Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Autophagy-related protein 2 homolog B

Gene

Atg2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 2 homolog B
Gene namesi
Name:Atg2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1923809. Atg2b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lipid droplet, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20752075Autophagy-related protein 2 homolog BPRO_0000089910Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei255 – 2551PhosphoserineBy similarity
Modified residuei379 – 3791PhosphoserineCombined sources
Modified residuei496 – 4961PhosphoserineBy similarity
Modified residuei839 – 8391PhosphoserineCombined sources
Modified residuei885 – 8851PhosphoserineBy similarity
Modified residuei898 – 8981PhosphoserineBy similarity
Modified residuei1007 – 10071PhosphoserineCombined sources
Modified residuei1011 – 10111PhosphotyrosineCombined sources
Modified residuei1015 – 10151PhosphoserineCombined sources
Modified residuei1017 – 10171PhosphoserineCombined sources
Modified residuei1021 – 10211PhosphothreonineCombined sources
Modified residuei1525 – 15251PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80XK6.
MaxQBiQ80XK6.
PaxDbiQ80XK6.
PeptideAtlasiQ80XK6.
PRIDEiQ80XK6.

PTM databases

iPTMnetiQ80XK6.
PhosphoSiteiQ80XK6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041341.
GenevisibleiQ80XK6. MM.

Interactioni

Protein-protein interaction databases

IntActiQ80XK6. 3 interactions.
STRINGi10090.ENSMUSP00000037441.

Structurei

3D structure databases

ProteinModelPortaliQ80XK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG2 family.Curated

Phylogenomic databases

eggNOGiKOG2993. Eukaryota.
ENOG410XRAR. LUCA.
GeneTreeiENSGT00620000087966.
HOGENOMiHOG000034149.
HOVERGENiHBG079553.
InParanoidiQ80XK6.
KOiK17906.
OMAiKHGEFWL.
OrthoDBiEOG091G0W87.
PhylomeDBiQ80XK6.
TreeFamiTF313482.

