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Protein

Calcium-transporting ATPase type 2C member 1

Gene

Atp2c1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.By similarity

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei349 – 34914-aspartylphosphate intermediateBy similarity
Metal bindingi643 – 6431MagnesiumBy similarity
Metal bindingi647 – 6471MagnesiumBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. calcium ion binding Source: UniProtKB
  3. calcium-transporting ATPase activity Source: UniProtKB
  4. manganese ion binding Source: UniProtKB
  5. manganese-transporting ATPase activity Source: UniProtKB
  6. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. actin cytoskeleton reorganization Source: UniProtKB
  2. calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  3. calcium ion transmembrane transport Source: MGI
  4. calcium ion transport Source: UniProtKB
  5. cellular calcium ion homeostasis Source: UniProtKB
  6. cellular manganese ion homeostasis Source: UniProtKB
  7. epidermis development Source: UniProtKB
  8. Golgi calcium ion homeostasis Source: UniProtKB
  9. Golgi calcium ion transport Source: UniProtKB
  10. manganese ion transmembrane transport Source: MGI
  11. manganese ion transport Source: UniProtKB
  12. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  13. signal transduction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_338561. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase type 2C member 1 (EC:3.6.3.8)
Short name:
ATPase 2C1
Alternative name(s):
ATP-dependent Ca(2+) pump PMR1
Gene namesi
Name:Atp2c1
Synonyms:Pmr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1889008. Atp2c1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7878CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei79 – 9517HelicalSequence AnalysisAdd
BLAST
Topological domaini96 – 994ExtracellularSequence Analysis
Transmembranei100 – 12122HelicalSequence AnalysisAdd
BLAST
Topological domaini122 – 262141CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei263 – 28220HelicalSequence AnalysisAdd
BLAST
Topological domaini283 – 29412ExtracellularSequence AnalysisAdd
BLAST
Transmembranei295 – 31622HelicalSequence AnalysisAdd
BLAST
Topological domaini317 – 699383CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei700 – 72223HelicalSequence AnalysisAdd
BLAST
Topological domaini723 – 7275ExtracellularSequence Analysis
Transmembranei728 – 75124HelicalSequence AnalysisAdd
BLAST
Topological domaini752 – 77524CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei776 – 79419HelicalSequence AnalysisAdd
BLAST
Topological domaini795 – 8017ExtracellularSequence Analysis
Transmembranei802 – 82726HelicalSequence AnalysisAdd
BLAST
Topological domaini828 – 84215CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei843 – 86220HelicalSequence AnalysisAdd
BLAST
Topological domaini863 – 87513ExtracellularSequence AnalysisAdd
BLAST
Transmembranei876 – 89217HelicalSequence AnalysisAdd
BLAST
Topological domaini893 – 91826CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. Golgi cisterna membrane Source: UniProtKB-SubCell
  3. Golgi membrane Source: UniProtKB
  4. integral component of membrane Source: UniProtKB-KW
  5. membrane Source: MGI
  6. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 918918Calcium-transporting ATPase type 2C member 1PRO_0000046224Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei234 – 2341PhosphothreonineBy similarity
Modified residuei238 – 2381PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80XR2.
PaxDbiQ80XR2.
PRIDEiQ80XR2.

PTM databases

PhosphoSiteiQ80XR2.

Expressioni

Gene expression databases

BgeeiQ80XR2.
CleanExiMM_ATP2C1.
ExpressionAtlasiQ80XR2. baseline and differential.
GenevestigatoriQ80XR2.

