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Protein

Acyl-CoA dehydrogenase family member 11

Gene

Acad11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA.By similarity

Catalytic activityi

Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei513 – 5131Substrate; via carbonyl oxygenBy similarity
Binding sitei539 – 5391FADBy similarity
Binding sitei656 – 6561FADBy similarity
Binding sitei656 – 6561FAD; shared with dimeric partnerBy similarity
Binding sitei726 – 7261FADBy similarity
Binding sitei754 – 7541Substrate; via amide nitrogenBy similarity
Binding sitei757 – 7571FADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi503 – 51311FADBy similarityAdd
BLAST
Nucleotide bindingi503 – 5064FADBy similarity
Nucleotide bindingi511 – 5133FADBy similarity
Nucleotide bindingi537 – 5393FADBy similarity
Nucleotide bindingi726 – 7305FAD; shared with dimeric partnerBy similarity
Nucleotide bindingi755 – 7573FADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA dehydrogenase family member 11 (EC:1.3.99.-)
Short name:
ACAD-11
Gene namesi
Name:Acad11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2143169. Acad11.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial membrane Source: MGI
  • mitochondrion Source: MGI
  • nucleus Source: MGI
  • peroxisome Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 779779Acyl-CoA dehydrogenase family member 11PRO_0000254146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei163 – 1631N6-acetyllysineCombined sources
Modified residuei166 – 1661N6-acetyllysineCombined sources
Modified residuei175 – 1751N6-acetyllysineCombined sources
Modified residuei210 – 2101PhosphoserineCombined sources
Modified residuei323 – 3231PhosphotyrosineCombined sources
Modified residuei368 – 3681N6-succinyllysineCombined sources
Modified residuei390 – 3901N6-succinyllysineCombined sources
Modified residuei765 – 7651N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ80XL6.
MaxQBiQ80XL6.
PaxDbiQ80XL6.
PeptideAtlasiQ80XL6.
PRIDEiQ80XL6.

PTM databases

iPTMnetiQ80XL6.
PhosphoSiteiQ80XL6.
SwissPalmiQ80XL6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000090150.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ80XL6. 2 interactions.
MINTiMINT-4111042.
STRINGi10090.ENSMUSP00000043424.

