Q80XA5 (Q80XA5_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Toll-like receptor 9 EMBL AAO93109.1

Gene names

Name:

Tlr9 EMBL AAO93109.1 RGD 631352

Organism

Rattus norvegicus (Rat) EMBL AAO93109.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	388 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 TIR domain. SAAS SAAS000157

Ontologies

Keywords
Molecular function	Receptor EMBL AAO93109.1
Gene Ontology (GO)
Biological_process	MyD88-dependent toll-like receptor signaling pathway Inferred from electronic annotation. Source: InterPro cellular response to lipopolysaccharide Inferred from expression pattern PubMed 20655116PubMed 21308757. Source: RGD cellular response to metal ion Inferred from expression pattern PubMed 17415764PubMed 21308757. Source: RGD defense response to bacterium Inferred from direct assay PubMed 16973131. Source: RGD defense response to virus Inferred from mutant phenotype PubMed 17202329. Source: RGD innate immune response Inferred from electronic annotation. Source: InterPro maintenance of gastrointestinal epithelium Inferred from electronic annotation. Source: Compara male gonad development Inferred from expression pattern PubMed 19703144. Source: RGD microglial cell activation involved in immune response Inferred from direct assay PubMed 16973131. Source: RGD negative regulation of interleukin-6 production Inferred from electronic annotation. Source: Compara pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response Inferred from direct assay PubMed 16973131. Source: RGD positive regulation of autophagy Inferred from direct assay PubMed 18632594. Source: RGD positive regulation of inflammatory response Inferred from electronic annotation. Source: InterPro positive regulation of interferon-beta production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-10 production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-12 production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-18 production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-6 production Inferred from electronic annotation. Source: Compara positive regulation of nitric-oxide synthase biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of tumor necrosis factor production Inferred from electronic annotation. Source: Compara regulation of cytokine secretion Inferred from electronic annotation. Source: InterPro toll-like receptor 9 signaling pathway Inferred from electronic annotation. Source: InterPro toll-like receptor signaling pathway Inferred from direct assay PubMed 16973131. Source: RGD
Cellular_component	early phagosome Inferred from electronic annotation. Source: Compara endoplasmic reticulum Inferred from electronic annotation. Source: Compara endosome Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: InterPro lysosome Inferred from electronic annotation. Source: Compara
Molecular_function	transmembrane signaling receptor activity Inferred from electronic annotation. Source: InterPro unmethylated CpG binding Inferred from direct assay PubMed 16973131. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAO93109.1
	Non-terminal residue	388	1	EMBL AAO93109.1

Sequences

	Sequence		Length	Mass (Da)
	Q80XA5 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 4E17AF770F65CF41	FASTA	388	43,970
	10 20 30 40 50 60 SLIHLDLSQN KLHILRPQNL NYLPKSLTKL SFRDNHLSFF NWSSLAFLPN LRDLDLAGNL 70 80 90 100 110 120 LKALTNGTLP NGTLLQKLDV SSNSIVFVVP AFFALAVELK EVNLSHNILK TVDRSWFGPI 130 140 150 160 170 180 VMNLTVLDVS SNPLHCACGA PFVDLLLEVQ TKVPGLANGV KCGSPRQLQG RSIFAQDLRL 190 200 210 220 230 240 CLDDVLSRDC FGLSLLAVAV GTVLPLLQHL CGWDVWYCFH LCLAWLPLLT RGRRSAQALP 250 260 270 280 290 300 YDAFVVFDKA QSAVADWVYN ELRVRLEERR GRRALRLCLE DRDWLPGQTL FENLWASIYG 310 320 330 340 350 360 SRKTLFVLAH TDKVSGLLRT SFLLAQQRLL EDRKDVVVLV ILRPDAHRSR YVRLRQRLCR 370 380 QSVLFWPHQP NGQGSFWAQL STALTRDN

References

[1]	Cerovic V., Woods A.M., Klavinskis L.S. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: LEW EMBL AAO93109.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY258139 mRNA. Translation: AAO93109.1.
IPI	IPI00382375.
UniGene	Rn.92495.
3D structure databases
HSSP	HSSP built from PDB template 1O77 based on UniProtKB O60603.
ProteinModelPortal	Q80XA5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
RGD	631352. Tlr9.
Gene expression databases
Genevestigator	Q80XA5.
Family and domain databases
InterPro	IPR000157. TIR_dom. IPR027181. TLR9. [Graphical view]
PANTHER	PTHR24373:SF37. PTHR24373:SF37. 1 hit.
Pfam	PF01582. TIR. 1 hit. [Graphical view]
SUPFAM	SSF52200. TIR. 1 hit.
PROSITE	PS50104. TIR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q80XA5_RAT

Accession

Primary (citable) accession number: Q80XA5

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)