Q80XI3 (IF4G3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Eukaryotic translation initiation factor 4 gamma 3
Short name=eIF-4-gamma 3
Short name=eIF-4G 3
Short name=eIF4G 3

Alternative name(s):
eIF-4-gamma II
Short name=eIF4GII

Gene names

Name:

Eif4g3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1579 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1 By similarity.
Subunit structure	Interacts with EIF4A, EIF4E, eIF3 and PABPC1. Part of a complex with EIF4E. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4G1/EIF4G3 interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate eIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIFG3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA By similarity.
Sequence similarities	Belongs to the eukaryotic initiation factor 4G family. Contains 5 HEAT repeats. Contains 1 MI domain. Contains 1 MIF4G domain. Contains 1 W2 domain.
Sequence caution	The sequence AAH23898.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence AAH23898.1 differs from that shown. Reason: Contaminating sequence. Sequence of unknown origin in the N-terminal part.

Ontologies

Keywords
Biological process	Protein biosynthesis Translation regulation
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat
Ligand	RNA-binding
Molecular function	Initiation factor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA metabolic process Inferred from electronic annotation. Source: InterPro positive regulation of meiosis I Inferred from mutant phenotype PubMed 20430745. Source: MGI positive regulation of protein phosphorylation Inferred from mutant phenotype PubMed 20430745. Source: MGI positive regulation of translation Inferred from mutant phenotype PubMed 20430745. Source: MGI spermatogenesis Inferred from mutant phenotype PubMed 20430745. Source: MGI
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q80XI3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q80XI3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1084-1102: Missing.

Isoform 3 (identifier: Q80XI3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     11-11: F → FAAGPRPAHHQF

Note: No experimental confirmation available.

