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Q80XA5

- Q80XA5_RAT

UniProt

Q80XA5 - Q80XA5_RAT

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Protein
Submitted name:

Toll-like receptor 9

Gene
Tlr9
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. transmembrane signaling receptor activity Source: InterPro
  2. unmethylated CpG binding Source: RGD

GO - Biological processi

  1. cellular response to lipopolysaccharide Source: RGD
  2. cellular response to metal ion Source: RGD
  3. defense response to virus Source: RGD
  4. innate immune response Source: InterPro
  5. maintenance of gastrointestinal epithelium Source: Ensembl
  6. male gonad development Source: RGD
  7. microglial cell activation Source: RGD
  8. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
  9. negative regulation of interleukin-6 production Source: Ensembl
  10. positive regulation of autophagy Source: RGD
  11. positive regulation of inflammatory response Source: InterPro
  12. positive regulation of interferon-beta production Source: Ensembl
  13. positive regulation of interleukin-10 production Source: Ensembl
  14. positive regulation of interleukin-12 production Source: Ensembl
  15. positive regulation of interleukin-18 production Source: Ensembl
  16. positive regulation of interleukin-6 production Source: Ensembl
  17. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  18. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  19. positive regulation of tumor necrosis factor production Source: Ensembl
  20. regulation of cytokine secretion Source: InterPro
  21. toll-like receptor 9 signaling pathway Source: InterPro
  22. toll-like receptor signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiREACT_198631. Trafficking and processing of endosomal TLR.
REACT_199005. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Toll-like receptor 9Imported
Gene namesi
Name:Tlr9Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi631352. Tlr9.

Subcellular locationi

GO - Cellular componenti

  1. early phagosome Source: Ensembl
  2. endoplasmic reticulum Source: Ensembl
  3. endosome Source: Ensembl
  4. integral component of membrane Source: InterPro
  5. lysosome Source: Ensembl
  6. plasma membrane Source: RGD
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ80XA5.

Structurei

3D structure databases

ProteinModelPortaliQ80XA5.

Family & Domainsi

Sequence similaritiesi

Contains TIR domain.SAAS annotations

Keywords - Domaini

Leucine-rich repeatSAAS annotations, RepeatSAAS annotations

Phylogenomic databases

PhylomeDBiQ80XA5.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR001611. Leu-rich_rpt.
IPR000157. TIR_dom.
IPR027181. TLR9.
[Graphical view]
PANTHERiPTHR24373:SF37. PTHR24373:SF37. 1 hit.
PfamiPF13504. LRR_7. 1 hit.
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q80XA5-1 [UniParc]FASTAAdd to Basket

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SLIHLDLSQN KLHILRPQNL NYLPKSLTKL SFRDNHLSFF NWSSLAFLPN    50
LRDLDLAGNL LKALTNGTLP NGTLLQKLDV SSNSIVFVVP AFFALAVELK 100
EVNLSHNILK TVDRSWFGPI VMNLTVLDVS SNPLHCACGA PFVDLLLEVQ 150
TKVPGLANGV KCGSPRQLQG RSIFAQDLRL CLDDVLSRDC FGLSLLAVAV 200
GTVLPLLQHL CGWDVWYCFH LCLAWLPLLT RGRRSAQALP YDAFVVFDKA 250
QSAVADWVYN ELRVRLEERR GRRALRLCLE DRDWLPGQTL FENLWASIYG 300
SRKTLFVLAH TDKVSGLLRT SFLLAQQRLL EDRKDVVVLV ILRPDAHRSR 350
YVRLRQRLCR QSVLFWPHQP NGQGSFWAQL STALTRDN 388
Length:388
Mass (Da):43,970
Last modified:June 1, 2003 - v1
Checksum:i4E17AF770F65CF41
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei388 – 3881Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY258139 mRNA. Translation: AAO93109.1.
UniGeneiRn.92495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY258139 mRNA. Translation: AAO93109.1 .
UniGenei Rn.92495.

3D structure databases

ProteinModelPortali Q80XA5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 631352. Tlr9.

Phylogenomic databases

PhylomeDBi Q80XA5.

Enzyme and pathway databases

Reactomei REACT_198631. Trafficking and processing of endosomal TLR.
REACT_199005. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.

Gene expression databases

Genevestigatori Q80XA5.

Family and domain databases

Gene3Di 3.40.50.10140. 1 hit.
InterProi IPR001611. Leu-rich_rpt.
IPR000157. TIR_dom.
IPR027181. TLR9.
[Graphical view ]
PANTHERi PTHR24373:SF37. PTHR24373:SF37. 1 hit.
Pfami PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cerovic V., Woods A.M., Klavinskis L.S.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LEWImported.

Entry informationi

Entry nameiQ80XA5_RAT
AccessioniPrimary (citable) accession number: Q80XA5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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