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Protein

UDP-glucuronosyltransferase 2A1

Gene

Ugt2a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processOlfaction, Sensory transduction

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2A1 (EC:2.4.1.17)
Short name:
UDPGT 2A1
Gene namesi
Name:Ugt2a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2149905 Ugt2a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 494ExtracellularSequence analysisAdd BLAST473
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21
Topological domaini516 – 528CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000029914322 – 528UDP-glucuronosyltransferase 2A1Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi314N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ80X89
PRIDEiQ80X89

PTM databases

iPTMnetiQ80X89
PhosphoSitePlusiQ80X89

Expressioni

Gene expression databases

BgeeiENSMUSG00000106677
GenevisibleiQ80X89 MM

Structurei

3D structure databases

ProteinModelPortaliQ80X89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118949
HOGENOMiHOG000220831
HOVERGENiHBG004033
KOiK00699
OrthoDBiEOG091G06JC
PhylomeDBiQ80X89

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80X89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKNILLCSL QISLLGMSLG GNVLIWPMEG SHWLNVKIII DELLRKEHNV
60 70 80 90 100
TVLVASGALF ITPSSISPSL TFEIYPVPFG KEKIESVIKD FVLTWLENRP
110 120 130 140 150
SPSTIWTFYK EMAKVIEEFH LVSRGICDGV LKNEKLMSKL QKEKFEVLLS
160 170 180 190 200
DPVFPCGDIV ALKLGIPFIY SLRFSPASTV EKHCGKVPFP PSYVPAILSE
210 220 230 240 250
LTDQMSFTDR VRNFISYRMQ DYMFETLWKQ WDSYYTKALG RPTTLCETMG
260 270 280 290 300
KAEIWLMRTY WDFEFPRPYL PNFEFVGGLH CKPAKPLPKE MEEFVQTSGE
310 320 330 340 350
HGIVVFSLGS MVKNLTDEKA NLIASALAQI PQKVLWRYKG KIPDTLGSNT
360 370 380 390 400
RLFDWIPQND LLGHPKTRAF ITHGGTNGIY EAIYHGIPMV GVPMFADQPD
410 420 430 440 450
NIAHMKAKGA AVEVNMNTMT SSDLLNALRT VINEPSYKEN AMRLSRIHHD
460 470 480 490 500
QPVKPLDRAV FWIEFVMRHK GAKHLRVAAH DLSWFQYHSL DVIGFLLACV
510 520
ASAILLVAKC CLFIFQKVGK TGKKKKRD
Length:528
Mass (Da):59,965
Last modified:June 1, 2003 - v1
Checksum:iB53F1CB6680E2F95
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64Missing in AAG17003 (PubMed:11376859).Curated1
Sequence conflicti208T → A in AAG17003 (PubMed:11376859).Curated1
Sequence conflicti522G → R in AAG17003 (PubMed:11376859).Curated1
Sequence conflicti527R → S in AAG17003 (PubMed:11376859).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF184901 mRNA Translation: AAG17003.1
AK140757 mRNA Translation: BAE24468.1
BC048926 mRNA Translation: AAH48926.1
CCDSiCCDS39129.1
RefSeqiNP_444414.2, NM_053184.2
UniGeneiMm.26794

Genome annotation databases

EnsembliENSMUST00000147854; ENSMUSP00000114583; ENSMUSG00000106677
GeneIDi94215
KEGGimmu:94215
UCSCiuc008xyl.2 mouse

Similar proteinsi

Entry informationi

Entry nameiUD2A1_MOUSE
AccessioniPrimary (citable) accession number: Q80X89
Secondary accession number(s): Q9ESE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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