Isoform 4 (identifier: Q80XI3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     10-10: P → PFAAGPRPAHHQGGFRPIQ
     1084-1102: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1579	1579	Eukaryotic translation initiation factor 4 gamma 3		PRO_0000213330
Regions
	Repeat	740 – 778	39	HEAT 1
	Domain	750 – 978	229	MIF4G
	Repeat	779 – 826	48	HEAT 2
	Repeat	827 – 900	74	HEAT 3
	Repeat	901 – 939	39	HEAT 4
	Repeat	940 – 979	40	HEAT 5
	Domain	1215 – 1337	123	MI
	Domain	1410 – 1579	170	W2
	Region	134 – 162	29	PABPC1-binding By similarity
	Region	614 – 625	12	EIF4E-binding By similarity
	Region	694 – 1014	321	eIF3/EIF4A-binding By similarity
	Region	1427 – 1579	153	EIF4A-binding By similarity
	Region	1565 – 1579	15	Necessary but not sufficient for MKNK1-binding By similarity
	Coiled coil	989 – 1018	30	Potential
	Coiled coil	1154 – 1176	23	Potential
	Coiled coil	1406 – 1438	33	Potential
Amino acid modifications
	Modified residue	230	1	Phosphoserine By similarity
	Modified residue	232	1	Phosphoserine By similarity
	Modified residue	240	1	Phosphoserine Ref.6
	Modified residue	267	1	Phosphoserine Ref.4
	Modified residue	470	1	Phosphoserine Ref.5
	Modified residue	472	1	Phosphoserine Ref.5
	Modified residue	490	1	Phosphoserine By similarity
	Modified residue	884	1	Phosphoserine By similarity
	Modified residue	1150	1	Phosphoserine; by CaMK1 By similarity
Natural variations
	Alternative sequence	10	1	P → PFAAGPRPAHHQGGFRPIQ in isoform 4.		VSP_026029
	Alternative sequence	11	1	F → FAAGPRPAHHQF in isoform 3.		VSP_010490
	Alternative sequence	1084 – 1102	19	Missing in isoform 2 and isoform 4.		VSP_010491
Experimental info
	Sequence conflict	183	1	Missing in CF743072. Ref.2
	Sequence conflict	410	1	A → G in CF743072. Ref.2
	Sequence conflict	492	1	A → P in CB522417. Ref.2
	Sequence conflict	1324	1	E → G in BAC26452. Ref.1
	Sequence conflict	1324	1	E → G in AAH72600. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 7, 2004. Version 2. Checksum: EB4854590D250450	FASTA	1,579	174,890
	10 20 30 40 50 60 MNSQPQARSP FFQRPQIQPP RAAIPNSSPS IRPGVQTPTA VYQANQHIMM VNHLPMPYPV 70 80 90 100 110 120 TQGHQYCIPQ YRHSGPPYVG PPQQYPVQPP GPGPFYPGPG PGDFANAYGT PFYPSQPVYQ 130 140 150 160 170 180 SAPIIVPTQQ QPPPAKREKK TIRIRDPNQG GKDITEEIMS GGGSRNPTPP IGRPASTPTP 190 200 210 220 230 240 PQQLPSQVPE HSPVVYGTVE SAHLAASTPV TAASDQKQEE KPKPDPVFQS PSTVLRLVLS 250 260 270 280 