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Q80X82

- SYMPK_MOUSE

UniProt

Q80X82 - SYMPK_MOUSE

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Protein

Symplekin

Gene
Sympk
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity By similarity.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. mRNA polyadenylation Source: UniProtKB
  3. positive regulation of protein dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion, mRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Symplekin
Gene namesi
Name:Sympk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1915438. Sympk.

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Cell junctiontight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Cell junction By similarity. Nucleusnucleoplasm By similarity
Note: Cytoplasmic face of adhesion plaques (major) and nucleoplasm (minor) (in cells with TJ). Nucleoplasm (in cells without TJ). Nuclear bodies of heat-stressed cells By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
  3. nucleoplasm Source: UniProtKB-SubCell
  4. plasma membrane Source: UniProtKB-SubCell
  5. tight junction Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12841284SymplekinPRO_0000072386Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei494 – 4941Phosphoserine By similarity
Modified residuei1256 – 12561Phosphoserine By similarity
Modified residuei1270 – 12701Phosphothreonine By similarity
Modified residuei1272 – 12721Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80X82.
PaxDbiQ80X82.
PRIDEiQ80X82.

PTM databases

PhosphoSiteiQ80X82.

Expressioni

Gene expression databases

ArrayExpressiQ80X82.
BgeeiQ80X82.
CleanExiMM_SYMPK.
GenevestigatoriQ80X82.

Interactioni

Subunit structurei

Found in a heat-sensitive complex at least composed of several cleavage and polyadenylation specific and cleavage stimulation factors. Interacts with CPSF2, CPSF3 and CSTF2. Interacts with HSF1 in heat-stressed cells. Interacts with SSU72 By similarity.

Protein-protein interaction databases

IntActiQ80X82. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ80X82.
SMRiQ80X82. Positions 30-340.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati31 – 6434HEAT 1Add
BLAST
Repeati67 – 10135HEAT 2Add
BLAST
Repeati104 – 14643HEAT 3Add
BLAST
Repeati153 – 19240HEAT 4Add
BLAST
Repeati227 – 26640HEAT 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 124124Interaction with HSF1 By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi345 – 36016Nuclear localization signal Reviewed predictionAdd
BLAST

Domaini

The HEAT repeats have been determined based on 3D-structure analysis of the D.melanogaster ortholog and are not detected by sequence-based prediction programs.

Sequence similaritiesi

Belongs to the Symplekin family.
Contains 5 HEAT repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG273943.
HOGENOMiHOG000046745.
HOVERGENiHBG062441.
InParanoidiQ80X82.
PhylomeDBiQ80X82.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021850. Symplekin/Pta1.
IPR022075. Symplekin_C.
[Graphical view]
PANTHERiPTHR15245:SF20. PTHR15245:SF20. 1 hit.
PfamiPF12295. Symplekin_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

Q80X82-1 [UniParc]FASTAAdd to Basket

« Hide

MASSSGDSVT RRSVASQFFT QEEGPSIDGM TTSERVVDLL NQAALITNDS     50
KITVLKQVQE LIINKDPTLL DNFLDEIIAF QADKSIEVRK FVIGFIEEAC 100
KRDIELLLKL IANLNMLLRD ENVNVVKKAI LTMTQLYKVA LQWMVKSRVI 150
SDLQEACWDM VSSMAGEIIL LLDSDNDGIR THAIKFVEGL IVTLSPRMAD 200
SEVPRRQEHD ISLDRIPRDH PYIQYNVLWE EGKAAVEQLL KFMVHPAISS 250
INLTTALGSL ANIARQRPMF MSEVIQAYET LHANLPPTLA KSQVSSVRKN 300
LKLHLLSVLK HPASLEFQAQ ITTLLVDLGT PQAEIARNMP SSKDSRKRPR 350
DDTDSTLKKM KLEPNLGEDD EDKDLEPGPS GTSKASAQIS GQSDTDITAE 400
FLQPLLTPDN VANLVLISMV YLPETMPASF QAIYTPVESA GTEAQIKHLA 450
RLMATQMTAA GLGPGVEQTK QCKEEPKEEK VVKPESVLIK RRLSVQGQAI 500
SVVGSQSTMS PLEEEVPQAK RRPEPIIPVT QPRLAGAGGR KKIFRLSDVL 550
KPLTDAQVEA MKLGAVKRIL RAEKAVACSG AAQVRIKILA SLVTQFDSGF 600
KAEVLSFILE DVRARLDLAF AWLYQEYNAY LAAGTSGTLD KYEDCLICLL 650
SGLQEKPDQK DGIFTKVVLE APLITESALE VIRKYCEDES RAYLGMSTLG 700
DLIFKRPSRQ FQYLHVLLDL SSHEKDRVRS QALLFIKRMY EKEQLREYVE 750
KFALNYLQLL VHPNPPSVLF GADKDTEVAA PWTEETVKQC LYLYLALLPQ 800
NHKLIHELAA VYTEAIADIK RTVLRVIEQP IRGMGMNSPE LLLLVENCPK 850
GAETLVTRCL HSLTDKVPPS PELVKRVRDL YHKRLPDVRF LIPVLNGLEK 900
KEVIQALPKL IKLNPIVVKE VFNRLLGTQH GEGNSALSPL NPGELLIALH 950
NIDSVKCDMK SIIKATNLCF AERNVYTSEV LAVVMQQLME QSPLPMLLMR 1000
TVIQSLTMYP RLGGFVMNIL ARLIMKQVWK YPKVWEGFIK CCQRTKPQSF 1050
QVILQLPPQQ LGAVFDKCPE LREPLLAHVR SFTPHQQAHI PNSIMTILEA 1100
TGKQEPEVKE APSGPLEEDD LEPLALALAP APAPAPAPAP APRPPQDLIG 1150
LRLAQEKALK RQLEEEQKQK PTGIGAPAAC VSSTPSVPAA ARAGPTPAEE 1200
VMEYREEGPE CETPAIFISM DDDSGLAETT LLDSSLEGPL PKEAAAVGSS 1250
SKDERSPQNL SHAVEEALKT SSPETREPES KGNS 1284
Length:1,284
Mass (Da):142,284
Last modified:June 1, 2003 - v1
Checksum:i983FA5300374DC5B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC049852 mRNA. Translation: AAH49852.1.
UniGeneiMm.130902.

Genome annotation databases

UCSCiuc009fkg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC049852 mRNA. Translation: AAH49852.1 .
UniGenei Mm.130902.

3D structure databases

ProteinModelPortali Q80X82.
SMRi Q80X82. Positions 30-340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q80X82. 1 interaction.

PTM databases

PhosphoSitei Q80X82.

Proteomic databases

MaxQBi Q80X82.
PaxDbi Q80X82.
PRIDEi Q80X82.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc009fkg.2. mouse.

Organism-specific databases

MGIi MGI:1915438. Sympk.

Phylogenomic databases

eggNOGi NOG273943.
HOGENOMi HOG000046745.
HOVERGENi HBG062441.
InParanoidi Q80X82.
PhylomeDBi Q80X82.

Miscellaneous databases

PROi Q80X82.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q80X82.
Bgeei Q80X82.
CleanExi MM_SYMPK.
Genevestigatori Q80X82.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021850. Symplekin/Pta1.
IPR022075. Symplekin_C.
[Graphical view ]
PANTHERi PTHR15245:SF20. PTHR15245:SF20. 1 hit.
Pfami PF12295. Symplekin_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 3 hits.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSYMPK_MOUSE
AccessioniPrimary (citable) accession number: Q80X82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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