Family and domain databases

InterProiIPR026849. ATG2.
IPR026885. ATG2_CAD_motif.
IPR015412. Autophagy-rel_C.
IPR026854. VPS13_N.
[Graphical view]
PANTHERiPTHR13190. PTHR13190. 2 hits.
PfamiPF13329. ATG2_CAD. 1 hit.
PF09333. ATG_C. 1 hit.
PF12624. Chorein_N. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80XK6-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPWPFSESIK KRACRYLLQR YLGHFLQEKL SLEQLSLDLY QGTGSLAQVP
60 70 80 90 100
LDKWCLNEIL ESADAPLEVT EGFIQSISLS VPWGSLLQDN CALEVRGLEM
110 120 130 140 150
VFRPRPRVAT GSEPMYWSSF MTSSMQLAKE CLSQKLTDEQ GEASQPFEGL
160 170 180 190 200
EKFAETIETV LRRVKVTFID TVLRIEHVPE NSKTGAALEI RVDRTVYCDE
210 220 230 240 250
TADESSGVNV HQPTAFAHKL LQLSGVSLFW DEFSASAKSS PVCSTAPVET
260 270 280 290 300
EPKLSPSWNP KIVYEPHPQL TRTLPEIAPS DPVQIGRLLG RLELSLTLKQ
310 320 330 340 350
NEVLPGAKLD VDGQIDSFHL FLSPRQVHLL LDMLAAIAGP ENSSKIGLAN
360 370 380 390 400
KDRKNRPMQQ EDEYRIQMEL NRYYLRKDSL SMGVSSEKSF YETETARTPS
410 420 430 440 450
SREEEVFFSM ADMDMSHSLS SLPPLGDPPH MDLELSLTST YTNTPAGSPL
460 470 480 490 500
SATVLQPTWG EFADHKEQPV RGPAFQSDVV HPASLQKAAL SSRSASVDES
510 520 530 540 550
RPEFICRLAL GIFSVSVLHI DPLSPAETSL NVNPLTRMAT DFFSCVEKMD
560 570 580 590 600
PAIFSTGDFK SFRAVFAEAC SHDHLRFIGT GIKVSYEQRQ RSASRHFSTD
610 620 630 640 650
MSVGQMEFLE CLFPTDCHSV PSHYTELLTF HSKEGTDAHL PVCLQLHYKH
660 670 680 690 700
SETRGPQGNQ ARLSSVPQKA ELQIKLNPVC CELDISIVDR LNSLLQPQKL
710 720 730 740 750
TTVEMMASHM YASYNKHISL HKAFTEVFLD DSHSPANRRV SVQVATPALH
760 770 780 790 800
LSVRFPIPDL RSDQERGPWF KKSLQKETLH LEFTDLESKT EFVGGSTPEQ
810 820 830 840 850
TKLELTFREL SGSFQEEKGG PSVKFFHVSG GVDGDTASSD DFDWPRMVLK
860 870 880 890 900
INPPAMHSIL ERIAAEEEEE NDGHYQEEED GGAHSLKDVC DLRRPAPSPF
910 920 930 940 950
SSRRVMFENE QMVMPGDPVE MTEFQDKAIS NSHYVLELLL PNIHLTLPNK
960 970 980 990 1000
GFYEKLYNRI FNDLLLWEPT APSPVETLEN VSYGIGLSVA SQLINTFSKD
1010 1020 1030 1040 1050
SFSPFKSAVH YDEDSGSEEE TLQYFSAVDP NYRSRRKKKL DSQNKNSQSF
1060 1070 1080 1090 1100
LSVLLSINHG LMAVFTDVKQ ENGDPMESKH GEFWLEFNSG SFFCVTKYEG
1110 1120 1130 1140 1150
FEDKHYICLH SSSLRLYHKG IVDGAILPTE TRLPCSTRPH WLEPTIYSSE
1160 1170 1180 1190 1200
EDGLSRTASD GVGGDNLNML SVAVKILSDK SESNTKEFLV AVGLKGATLQ
1210 1220 1230 1240 1250
HRVLPAGLSW HEQILNFLNI ADEPVLGYNP PTSFTTFHVH LWSCALDYRP
1260 1270 1280 1290 1300
LHLPLRSLLT VETFSISSSV ALDKSSSTLR IIMDEAALHL SDKCNTVTVN
1310 1320 1330 1340 1350
LNRDYVRVMD MGLLELTITA VKSDSDGEQT APRFELHCSS DVVHIRTCSD
1360 1370 1380 1390 1400
SCAALMNLIQ YVASYGDLHG PHKAEMKPGV PQRKPKVDSS ARSSSHGPVL
1410 1420 1430 1440 1450
PEADQQILRD LMSDAMEEID LQQASAPVGP QANGVLDEKS HTQEPCCSDL
1460 1470 1480 1490 1500
FLFPDESGNV SQESSPAYPS LTHHLISDAV TGVTAENDDF CILFAPKTVV
1510 1520 1530 1540 1550
QEKEEEPVIK IMVDDAIVIK DDYFSLPITR TDSSKAPLHF PIPAVRYVVK
1560 1570 1580 1590 1600
EVSLVWHLYG GKDFATAPPT SPAKSYIPHS SPSQTPTRHG RHTVCGGKGR
1610 1620 1630 1640 1650
NHDFLMEIQL SKVKFQHEVY PPCKPECESS LLEHPVSRQV FIVQDLEIRD
1660 1670 1680 1690 1700
RLATSQMNKF LYLYCSKDMP RKAHSNMLTI KALHVRPESG RSPQECCLRV
1710 1720 1730 1740 1750
SLMPLRLNID QDALFFLKDF FTSLSTEVEL LLTPDPEVTK SPGADVTCSL
1760 1770 1780 1790 1800
PRHLSTSKEP NLVVSFPGPK QASPNHRANS AEGGNGLEED VSAEETSFSD
1810 1820 1830 1840 1850
QPVFFREFRF TAEVPIRLDY HGKHVSMDQG TLAGILIGLA QLNCSELKLK
1860 1870 1880 1890 1900
RLFYRHGLLG IDKLFSYAIS EWLSDIKKNQ LPGILGGVGP MHSLVQLVQG
1910 1920 1930 1940 1950
LKDLVWLPIE QYRKDGRIVR GFQRGAASFG TSTAMAALEL TNRMVQTIQA
1960 1970 1980 1990 2000
AAETAYDMVS PSTLSIEPKK AKRFPHHRLA HQPVDLREGV AKAYSVVKEG
2010 2020 2030 2040 2050
ITDTAQTIYE TAAREHESRG VTGAVGEVLR QIPPAVVRPL IVATEATSNV
2060 2070
LGGMRNQIRP DVRQDESQKW RHGED
Length:2,075
Mass (Da):231,399
Last modified:September 2, 2008 - v3
Checksum:iCF44446E4810C1EF
GO
Isoform 2 (identifier: Q80XK6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1890: Missing.

Note: No experimental confirmation available.
Show »
Length:185
Mass (Da):20,463
Checksum:iBDC369E8226F1FA3
GO
Isoform 3 (identifier: Q80XK6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     577-2075: Missing.