290 300 GEKKEQAGQM PETAAGEPTP EPPRTSSPTS LPPLARSSLP SPMSAALSSQ PLFTAEDKCE 310 320 330 340 350 360 LPSSKEEDAP PVPSPTSCTA ASGPSLTDNS DICKKPCSVA PHDSQLISST ILINEMNGVG 370 380 390 400 410 420 EKLSAKENTV GMLRQEVLPL TLELEILEHP QEELKVECTP TPIAPSMLPA FSPAPPTPPT 430 440 450 460 470 480 SPPCPPVVLS AAIARSPAVA TEVQRVADEG ESLRTCLSKD AKEMQDKAES ESDGQAEETA 490 500 510 520 530 540 DPQSLHSGRS PAPVQTATTA PKSWKKTKEQ TRTPDEVLEA EAEPKAEEEL AVDSVLEPEQ 550 560 570 580 590 600 EKMSQGFPSE RDPSALKRGK AEEGNGEEAE PVRNGAESAS EGEGGDGNSG SADSSADGLT 610 620 630 640 650 660 FPFKAESWKP ADTEGKKQYD REFLLDIQFM PACIQKPEGL PPISDVVLDK INQPRLSMRT 670 680 690 700 710 720 LDPRILPRGP DFTPAFADFP RQTPGGRGVP LLNVGPRRSQ PGQRREPRKI ITVSVKEDVH 730 740 750 760 770 780 LRKAENAWKP SQKRDSHADD PESIKTQELF RKVRSILNKL TPQMFNQLMK QVSALTVDTE 790 800 810 820 830 840 ERLKGVIDLV FEKAIDEPSF SVAYANMCRC LVTLKVPMAD KPGNTVNFRK LLLNRCQKEF 850 860 870 880 890 900 EKDKADDDVF EKKQKELEAA SAPEERTRLH DELEEAKDKA RRRSIGNIKF IGELFKLKML 910 920 930 940 950 960 TEAIMHDCVV KLLKNHDEES LECLCRLLTT IGKDLDFEKA KPRMDQYFNQ MEKIVKERKT 970 980 990 1000 1010 1020 SSRIRFMLQD VIDLRLCNWV SRRADQGPKT IEQIHKEAKI EEQEEQRKVQ QLMTKEKRRP 1030 1040 1050 1060 1070 1080 GVQRVDEGGW NTVQGAKNSR VLDPSKFLKI TKPTIDEKIQ LVPKAQLGSW GKGSSGGAKA 1090 1100 1110 1120 1130 1140 SESDALRSSA SSLNRFSPLQ PPAPSGSPSA TPLEFDSRRA LTSRGSMGRE KSDKPIPAGT 1150 1160 1170 1180 1190 1200 ARPNTFLRGS SKDLLDNQSQ EEQRREMLET VKQLTGGLDA ERASTEADRS KTRELAKSEM 1210 1220 1230 1240 1250 1260 CAVPAPDKPA LSEEEVERKS KSIIDEFLHI NDFKEATQCI EELSAQGPLH VFVKVGVEFT 1270 1280 1290 1300 1310 1320 LERSQITRDH MGHLLYQLVQ SEKLSKQDFF KGFSETLELA DDMAIDIPHI WLYLAELVTP 1330 1340 1350 1360 1370 1380 MLKEGGISMR ELIVEFSKPL LPVGRAGVLL SEILHLLCRQ MSHKKVGALW READLSWKDF 1390 1400 1410 1420 1430 1440 LPEGEDVHHF LLEQKLDFTE SEGPCSSEAL SKKELSAEEL SQRLEKLIME EKADDERIFD 1450 1460 1470 1480 1490 1500 WVEANLDESQ MSSPTFLRAL MTAVCKAAII ADCSTFRVDT AVIKQRVPIL LKYLDSDTEK 1510 1520 1530 1540 1550 1560 ELQALYALQA SIVKLDQPAN LLRMFFDCLY DEEVISEDAF YKWESSKDPA EQAGKGVALK 1570 SVTAFFTWLR EAEEESEDN
	Isoform 2 [UniParc]. Checksum: EBE892F0BBC70182	FASTA	1,560	172,865
