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Protein

Potassium voltage-gated channel subfamily G member 4

Gene

Kcng4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily G member 4
Alternative name(s):
Voltage-gated potassium channel subunit Kv6.4
Gene namesi
Name:Kcng4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1913983. Kcng4.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

  • Note: Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Colocalizes with KCNB1 at the plasma membrane. Remains intracellular in the absence of KCNB1.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 216CytoplasmicBy similarityAdd BLAST216
Transmembranei217 – 238Helical; Name=Segment S1By similarityAdd BLAST22
Topological domaini239 – 259ExtracellularBy similarityAdd BLAST21
Transmembranei260 – 281Helical; Name=Segment S2By similarityAdd BLAST22
Topological domaini282 – 292CytoplasmicBy similarityAdd BLAST11
Transmembranei293 – 312Helical; Name=Segment S3By similarityAdd BLAST20
Topological domaini313 – 326ExtracellularBy similarityAdd BLAST14
Transmembranei327 – 351Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST25
Topological domaini352 – 366CytoplasmicBy similarityAdd BLAST15
Transmembranei367 – 388Helical; Name=Segment S5By similarityAdd BLAST22
Topological domaini389 – 403ExtracellularBy similarityAdd BLAST15
Intramembranei404 – 415Helical; Name=Pore helixBy similarityAdd BLAST12
Intramembranei416 – 423By similarity8
Topological domaini424 – 430ExtracellularBy similarity7
Transmembranei431 – 459Helical; Name=Segment S6By similarityAdd BLAST29
Topological domaini460 – 506CytoplasmicCuratedAdd BLAST47

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003201421 – 506Potassium voltage-gated channel subfamily G member 4Add BLAST506

Proteomic databases

PaxDbiQ80XM3.
PRIDEiQ80XM3.

PTM databases

iPTMnetiQ80XM3.
PhosphoSitePlusiQ80XM3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000045246.
GenevisibleiQ80XM3. MM.

Interactioni

Subunit structurei

Heterotetramer with KCNB1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056552.

Structurei

3D structure databases

ProteinModelPortaliQ80XM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi416 – 421Selectivity filterBy similarity6

Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiQ80XM3.
KOiK04903.
OMAiCCLRKLL.
OrthoDBiEOG091G05DD.
PhylomeDBiQ80XM3.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80XM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMSSRDRDL HPGHHHFGSC SPLSQLWPGP EPKSVKGLYY SRARKVGNQD
60 70 80 90 100
ASPEANLKEI LVNVGGQRYL LPWSTLDAFP LSRLSRLRLC RSHEEITQLC
110 120 130 140 150
DDYDEDSQEF FFDRNPSAFG VIVSFLAAGK LVLLREMCAL SFREELSYWG
160 170 180 190 200
IEETNLERCC LRKLLKKLEE AAELRREEAA QRQQQRQACH SEVQASRWAR
210 220 230 240 250
SMNQLREMVE DPQSGLPGKV FACLSVLFVA TTAVSLCVST MPDFRAEEGK
260 270 280 290 300
GECTRKCYYI FVVESICVAW FSLEFCLRFV QAPNKCQFFR GPLNVIDILA
310 320 330 340 350
ISPYYVSLAV SDESPEAGER PSSSSYLEKV GLVLRVLRAL RILYVMRLAR
360 370 380 390 400
HSLGLQTLGL TVRRCAREFG LLMLFLAVAV TLFSPLVYVA ENESGRVLEF
410 420 430 440 450
TSIPASYWWA IISMTTVGYG DMVPRSVPGQ MVALSSILSG ILIMAFPATS
460 470 480 490 500
IFHTFSHSYL ELKREQEQVQ ARLRRLQNTN SASERELLSD VDDLVPEGLT

SPGRYM
Length:506
Mass (Da):57,177
Last modified:June 1, 2003 - v1
Checksum:i7CA48F0F71D58213
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043936 mRNA. Translation: AAH43936.1.
AF450109 mRNA. Translation: AAP46290.1.
CCDSiCCDS22710.1.
RefSeqiNP_080010.2. NM_025734.2.
XP_006531352.1. XM_006531289.3.
UniGeneiMm.358699.

Genome annotation databases

EnsembliENSMUST00000061828; ENSMUSP00000056552; ENSMUSG00000045246.
ENSMUST00000164382; ENSMUSP00000129687; ENSMUSG00000045246.
GeneIDi66733.
KEGGimmu:66733.
UCSCiuc009nqb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC043936 mRNA. Translation: AAH43936.1.
AF450109 mRNA. Translation: AAP46290.1.
CCDSiCCDS22710.1.
RefSeqiNP_080010.2. NM_025734.2.
XP_006531352.1. XM_006531289.3.
UniGeneiMm.358699.

3D structure databases

ProteinModelPortaliQ80XM3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056552.

PTM databases

iPTMnetiQ80XM3.
PhosphoSitePlusiQ80XM3.

Proteomic databases

PaxDbiQ80XM3.
PRIDEiQ80XM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061828; ENSMUSP00000056552; ENSMUSG00000045246.
ENSMUST00000164382; ENSMUSP00000129687; ENSMUSG00000045246.
GeneIDi66733.
KEGGimmu:66733.
UCSCiuc009nqb.1. mouse.

Organism-specific databases

CTDi93107.
MGIiMGI:1913983. Kcng4.

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231014.
HOVERGENiHBG100172.
InParanoidiQ80XM3.
KOiK04903.
OMAiCCLRKLL.
OrthoDBiEOG091G05DD.
PhylomeDBiQ80XM3.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiR-MMU-1296072. Voltage gated Potassium channels.

Miscellaneous databases

PROiQ80XM3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045246.
GenevisibleiQ80XM3. MM.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNG4_MOUSE
AccessioniPrimary (citable) accession number: Q80XM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.