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Protein

Calcium-transporting ATPase type 2C member 1

Gene

Atp2c1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.By similarity1 Publication

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3494-aspartylphosphate intermediateBy similarity1
Metal bindingi643MagnesiumBy similarity1
Metal bindingi647MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase type 2C member 1 (EC:3.6.3.8)
Short name:
ATPase 2C1
Alternative name(s):
ATP-dependent Ca(2+) pump PMR1
Gene namesi
Name:Atp2c1
Synonyms:Pmr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1889008. Atp2c1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 78CytoplasmicSequence analysisAdd BLAST78
Transmembranei79 – 95HelicalSequence analysisAdd BLAST17
Topological domaini96 – 99ExtracellularSequence analysis4
Transmembranei100 – 121HelicalSequence analysisAdd BLAST22
Topological domaini122 – 262CytoplasmicSequence analysisAdd BLAST141
Transmembranei263 – 282HelicalSequence analysisAdd BLAST20
Topological domaini283 – 294ExtracellularSequence analysisAdd BLAST12
Transmembranei295 – 316HelicalSequence analysisAdd BLAST22
Topological domaini317 – 699CytoplasmicSequence analysisAdd BLAST383
Transmembranei700 – 722HelicalSequence analysisAdd BLAST23
Topological domaini723 – 727ExtracellularSequence analysis5
Transmembranei728 – 751HelicalSequence analysisAdd BLAST24
Topological domaini752 – 775CytoplasmicSequence analysisAdd BLAST24
Transmembranei776 – 794HelicalSequence analysisAdd BLAST19
Topological domaini795 – 801ExtracellularSequence analysis7
Transmembranei802 – 827HelicalSequence analysisAdd BLAST26
Topological domaini828 – 842CytoplasmicSequence analysisAdd BLAST15
Transmembranei843 – 862HelicalSequence analysisAdd BLAST20
Topological domaini863 – 875ExtracellularSequence analysisAdd BLAST13
Transmembranei876 – 892HelicalSequence analysisAdd BLAST17
Topological domaini893 – 918CytoplasmicSequence analysisAdd BLAST26

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000462241 – 918Calcium-transporting ATPase type 2C member 1Add BLAST918

Proteomic databases

EPDiQ80XR2.
MaxQBiQ80XR2.
PaxDbiQ80XR2.
PRIDEiQ80XR2.

PTM databases

iPTMnetiQ80XR2.
PhosphoSitePlusiQ80XR2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032570.
CleanExiMM_ATP2C1.
ExpressionAtlasiQ80XR2. baseline and differential.
GenevisibleiQ80XR2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082220.