	10 20 30 40 50 60 MNSQPQARSP FFQRPQIQPP RAAIPNSSPS IRPGVQTPTA VYQANQHIMM VNHLPMPYPV 70 80 90 100 110 120 TQGHQYCIPQ YRHSGPPYVG PPQQYPVQPP GPGPFYPGPG PGDFANAYGT PFYPSQPVYQ 130 140 150 160 170 180 SAPIIVPTQQ QPPPAKREKK TIRIRDPNQG GKDITEEIMS GGGSRNPTPP IGRPASTPTP 190 200 210 220 230 240 PQQLPSQVPE HSPVVYGTVE SAHLAASTPV TAASDQKQEE KPKPDPVFQS PSTVLRLVLS 250 260 270 280 290 300 GEKKEQAGQM PETAAGEPTP EPPRTSSPTS LPPLARSSLP SPMSAALSSQ PLFTAEDKCE 310 320 330 340 350 360 LPSSKEEDAP PVPSPTSCTA ASGPSLTDNS DICKKPCSVA PHDSQLISST ILINEMNGVG 370 380 390 400 410 420 EKLSAKENTV GMLRQEVLPL TLELEILEHP QEELKVECTP TPIAPSMLPA FSPAPPTPPT 430 440 450 460 470 480 SPPCPPVVLS AAIARSPAVA TEVQRVADEG ESLRTCLSKD AKEMQDKAES ESDGQAEETA 490 500 510 520 530 540 DPQSLHSGRS PAPVQTATTA PKSWKKTKEQ TRTPDEVLEA EAEPKAEEEL AVDSVLEPEQ 550 560 570 580 590 600 EKMSQGFPSE RDPSALKRGK AEEGNGEEAE PVRNGAESAS EGEGGDGNSG SADSSADGLT 610 620 630 640 650 660 FPFKAESWKP ADTEGKKQYD REFLLDIQFM PACIQKPEGL PPISDVVLDK INQPRLSMRT 670 680 690 700 710 720 LDPRILPRGP DFTPAFADFP RQTPGGRGVP LLNVGPRRSQ PGQRREPRKI ITVSVKEDVH 730 740 750 760 770 780 LRKAENAWKP SQKRDSHADD PESIKTQELF RKVRSILNKL TPQMFNQLMK QVSALTVDTE 790 800 810 820 830 840 ERLKGVIDLV FEKAIDEPSF SVAYANMCRC LVTLKVPMAD KPGNTVNFRK LLLNRCQKEF 850 860 870 880 890 900 EKDKADDDVF EKKQKELEAA SAPEERTRLH DELEEAKDKA RRRSIGNIKF IGELFKLKML 910 920 930 940 950 960 TEAIMHDCVV KLLKNHDEES LECLCRLLTT IGKDLDFEKA KPRMDQYFNQ MEKIVKERKT 970 980 990 1000 1010 1020 SSRIRFMLQD VIDLRLCNWV SRRADQGPKT IEQIHKEAKI EEQEEQRKVQ QLMTKEKRRP 1030 1040 1050 1060 1070 1080 GVQRVDEGGW NTVQGAKNSR VLDPSKFLKI TKPTIDEKIQ LVPKAQLGSW GKGSSGGAKA 1090 1100 1110 1120 1130 1140 SESAPSGSPS ATPLEFDSRR ALTSRGSMGR EKSDKPIPAG TARPNTFLRG SSKDLLDNQS 1150 1160 1170 1180 1190 1200 QEEQRREMLE TVKQLTGGLD AERASTEADR SKTRELAKSE MCAVPAPDKP ALSEEEVERK 1210 1220 1230 1240 1250 1260 SKSIIDEFLH INDFKEATQC IEELSAQGPL HVFVKVGVEF TLERSQITRD HMGHLLYQLV 1270 1280 1290 1300 1310 1320 QSEKLSKQDF FKGFSETLEL ADDMAIDIPH IWLYLAELVT PMLKEGGISM RELIVEFSKP 1330 1340 1350 1360 1370 1380 LLPVGRAGVL LSEILHLLCR QMSHKKVGAL WREADLSWKD FLPEGEDVHH FLLEQKLDFT 1390 1400 1410 1420 1430 1440 ESEGPCSSEA LSKKELSAEE LSQRLEKLIM EEKADDERIF DWVEANLDES QMSSPTFLRA 1450 1460 1470 1480 1490 1500 LMTAVCKAAI IADCSTFRVD TAVIKQRVPI LLKYLDSDTE KELQALYALQ ASIVKLDQPA 1510 1520 1530 1540 1550 1560 NLLRMFFDCL YDEEVISEDA FYKWESSKDP AEQAGKGVAL KSVTAFFTWL REAEEESEDN
	Isoform 3 [UniParc]. Checksum: 384A47C5E2EE294C	FASTA	1,590	176,060
