EnsembliENSMUST00000038118; ENSMUSP00000039103; ENSMUSG00000032570.
ENSMUST00000112558; ENSMUSP00000108177; ENSMUSG00000032570.
GeneIDi235574.
KEGGimmu:235574.
UCSCiuc009rif.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ551270 mRNA. Translation: CAD82864.1 .
AC113016 Genomic DNA. No translation available.
AC117679 Genomic DNA. No translation available.
BC043091 mRNA. Translation: AAH43091.1 .
CCDSi CCDS40752.1.
RefSeqi NP_001240760.1. NM_001253831.1.
NP_001240763.1. NM_001253834.1.
NP_778190.3. NM_175025.4.
UniGenei Mm.326247.
Mm.489853.

3D structure databases

ProteinModelPortali Q80XR2.
SMRi Q80XR2. Positions 45-900.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q80XR2.

Proteomic databases

MaxQBi Q80XR2.
PaxDbi Q80XR2.
PRIDEi Q80XR2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038118 ; ENSMUSP00000039103 ; ENSMUSG00000032570 .
ENSMUST00000112558 ; ENSMUSP00000108177 ; ENSMUSG00000032570 .
GeneIDi 235574.
KEGGi mmu:235574.
UCSCi uc009rif.3. mouse.

Organism-specific databases

CTDi 27032.
MGIi MGI:1889008. Atp2c1.

Phylogenomic databases

eggNOGi COG0474.
GeneTreei ENSGT00760000119003.
HOGENOMi HOG000265621.
HOVERGENi HBG106478.
InParanoidi Q80XR2.
KOi K01537.
TreeFami TF354251.

Miscellaneous databases

ChiTaRSi ATP2C1. mouse.
NextBioi 382755.
PROi Q80XR2.
SOURCEi Search...

Gene expression databases

Bgeei Q80XR2.
CleanExi MM_ATP2C1.
ExpressionAtlasi Q80XR2. baseline and differential.
Genevestigatori Q80XR2.

Family and domain databases

Gene3Di 1.20.1110.10. 3 hits.
InterProi IPR006413. ATPase_P-typ_Ca-transp_PMR1.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
PR00120. HATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Role for plasma membrane-related Ca2+-ATPase-1 (ATP2C1) in pancreatic beta-cell Ca2+ homeostasis revealed by RNA silencing."
    Mitchell K.J., Tsuboi T., Rutter G.A.
    Diabetes 53:393-400(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 127-133, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiAT2C1_MOUSE
AccessioniPrimary (citable) accession number: Q80XR2
Secondary accession number(s): E9QMB9, Q80YZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3