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Protein

Potassium voltage-gated channel subfamily G member 4

Gene

Kcng4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values (By similarity).By similarity

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: GO_Central

GO - Biological processi

  1. potassium ion transmembrane transport Source: GO_Central
  2. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_287159. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily G member 4
Alternative name(s):
Voltage-gated potassium channel subunit Kv6.4
Gene namesi
Name:Kcng4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1913983. Kcng4.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 219219CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei220 – 24021Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei257 – 27721Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Topological domaini278 – 28710CytoplasmicSequence Analysis
Transmembranei288 – 30821Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei333 – 35321Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Topological domaini354 – 36815CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei369 – 38921Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Intramembranei404 – 42421Pore-forming; Name=Segment H5Sequence AnalysisAdd
BLAST
Transmembranei432 – 45221Helical; Name=Segment S6Sequence AnalysisAdd
BLAST
Topological domaini453 – 50654CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Potassium voltage-gated channel subfamily G member 4PRO_0000320142Add
BLAST

Proteomic databases

PaxDbiQ80XM3.
PRIDEiQ80XM3.

PTM databases

PhosphoSiteiQ80XM3.

Expressioni

Gene expression databases

BgeeiQ80XM3.
GenevestigatoriQ80XM3.

Interactioni

Subunit structurei

Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056552.

Structurei

3D structure databases

ProteinModelPortaliQ80XM3.
SMRiQ80XM3. Positions 58-459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi416 – 4216Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiQ80XM3.
KOiK04903.
OMAiEMVENPQ.
OrthoDBiEOG7K9K2K.
PhylomeDBiQ80XM3.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80XM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMSSRDRDL HPGHHHFGSC SPLSQLWPGP EPKSVKGLYY SRARKVGNQD
60 70 80 90 100
ASPEANLKEI LVNVGGQRYL LPWSTLDAFP LSRLSRLRLC RSHEEITQLC
110 120 130 140 150
DDYDEDSQEF FFDRNPSAFG VIVSFLAAGK LVLLREMCAL SFREELSYWG
160 170 180 190 200
IEETNLERCC LRKLLKKLEE AAELRREEAA QRQQQRQACH SEVQASRWAR
210 220 230 240 250
SMNQLREMVE DPQSGLPGKV FACLSVLFVA TTAVSLCVST MPDFRAEEGK
260 270 280 290 300
GECTRKCYYI FVVESICVAW FSLEFCLRFV QAPNKCQFFR GPLNVIDILA
310 320 330 340 350
ISPYYVSLAV SDESPEAGER PSSSSYLEKV GLVLRVLRAL RILYVMRLAR
360 370 380 390 400
HSLGLQTLGL TVRRCAREFG LLMLFLAVAV TLFSPLVYVA ENESGRVLEF
410 420 430 440 450
TSIPASYWWA IISMTTVGYG DMVPRSVPGQ MVALSSILSG ILIMAFPATS
460 470 480 490 500
IFHTFSHSYL ELKREQEQVQ ARLRRLQNTN SASERELLSD VDDLVPEGLT

SPGRYM
Length:506
Mass (Da):57,177
Last modified:June 1, 2003 - v1
Checksum:i7CA48F0F71D58213
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043936 mRNA. Translation: AAH43936.1.
AF450109 mRNA. Translation: AAP46290.1.
CCDSiCCDS22710.1.
RefSeqiNP_080010.2. NM_025734.2.
XP_006531352.1. XM_006531289.2.
UniGeneiMm.358699.

Genome annotation databases

EnsembliENSMUST00000061828; ENSMUSP00000056552; ENSMUSG00000045246.
ENSMUST00000164382; ENSMUSP00000129687; ENSMUSG00000045246.
GeneIDi66733.
KEGGimmu:66733.
UCSCiuc009nqb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043936 mRNA. Translation: AAH43936.1.
AF450109 mRNA. Translation: AAP46290.1.
CCDSiCCDS22710.1.
RefSeqiNP_080010.2. NM_025734.2.
XP_006531352.1. XM_006531289.2.
UniGeneiMm.358699.

3D structure databases

ProteinModelPortaliQ80XM3.
SMRiQ80XM3. Positions 58-459.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056552.

PTM databases

PhosphoSiteiQ80XM3.

Proteomic databases

PaxDbiQ80XM3.
PRIDEiQ80XM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061828; ENSMUSP00000056552; ENSMUSG00000045246.
ENSMUST00000164382; ENSMUSP00000129687; ENSMUSG00000045246.
GeneIDi66733.
KEGGimmu:66733.
UCSCiuc009nqb.1. mouse.

Organism-specific databases

CTDi93107.
MGIiMGI:1913983. Kcng4.

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiQ80XM3.
KOiK04903.
OMAiEMVENPQ.
OrthoDBiEOG7K9K2K.
PhylomeDBiQ80XM3.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiREACT_287159. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi322503.
PROiQ80XM3.
SOURCEiSearch...

Gene expression databases

BgeeiQ80XM3.
GenevestigatoriQ80XM3.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of two novel gamma Kv subunits."
    Preisig-Mueller R., Derst C., Schnitzler M.M., Daut J.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiKCNG4_MOUSE
AccessioniPrimary (citable) accession number: Q80XM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: April 1, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.