	10 20 30 40 50 60 MNSQPQARSP FAAGPRPAHH QFFQRPQIQP PRAAIPNSSP SIRPGVQTPT AVYQANQHIM 70 80 90 100 110 120 MVNHLPMPYP VTQGHQYCIP QYRHSGPPYV GPPQQYPVQP PGPGPFYPGP GPGDFANAYG 130 140 150 160 170 180 TPFYPSQPVY QSAPIIVPTQ QQPPPAKREK KTIRIRDPNQ GGKDITEEIM SGGGSRNPTP 190 200 210 220 230 240 PIGRPASTPT PPQQLPSQVP EHSPVVYGTV ESAHLAASTP VTAASDQKQE EKPKPDPVFQ 250 260 270 280 290 300 SPSTVLRLVL SGEKKEQAGQ MPETAAGEPT PEPPRTSSPT SLPPLARSSL PSPMSAALSS 310 320 330 340 350 360 QPLFTAEDKC ELPSSKEEDA PPVPSPTSCT AASGPSLTDN SDICKKPCSV APHDSQLISS 370 380 390 400 410 420 TILINEMNGV GEKLSAKENT VGMLRQEVLP LTLELEILEH PQEELKVECT PTPIAPSMLP 430 440 450 460 470 480 AFSPAPPTPP TSPPCPPVVL SAAIARSPAV ATEVQRVADE GESLRTCLSK DAKEMQDKAE 490 500 510 520 530 540 SESDGQAEET ADPQSLHSGR SPAPVQTATT APKSWKKTKE QTRTPDEVLE AEAEPKAEEE 550 560 570 580 590 600 LAVDSVLEPE QEKMSQGFPS ERDPSALKRG KAEEGNGEEA EPVRNGAESA SEGEGGDGNS 610 620 630 640 650 660 GSADSSADGL TFPFKAESWK PADTEGKKQY DREFLLDIQF MPACIQKPEG LPPISDVVLD 670 680 690 700 710 720 KINQPRLSMR TLDPRILPRG PDFTPAFADF PRQTPGGRGV PLLNVGPRRS QPGQRREPRK 730 740 750 760 770 780 IITVSVKEDV HLRKAENAWK PSQKRDSHAD DPESIKTQEL FRKVRSILNK LTPQMFNQLM 790 800 810 820 830 840 KQVSALTVDT EERLKGVIDL VFEKAIDEPS FSVAYANMCR CLVTLKVPMA DKPGNTVNFR 850 860 870 880 890 900 KLLLNRCQKE FEKDKADDDV FEKKQKELEA ASAPEERTRL HDELEEAKDK ARRRSIGNIK 910 920 930 940 950 960 FIGELFKLKM LTEAIMHDCV VKLLKNHDEE SLECLCRLLT TIGKDLDFEK AKPRMDQYFN 970 980 990 1000 1010 1020 QMEKIVKERK TSSRIRFMLQ DVIDLRLCNW VSRRADQGPK TIEQIHKEAK IEEQEEQRKV 1030 1040 1050 1060 1070 1080 QQLMTKEKRR PGVQRVDEGG WNTVQGAKNS RVLDPSKFLK ITKPTIDEKI QLVPKAQLGS 1090 1100 1110 1120 1130 1140 WGKGSSGGAK ASESDALRSS ASSLNRFSPL QPPAPSGSPS ATPLEFDSRR ALTSRGSMGR 1150 1160 1170 1180 1190 1200 EKSDKPIPAG TARPNTFLRG SSKDLLDNQS QEEQRREMLE TVKQLTGGLD AERASTEADR 1210 1220 1230 1240 1250 1260 SKTRELAKSE MCAVPAPDKP ALSEEEVERK SKSIIDEFLH INDFKEATQC IEELSAQGPL 1270 1280 1290 1300 1310 1320 HVFVKVGVEF TLERSQITRD HMGHLLYQLV QSEKLSKQDF FKGFSETLEL ADDMAIDIPH 1330 1340 1350 1360 1370 1380 IWLYLAELVT PMLKEGGISM RELIVEFSKP LLPVGRAGVL LSEILHLLCR QMSHKKVGAL 1390 1400 1410 1420 1430 1440 WREADLSWKD FLPEGEDVHH FLLEQKLDFT ESEGPCSSEA LSKKELSAEE LSQRLEKLIM 1450 1460 1470 1480 1490 1500 EEKADDERIF DWVEANLDES QMSSPTFLRA LMTAVCKAAI IADCSTFRVD TAVIKQRVPI 1510 1520 1530 1540 1550 1560 LLKYLDSDTE KELQALYALQ ASIVKLDQPA NLLRMFFDCL YDEEVISEDA FYKWESSKDP 1570 1580 1590 AEQAGKGVAL KSVTAFFTWL REAEEESEDN
	Isoform 4 [UniParc]. Checksum: 05FEAAD3A5AB616D	FASTA	1,578	174,791
