Reviewed,
UniProtKB/Swiss-Prot Q80XR2 (AT2C1_MOUSE)
Last modified
October 13, 2009.
Version 61.
History...
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90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Calcium-transporting ATPase type 2C member 1 Short name=ATPase 2C1 EC=3.6.3.8 Alternative name(s): ATP-dependent Ca(2+) pump PMR1 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 918 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium By similarity. |
| Catalytic activity | ATP + H2O + Ca2+(Cis) = ADP + phosphate + Ca2+(Trans). |
| Subcellular location | Golgi apparatus › Golgi stack membrane; Multi-pass membrane protein By similarity. |
| Sequence similarities | Belongs to the cation transport ATPase (P-type) family. Type IIA subfamily. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 918 | 918 | Calcium-transporting ATPase type 2C member 1 | PRO_0000046224 | |||||
Regions | |||||||||
| Topological domain | 1 – 78 | 78 | Cytoplasmic Potential | ||||||
| Transmembrane | 79 – 95 | 17 | Potential | ||||||
| Topological domain | 96 – 99 | 4 | Extracellular Potential | ||||||
| Transmembrane | 100 – 121 | 22 | Potential | ||||||
| Topological domain | 122 – 262 | 141 | Cytoplasmic Potential | ||||||
| Transmembrane | 263 – 282 | 20 | Potential | ||||||
| Topological domain | 283 – 294 | 12 | Extracellular Potential | ||||||
| Transmembrane | 295 – 316 | 22 | Potential | ||||||
| Topological domain | 317 – 699 | 383 | Cytoplasmic Potential | ||||||
| Transmembrane | 700 – 722 | 23 | Potential | ||||||
| Topological domain | 723 – 727 | 5 | Extracellular Potential | ||||||
| Transmembrane | 728 – 751 | 24 | Potential | ||||||
| Topological domain | 752 – 775 | 24 | Cytoplasmic Potential | ||||||
| Transmembrane | 776 – 794 | 19 | Potential | ||||||
| Topological domain | 795 – 801 | 7 | Extracellular Potential | ||||||
| Transmembrane | 802 – 827 | 26 | Potential | ||||||
| Topological domain | 828 – 842 | 15 | Cytoplasmic Potential | ||||||
| Transmembrane | 843 – 862 | 20 | Potential | ||||||
| Topological domain | 863 – 875 | 13 | Extracellular Potential | ||||||
| Transmembrane | 876 – 892 | 17 | Potential | ||||||
| Topological domain | 893 – 918 | 26 | Cytoplasmic Potential | ||||||
Sites | |||||||||
| Active site | 349 | 1 | 4-aspartylphosphate intermediate By similarity | ||||||
| Metal binding | 643 | 1 | Magnesium By similarity | ||||||
| Metal binding | 647 | 1 | Magnesium By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 156 | 1 | V → A in CAD82864. Ref.1 | ||||||
| Sequence conflict | 189 | 1 | I → T in CAD82864. Ref.1 | ||||||
| Sequence conflict | 217 | 1 | F → S in CAD82864. Ref.1 | ||||||
| Sequence conflict | 280 | 1 | M → T in CAD82864. Ref.1 | ||||||
| Sequence conflict | 743 | 1 | S → P in CAD82864. Ref.1 | ||||||
| Sequence conflict | 813 | 1 | C → R in CAD82864. Ref.1 | ||||||
| Sequence conflict | 902 | 1 | E → G in CAD82864. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Role for plasma membrane-related Ca2+-ATPase-1 (ATP2C1) in pancreatic beta-cell Ca2+ homeostasis revealed by RNA silencing." Mitchell K.J., Tsuboi T., Rutter G.A. Diabetes 53:393-400(2004) [PubMed: 14747290] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain. |
| [3] | Lubec G., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 127-133, MASS SPECTROMETRY. Strain: OF1. Tissue: Hippocampus. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AJ551270 mRNA. Translation: CAD82864.1. BC043091 mRNA. Translation: AAH43091.1. | |
| IPI | IPI00336323. |
| RefSeq | NP_778190.3. |
| UniGene | Mm.326247 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1EUL based on UniProtKB P04191. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q80XR2. |
PTM databases | |
| PhosphoSite | Q80XR2. |
Proteomic databases | |
| PRIDE | Q80XR2. |
Genome annotation databases | |
| Ensembl | ENSMUST00000038118; ENSMUSP00000039103; ENSMUSG00000032570; Mus musculus. [Genome view] ENSMUST00000085133; ENSMUSP00000082220; ENSMUSG00000032570; Mus musculus. [Genome view] |
| GeneID | 235574. |
| KEGG | mmu:235574. |
| UCSC | uc009rif.1. mouse. |
Organism-specific databases | |
| MGI | MGI:1889008. Atp2c1. |
Phylogenomic databases | |
| HOVERGEN | Q80XR2. |
Enzyme and pathway databases | |
| BRENDA | 3.6.3.8. 244. |
Gene expression databases | |
| ArrayExpress | Q80XR2. |
| Bgee | Q80XR2. |
| CleanEx | MM_ATP2C1. |
| Genevestigator | Q80XR2. |
| GermOnline | ENSMUSG00000032570. Mus musculus. |
Family and domain databases | |
| InterPro | IPR008250. ATPase_P-typ_ATPase-assoc-reg. IPR006413. ATPase_P-typ_Ca-transp_PMR1. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR000695. ATPase_P-typ_H-transp. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR005834. Dehalogen-like_hydro. [Graphical view] |
| PANTHER | PTHR11939. ATPase_P. 1 hit. |
| Pfam | PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view] |
| PRINTS | PR00119. CATATPASE. PR00120. HATPASE. |
| TIGRFAMs | TIGR01522. ATPase-IIA2_Ca. 1 hit. TIGR01494. ATPase_P-type. 4 hits. |
| PROSITE | PS00154. ATPASE_E1_E2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 382755. |
| SOURCE | Search... |
Entry information
| Entry name | AT2C1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q80XR2 Secondary accession number(s): Q80YZ2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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