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Protein
Submitted name:

Toll-like receptor 9

Gene

Tlr9

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiREACT_291658. PI3K Cascade.
REACT_294458. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
REACT_310005. MyD88 dependent cascade initiated on endosome.
REACT_317927. Toll Like Receptor 9 (TLR9) Cascade.
REACT_318933. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
REACT_335583. Trafficking and processing of endosomal TLR.

Names & Taxonomyi

Protein namesi
Submitted name:
Toll-like receptor 9Imported
Gene namesi
Name:Tlr9Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi631352. Tlr9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ80XA5. baseline and differential.
GenevestigatoriQ80XA5.

Structurei

3D structure databases

ProteinModelPortaliQ80XA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Leucine-rich repeatSAAS annotation

Phylogenomic databases

PhylomeDBiQ80XA5.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR001611. Leu-rich_rpt.
IPR000157. TIR_dom.
IPR027181. TLR9.
[Graphical view]
PANTHERiPTHR24373:SF37. PTHR24373:SF37. 1 hit.
PfamiPF13504. LRR_7. 1 hit.
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q80XA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SLIHLDLSQN KLHILRPQNL NYLPKSLTKL SFRDNHLSFF NWSSLAFLPN
60 70 80 90 100
LRDLDLAGNL LKALTNGTLP NGTLLQKLDV SSNSIVFVVP AFFALAVELK
110 120 130 140 150
EVNLSHNILK TVDRSWFGPI VMNLTVLDVS SNPLHCACGA PFVDLLLEVQ
160 170 180 190 200
TKVPGLANGV KCGSPRQLQG RSIFAQDLRL CLDDVLSRDC FGLSLLAVAV
210 220 230 240 250
GTVLPLLQHL CGWDVWYCFH LCLAWLPLLT RGRRSAQALP YDAFVVFDKA
260 270 280 290 300
QSAVADWVYN ELRVRLEERR GRRALRLCLE DRDWLPGQTL FENLWASIYG
310 320 330 340 350
SRKTLFVLAH TDKVSGLLRT SFLLAQQRLL EDRKDVVVLV ILRPDAHRSR
360 370 380
YVRLRQRLCR QSVLFWPHQP NGQGSFWAQL STALTRDN
Length:388
Mass (Da):43,970
Last modified:June 1, 2003 - v1
Checksum:i4E17AF770F65CF41
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei388 – 3881Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY258139 mRNA. Translation: AAO93109.1.
UniGeneiRn.92495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY258139 mRNA. Translation: AAO93109.1.
UniGeneiRn.92495.

3D structure databases

ProteinModelPortaliQ80XA5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi631352. Tlr9.

Phylogenomic databases

PhylomeDBiQ80XA5.

Enzyme and pathway databases

ReactomeiREACT_291658. PI3K Cascade.
REACT_294458. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
REACT_310005. MyD88 dependent cascade initiated on endosome.
REACT_317927. Toll Like Receptor 9 (TLR9) Cascade.
REACT_318933. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
REACT_335583. Trafficking and processing of endosomal TLR.

Gene expression databases

ExpressionAtlasiQ80XA5. baseline and differential.
GenevestigatoriQ80XA5.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR001611. Leu-rich_rpt.
IPR000157. TIR_dom.
IPR027181. TLR9.
[Graphical view]
PANTHERiPTHR24373:SF37. PTHR24373:SF37. 1 hit.
PfamiPF13504. LRR_7. 1 hit.
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cerovic V., Woods A.M., Klavinskis L.S.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LEWImported.

Entry informationi

Entry nameiQ80XA5_RAT
AccessioniPrimary (citable) accession number: Q80XA5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: May 27, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.