	10 20 30 40 50 60 MNSQPQARSP FAAGPRPAHH QGGFRPIQFF QRPQIQPPRA AIPNSSPSIR PGVQTPTAVY 70 80 90 100 110 120 QANQHIMMVN HLPMPYPVTQ GHQYCIPQYR HSGPPYVGPP QQYPVQPPGP GPFYPGPGPG 130 140 150 160 170 180 DFANAYGTPF YPSQPVYQSA PIIVPTQQQP PPAKREKKTI RIRDPNQGGK DITEEIMSGG 190 200 210 220 230 240 GSRNPTPPIG RPASTPTPPQ QLPSQVPEHS PVVYGTVESA HLAASTPVTA ASDQKQEEKP 250 260 270 280 290 300 KPDPVFQSPS TVLRLVLSGE KKEQAGQMPE TAAGEPTPEP PRTSSPTSLP PLARSSLPSP 310 320 330 340 350 360 MSAALSSQPL FTAEDKCELP SSKEEDAPPV PSPTSCTAAS GPSLTDNSDI CKKPCSVAPH 370 380 390 400 410 420 DSQLISSTIL INEMNGVGEK LSAKENTVGM LRQEVLPLTL ELEILEHPQE ELKVECTPTP 430 440 450 460 470 480 IAPSMLPAFS PAPPTPPTSP PCPPVVLSAA IARSPAVATE VQRVADEGES LRTCLSKDAK 490 500 510 520 530 540 EMQDKAESES DGQAEETADP QSLHSGRSPA PVQTATTAPK SWKKTKEQTR TPDEVLEAEA 550 560 570 580 590 600 EPKAEEELAV DSVLEPEQEK MSQGFPSERD PSALKRGKAE EGNGEEAEPV RNGAESASEG 610 620 630 640 650 660 EGGDGNSGSA DSSADGLTFP FKAESWKPAD TEGKKQYDRE FLLDIQFMPA CIQKPEGLPP 670 680 690 700 710 720 ISDVVLDKIN QPRLSMRTLD PRILPRGPDF TPAFADFPRQ TPGGRGVPLL NVGPRRSQPG 730 740 750 760 770 780 QRREPRKIIT VSVKEDVHLR KAENAWKPSQ KRDSHADDPE SIKTQELFRK VRSILNKLTP 790 800 810 820 830 840 QMFNQLMKQV SALTVDTEER LKGVIDLVFE KAIDEPSFSV AYANMCRCLV TLKVPMADKP 850 860 870 880 890 900 GNTVNFRKLL LNRCQKEFEK DKADDDVFEK KQKELEAASA PEERTRLHDE LEEAKDKARR 910 920 930 940 950 960 RSIGNIKFIG ELFKLKMLTE AIMHDCVVKL LKNHDEESLE CLCRLLTTIG KDLDFEKAKP 970 980 990 1000 1010 1020 RMDQYFNQME KIVKERKTSS RIRFMLQDVI DLRLCNWVSR RADQGPKTIE QIHKEAKIEE 1030 1040 1050 1060 1070 1080 QEEQRKVQQL MTKEKRRPGV QRVDEGGWNT VQGAKNSRVL DPSKFLKITK PTIDEKIQLV 1090 1100 1110 1120 1130 1140 PKAQLGSWGK GSSGGAKASE SAPSGSPSAT PLEFDSRRAL TSRGSMGREK SDKPIPAGTA 1150 1160 1170 1180 1190 1200 RPNTFLRGSS KDLLDNQSQE EQRREMLETV KQLTGGLDAE RASTEADRSK TRELAKSEMC 1210 1220 1230 1240 1250 1260 AVPAPDKPAL SEEEVERKSK SIIDEFLHIN DFKEATQCIE ELSAQGPLHV FVKVGVEFTL 1270 1280 1290 1300 1310 1320 ERSQITRDHM GHLLYQLVQS EKLSKQDFFK GFSETLELAD DMAIDIPHIW LYLAELVTPM 1330 1340 1350 1360 1370 1380 LKEGGISMRE LIVEFSKPLL PVGRAGVLLS EILHLLCRQM SHKKVGALWR EADLSWKDFL 1390 1400 1410 1420 1430 1440 PEGEDVHHFL LEQKLDFTES EGPCSSEALS KKELSAEELS QRLEKLIMEE KADDERIFDW 1450 1460 1470 1480 1490 1500 VEANLDESQM SSPTFLRALM TAVCKAAIIA DCSTFRVDTA VIKQRVPILL KYLDSDTEKE 1510 1520 1530 1540 1550 1560 LQALYALQAS IVKLDQPANL LRMFFDCLYD EEVISEDAFY KWESSKDPAE QAGKGVALKS 1570 VTAFFTWLRE AEEESEDN

