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Q80XA5

- Q80XA5_RAT

UniProt

Q80XA5 - Q80XA5_RAT

Protein
Submitted name:

Toll-like receptor 9

Gene

Tlr9

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. transmembrane signaling receptor activity Source: InterPro
    2. unmethylated CpG binding Source: RGD

    GO - Biological processi

    1. cellular response to lipopolysaccharide Source: RGD
    2. cellular response to metal ion Source: RGD
    3. defense response to virus Source: RGD
    4. innate immune response Source: InterPro
    5. maintenance of gastrointestinal epithelium Source: Ensembl
    6. male gonad development Source: RGD
    7. microglial cell activation Source: RGD
    8. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
    9. negative regulation of interleukin-6 production Source: Ensembl
    10. positive regulation of autophagy Source: RGD
    11. positive regulation of inflammatory response Source: InterPro
    12. positive regulation of interferon-beta production Source: Ensembl
    13. positive regulation of interleukin-10 production Source: Ensembl
    14. positive regulation of interleukin-12 production Source: Ensembl
    15. positive regulation of interleukin-18 production Source: Ensembl
    16. positive regulation of interleukin-6 production Source: Ensembl
    17. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
    18. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    19. positive regulation of tumor necrosis factor production Source: Ensembl
    20. regulation of cytokine secretion Source: InterPro
    21. toll-like receptor 9 signaling pathway Source: InterPro
    22. toll-like receptor signaling pathway Source: RGD

    Keywords - Molecular functioni

    ReceptorImported

    Enzyme and pathway databases

    ReactomeiREACT_198631. Trafficking and processing of endosomal TLR.
    REACT_199005. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Toll-like receptor 9Imported
    Gene namesi
    Name:Tlr9Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi631352. Tlr9.

    Subcellular locationi

    GO - Cellular componenti

    1. early phagosome Source: Ensembl
    2. endoplasmic reticulum Source: Ensembl
    3. endosome Source: Ensembl
    4. integral component of membrane Source: InterPro
    5. lysosome Source: Ensembl
    6. plasma membrane Source: RGD

    Expressioni

    Gene expression databases

    GenevestigatoriQ80XA5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80XA5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Leucine-rich repeatSAAS annotation

    Phylogenomic databases

    PhylomeDBiQ80XA5.

    Family and domain databases

    Gene3Di3.40.50.10140. 1 hit.
    InterProiIPR001611. Leu-rich_rpt.
    IPR000157. TIR_dom.
    IPR027181. TLR9.
    [Graphical view]
    PANTHERiPTHR24373:SF37. PTHR24373:SF37. 1 hit.
    PfamiPF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS50104. TIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q80XA5-1 [UniParc]FASTAAdd to Basket

    « Hide

    SLIHLDLSQN KLHILRPQNL NYLPKSLTKL SFRDNHLSFF NWSSLAFLPN    50
    LRDLDLAGNL LKALTNGTLP NGTLLQKLDV SSNSIVFVVP AFFALAVELK 100
    EVNLSHNILK TVDRSWFGPI VMNLTVLDVS SNPLHCACGA PFVDLLLEVQ 150
    TKVPGLANGV KCGSPRQLQG RSIFAQDLRL CLDDVLSRDC FGLSLLAVAV 200
    GTVLPLLQHL CGWDVWYCFH LCLAWLPLLT RGRRSAQALP YDAFVVFDKA 250
    QSAVADWVYN ELRVRLEERR GRRALRLCLE DRDWLPGQTL FENLWASIYG 300
    SRKTLFVLAH TDKVSGLLRT SFLLAQQRLL EDRKDVVVLV ILRPDAHRSR 350
    YVRLRQRLCR QSVLFWPHQP NGQGSFWAQL STALTRDN 388
    Length:388
    Mass (Da):43,970
    Last modified:June 1, 2003 - v1
    Checksum:i4E17AF770F65CF41
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei388 – 3881Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY258139 mRNA. Translation: AAO93109.1.
    UniGeneiRn.92495.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY258139 mRNA. Translation: AAO93109.1 .
    UniGenei Rn.92495.

    3D structure databases

    ProteinModelPortali Q80XA5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 631352. Tlr9.

    Phylogenomic databases

    PhylomeDBi Q80XA5.

    Enzyme and pathway databases

    Reactomei REACT_198631. Trafficking and processing of endosomal TLR.
    REACT_199005. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.

    Gene expression databases

    Genevestigatori Q80XA5.

    Family and domain databases

    Gene3Di 3.40.50.10140. 1 hit.
    InterProi IPR001611. Leu-rich_rpt.
    IPR000157. TIR_dom.
    IPR027181. TLR9.
    [Graphical view ]
    PANTHERi PTHR24373:SF37. PTHR24373:SF37. 1 hit.
    Pfami PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cerovic V., Woods A.M., Klavinskis L.S.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: LEWImported.

    Entry informationi

    Entry nameiQ80XA5_RAT
    AccessioniPrimary (citable) accession number: Q80XA5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)