Structurei

3D structure databases

ProteinModelPortaliQ80XR2.
SMRiQ80XR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0202. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00850000132256.
HOGENOMiHOG000265621.
HOVERGENiHBG106478.
InParanoidiQ80XR2.
KOiK01537.
TreeFamiTF354251.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR030336. ATP2C1.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF214. PTHR24093:SF214. 1 hit.
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80XR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVARFQKIP NVENETMIPV LTSKRASELA VSEVAGLLQA DLQNGLNKSE
60 70 80 90 100
VSHRRAFHGW NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISILMRQF
110 120 130 140 150
DDAVSITVAI VIVVTVAFVQ EYRSEKSLEE LSKLVPPECH CVREGKLEHT
160 170 180 190 200
LARDLVPGDT VCLSVGDRVP ADLRLFEAVD LSVDESSLTG ETAPCSKVTA
210 220 230 240 250
PQPAANGDLA SRSNIAFMGT LVRCGKAKGI VIGTGENSEF GEVFKMMQAE
260 270 280 290 300
EAPKTPLQKS MDLLGKQLSF YSFGIIGIIM LVGWLLGKDI LEMFTISVSL
310 320 330 340 350
AVAAIPEGLP IVVTVTLALG VMRMVKKRAI VKKLPIVETL GCCNVICSDK
360 370 380 390 400
TGTLTKNEMT VTHILTSDGL HAEVTGVGYN QFGEVIVDGD VVHGFYNPAV
410 420 430 440 450
SRIVEAGCVC NDAVIRNNTL MGKPTEGALI ALAMKMGLDG LQQDYIRKAE
460 470 480 490 500
YPFSSEQKWM AVKCVHRTQQ DRPEICFMKG AYEQVIKYCT TYNSKGQTLA
510 520 530 540 550
LTQQQRDLYQ QEKARMGSAG LRVLALASGP ELGQLTFLGL VGIIDPPRTG
560 570 580 590 600
VKEAVTTLIA SGVSIKMITG DSQETAIAIA SRLGLYSKTS QSVSGEEVDT
610 620 630 640 650
MEVQHLSQIV PKVAVFYRAS PRHKMKIIKS LQKNGAVVAM TGDGVNDAVA
660 670 680 690 700
LKAADIGVAM GQTGTDVCKE AADMILVDDD FQTIMSAIEE GKGIYNNIKN
710 720 730 740 750
FVRFQLSTSI AALTLISLAT LMNFPNPLNA MQILWINIIM DGPPAQSLGV
760 770 780 790 800
EPVDKDVIRK PPRNWKDSIL TKNLILKILV SSIIIVCGTL FVFWRELRDN
810 820 830 840 850
VITPRDTTMT FTCFVFFDMF NALSSRSQTK SVFEIGLCSN KMFCYAVLGS
860 870 880 890 900
IMGQLLVIYF PPLQKVFQTE SLSILDLLFL LGLTSSVCIV SEIIKKVERS
910
REKVQKNAGS ASSSFLEV
Length:918
Mass (Da):100,299
Last modified:July 27, 2011 - v2
Checksum:i8C57096C69AA7C15
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156V → A in CAD82864 (PubMed:14747290).Curated1
Sequence conflicti189T → I in AAH43091 (PubMed:15489334).Curated1
Sequence conflicti217F → S in CAD82864 (PubMed:14747290).Curated1
Sequence conflicti280M → T in CAD82864 (PubMed:14747290).Curated1
Sequence conflicti743P → S in AAH43091 (PubMed:15489334).Curated1
Sequence conflicti813C → R in CAD82864 (PubMed:14747290).Curated1
Sequence conflicti902E → G in CAD82864 (PubMed:14747290).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ551270 mRNA. Translation: CAD82864.1.
AC113016 Genomic DNA. No translation available.
AC117679 Genomic DNA. No translation available.
BC043091 mRNA. Translation: AAH43091.1.
CCDSiCCDS40752.1.
RefSeqiNP_001240760.1. NM_001253831.1.
NP_001240763.1. NM_001253834.1.
NP_778190.3. NM_175025.4.
UniGeneiMm.326247.
Mm.489853.

Genome annotation databases

EnsembliENSMUST00000038118; ENSMUSP00000039103; ENSMUSG00000032570.
ENSMUST00000112558; ENSMUSP00000108177; ENSMUSG00000032570.
GeneIDi235574.
KEGGimmu:235574.
UCSCiuc009rif.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ551270 mRNA. Translation: CAD82864.1.
AC113016 Genomic DNA. No translation available.
AC117679 Genomic DNA. No translation available.
BC043091 mRNA. Translation: AAH43091.1.
CCDSiCCDS40752.1.
RefSeqiNP_001240760.1. NM_001253831.1.
NP_001240763.1. NM_001253834.1.
NP_778190.3. NM_175025.4.
UniGeneiMm.326247.
Mm.489853.

3D structure databases

ProteinModelPortaliQ80XR2.
SMRiQ80XR2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082220.

PTM databases

iPTMnetiQ80XR2.
PhosphoSitePlusiQ80XR2.

Proteomic databases

EPDiQ80XR2.
MaxQBiQ80XR2.
PaxDbiQ80XR2.
PRIDEiQ80XR2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038118; ENSMUSP00000039103; ENSMUSG00000032570.
ENSMUST00000112558; ENSMUSP00000108177; ENSMUSG00000032570.
GeneIDi235574.
KEGGimmu:235574.
UCSCiuc009rif.3. mouse.

Organism-specific databases

CTDi27032.
MGIiMGI:1889008. Atp2c1.

Phylogenomic databases

eggNOGiKOG0202. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00850000132256.
HOGENOMiHOG000265621.
HOVERGENiHBG106478.
InParanoidiQ80XR2.
KOiK01537.
TreeFamiTF354251.

Enzyme and pathway databases

ReactomeiR-MMU-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiAtp2c1. mouse.
PROiQ80XR2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032570.
CleanExiMM_ATP2C1.
ExpressionAtlasiQ80XR2. baseline and differential.
GenevisibleiQ80XR2. MM.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR030336. ATP2C1.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF214. PTHR24093:SF214. 1 hit.
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT2C1_MOUSE
AccessioniPrimary (citable) accession number: Q80XR2
Secondary accession number(s): E9QMB9, Q80YZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.