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Q80XR2

- AT2C1_MOUSE

UniProt

Q80XR2 - AT2C1_MOUSE

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Protein

Calcium-transporting ATPase type 2C member 1

Gene
Atp2c1, Pmr1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium By similarity.1 Publication

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei349 – 34914-aspartylphosphate intermediate By similarity
Metal bindingi643 – 6431Magnesium By similarity
Metal bindingi647 – 6471Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. calcium ion binding Source: UniProtKB
  3. calcium-transporting ATPase activity Source: UniProtKB
  4. manganese ion binding Source: UniProtKB
  5. manganese-transporting ATPase activity Source: UniProtKB
  6. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. actin cytoskeleton reorganization Source: UniProtKB
  2. calcium-dependent cell-cell adhesion Source: UniProtKB
  3. calcium ion transmembrane transport Source: GOC
  4. calcium ion transport Source: UniProtKB
  5. cellular calcium ion homeostasis Source: UniProtKB
  6. cellular manganese ion homeostasis Source: UniProtKB
  7. epidermis development Source: UniProtKB
  8. Golgi calcium ion homeostasis Source: UniProtKB
  9. Golgi calcium ion transport Source: UniProtKB
  10. manganese ion transmembrane transport Source: GOC
  11. manganese ion transport Source: UniProtKB
  12. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  13. signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase type 2C member 1 (EC:3.6.3.8)
Short name:
ATPase 2C1
Alternative name(s):
ATP-dependent Ca(2+) pump PMR1
Gene namesi
Name:Atp2c1
Synonyms:Pmr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1889008. Atp2c1.

Subcellular locationi

Golgi apparatusGolgi stack membrane; Multi-pass membrane protein By similarity 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7878Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei79 – 9517Helical; Reviewed predictionAdd
BLAST
Topological domaini96 – 994Extracellular Reviewed prediction
Transmembranei100 – 12122Helical; Reviewed predictionAdd
BLAST
Topological domaini122 – 262141Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei263 – 28220Helical; Reviewed predictionAdd
BLAST
Topological domaini283 – 29412Extracellular Reviewed predictionAdd
BLAST
Transmembranei295 – 31622Helical; Reviewed predictionAdd
BLAST
Topological domaini317 – 699383Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei700 – 72223Helical; Reviewed predictionAdd
BLAST
Topological domaini723 – 7275Extracellular Reviewed prediction
Transmembranei728 – 75124Helical; Reviewed predictionAdd
BLAST
Topological domaini752 – 77524Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei776 – 79419Helical; Reviewed predictionAdd
BLAST
Topological domaini795 – 8017Extracellular Reviewed prediction
Transmembranei802 – 82726Helical; Reviewed predictionAdd
BLAST
Topological domaini828 – 84215Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei843 – 86220Helical; Reviewed predictionAdd
BLAST
Topological domaini863 – 87513Extracellular Reviewed predictionAdd
BLAST
Transmembranei876 – 89217Helical; Reviewed predictionAdd
BLAST
Topological domaini893 – 91826Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. Golgi cisterna membrane Source: UniProtKB-SubCell
  3. Golgi membrane Source: UniProtKB
  4. integral component of membrane Source: UniProtKB-KW
  5. membrane Source: MGI
  6. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 918918Calcium-transporting ATPase type 2C member 1PRO_0000046224Add
BLAST

Proteomic databases

PaxDbiQ80XR2.
PRIDEiQ80XR2.

PTM databases

PhosphoSiteiQ80XR2.

Expressioni

Gene expression databases

ArrayExpressiQ80XR2.
BgeeiQ80XR2.
CleanExiMM_ATP2C1.
GenevestigatoriQ80XR2.

Structurei

3D structure databases

ProteinModelPortaliQ80XR2.
SMRiQ80XR2. Positions 45-900.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
GeneTreeiENSGT00560000076887.
HOGENOMiHOG000265621.
HOVERGENiHBG106478.
KOiK01537.
TreeFamiTF354251.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR006413. ATPase_P-typ_Ca-transp_PMR1.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
PR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80XR2-1 [UniParc]FASTAAdd to Basket

