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Q80XR2

- AT2C1_MOUSE

UniProt

Q80XR2 - AT2C1_MOUSE

Protein

Calcium-transporting ATPase type 2C member 1

Gene

Atp2c1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.By similarity

    Catalytic activityi

    ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei349 – 34914-aspartylphosphate intermediateBy similarity
    Metal bindingi643 – 6431MagnesiumBy similarity
    Metal bindingi647 – 6471MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. calcium ion binding Source: UniProtKB
    3. calcium-transporting ATPase activity Source: UniProtKB
    4. manganese ion binding Source: UniProtKB
    5. manganese-transporting ATPase activity Source: UniProtKB
    6. signal transducer activity Source: UniProtKB

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: UniProtKB
    2. calcium-dependent cell-cell adhesion Source: UniProtKB
    3. calcium ion transmembrane transport Source: GOC
    4. calcium ion transport Source: UniProtKB
    5. cellular calcium ion homeostasis Source: UniProtKB
    6. cellular manganese ion homeostasis Source: UniProtKB
    7. epidermis development Source: UniProtKB
    8. Golgi calcium ion homeostasis Source: UniProtKB
    9. Golgi calcium ion transport Source: UniProtKB
    10. manganese ion transmembrane transport Source: GOC
    11. manganese ion transport Source: UniProtKB
    12. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    13. signal transduction Source: GOC

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-transporting ATPase type 2C member 1 (EC:3.6.3.8)
    Short name:
    ATPase 2C1
    Alternative name(s):
    ATP-dependent Ca(2+) pump PMR1
    Gene namesi
    Name:Atp2c1
    Synonyms:Pmr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1889008. Atp2c1.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB
    2. Golgi cisterna membrane Source: UniProtKB-SubCell
    3. Golgi membrane Source: UniProtKB
    4. integral component of membrane Source: UniProtKB-KW
    5. membrane Source: MGI
    6. trans-Golgi network Source: UniProtKB

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 918918Calcium-transporting ATPase type 2C member 1PRO_0000046224Add
    BLAST

    Proteomic databases

    PaxDbiQ80XR2.
    PRIDEiQ80XR2.

    PTM databases

    PhosphoSiteiQ80XR2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ80XR2.
    BgeeiQ80XR2.
    CleanExiMM_ATP2C1.
    GenevestigatoriQ80XR2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80XR2.
    SMRiQ80XR2. Positions 45-900.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7878CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini96 – 994ExtracellularSequence Analysis
    Topological domaini122 – 262141CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini283 – 29412ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini317 – 699383CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini723 – 7275ExtracellularSequence Analysis
    Topological domaini752 – 77524CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini795 – 8017ExtracellularSequence Analysis
    Topological domaini828 – 84215CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini863 – 87513ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini893 – 91826CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei79 – 9517HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12122HelicalSequence AnalysisAdd
    BLAST
    Transmembranei263 – 28220HelicalSequence AnalysisAdd
    BLAST
    Transmembranei295 – 31622HelicalSequence AnalysisAdd
    BLAST
    Transmembranei700 – 72223HelicalSequence AnalysisAdd
    BLAST
    Transmembranei728 – 75124HelicalSequence AnalysisAdd
    BLAST
    Transmembranei776 – 79419HelicalSequence AnalysisAdd
    BLAST
    Transmembranei802 – 82726HelicalSequence AnalysisAdd
    BLAST
    Transmembranei843 – 86220HelicalSequence AnalysisAdd
    BLAST
    Transmembranei876 – 89217HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    GeneTreeiENSGT00560000076887.
    HOGENOMiHOG000265621.
    HOVERGENiHBG106478.
    KOiK01537.
    TreeFamiTF354251.

