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Q80XM3 (KCNG4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily G member 4
Alternative name(s):
Voltage-gated potassium channel subunit Kv6.4
Gene names
Name:Kcng4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length506 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values By similarity.

Subunit structure

Heteromultimer with KCNB1, KCNC1 and KCNF1. Does not form homomultimers By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position By similarity.

Sequence similarities

Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 506506Potassium voltage-gated channel subfamily G member 4
PRO_0000320142

Regions

Topological domain1 – 117117Cytoplasmic Potential
Transmembrane118 – 13821Helical; Name=Segment S1; Potential
Transmembrane257 – 27721Helical; Name=Segment S2; Potential
Topological domain278 – 28710Cytoplasmic Potential
Transmembrane288 – 30821Helical; Name=Segment S3; Potential
Transmembrane333 – 35321Helical; Voltage-sensor; Name=Segment S4; Potential
Topological domain354 – 36815Cytoplasmic Potential
Transmembrane369 – 38921Helical; Name=Segment S5; Potential
Intramembrane404 – 42421Pore-forming; Name=Segment H5; Potential
Transmembrane432 – 45221Helical; Name=Segment S6; Potential
Topological domain453 – 50654Cytoplasmic Potential
Motif416 – 4216Selectivity filter By similarity

Sequences

Sequence LengthMass (Da)Tools
Q80XM3 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 7CA48F0F71D58213

FASTA50657,177
        10         20         30         40         50         60 
MPMSSRDRDL HPGHHHFGSC SPLSQLWPGP EPKSVKGLYY SRARKVGNQD ASPEANLKEI 

        70         80         90        100        110        120 
LVNVGGQRYL LPWSTLDAFP LSRLSRLRLC RSHEEITQLC DDYDEDSQEF FFDRNPSAFG 

       130        140        150        160        170        180 
VIVSFLAAGK LVLLREMCAL SFREELSYWG IEETNLERCC LRKLLKKLEE AAELRREEAA 

       190        200        210        220        230        240 
QRQQQRQACH SEVQASRWAR SMNQLREMVE DPQSGLPGKV FACLSVLFVA TTAVSLCVST 

       250        260        270        280        290        300 
MPDFRAEEGK GECTRKCYYI FVVESICVAW FSLEFCLRFV QAPNKCQFFR GPLNVIDILA 

       310        320        330        340        350        360 
ISPYYVSLAV SDESPEAGER PSSSSYLEKV GLVLRVLRAL RILYVMRLAR HSLGLQTLGL 

       370        380        390        400        410        420 
TVRRCAREFG LLMLFLAVAV TLFSPLVYVA ENESGRVLEF TSIPASYWWA IISMTTVGYG 

       430        440        450        460        470        480 
DMVPRSVPGQ MVALSSILSG ILIMAFPATS IFHTFSHSYL ELKREQEQVQ ARLRRLQNTN 

       490        500 
SASERELLSD VDDLVPEGLT SPGRYM

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of two novel gamma Kv subunits."
Preisig-Mueller R., Derst C., Schnitzler M.M., Daut J.
Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC043936 mRNA. Translation: AAH43936.1.
AF450109 mRNA. Translation: AAP46290.1.
IPIIPI00177145.
RefSeqNP_080010.2. NM_025734.2.
UniGeneMm.358699.

3D structure databases

HSSPHSSP built from PDB template 2A79 based on UniProtKB P63142.
ProteinModelPortalQ80XM3.
SMRQ80XM3. Positions 58-459.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000056552.

PTM databases

PhosphoSiteQ80XM3.

Proteomic databases

PaxDbQ80XM3.
PRIDEQ80XM3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000061828; ENSMUSP00000056552; ENSMUSG00000045246.
ENSMUST00000164382; ENSMUSP00000129687; ENSMUSG00000045246.
GeneID66733.
KEGGmmu:66733.
UCSCuc009nqb.1. mouse.

Organism-specific databases

CTD93107.
MGIMGI:1913983. Kcng4.

Phylogenomic databases

eggNOGCOG1226.
GeneTreeENSGT00680000099716.
HOGENOMHOG000231014.
HOVERGENHBG100172.
InParanoidQ80XM3.
KOK04903.
OMAEMVENPQ.
OrthoDBEOG4HT8S4.

Gene expression databases

BgeeQ80XM3.
GenevestigatorQ80XM3.

Family and domain databases

Gene3D3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF00520. Ion_trans. 1 hit.
PF02214. K_tetra. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. BTB/POZ_fold. 1 hit.
ProtoNetSearch...

Other

NextBio322503.
SOURCESearch...

Entry information

Entry nameKCNG4_MOUSE
AccessionPrimary (citable) accession number: Q80XM3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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