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Q80XR2 (AT2C1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcium-transporting ATPase type 2C member 1

Short name=ATPase 2C1
EC=3.6.3.8
Alternative name(s):
ATP-dependent Ca(2+) pump PMR1
Gene names
Name:Atp2c1
Synonyms:Pmr1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length918 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium By similarity. Ref.1

Catalytic activity

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Subcellular location

Golgi apparatusGolgi stack membrane; Multi-pass membrane protein By similarity Ref.1.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]

Ontologies

Keywords
   Biological processCalcium transport
Ion transport
Transport
   Cellular componentGolgi apparatus
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Calcium
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processGolgi calcium ion homeostasis

Inferred from sequence or structural similarity. Source: UniProtKB

Golgi calcium ion transport

Inferred from sequence or structural similarity. Source: UniProtKB

actin cytoskeleton reorganization

Inferred from sequence or structural similarity. Source: UniProtKB

calcium ion transmembrane transport

Inferred from sequence or structural similarity. Source: GOC

calcium ion transport

Inferred from sequence or structural similarity. Source: UniProtKB

calcium-dependent cell-cell adhesion

Inferred from sequence or structural similarity. Source: UniProtKB

cellular calcium ion homeostasis

Inferred from sequence or structural similarity. Source: UniProtKB

cellular manganese ion homeostasis

Inferred from sequence or structural similarity. Source: UniProtKB

epidermis development

Inferred from sequence or structural similarity. Source: UniProtKB

manganese ion transmembrane transport

Inferred from sequence or structural similarity. Source: GOC

manganese ion transport

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred from sequence or structural similarity. Source: UniProtKB

signal transduction

Inferred from sequence or structural similarity. Source: GOC

   Cellular_componentGolgi apparatus

Inferred from sequence or structural similarity. Source: UniProtKB

Golgi cisterna membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Golgi membrane

Inferred from sequence or structural similarity. Source: UniProtKB

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Traceable author statement PubMed 10951186. Source: MGI

trans-Golgi network

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionATP binding

Inferred from sequence or structural similarity. Source: UniProtKB

calcium ion binding

Inferred from sequence or structural similarity. Source: UniProtKB

calcium-transporting ATPase activity

Inferred from sequence or structural similarity. Source: UniProtKB

manganese ion binding

Inferred from sequence or structural similarity. Source: UniProtKB

manganese-transporting ATPase activity

Inferred from sequence or structural similarity. Source: UniProtKB

signal transducer activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 918918Calcium-transporting ATPase type 2C member 1
PRO_0000046224

Regions

Topological domain1 – 7878Cytoplasmic Potential
Transmembrane79 – 9517Helical; Potential
Topological domain96 – 994Extracellular Potential
Transmembrane100 – 12122Helical; Potential
Topological domain122 – 262141Cytoplasmic Potential
Transmembrane263 – 28220Helical; Potential
Topological domain283 – 29412Extracellular Potential
Transmembrane295 – 31622Helical; Potential
Topological domain317 – 699383Cytoplasmic Potential
Transmembrane700 – 72223Helical; Potential
Topological domain723 – 7275Extracellular Potential
Transmembrane728 – 75124Helical; Potential
Topological domain752 – 77524Cytoplasmic Potential
Transmembrane776 – 79419Helical; Potential
Topological domain795 – 8017Extracellular Potential
Transmembrane802 – 82726Helical; Potential
Topological domain828 – 84215Cytoplasmic Potential
Transmembrane843 – 86220Helical; Potential
Topological domain863 – 87513Extracellular Potential
Transmembrane876 – 89217Helical; Potential
Topological domain893 – 91826Cytoplasmic Potential

Sites

Active site34914-aspartylphosphate intermediate By similarity
Metal binding6431Magnesium By similarity
Metal binding6471Magnesium By similarity

Experimental info

Sequence conflict1561V → A in CAD82864. Ref.1
Sequence conflict1891T → I in AAH43091. Ref.3
Sequence conflict2171F → S in CAD82864. Ref.1
Sequence conflict2801M → T in CAD82864. Ref.1
Sequence conflict7431P → S in AAH43091. Ref.3
Sequence conflict8131C → R in CAD82864. Ref.1
Sequence conflict9021E → G in CAD82864. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q80XR2 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 8C57096C69AA7C15

FASTA918100,299
        10         20         30         40         50         60 
MKVARFQKIP NVENETMIPV LTSKRASELA VSEVAGLLQA DLQNGLNKSE VSHRRAFHGW 

        70         80         90        100        110        120 
NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISILMRQF DDAVSITVAI VIVVTVAFVQ 