Structurei

3D structure databases

ProteinModelPortaliQ80XL6.
SMRiQ80XL6. Positions 17-356, 374-775.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni628 – 6314Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the acyl-CoA dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG410IIP9. Eukaryota.
COG3173. LUCA.
HOGENOMiHOG000131666.
HOVERGENiHBG057142.
InParanoidiQ80XL6.
KOiK11730.
PhylomeDBiQ80XL6.
TreeFamiTF333953.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
IPR002575. Aminoglycoside_PTrfase.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
PF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF56645. SSF56645. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80XL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METDVTSDTV EVLPQHKFDL RSLEAYLNQH LPGFGSDSRA VLTVTQYRSG
60 70 80 90 100
QSNPTFFLQK GSQAYVLRKK PPGSLLPKAH KIDREFKIQK ALFSIGFPVA
110 120 130 140 150
KPLLYCRDAS VIGTEFYVME HVQGRIFRDF SIPGVSSAER AAIYVSVAET
160 170 180 190 200
LAWLHSLDIR SLKLDKYGTG VGYCKRQVST WTKQYQASAH QSIPAMDQLS
210 220 230 240 250
TWLMKNLPDS DSEECLVHGD FKLDNIVFHP KECRVIAVLD WELSTFGHPL
260 270 280 290 300
TDLAHLSLFY YWPRTLPMIN RGSHIPENTG IPLMEELISI YCHRRGIDPN
310 320 330 340 350
LPNWNFFMAL SFFKLAGISQ GVYRRYLMGN NSSEDSFLTA NTVQPLAETG
360 370 380 390 400
LQLSKRTLRT TPPQADAKSQ LFAQSRRGQE VLTRVKQFMK QHVFPAEKEV
410 420 430 440 450
AEYYAQSGNS AEKWGHPLVI EKLKEMAKAE GLWNLFLPAV SGLSQVDYAL
460 470 480 490 500
IAEETGKCFF APDVFNCQAP DTGNMEVLHL YGSEQQKKQW LEPLLRGDIT
510 520 530 540 550
SVFCMTEPNV SSSDATNIEC TIQRDGGGYI VNGKKWWSSG AGNPKCKIAI
560 570 580 590 600
VLGRTESPSA SRHRQHSMIL VPMDTPGVEL IRPLSVFGYM DNMHGGHWEV
610 620 630 640 650
HFNHVRVPAS NLILGEGRGF EISQGRLGPG RIHHCMRTVG LAERILQIMC
660 670 680 690 700
DRAVQREAFK KKLYEHEVVA HWIAKSRIAI EEIRLLTLKA AHSIDTLGSA
710 720 730 740 750
SARKEIAMIK VAAPKAVCKI ADWAIQVHGG AGVSQDYPLA NMYAIIRTLR
760 770
LADGPDEVHL SAIAKMELQD QARRLTARM
Length:779
Mass (Da):87,366
Last modified:October 31, 2006 - v2
Checksum:iABE9D1919D23426E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti426 – 4261M → I in BAC36849 (PubMed:16141072).Curated
Sequence conflicti426 – 4261M → I in BAE26511 (PubMed:16141072).Curated
Sequence conflicti426 – 4261M → I in BAE26684 (PubMed:16141072).Curated
Sequence conflicti555 – 5551T → M in AAH45199 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077531 mRNA. Translation: BAC36849.2.
AK145561 mRNA. Translation: BAE26511.1.
AK145834 mRNA. Translation: BAE26684.1.
BC045199 mRNA. Translation: AAH45199.1.
CCDSiCCDS23458.1.
RefSeqiNP_780533.2. NM_175324.3.
UniGeneiMm.269254.
Mm.41274.

Genome annotation databases

GeneIDi102632.
KEGGimmu:102632.
UCSCiuc009rhg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK077531 mRNA. Translation: BAC36849.2.
AK145561 mRNA. Translation: BAE26511.1.
AK145834 mRNA. Translation: BAE26684.1.
BC045199 mRNA. Translation: AAH45199.1.
CCDSiCCDS23458.1.
RefSeqiNP_780533.2. NM_175324.3.
UniGeneiMm.269254.
Mm.41274.

3D structure databases

ProteinModelPortaliQ80XL6.
SMRiQ80XL6. Positions 17-356, 374-775.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80XL6. 2 interactions.
MINTiMINT-4111042.
STRINGi10090.ENSMUSP00000043424.

PTM databases

iPTMnetiQ80XL6.
PhosphoSiteiQ80XL6.
SwissPalmiQ80XL6.

Proteomic databases

EPDiQ80XL6.
MaxQBiQ80XL6.
PaxDbiQ80XL6.
PeptideAtlasiQ80XL6.
PRIDEiQ80XL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102632.
KEGGimmu:102632.
UCSCiuc009rhg.1. mouse.

Organism-specific databases

CTDi84129.
MGIiMGI:2143169. Acad11.

Phylogenomic databases

eggNOGiENOG410IIP9. Eukaryota.
COG3173. LUCA.
HOGENOMiHOG000131666.
HOVERGENiHBG057142.
InParanoidiQ80XL6.
KOiK11730.
PhylomeDBiQ80XL6.
TreeFamiTF333953.

Miscellaneous databases

ChiTaRSiAcad11. mouse.
PROiQ80XL6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000090150.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
IPR002575. Aminoglycoside_PTrfase.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
PF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56112. SSF56112. 1 hit.
SSF56645. SSF56645. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACD11_MOUSE
AccessioniPrimary (citable) accession number: Q80XL6
Secondary accession number(s): Q8BK19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: September 7, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.