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Protein

Tetratricopeptide repeat protein 28

Gene

Ttc28

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.By similarity
Essential for the formation and integrity of the midbody. Max play a critical role in the progress of mitosis and cytokinesis during cell cycle (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 28
Short name:
TPR repeat protein 28
Gene namesi
Name:Ttc28
Synonyms:Kiaa1043, Tprbk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2140873. Ttc28.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001064281 – 2450Tetratricopeptide repeat protein 28Add BLAST2450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei24PhosphoserineBy similarity1
Modified residuei1584PhosphoserineCombined sources1
Modified residuei2098PhosphoserineBy similarity1
Modified residuei2216PhosphoserineBy similarity1
Modified residuei2365PhosphoserineBy similarity1
Modified residuei2370PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ80XJ3.
MaxQBiQ80XJ3.
PaxDbiQ80XJ3.
PeptideAtlasiQ80XJ3.
PRIDEiQ80XJ3.

PTM databases

iPTMnetiQ80XJ3.
PhosphoSitePlusiQ80XJ3.

Expressioni

Tissue specificityi

Expressed in embryos at all stages examined. In adult tissues, detected in heart and at low levels in kidney and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000033209.
CleanExiMM_TTC28.
ExpressionAtlasiQ80XJ3. baseline and differential.
GenevisibleiQ80XJ3. MM.

Interactioni

Subunit structurei

Interacts with AURKB.By similarity

Protein-protein interaction databases

IntActiQ80XJ3. 2 interactors.
STRINGi10090.ENSMUSP00000136116.

Structurei

3D structure databases

ProteinModelPortaliQ80XJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati52 – 85TPR 1Add BLAST34
Repeati87 – 119TPR 2Add BLAST33
Repeati120 – 153TPR 3Add BLAST34
Repeati190 – 223TPR 4Add BLAST34
Repeati228 – 261TPR 5Add BLAST34
Repeati268 – 301TPR 6Add BLAST34
Repeati308 – 341TPR 7Add BLAST34
Repeati348 – 381TPR 8Add BLAST34
Repeati388 – 421TPR 9Add BLAST34
Repeati428 – 461TPR 10Add BLAST34
Repeati468 – 501TPR 11Add BLAST34
Repeati508 – 541TPR 12Add BLAST34
Repeati548 – 581TPR 13Add BLAST34
Repeati588 – 621TPR 14Add BLAST34
Repeati628 – 661TPR 15Add BLAST34
Repeati668 – 701TPR 16Add BLAST34
Repeati708 – 741TPR 17Add BLAST34
Repeati748 – 781TPR 18Add BLAST34
Repeati788 – 821TPR 19Add BLAST34
Repeati828 – 861TPR 20Add BLAST34
Repeati871 – 904TPR 21Add BLAST34
Repeati911 – 944TPR 22Add BLAST34
Repeati951 – 984TPR 23Add BLAST34
Repeati991 – 1024TPR 24Add BLAST34
Repeati1031 – 1064TPR 25Add BLAST34
Repeati1071 – 1104TPR 26Add BLAST34
Repeati1111 – 1144TPR 27Add BLAST34
Repeati1163 – 1196TPR 28Add BLAST34

Sequence similaritiesi

Contains 28 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0548. Eukaryota.
COG0457. LUCA.
COG4995. LUCA.
GeneTreeiENSGT00530000063126.
HOVERGENiHBG052194.
InParanoidiQ80XJ3.
TreeFamiTF328344.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR024983. CHAT_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR028833. TTC28.
[Graphical view]
PANTHERiPTHR10098:SF106. PTHR10098:SF106. 4 hits.
PfamiPF12770. CHAT. 1 hit.
PF13176. TPR_7. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 25 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 7 hits.
PROSITEiPS50005. TPR. 25 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80XJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQPPPLAPE PASARSRRRR EPESPPAPIP LFGARTVVQR SPDEPALSKA
60 70 80 90 100
EFVEKVRQSN QACHDGDFHT AIVLYNEALA VDPQNCILYS NRSAAYMKTQ
110 120 130 140 150
QYHKALDDAI KARLLNPKWP KAYFRQGVAL QYLGRHADAL AAFASGLAQD
160 170 180 190 200
PKSLQLLVGM VEAAMKSPMR DTLEPTYQQL QKMKLDKSPF VVVSVVGQEL
210 220 230 240 250
LTAGHHGASV VVLEAALKIG TCSLKLRGSV FSALSSAHWS LGNTEKSTGY
260 270 280 290 300
MQQDLDVAKT LGDQTGECRA HGNLGSAFFS KGNYREALTN HRHQLVLAMK
310 320 330 340 350
LKDREAASSA LSSLGHVYTA IGDYPNALAS HKQCVLLAKQ SKDDLSEARE
360 370 380 390 400
LGNMGAVYIA MGDFENAVQC HEQHLRIAKD LGSKREEARA YSNLGSAYHY
410 420 430 440 450
RRNFDKAMSY HNCVLELAQE LMEKPIEMRA YAGLGHAARC MQDLERAKQY
460 470 480 490 500
HEQQLGIAED LKDRAAEGRA SSNLGIIHQM KGDYDTALKL HKTHLCIAQE
510 520 530 540 550
LSDYAAQGRA YGNMGNAYNA LGMYDQAVKY HRQELQISME VNDRASQAST
560 570 580 590 600
HGNLAVAYQA LGAHDRALQH YQNHLNIARE LRDIQSEARA LSNLGNFHCS
610 620 630 640 650
RGEYVQAAPY YEQYLRLAPD LQDMEGEGKV CHNLGYAHYC LGNYQEAVKY
660 670 680 690 700
YEQDLALAKD LHDKLSQAKA YCNLGLAFKA LLNFAKAEEC QKYLLSLAQS
710 720 730 740 750
LDNSQAKFRA LGNLGDIFIC KKDINGAIKF YEQQLGLSHH VKDRRLEASA
760 770 780 790 800
YAALGTAYRM VQKYDKALGY HTQELEVYQE LSDLPGECRA HGHLAAVYMA
810 820 830 840 850
LGKYTMAFKC YQEQLELGRK LKEPSLEAQV YGNMGITKMN MNVMEDAIGY
860 870 880 890 900
FEQQLAMLQQ LSGNESVLDR GRAYGNLGDC YEALGDYEEA IKYYEQYLSV
910 920 930 940 950
AQSLNRMQDQ AKAYRGLGNG HRATGSLQQA LVCFEKRLVV AHELGEASNK
960 970 980 990 1000
AQAYGELGSL HSQLGNYEQA ISCLERQLNI ARDMKDRALE SDAACGLGGV
1010 1020 1030 1040 1050
YQQMGEYDTA LQYHQLDLQI AEETDNPTCQ GRAYGNLGLT YESLGTFERA
1060 1070 1080 1090 1100
VVYQEQHLSI AAQMNDLVAK TVSYSSLGRT HHALQNYSQA VMYLQEGLRL
1110 1120 1130 1140 1150
AEQLGRREDE AKIRHGLGLS LWASGNLEEA QHQLYRASAL FETIRHEAQL
1160 1170 1180 1190 1200
STDYKLSLFD LQTSSYQALQ RVLVSLGHHD EALAVAERGR TRAFADLLVE
1210 1220 1230 1240 1250
RQTGQQDSDP YSPITIDQIL EMVNAQRGLV LYYSLAAGYL YSWLLAPGAG
1260 1270 1280 1290 1300
ILKFHEHYLG DNSVESSSDF QAGSSAALPV ATNSTLEQHI ASVREALGVE
1310 1320 1330 1340 1350
SYYSRACASS ETESEAGDIM EQQLEEMNKQ LNSVTDPTGF LRMVRHNNLL
1360 1370 1380 1390 1400
HRSCQSMTSL FSGTVSPSKD GTSSLPRRQN SLAKPPLRAL YDLLIAPMEG
1410 1420 1430 1440 1450
GLMHSSGPVG RHRQLVLVLE GELYFVPFAL LKGSASNEYL YERFTLIAVP
1460 1470 1480 1490 1500
AVRSLGPHSK CHLRKTPPTY SSSTTMAAVI GNPKLPSAVM DRWLWGPMPS
1510 1520 1530 1540 1550
AEEEAFMVSE LLGCQPLVGS MATKERVMSA LTQAECVHFA THVSWKLSAL
1560 1570 1580 1590 1600
VLTPNTEGNP AGSKSSFGHP YTIPESLRVQ DDASDVESIS DCPPLRELLL
1610 1620 1630 1640 1650
TAADLLDLRL SVKLVVLSSS QEANGRVTAD GLVALTRAFL AAGAQCVLVA
1660 1670 1680 1690 1700
LWPVPVAASK MFVHAFYSSL LNGLKASASL GEAMKVVQSS KAFSHPSNWA
1710 1720 1730 1740 1750
GFTLIGSDVK LNSPSSLIGQ ALTEILQHPE RARDALRVLL HLVEKSLQRI
1760 1770 1780 1790 1800
QNGQRNAMYT SQQSVENKVG GIPGWQALLT AVGFRLDPAA SGLPAAVFFP
1810 1820 1830 1840 1850
TSDPGDRLQQ CSSTLQALLG LPNPALQALC KLITASETGE QLISRAVKNM
1860 1870 1880 1890 1900
VGMLHQVLVQ LQACEKEQDF ASAPIPVSLS VQLWRLPGCH EFLAALGFDL
1910 1920 1930 1940 1950
CEVGQEEVIL KTGKQASRRT THFALQSLLS LFDSTELPKR LSLDSSSSLE
1960 1970 1980 1990 2000
SLASAQSVSN ALPLGYQHPP FSPTGADSIA SDAISVYSLS SIASSMSFVS
2010 2020 2030 2040 2050
KPEGGLEGGG PRGRQDYDRS KSTHPQRATL PRRQTSPQAR RGASKEEEEY
2060 2070 2080 2090 2100
EGFSIISMEP LATYQGEGKT RFSPDPKQPC VKAPGGVRLS VSSKGSVSTP
2110 2120 2130 2140 2150
NSPVKMTLIP SPNSPFQKVG KLASSDTGES DQSSTETDST VKSQEESTPK
2160 2170 2180 2190 2200
LDPQELAQRI LEETKSHLLA VERLQRSGGP AGPDREDSVV APSSTTVFRA
2210 2220 2230 2240 2250
SETSAFSKPI LSHQRSQLSP LTVKPQPPAR SSSLPKVSSP ATSEVSGKDG
2260 2270 2280 2290 2300
LSPPGSSHPS PGRDTPVSPA DPPLFRLKYP SSPYSAHISK SPRNTSPACS
2310 2320 2330 2340 2350
APSPALSYSS AGSARSSPAD APDEKVQAVH SLKMLWQSTP QPPRGPRKTC
2360 2370 2380 2390 2400
RGAPGTLTSK RDVLSLLNLS PRHGKEEGGA DRLELKELSV QRHDEVPPKV
2410 2420 2430 2440 2450
PTNGHWCTDT ATLTTAGGRS TTAAPRPLRL PLANGYKFLS PGRLFPSSKC
Length:2,450
Mass (Da):267,459
Last modified:May 1, 2013 - v3
Checksum:i5E1B47053C61AC99
GO

Sequence cautioni

The sequence AAH46779 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH60735 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC65709 differs from that shown. Several sequencing errors and erroneous CDS prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1769V → L in BAC27414 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121934 Genomic DNA. No translation available.
AC122226 Genomic DNA. No translation available.
AC124425 Genomic DNA. No translation available.
AC147632 Genomic DNA. No translation available.
AC155173 Genomic DNA. No translation available.
BC046779 mRNA. Translation: AAH46779.2. Different initiation.
BC060735 mRNA. Translation: AAH60735.1. Different initiation.
AK122427 mRNA. Translation: BAC65709.2. Sequence problems.
AK031458 mRNA. Translation: BAC27414.1.
AK081382 mRNA. Translation: BAC38208.1.
CCDSiCCDS59682.1.
RefSeqiNP_001254551.1. NM_001267622.1.
UniGeneiMm.295660.

Genome annotation databases

EnsembliENSMUST00000156290; ENSMUSP00000137609; ENSMUSG00000033209.
GeneIDi209683.
KEGGimmu:209683.
UCSCiuc033ild.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121934 Genomic DNA. No translation available.
AC122226 Genomic DNA. No translation available.
AC124425 Genomic DNA. No translation available.
AC147632 Genomic DNA. No translation available.
AC155173 Genomic DNA. No translation available.
BC046779 mRNA. Translation: AAH46779.2. Different initiation.
BC060735 mRNA. Translation: AAH60735.1. Different initiation.
AK122427 mRNA. Translation: BAC65709.2. Sequence problems.
AK031458 mRNA. Translation: BAC27414.1.
AK081382 mRNA. Translation: BAC38208.1.
CCDSiCCDS59682.1.
RefSeqiNP_001254551.1. NM_001267622.1.
UniGeneiMm.295660.

3D structure databases

ProteinModelPortaliQ80XJ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80XJ3. 2 interactors.
STRINGi10090.ENSMUSP00000136116.

PTM databases

iPTMnetiQ80XJ3.
PhosphoSitePlusiQ80XJ3.

Proteomic databases

EPDiQ80XJ3.
MaxQBiQ80XJ3.
PaxDbiQ80XJ3.
PeptideAtlasiQ80XJ3.
PRIDEiQ80XJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000156290; ENSMUSP00000137609; ENSMUSG00000033209.
GeneIDi209683.
KEGGimmu:209683.
UCSCiuc033ild.1. mouse.

Organism-specific databases

CTDi23331.
MGIiMGI:2140873. Ttc28.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0548. Eukaryota.
COG0457. LUCA.
COG4995. LUCA.
GeneTreeiENSGT00530000063126.
HOVERGENiHBG052194.
InParanoidiQ80XJ3.
TreeFamiTF328344.

Miscellaneous databases

ChiTaRSiTtc28. mouse.
PROiQ80XJ3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033209.
CleanExiMM_TTC28.
ExpressionAtlasiQ80XJ3. baseline and differential.
GenevisibleiQ80XJ3. MM.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR024983. CHAT_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
IPR028833. TTC28.
[Graphical view]
PANTHERiPTHR10098:SF106. PTHR10098:SF106. 4 hits.
PfamiPF12770. CHAT. 1 hit.
PF13176. TPR_7. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 25 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 7 hits.
PROSITEiPS50005. TPR. 25 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTTC28_MOUSE
AccessioniPrimary (citable) accession number: Q80XJ3
Secondary accession number(s): J3QM46
, J3QQ36, Q6P9J6, Q80TL5, Q8BV10, Q8C0F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 1, 2013
Last modified: November 2, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.