       130        140        150        160        170        180 
EYRSEKSLEE LSKLVPPECH CVREGKLEHT LARDLVPGDT VCLSVGDRVP ADLRLFEAVD 

       190        200        210        220        230        240 
LSVDESSLTG ETAPCSKVTA PQPAANGDLA SRSNIAFMGT LVRCGKAKGI VIGTGENSEF 

       250        260        270        280        290        300 
GEVFKMMQAE EAPKTPLQKS MDLLGKQLSF YSFGIIGIIM LVGWLLGKDI LEMFTISVSL 

       310        320        330        340        350        360 
AVAAIPEGLP IVVTVTLALG VMRMVKKRAI VKKLPIVETL GCCNVICSDK TGTLTKNEMT 

       370        380        390        400        410        420 
VTHILTSDGL HAEVTGVGYN QFGEVIVDGD VVHGFYNPAV SRIVEAGCVC NDAVIRNNTL 

       430        440        450        460        470        480 
MGKPTEGALI ALAMKMGLDG LQQDYIRKAE YPFSSEQKWM AVKCVHRTQQ DRPEICFMKG 

       490        500        510        520        530        540 
AYEQVIKYCT TYNSKGQTLA LTQQQRDLYQ QEKARMGSAG LRVLALASGP ELGQLTFLGL 

       550        560        570        580        590        600 
VGIIDPPRTG VKEAVTTLIA SGVSIKMITG DSQETAIAIA SRLGLYSKTS QSVSGEEVDT 

       610        620        630        640        650        660 
MEVQHLSQIV PKVAVFYRAS PRHKMKIIKS LQKNGAVVAM TGDGVNDAVA LKAADIGVAM 

       670        680        690        700        710        720 
GQTGTDVCKE AADMILVDDD FQTIMSAIEE GKGIYNNIKN FVRFQLSTSI AALTLISLAT 

       730        740        750        760        770        780 
LMNFPNPLNA MQILWINIIM DGPPAQSLGV EPVDKDVIRK PPRNWKDSIL TKNLILKILV 

       790        800        810        820        830        840 
SSIIIVCGTL FVFWRELRDN VITPRDTTMT FTCFVFFDMF NALSSRSQTK SVFEIGLCSN 

       850        860        870        880        890        900 
KMFCYAVLGS IMGQLLVIYF PPLQKVFQTE SLSILDLLFL LGLTSSVCIV SEIIKKVERS 

       910 
REKVQKNAGS ASSSFLEV 

« Hide

References

« Hide 'large scale' references
[1]"Role for plasma membrane-related Ca2+-ATPase-1 (ATP2C1) in pancreatic beta-cell Ca2+ homeostasis revealed by RNA silencing."
Mitchell K.J., Tsuboi T., Rutter G.A.
Diabetes 53:393-400(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[4]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 127-133, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ551270 mRNA. Translation: CAD82864.1.
AC113016 Genomic DNA. No translation available.
AC117679 Genomic DNA. No translation available.
BC043091 mRNA. Translation: AAH43091.1.
RefSeqNP_001240760.1. NM_001253831.1.
NP_001240763.1. NM_001253834.1.
NP_778190.3. NM_175025.4.
UniGeneMm.326247.
Mm.489853.

3D structure databases

ProteinModelPortalQ80XR2.
SMRQ80XR2. Positions 45-900.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ80XR2.

Proteomic databases

PaxDbQ80XR2.
PRIDEQ80XR2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038118; ENSMUSP00000039103; ENSMUSG00000032570.
ENSMUST00000112558; ENSMUSP00000108177; ENSMUSG00000032570.
GeneID235574.
KEGGmmu:235574.
UCSCuc009rif.3. mouse.

Organism-specific databases

CTD27032.
MGIMGI:1889008. Atp2c1.

Phylogenomic databases

eggNOGCOG0474.
GeneTreeENSGT00560000076887.
HOGENOMHOG000265621.
HOVERGENHBG106478.
KOK01537.
TreeFamTF354251.

Gene expression databases

ArrayExpressQ80XR2.
BgeeQ80XR2.
CleanExMM_ATP2C1.
GenevestigatorQ80XR2.

Family and domain databases

Gene3D1.20.1110.10. 3 hits.
InterProIPR006413. ATPase_P-typ_Ca-transp_PMR1.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00120. HATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSATP2C1. mouse.
NextBio382755.
PROQ80XR2.
SOURCESearch...

Entry information

Entry nameAT2C1_MOUSE
AccessionPrimary (citable) accession number: Q80XR2
Secondary accession number(s): E9QMB9, Q80YZ2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot