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Protein
Submitted name:

Toll-like receptor 9

Gene

Tlr9

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • interleukin-1 receptor binding Source: RGD
  • siRNA binding Source: RGD
  • transmembrane signaling receptor activity Source: InterPro
  • unmethylated CpG binding Source: RGD

GO - Biological processi

  • activation of innate immune response Source: RGD
  • cellular response to chloroquine Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • cellular response to metal ion Source: RGD
  • cytokine production Source: RGD
  • defense response to Gram-negative bacterium Source: RGD
  • defense response to virus Source: RGD
  • I-kappaB kinase/NF-kappaB signaling Source: RGD
  • I-kappaB phosphorylation Source: RGD
  • immune response Source: RGD
  • innate immune response Source: InterPro
  • maintenance of gastrointestinal epithelium Source: RGD
  • male gonad development Source: RGD
  • microglial cell activation Source: RGD
  • MyD88-dependent toll-like receptor signaling pathway Source: RGD
  • negative regulation of calcium-transporting ATPase activity Source: RGD
  • negative regulation of interleukin-6 production Source: RGD
  • negative regulation of interleukin-8 production Source: RGD
  • negative regulation of NF-kappaB transcription factor activity Source: RGD
  • negative regulation of toll-like receptor signaling pathway Source: RGD
  • positive regulation of autophagy Source: RGD
  • positive regulation of B cell activation Source: RGD
  • positive regulation of B cell proliferation Source: RGD
  • positive regulation of chemokine production Source: RGD
  • positive regulation of gene expression Source: RGD
  • positive regulation of granulocyte macrophage colony-stimulating factor production Source: RGD
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: RGD
  • positive regulation of immunoglobulin production Source: RGD
  • positive regulation of inflammatory response Source: InterPro
  • positive regulation of interferon-alpha biosynthetic process Source: RGD
  • positive regulation of interferon-beta biosynthetic process Source: RGD
  • positive regulation of interferon-beta production Source: RGD
  • positive regulation of interferon-gamma biosynthetic process Source: RGD
  • positive regulation of interleukin-10 production Source: RGD
  • positive regulation of interleukin-12 production Source: RGD
  • positive regulation of interleukin-18 production Source: RGD
  • positive regulation of interleukin-6 production Source: RGD
  • positive regulation of interleukin-8 production Source: RGD
  • positive regulation of JUN kinase activity Source: RGD
  • positive regulation of MAPK cascade Source: RGD
  • positive regulation of NF-kappaB import into nucleus Source: RGD
  • positive regulation of NF-kappaB transcription factor activity Source: RGD
  • positive regulation of nitric-oxide synthase biosynthetic process Source: RGD
  • positive regulation of toll-like receptor 9 signaling pathway Source: RGD
  • positive regulation of toll-like receptor signaling pathway Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
  • positive regulation of tumor necrosis factor production Source: RGD
  • regulation of B cell activation Source: RGD
  • regulation of B cell differentiation Source: RGD
  • regulation of cytokine secretion Source: InterPro
  • regulation of dendritic cell cytokine production Source: RGD
  • regulation of inflammatory response Source: RGD
  • regulation of protein phosphorylation Source: RGD
  • regulation of toll-like receptor 9 signaling pathway Source: RGD
  • response to virus Source: RGD
  • toll-like receptor 9 signaling pathway Source: InterPro
  • toll-like receptor signaling pathway Source: RGD
  • tumor necrosis factor production Source: RGD

Keywordsi

Molecular functionReceptor0 Publication

Names & Taxonomyi

Protein namesi
Submitted name:
Toll-like receptor 90 Publication
Gene namesi
Name:Tlr90 Publication
OrganismiRattus norvegicus (Rat)0 Publication
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi631352. Tlr9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiQ80XA5.

Interactioni

GO - Molecular functioni

  • interleukin-1 receptor binding Source: RGD

Structurei

3D structure databases

ProteinModelPortaliQ80XA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini239 – 387TIRImportedAdd BLAST149

Keywords - Domaini

Leucine-rich repeatCurated, RepeatCurated

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
PhylomeDBiQ80XA5.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR001611. Leu-rich_rpt.
IPR032675. LRR_dom_sf.
IPR000157. TIR_dom.
IPR027181. TLR9.
IPR035897. Toll_tir_struct_dom_sf.
PANTHERiPTHR24373:SF37. PTHR24373:SF37. 1 hit.
PfamiView protein in Pfam
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
SMARTiView protein in SMART
SM00255. TIR. 1 hit.
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF52200. SSF52200. 1 hit.
PROSITEiView protein in PROSITE
PS50104. TIR. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q80XA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SLIHLDLSQN KLHILRPQNL NYLPKSLTKL SFRDNHLSFF NWSSLAFLPN
60 70 80 90 100
LRDLDLAGNL LKALTNGTLP NGTLLQKLDV SSNSIVFVVP AFFALAVELK
110 120 130 140 150
EVNLSHNILK TVDRSWFGPI VMNLTVLDVS SNPLHCACGA PFVDLLLEVQ
160 170 180 190 200
TKVPGLANGV KCGSPRQLQG RSIFAQDLRL CLDDVLSRDC FGLSLLAVAV
210 220 230 240 250
GTVLPLLQHL CGWDVWYCFH LCLAWLPLLT RGRRSAQALP YDAFVVFDKA
260 270 280 290 300
QSAVADWVYN ELRVRLEERR GRRALRLCLE DRDWLPGQTL FENLWASIYG
310 320 330 340 350
SRKTLFVLAH TDKVSGLLRT SFLLAQQRLL EDRKDVVVLV ILRPDAHRSR
360 370 380
YVRLRQRLCR QSVLFWPHQP NGQGSFWAQL STALTRDN
Length:388
Mass (Da):43,970
Last modified:June 1, 2003 - v1
Checksum:i4E17AF770F65CF41
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei10 Publication1
Non-terminal residuei3880 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY258139 mRNA. Translation: AAO93109.1.
UniGeneiRn.92495.

Similar proteinsi

Entry informationi

Entry nameiQ80XA5_RAT
AccessioniPrimary (citable) accession number: Q80XA5
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 22, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)