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Protein

Myelin-associated neurite-outgrowth inhibitor

Gene

Fam168b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin-associated neurite-outgrowth inhibitor
Short name:
Mani
Gene namesi
Name:Fam168b
Synonyms:Kiaa4042
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2448487. Fam168b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818CytoplasmicSequence analysisAdd
BLAST
Transmembranei19 – 4123HelicalSequence analysisAdd
BLAST
Topological domaini42 – 141100ExtracellularSequence analysisAdd
BLAST
Transmembranei142 – 16322HelicalSequence analysisAdd
BLAST
Topological domaini164 – 19431CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Myelin-associated neurite-outgrowth inhibitorPRO_0000325979Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ80XQ8.
PRIDEiQ80XQ8.

PTM databases

PhosphoSiteiQ80XQ8.

Expressioni

Tissue specificityi

Predominantly expressed in the brain, including olfactory bulb, cortex and cerebellum (at protein level).1 Publication

Developmental stagei

Specifically expressed in differentiated neurons, but absent from proliferating neural stem cells.1 Publication

Inductioni

Up-regulated by different neurotrophins, including NGF and BDNF, but not by growth factors, such as EGF.1 Publication

Gene expression databases

BgeeiQ80XQ8.
ExpressionAtlasiQ80XQ8. baseline and differential.
GenevisibleiQ80XQ8. MM.

Interactioni

Subunit structurei

May form homodimers (By similarity). May interact with DAZAP2, FAM168A, PRDX6, RBM6, TMTC1 and YPEL2 (By similarity). Interacts with CDC27.By similarity1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM168 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000005140.
HOGENOMiHOG000073527.
HOVERGENiHBG052179.
InParanoidiQ80XQ8.
OrthoDBiEOG7HB5BT.
PhylomeDBiQ80XQ8.
TreeFamiTF331128.

Family and domain databases

InterProiIPR029247. FAM168A/MANI.
[Graphical view]
PfamiPF14944. TCRP1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80XQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPVYSPGSS GVPYANAKGI GYPAGFPVGY AAAPAYSPNM YPGANPTFQT
60 70 80 90 100
GYTPGTPYKV SCSPTSGAVP PYSSSPNPYQ TAVYPVRSAY PQQSPYAQQG
110 120 130 140 150
TYYTQPLYAA PPHVIHHTTV VQPNGMPATV YPAPIPPPRG SGVTMGMVAG
160 170 180 190
TTMAMSAGTL LTAHSPTPVA PHPVTVPTYR APGTPTYSYV PPQW
Length:194
Mass (Da):20,194
Last modified:June 1, 2003 - v1
Checksum:iB59FCF5407B00518
GO

Sequence cautioni

The sequence BAD90278.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491Q → L in BAE25820 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220453 mRNA. Translation: BAD90278.1. Different initiation.
AK144298 mRNA. Translation: BAE25820.1.
BC040511 mRNA. Translation: AAH40511.1.
BC043098 mRNA. Translation: AAH43098.1.
BC059247 mRNA. Translation: AAH59247.1.
CCDSiCCDS14873.1.
RefSeqiNP_001153707.1. NM_001160235.1.
NP_001153708.1. NM_001160236.1.
NP_778162.1. NM_174997.2.
UniGeneiMm.120151.

Genome annotation databases

EnsembliENSMUST00000047534; ENSMUSP00000042212; ENSMUSG00000037503.
GeneIDi214469.
KEGGimmu:214469.
UCSCiuc007apj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220453 mRNA. Translation: BAD90278.1. Different initiation.
AK144298 mRNA. Translation: BAE25820.1.
BC040511 mRNA. Translation: AAH40511.1.
BC043098 mRNA. Translation: AAH43098.1.
BC059247 mRNA. Translation: AAH59247.1.
CCDSiCCDS14873.1.
RefSeqiNP_001153707.1. NM_001160235.1.
NP_001153708.1. NM_001160236.1.
NP_778162.1. NM_174997.2.
UniGeneiMm.120151.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ80XQ8.

Proteomic databases

MaxQBiQ80XQ8.
PRIDEiQ80XQ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047534; ENSMUSP00000042212; ENSMUSG00000037503.
GeneIDi214469.
KEGGimmu:214469.
UCSCiuc007apj.2. mouse.

Organism-specific databases

CTDi130074.
MGIiMGI:2448487. Fam168b.
RougeiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000005140.
HOGENOMiHOG000073527.
HOVERGENiHBG052179.
InParanoidiQ80XQ8.
OrthoDBiEOG7HB5BT.
PhylomeDBiQ80XQ8.
TreeFamiTF331128.

Miscellaneous databases

ChiTaRSiFam168b. mouse.
PROiQ80XQ8.
SOURCEiSearch...

Gene expression databases

BgeeiQ80XQ8.
ExpressionAtlasiQ80XQ8. baseline and differential.
GenevisibleiQ80XQ8. MM.

Family and domain databases

InterProiIPR029247. FAM168A/MANI.
[Graphical view]
PfamiPF14944. TCRP1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Diencephalon.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain and Mammary tumor.
  4. "The novel protein MANI modulates neurogenesis and neurite-cone growth."
    Mishra M., Akatsu H., Heese K.
    J. Cell. Mol. Med. 15:1713-1725(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CDC27, SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, GLYCOSYLATION.

Entry informationi

Entry nameiF168B_MOUSE
AccessioniPrimary (citable) accession number: Q80XQ8
Secondary accession number(s): Q3UNC7, Q5DTR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.