Show »
Length:576
Mass (Da):64,176
Checksum:i41B7D46A91F5C72F
GO

Sequence cautioni

The sequence AAH46427 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AK085790 differs from that shown. Reason: Frameshift at positions 32, 52 and 352. Curated
The sequence BAC28052 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281A → T in BAC28052 (PubMed:15489334).Curated
Sequence conflicti356 – 3561R → Q in BAC38812 (PubMed:15489334).Curated
Sequence conflicti1577 – 15771I → IS in AAH46427 (PubMed:16141072).Curated
Sequence conflicti1914 – 19141K → R in AAH62182 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 18901890Missing in isoform 2. 1 PublicationVSP_035038Add
BLAST
Alternative sequencei577 – 20751499Missing in isoform 3. 1 PublicationVSP_035039Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010577 mRNA. Translation: BAB27040.1.
AK032840 mRNA. Translation: BAC28052.1. Different initiation.
AK083213 mRNA. Translation: BAC38812.1.
AK085790 mRNA. No translation available.
BC024533 mRNA. Translation: AAH24533.1.
BC046427 mRNA. Translation: AAH46427.3. Different initiation.
BC062182 mRNA. Translation: AAH62182.1.
CCDSiCCDS36550.1. [Q80XK6-2]
RefSeqiNP_083930.5. NM_029654.4. [Q80XK6-2]
UniGeneiMm.114362.
Mm.125279.

Genome annotation databases

EnsembliENSMUST00000041055; ENSMUSP00000037441; ENSMUSG00000041341. [Q80XK6-2]
GeneIDi76559.
KEGGimmu:76559.
UCSCiuc007oyp.2. mouse. [Q80XK6-2]
uc007oyq.1. mouse. [Q80XK6-5]
uc029rxu.1. mouse. [Q80XK6-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010577 mRNA. Translation: BAB27040.1.
AK032840 mRNA. Translation: BAC28052.1. Different initiation.
AK083213 mRNA. Translation: BAC38812.1.
AK085790 mRNA. No translation available.
BC024533 mRNA. Translation: AAH24533.1.
BC046427 mRNA. Translation: AAH46427.3. Different initiation.
BC062182 mRNA. Translation: AAH62182.1.
CCDSiCCDS36550.1. [Q80XK6-2]
RefSeqiNP_083930.5. NM_029654.4. [Q80XK6-2]
UniGeneiMm.114362.
Mm.125279.

3D structure databases

ProteinModelPortaliQ80XK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80XK6. 3 interactions.
STRINGi10090.ENSMUSP00000037441.

PTM databases

iPTMnetiQ80XK6.
PhosphoSiteiQ80XK6.

Proteomic databases

EPDiQ80XK6.
MaxQBiQ80XK6.
PaxDbiQ80XK6.
PeptideAtlasiQ80XK6.
PRIDEiQ80XK6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041055; ENSMUSP00000037441; ENSMUSG00000041341. [Q80XK6-2]
GeneIDi76559.
KEGGimmu:76559.
UCSCiuc007oyp.2. mouse. [Q80XK6-2]
uc007oyq.1. mouse. [Q80XK6-5]
uc029rxu.1. mouse. [Q80XK6-4]

Organism-specific databases

CTDi55102.
MGIiMGI:1923809. Atg2b.

Phylogenomic databases

eggNOGiKOG2993. Eukaryota.
ENOG410XRAR. LUCA.
GeneTreeiENSGT00620000087966.
HOGENOMiHOG000034149.
HOVERGENiHBG079553.
InParanoidiQ80XK6.
KOiK17906.
OMAiKHGEFWL.
OrthoDBiEOG091G0W87.
PhylomeDBiQ80XK6.
TreeFamiTF313482.

Miscellaneous databases

ChiTaRSiAtg2b. mouse.
PROiQ80XK6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041341.
GenevisibleiQ80XK6. MM.

Family and domain databases

InterProiIPR026849. ATG2.
IPR026885. ATG2_CAD_motif.
IPR015412. Autophagy-rel_C.
IPR026854. VPS13_N.
[Graphical view]
PANTHERiPTHR13190. PTHR13190. 2 hits.
PfamiPF13329. ATG2_CAD. 1 hit.
PF09333. ATG_C. 1 hit.
PF12624. Chorein_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATG2B_MOUSE
AccessioniPrimary (citable) accession number: Q80XK6
Secondary accession number(s): A0PJL7
, Q8BIQ4, Q8BIV0, Q8R1H5, Q9CWK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: September 2, 2008
Last modified: September 7, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.