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-217 AND 807-1579 (ISOFORM 2), NUCLEOTIDE SEQUENCE OF 1-135 (ISOFORM 3). Strain: C57BL/6J. Tissue: Adipose tissue, Head and Oviduct.
[2]	The MGC Project Team Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 164-492.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4). Strain: C57BL/6 and FVB/N. Tissue: Brain, Colon, Kidney, Liver and Mammary tumor.
[4]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267, MASS SPECTROMETRY. Tissue: Brain cortex.
[5]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-470 AND SER-472, MASS SPECTROMETRY. Tissue: Liver.
[6]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240, MASS SPECTROMETRY. Tissue: Macrophage.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK029440 mRNA. Translation: BAC26452.1. AK050887 mRNA. Translation: BAC34445.1. AK054068 mRNA. Translation: BAC35644.1. CB522417 mRNA. No translation available. CF743072 mRNA. No translation available. BC023898 mRNA. Translation: AAH23898.1. Different initiation. BC047531 mRNA. Translation: AAH47531.1. BC048848 mRNA. Translation: AAH48848.1. BC057913 mRNA. Translation: AAH57913.1. BC072600 mRNA. Translation: AAH72600.1.
IPI	IPI00417153. IPI00417154. IPI00417155. IPI00626707.
RefSeq	NP_766291.2. NM_172703.3.
UniGene	Mm.268903. Mm.407375. Mm.489798.
3D structure databases
ProteinModelPortal	Q80XI3.
SMR	Q80XI3. Positions 136-161, 740-981, 1208-1545.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1864762.
PTM databases
PhosphoSite	Q80XI3.
Proteomic databases
PaxDb	Q80XI3.
PRIDE	Q80XI3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000084214; ENSMUSP00000081232; ENSMUSG00000028760.
GeneID	230861.
KEGG	mmu:230861.
UCSC	uc008vka.2. mouse. uc008vkb.2. mouse.
Organism-specific databases
CTD	8672.
MGI	MGI:1923935. Eif4g3.
Phylogenomic databases
eggNOG	NOG301289.
GeneTree	ENSGT00530000063038.
HOVERGEN	HBG052083.
KO	K03260.
OrthoDB	EOG45X7V7.
Gene expression databases
ArrayExpress	Q80XI3.
Bgee	Q80XI3.
Genevestigator	Q80XI3.
GermOnline	ENSMUSG00000028760. Mus musculus.
Family and domain databases
Gene3D	1.25.40.180. 3 hits.
InterPro	IPR016024. ARM-type_fold. IPR003891. Initiation_fac_eIF4g_MI. IPR016021. MIF4-like_typ_1/2/3. IPR003890. MIF4G-like_typ-3. IPR003307. W2_domain. [Graphical view]
Pfam	PF02847. MA3. 1 hit. PF02854. MIF4G. 1 hit. PF02020. W2. 1 hit. [Graphical view]
SMART	SM00515. eIF5C. 1 hit. SM00544. MA3. 1 hit. SM00543. MIF4G. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 3 hits.
PROSITE	PS50077. HEAT_REPEAT. False negative. PS51366. MI. 1 hit. PS51363. W2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	EIF4G3. mouse.
NextBio	380218.
SOURCE	Search...

Entry information

Entry name

IF4G3_MOUSE

Accession

Primary (citable) accession number: Q80XI3
Secondary accession number(s): Q6GQV5 , Q80Y69, Q8BJ68, Q8BQF3, Q8C6Q3, Q8CIH0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	June 7, 2004
Last modified:	May 29, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program