Structurei

3D structure databases

ProteinModelPortaliQ80XR2.
SMRiQ80XR2. Positions 45-900.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
GeneTreeiENSGT00760000119003.
HOGENOMiHOG000265621.
HOVERGENiHBG106478.
InParanoidiQ80XR2.
KOiK01537.
TreeFamiTF354251.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR030336. ATP2C1.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF214. PTHR24093:SF214. 1 hit.
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
PR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80XR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVARFQKIP NVENETMIPV LTSKRASELA VSEVAGLLQA DLQNGLNKSE
60 70 80 90 100
VSHRRAFHGW NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISILMRQF
110 120 130 140 150
DDAVSITVAI VIVVTVAFVQ EYRSEKSLEE LSKLVPPECH CVREGKLEHT
160 170 180 190 200
LARDLVPGDT VCLSVGDRVP ADLRLFEAVD LSVDESSLTG ETAPCSKVTA
210 220 230 240 250
PQPAANGDLA SRSNIAFMGT LVRCGKAKGI VIGTGENSEF GEVFKMMQAE
260 270 280 290 300
EAPKTPLQKS MDLLGKQLSF YSFGIIGIIM LVGWLLGKDI LEMFTISVSL
310 320 330 340 350
AVAAIPEGLP IVVTVTLALG VMRMVKKRAI VKKLPIVETL GCCNVICSDK
360 370 380 390 400
TGTLTKNEMT VTHILTSDGL HAEVTGVGYN QFGEVIVDGD VVHGFYNPAV
410 420 430 440 450
SRIVEAGCVC NDAVIRNNTL MGKPTEGALI ALAMKMGLDG LQQDYIRKAE
460 470 480 490 500
YPFSSEQKWM AVKCVHRTQQ DRPEICFMKG AYEQVIKYCT TYNSKGQTLA
510 520 530 540 550
LTQQQRDLYQ QEKARMGSAG LRVLALASGP ELGQLTFLGL VGIIDPPRTG
560 570 580 590 600
VKEAVTTLIA SGVSIKMITG DSQETAIAIA SRLGLYSKTS QSVSGEEVDT
610 620 630 640 650
MEVQHLSQIV PKVAVFYRAS PRHKMKIIKS LQKNGAVVAM TGDGVNDAVA
660 670 680 690 700
LKAADIGVAM GQTGTDVCKE AADMILVDDD FQTIMSAIEE GKGIYNNIKN
710 720 730 740 750
FVRFQLSTSI AALTLISLAT LMNFPNPLNA MQILWINIIM DGPPAQSLGV
760 770 780 790 800
EPVDKDVIRK PPRNWKDSIL TKNLILKILV SSIIIVCGTL FVFWRELRDN
810 820 830 840 850
VITPRDTTMT FTCFVFFDMF NALSSRSQTK SVFEIGLCSN KMFCYAVLGS
860 870 880 890 900
IMGQLLVIYF PPLQKVFQTE SLSILDLLFL LGLTSSVCIV SEIIKKVERS
910
REKVQKNAGS ASSSFLEV
Length:918
Mass (Da):100,299
Last modified:July 26, 2011 - v2
Checksum:i8C57096C69AA7C15
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561V → A in CAD82864 (PubMed:14747290).Curated
Sequence conflicti189 – 1891T → I in AAH43091 (PubMed:15489334).Curated
Sequence conflicti217 – 2171F → S in CAD82864 (PubMed:14747290).Curated
Sequence conflicti280 – 2801M → T in CAD82864 (PubMed:14747290).Curated
Sequence conflicti743 – 7431P → S in AAH43091 (PubMed:15489334).Curated
Sequence conflicti813 – 8131C → R in CAD82864 (PubMed:14747290).Curated
Sequence conflicti902 – 9021E → G in CAD82864 (PubMed:14747290).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ551270 mRNA. Translation: CAD82864.1.
AC113016 Genomic DNA. No translation available.
AC117679 Genomic DNA. No translation available.
BC043091 mRNA. Translation: AAH43091.1.
CCDSiCCDS40752.1.
RefSeqiNP_001240760.1. NM_001253831.1.
NP_001240763.1. NM_001253834.1.
NP_778190.3. NM_175025.4.
UniGeneiMm.326247.
Mm.489853.

Genome annotation databases

EnsembliENSMUST00000038118; ENSMUSP00000039103; ENSMUSG00000032570.
ENSMUST00000112558; ENSMUSP00000108177; ENSMUSG00000032570.
GeneIDi235574.
KEGGimmu:235574.
UCSCiuc009rif.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ551270 mRNA. Translation: CAD82864.1.
AC113016 Genomic DNA. No translation available.
AC117679 Genomic DNA. No translation available.
BC043091 mRNA. Translation: AAH43091.1.
CCDSiCCDS40752.1.
RefSeqiNP_001240760.1. NM_001253831.1.
NP_001240763.1. NM_001253834.1.
NP_778190.3. NM_175025.4.
UniGeneiMm.326247.
Mm.489853.

3D structure databases

ProteinModelPortaliQ80XR2.
SMRiQ80XR2. Positions 45-900.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ80XR2.

Proteomic databases

MaxQBiQ80XR2.
PaxDbiQ80XR2.
PRIDEiQ80XR2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038118; ENSMUSP00000039103; ENSMUSG00000032570.
ENSMUST00000112558; ENSMUSP00000108177; ENSMUSG00000032570.
GeneIDi235574.
KEGGimmu:235574.
UCSCiuc009rif.3. mouse.

Organism-specific databases

CTDi27032.
MGIiMGI:1889008. Atp2c1.

Phylogenomic databases

eggNOGiCOG0474.
GeneTreeiENSGT00760000119003.
HOGENOMiHOG000265621.
HOVERGENiHBG106478.
InParanoidiQ80XR2.
KOiK01537.
TreeFamiTF354251.

Enzyme and pathway databases

ReactomeiREACT_338561. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiAtp2c1. mouse.
NextBioi382755.
PROiQ80XR2.
SOURCEiSearch...

Gene expression databases

BgeeiQ80XR2.
CleanExiMM_ATP2C1.
ExpressionAtlasiQ80XR2. baseline and differential.
GenevestigatoriQ80XR2.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR030336. ATP2C1.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
[Graphical view]
PANTHERiPTHR24093:SF214. PTHR24093:SF214. 1 hit.
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
PR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Role for plasma membrane-related Ca2+-ATPase-1 (ATP2C1) in pancreatic beta-cell Ca2+ homeostasis revealed by RNA silencing."
    Mitchell K.J., Tsuboi T., Rutter G.A.
    Diabetes 53:393-400(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 127-133, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiAT2C1_MOUSE
AccessioniPrimary (citable) accession number: Q80XR2
Secondary accession number(s): E9QMB9, Q80YZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 18, 2004
Last sequence update: July 26, 2011
Last modified: March 31, 2015
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.