« Hide

MKVARFQKIP NVENETMIPV LTSKRASELA VSEVAGLLQA DLQNGLNKSE    50
VSHRRAFHGW NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISILMRQF 100
DDAVSITVAI VIVVTVAFVQ EYRSEKSLEE LSKLVPPECH CVREGKLEHT 150
LARDLVPGDT VCLSVGDRVP ADLRLFEAVD LSVDESSLTG ETAPCSKVTA 200
PQPAANGDLA SRSNIAFMGT LVRCGKAKGI VIGTGENSEF GEVFKMMQAE 250
EAPKTPLQKS MDLLGKQLSF YSFGIIGIIM LVGWLLGKDI LEMFTISVSL 300
AVAAIPEGLP IVVTVTLALG VMRMVKKRAI VKKLPIVETL GCCNVICSDK 350
TGTLTKNEMT VTHILTSDGL HAEVTGVGYN QFGEVIVDGD VVHGFYNPAV 400
SRIVEAGCVC NDAVIRNNTL MGKPTEGALI ALAMKMGLDG LQQDYIRKAE 450
YPFSSEQKWM AVKCVHRTQQ DRPEICFMKG AYEQVIKYCT TYNSKGQTLA 500
LTQQQRDLYQ QEKARMGSAG LRVLALASGP ELGQLTFLGL VGIIDPPRTG 550
VKEAVTTLIA SGVSIKMITG DSQETAIAIA SRLGLYSKTS QSVSGEEVDT 600
MEVQHLSQIV PKVAVFYRAS PRHKMKIIKS LQKNGAVVAM TGDGVNDAVA 650
LKAADIGVAM GQTGTDVCKE AADMILVDDD FQTIMSAIEE GKGIYNNIKN 700
FVRFQLSTSI AALTLISLAT LMNFPNPLNA MQILWINIIM DGPPAQSLGV 750
EPVDKDVIRK PPRNWKDSIL TKNLILKILV SSIIIVCGTL FVFWRELRDN 800
VITPRDTTMT FTCFVFFDMF NALSSRSQTK SVFEIGLCSN KMFCYAVLGS 850
IMGQLLVIYF PPLQKVFQTE SLSILDLLFL LGLTSSVCIV SEIIKKVERS 900
REKVQKNAGS ASSSFLEV 918
Length:918
Mass (Da):100,299
Last modified:July 27, 2011 - v2
Checksum:i8C57096C69AA7C15
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561V → A in CAD82864. 1 Publication
Sequence conflicti189 – 1891T → I in AAH43091. 1 Publication
Sequence conflicti217 – 2171F → S in CAD82864. 1 Publication
Sequence conflicti280 – 2801M → T in CAD82864. 1 Publication
Sequence conflicti743 – 7431P → S in AAH43091. 1 Publication
Sequence conflicti813 – 8131C → R in CAD82864. 1 Publication
Sequence conflicti902 – 9021E → G in CAD82864. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ551270 mRNA. Translation: CAD82864.1.
AC113016 Genomic DNA. No translation available.
AC117679 Genomic DNA. No translation available.
BC043091 mRNA. Translation: AAH43091.1.
CCDSiCCDS40752.1.
RefSeqiNP_001240760.1. NM_001253831.1.
NP_001240763.1. NM_001253834.1.
NP_778190.3. NM_175025.4.
UniGeneiMm.326247.
Mm.489853.

Genome annotation databases

EnsembliENSMUST00000038118; ENSMUSP00000039103; ENSMUSG00000032570.
ENSMUST00000112558; ENSMUSP00000108177; ENSMUSG00000032570.
GeneIDi235574.
KEGGimmu:235574.
UCSCiuc009rif.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ551270 mRNA. Translation: CAD82864.1 .
AC113016 Genomic DNA. No translation available.
AC117679 Genomic DNA. No translation available.
BC043091 mRNA. Translation: AAH43091.1 .
CCDSi CCDS40752.1.
RefSeqi NP_001240760.1. NM_001253831.1.
NP_001240763.1. NM_001253834.1.
NP_778190.3. NM_175025.4.
UniGenei Mm.326247.
Mm.489853.

3D structure databases

ProteinModelPortali Q80XR2.
SMRi Q80XR2. Positions 45-900.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q80XR2.

Proteomic databases

PaxDbi Q80XR2.
PRIDEi Q80XR2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038118 ; ENSMUSP00000039103 ; ENSMUSG00000032570 .
ENSMUST00000112558 ; ENSMUSP00000108177 ; ENSMUSG00000032570 .
GeneIDi 235574.
KEGGi mmu:235574.
UCSCi uc009rif.3. mouse.

Organism-specific databases

CTDi 27032.
MGIi MGI:1889008. Atp2c1.

Phylogenomic databases

eggNOGi COG0474.
GeneTreei ENSGT00560000076887.
HOGENOMi HOG000265621.
HOVERGENi HBG106478.
KOi K01537.
TreeFami TF354251.

Miscellaneous databases

ChiTaRSi ATP2C1. mouse.
NextBioi 382755.
PROi Q80XR2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q80XR2.
Bgeei Q80XR2.
CleanExi MM_ATP2C1.
Genevestigatori Q80XR2.

Family and domain databases

Gene3Di 1.20.1110.10. 3 hits.
InterProi IPR006413. ATPase_P-typ_Ca-transp_PMR1.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
PR00120. HATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Role for plasma membrane-related Ca2+-ATPase-1 (ATP2C1) in pancreatic beta-cell Ca2+ homeostasis revealed by RNA silencing."
    Mitchell K.J., Tsuboi T., Rutter G.A.
    Diabetes 53:393-400(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 127-133, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiAT2C1_MOUSE
AccessioniPrimary (citable) accession number: Q80XR2
Secondary accession number(s): E9QMB9, Q80YZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi