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Q80XA5 (Q80XA5_RAT) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Tlr9 EMBL AAO93109.1 RGD 631352
OrganismRattus norvegicus (Rat) EMBL AAO93109.1
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length388 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains TIR domain. SAAS SAAS000157

Ontologies

Keywords
   DomainLeucine-rich repeat SAAS SAAS000157
Repeat SAAS SAAS000157
   Molecular functionReceptor EMBL AAO93109.1
Gene Ontology (GO)
   Biological_processMyD88-dependent toll-like receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

cellular response to lipopolysaccharide

Inferred from expression pattern PubMed 20655116PubMed 21308757. Source: RGD

cellular response to metal ion

Inferred from expression pattern PubMed 17415764PubMed 21308757. Source: RGD

defense response to virus

Inferred from mutant phenotype PubMed 17202329. Source: RGD

innate immune response

Inferred from electronic annotation. Source: InterPro

maintenance of gastrointestinal epithelium

Inferred from electronic annotation. Source: Ensembl

male gonad development

Inferred from expression pattern PubMed 19703144. Source: RGD

microglial cell activation

Inferred from direct assay PubMed 16973131. Source: RGD

negative regulation of interleukin-6 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of autophagy

Inferred from direct assay PubMed 18632594. Source: RGD

positive regulation of inflammatory response

Inferred from electronic annotation. Source: InterPro

positive regulation of interferon-beta production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-10 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-12 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-18 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-6 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of nitric-oxide synthase biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of tumor necrosis factor production

Inferred from electronic annotation. Source: Ensembl

regulation of cytokine secretion

Inferred from electronic annotation. Source: InterPro

toll-like receptor 9 signaling pathway

Inferred from electronic annotation. Source: InterPro

toll-like receptor signaling pathway

Inferred from direct assay PubMed 16973131. Source: RGD

   Cellular_componentearly phagosome

Inferred from electronic annotation. Source: Ensembl

endoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

endosome

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: InterPro

lysosome

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from direct assay PubMed 22785180. Source: RGD

   Molecular_functiontransmembrane signaling receptor activity

Inferred from electronic annotation. Source: InterPro

unmethylated CpG binding

Inferred from direct assay PubMed 16973131. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAO93109.1
Non-terminal residue3881 EMBL AAO93109.1

Sequences

Sequence LengthMass (Da)Tools
Q80XA5 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 4E17AF770F65CF41

FASTA38843,970
        10         20         30         40         50         60 
SLIHLDLSQN KLHILRPQNL NYLPKSLTKL SFRDNHLSFF NWSSLAFLPN LRDLDLAGNL 

        70         80         90        100        110        120 
LKALTNGTLP NGTLLQKLDV SSNSIVFVVP AFFALAVELK EVNLSHNILK TVDRSWFGPI 

       130        140        150        160        170        180 
VMNLTVLDVS SNPLHCACGA PFVDLLLEVQ TKVPGLANGV KCGSPRQLQG RSIFAQDLRL 

       190        200        210        220        230        240 
CLDDVLSRDC FGLSLLAVAV GTVLPLLQHL CGWDVWYCFH LCLAWLPLLT RGRRSAQALP 

       250        260        270        280        290        300 
YDAFVVFDKA QSAVADWVYN ELRVRLEERR GRRALRLCLE DRDWLPGQTL FENLWASIYG 

       310        320        330        340        350        360 
SRKTLFVLAH TDKVSGLLRT SFLLAQQRLL EDRKDVVVLV ILRPDAHRSR YVRLRQRLCR 

       370        380 
QSVLFWPHQP NGQGSFWAQL STALTRDN 

« Hide

References

[1]Cerovic V., Woods A.M., Klavinskis L.S.
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: LEW EMBL AAO93109.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY258139 mRNA. Translation: AAO93109.1.
UniGeneRn.92495.

3D structure databases

ProteinModelPortalQ80XA5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD631352. Tlr9.

Phylogenomic databases

PhylomeDBQ80XA5.

Gene expression databases

GenevestigatorQ80XA5.

Family and domain databases

Gene3D3.40.50.10140. 1 hit.
InterProIPR001611. Leu-rich_rpt.
IPR000157. TIR_dom.
IPR027181. TLR9.
[Graphical view]
PANTHERPTHR24373:SF37. PTHR24373:SF37. 1 hit.
PfamPF13504. LRR_7. 1 hit.
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SUPFAMSSF52200. SSF52200. 1 hit.
PROSITEPS50104. TIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ80XA5_RAT
AccessionPrimary (citable) accession number: Q80XA5
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)