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Q80XM3

- KCNG4_MOUSE

UniProt

Q80XM3 - KCNG4_MOUSE

Protein

Potassium voltage-gated channel subfamily G member 4

Gene

Kcng4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values By similarity.By similarity

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome

    GO - Biological processi

    1. protein homooligomerization Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199077. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily G member 4
    Alternative name(s):
    Voltage-gated potassium channel subunit Kv6.4
    Gene namesi
    Name:Kcng4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1913983. Kcng4.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506Potassium voltage-gated channel subfamily G member 4PRO_0000320142Add
    BLAST

    Proteomic databases

    PaxDbiQ80XM3.
    PRIDEiQ80XM3.

    PTM databases

    PhosphoSiteiQ80XM3.

    Expressioni

    Gene expression databases

    BgeeiQ80XM3.
    GenevestigatoriQ80XM3.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000056552.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80XM3.
    SMRiQ80XM3. Positions 58-459.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 219219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini278 – 28710CytoplasmicSequence Analysis
    Topological domaini354 – 36815CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini453 – 50654CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei404 – 42421Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei220 – 24021Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei333 – 35321Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei369 – 38921Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei432 – 45221Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi416 – 4216Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    GeneTreeiENSGT00730000110784.
    HOGENOMiHOG000231014.
    HOVERGENiHBG100172.
    InParanoidiQ80XM3.
    KOiK04903.
    OMAiEMVENPQ.
    OrthoDBiEOG7K9K2K.
    PhylomeDBiQ80XM3.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q80XM3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPMSSRDRDL HPGHHHFGSC SPLSQLWPGP EPKSVKGLYY SRARKVGNQD    50
    ASPEANLKEI LVNVGGQRYL LPWSTLDAFP LSRLSRLRLC RSHEEITQLC 100
    DDYDEDSQEF FFDRNPSAFG VIVSFLAAGK LVLLREMCAL SFREELSYWG 150
    IEETNLERCC LRKLLKKLEE AAELRREEAA QRQQQRQACH SEVQASRWAR 200
    SMNQLREMVE DPQSGLPGKV FACLSVLFVA TTAVSLCVST MPDFRAEEGK 250
    GECTRKCYYI FVVESICVAW FSLEFCLRFV QAPNKCQFFR GPLNVIDILA 300
    ISPYYVSLAV SDESPEAGER PSSSSYLEKV GLVLRVLRAL RILYVMRLAR 350
    HSLGLQTLGL TVRRCAREFG LLMLFLAVAV TLFSPLVYVA ENESGRVLEF 400
    TSIPASYWWA IISMTTVGYG DMVPRSVPGQ MVALSSILSG ILIMAFPATS 450
    IFHTFSHSYL ELKREQEQVQ ARLRRLQNTN SASERELLSD VDDLVPEGLT 500
    SPGRYM 506
    Length:506
    Mass (Da):57,177
    Last modified:June 1, 2003 - v1
    Checksum:i7CA48F0F71D58213
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC043936 mRNA. Translation: AAH43936.1.
    AF450109 mRNA. Translation: AAP46290.1.
    CCDSiCCDS22710.1.
    RefSeqiNP_080010.2. NM_025734.2.
    XP_006531352.1. XM_006531289.1.
    UniGeneiMm.358699.

    Genome annotation databases

    EnsembliENSMUST00000061828; ENSMUSP00000056552; ENSMUSG00000045246.
    ENSMUST00000164382; ENSMUSP00000129687; ENSMUSG00000045246.
    GeneIDi66733.
    KEGGimmu:66733.
    UCSCiuc009nqb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC043936 mRNA. Translation: AAH43936.1 .
    AF450109 mRNA. Translation: AAP46290.1 .
    CCDSi CCDS22710.1.
    RefSeqi NP_080010.2. NM_025734.2.
    XP_006531352.1. XM_006531289.1.
    UniGenei Mm.358699.

    3D structure databases

    ProteinModelPortali Q80XM3.
    SMRi Q80XM3. Positions 58-459.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000056552.

    PTM databases

    PhosphoSitei Q80XM3.

    Proteomic databases

    PaxDbi Q80XM3.
    PRIDEi Q80XM3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000061828 ; ENSMUSP00000056552 ; ENSMUSG00000045246 .
    ENSMUST00000164382 ; ENSMUSP00000129687 ; ENSMUSG00000045246 .
    GeneIDi 66733.
    KEGGi mmu:66733.
    UCSCi uc009nqb.1. mouse.

    Organism-specific databases

    CTDi 93107.
    MGIi MGI:1913983. Kcng4.

    Phylogenomic databases

    eggNOGi COG1226.
    GeneTreei ENSGT00730000110784.
    HOGENOMi HOG000231014.
    HOVERGENi HBG100172.
    InParanoidi Q80XM3.
    KOi K04903.
    OMAi EMVENPQ.
    OrthoDBi EOG7K9K2K.
    PhylomeDBi Q80XM3.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_199077. Voltage gated Potassium channels.

    Miscellaneous databases

    NextBioi 322503.
    PROi Q80XM3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q80XM3.
    Genevestigatori Q80XM3.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of two novel gamma Kv subunits."
      Preisig-Mueller R., Derst C., Schnitzler M.M., Daut J.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiKCNG4_MOUSE
    AccessioniPrimary (citable) accession number: Q80XM3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3