    Family and domain databases

    Gene3Di1.20.1110.10. 3 hits.
    InterProiIPR006413. ATPase_P-typ_Ca-transp_PMR1.
    IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    PR00120. HATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q80XR2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVARFQKIP NVENETMIPV LTSKRASELA VSEVAGLLQA DLQNGLNKSE    50
    VSHRRAFHGW NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISILMRQF 100
    DDAVSITVAI VIVVTVAFVQ EYRSEKSLEE LSKLVPPECH CVREGKLEHT 150
    LARDLVPGDT VCLSVGDRVP ADLRLFEAVD LSVDESSLTG ETAPCSKVTA 200
    PQPAANGDLA SRSNIAFMGT LVRCGKAKGI VIGTGENSEF GEVFKMMQAE 250
    EAPKTPLQKS MDLLGKQLSF YSFGIIGIIM LVGWLLGKDI LEMFTISVSL 300
    AVAAIPEGLP IVVTVTLALG VMRMVKKRAI VKKLPIVETL GCCNVICSDK 350
    TGTLTKNEMT VTHILTSDGL HAEVTGVGYN QFGEVIVDGD VVHGFYNPAV 400
    SRIVEAGCVC NDAVIRNNTL MGKPTEGALI ALAMKMGLDG LQQDYIRKAE 450
    YPFSSEQKWM AVKCVHRTQQ DRPEICFMKG AYEQVIKYCT TYNSKGQTLA 500
    LTQQQRDLYQ QEKARMGSAG LRVLALASGP ELGQLTFLGL VGIIDPPRTG 550
    VKEAVTTLIA SGVSIKMITG DSQETAIAIA SRLGLYSKTS QSVSGEEVDT 600
    MEVQHLSQIV PKVAVFYRAS PRHKMKIIKS LQKNGAVVAM TGDGVNDAVA 650
    LKAADIGVAM GQTGTDVCKE AADMILVDDD FQTIMSAIEE GKGIYNNIKN 700
    FVRFQLSTSI AALTLISLAT LMNFPNPLNA MQILWINIIM DGPPAQSLGV 750
    EPVDKDVIRK PPRNWKDSIL TKNLILKILV SSIIIVCGTL FVFWRELRDN 800
    VITPRDTTMT FTCFVFFDMF NALSSRSQTK SVFEIGLCSN KMFCYAVLGS 850
    IMGQLLVIYF PPLQKVFQTE SLSILDLLFL LGLTSSVCIV SEIIKKVERS 900
    REKVQKNAGS ASSSFLEV 918
    Length:918
    Mass (Da):100,299
    Last modified:July 27, 2011 - v2
    Checksum:i8C57096C69AA7C15
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti156 – 1561V → A in CAD82864. (PubMed:14747290)Curated
    Sequence conflicti189 – 1891T → I in AAH43091. (PubMed:15489334)Curated
    Sequence conflicti217 – 2171F → S in CAD82864. (PubMed:14747290)Curated
    Sequence conflicti280 – 2801M → T in CAD82864. (PubMed:14747290)Curated
    Sequence conflicti743 – 7431P → S in AAH43091. (PubMed:15489334)Curated
    Sequence conflicti813 – 8131C → R in CAD82864. (PubMed:14747290)Curated
    Sequence conflicti902 – 9021E → G in CAD82864. (PubMed:14747290)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ551270 mRNA. Translation: CAD82864.1.
    AC113016 Genomic DNA. No translation available.
    AC117679 Genomic DNA. No translation available.
    BC043091 mRNA. Translation: AAH43091.1.
    CCDSiCCDS40752.1.
    RefSeqiNP_001240760.1. NM_001253831.1.
    NP_001240763.1. NM_001253834.1.
    NP_778190.3. NM_175025.4.
    UniGeneiMm.326247.
    Mm.489853.

    Genome annotation databases

    EnsembliENSMUST00000038118; ENSMUSP00000039103; ENSMUSG00000032570.
    ENSMUST00000112558; ENSMUSP00000108177; ENSMUSG00000032570.
    GeneIDi235574.
    KEGGimmu:235574.
    UCSCiuc009rif.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ551270 mRNA. Translation: CAD82864.1 .
    AC113016 Genomic DNA. No translation available.
    AC117679 Genomic DNA. No translation available.
    BC043091 mRNA. Translation: AAH43091.1 .
    CCDSi CCDS40752.1.
    RefSeqi NP_001240760.1. NM_001253831.1.
    NP_001240763.1. NM_001253834.1.
    NP_778190.3. NM_175025.4.
    UniGenei Mm.326247.
    Mm.489853.

    3D structure databases

    ProteinModelPortali Q80XR2.
    SMRi Q80XR2. Positions 45-900.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q80XR2.

    Proteomic databases

    PaxDbi Q80XR2.
    PRIDEi Q80XR2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038118 ; ENSMUSP00000039103 ; ENSMUSG00000032570 .
    ENSMUST00000112558 ; ENSMUSP00000108177 ; ENSMUSG00000032570 .
    GeneIDi 235574.
    KEGGi mmu:235574.
    UCSCi uc009rif.3. mouse.

    Organism-specific databases

    CTDi 27032.
    MGIi MGI:1889008. Atp2c1.

    Phylogenomic databases

    eggNOGi COG0474.
    GeneTreei ENSGT00560000076887.
    HOGENOMi HOG000265621.
    HOVERGENi HBG106478.
    KOi K01537.
    TreeFami TF354251.

    Miscellaneous databases

    ChiTaRSi ATP2C1. mouse.
    NextBioi 382755.
    PROi Q80XR2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q80XR2.
    Bgeei Q80XR2.
    CleanExi MM_ATP2C1.
    Genevestigatori Q80XR2.

    Family and domain databases

    Gene3Di 1.20.1110.10. 3 hits.
    InterProi IPR006413. ATPase_P-typ_Ca-transp_PMR1.
    IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    PR00120. HATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01522. ATPase-IIA2_Ca. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Role for plasma membrane-related Ca2+-ATPase-1 (ATP2C1) in pancreatic beta-cell Ca2+ homeostasis revealed by RNA silencing."
      Mitchell K.J., Tsuboi T., Rutter G.A.
      Diabetes 53:393-400(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    4. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 127-133, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiAT2C1_MOUSE
    AccessioniPrimary (citable) accession number: Q80XR2
    Secondary accession number(s): E9QMB9, Q80YZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3