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Protein

Protein pelota homolog

Gene

Pelo

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal chromosome segregation during cell division and genomic stability. May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential).Curated

Cofactori

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • cell proliferation Source: MGI
  • chromosome organization Source: MGI
  • nuclear-transcribed mRNA catabolic process, no-go decay Source: InterPro
  • nuclear-transcribed mRNA catabolic process, non-stop decay Source: InterPro
  • RNA surveillance Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein pelota homolog (EC:3.1.-.-)
Gene namesi
Name:Pelo
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2145154. Pelo.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryonic lethality due to defects in chromosome segregation during cell division, resulting in aneuploidy and loss of genomic stability.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Protein pelota homologPRO_0000143189Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei374 – 3741PhosphoserineBy similarity
Modified residuei380 – 3801PhosphoserineBy similarity
Modified residuei381 – 3811PhosphoserineBy similarity
Modified residuei382 – 3821PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80X73.
MaxQBiQ80X73.
PaxDbiQ80X73.
PRIDEiQ80X73.

PTM databases

iPTMnetiQ80X73.
PhosphoSiteiQ80X73.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000042275.
CleanExiMM_PELO.
GenevisibleiQ80X73. MM.

Interactioni

Protein-protein interaction databases

BioGridi222760. 1 interaction.
DIPiDIP-61683N.
STRINGi10090.ENSMUSP00000104849.

Structurei

3D structure databases

ProteinModelPortaliQ80X73.
SMRiQ80X73. Positions 8-383.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain has the RNA-binding Sm fold. It may harbor the endoribonuclease activity (Potential).Curated

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2869. Eukaryota.
COG1537. LUCA.
GeneTreeiENSGT00390000016326.
HOGENOMiHOG000184162.
HOVERGENiHBG053560.
InParanoidiQ80X73.
KOiK06965.
OMAiAFYGKKH.
OrthoDBiEOG091G0AVP.
TreeFamiTF105733.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR005140. eRF1_1_Pelota.
IPR005141. eRF1_2.
IPR005142. eRF1_3.
IPR029064. L30e-like.
IPR004405. Transl-rel_pelota.
[Graphical view]
PANTHERiPTHR10853. PTHR10853. 1 hit.
PfamiPF03463. eRF1_1. 1 hit.
PF03464. eRF1_2. 1 hit.
PF03465. eRF1_3. 1 hit.
[Graphical view]
SMARTiSM01194. eRF1_1. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
TIGRFAMsiTIGR00111. pelota. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80X73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVRKDIEK DNAGQVTLVP EEPEDMWHTF NLVQVGDSLR ASTIRKVQTE
60 70 80 90 100
SSTGSVGSNR VRTTLTLCVE AIDFDSQACQ LRVKGTNIQE NEYVKMGAYH
110 120 130 140 150
TIELEPNRQF TLAKKQWDSV VLERIEQACD PAWSADVAAV VMQEGLAHVC
160 170 180 190 200
LVTPSMTLTR AKVEVNIPRK RKGNCSQHDR ALERFYEQVV QAIQRHINFE
210 220 230 240 250
VVKCVLVASP GFVREQFCDY MFQQAVKTDN KVLLENRSKF LQVHASSGHK
260 270 280 290 300
YSLKEALCDP TVASRLSDTK AAGEVKALDD FYKMLQHEPD RAFYGLKQVE
310 320 330 340 350
RANEALAIDT LLISDELFRH QDVATRSRYV RLVDSVKENA GTVRIFSSLH
360 370 380
VSGEQLGQLT GVAAILRFPV PELSDQEDDS SSEED
Length:385
Mass (Da):43,349
Last modified:July 27, 2011 - v3
Checksum:i6D1022BF319FACCE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301F → Y in AAK58116 (PubMed:12438745).Curated
Sequence conflicti30 – 301F → Y in AAK58117 (PubMed:12438745).Curated
Sequence conflicti30 – 301F → Y in AAH57160 (PubMed:15489334).Curated
Sequence conflicti125 – 1251I → F in AAK58116 (PubMed:12438745).Curated
Sequence conflicti125 – 1251I → F in AAK58117 (PubMed:12438745).Curated
Sequence conflicti180 – 1801R → P in AAK58116 (PubMed:12438745).Curated
Sequence conflicti180 – 1801R → P in AAK58117 (PubMed:12438745).Curated
Sequence conflicti268 – 2681D → H in AAK58116 (PubMed:12438745).Curated
Sequence conflicti268 – 2681D → H in AAK58117 (PubMed:12438745).Curated
Sequence conflicti273 – 2731G → V in AAH50209 (PubMed:15489334).Curated
Sequence conflicti366 – 3661L → F in AAH50209 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148638 mRNA. Translation: AAK58116.1.
AF148639 Genomic DNA. Translation: AAK58117.1.
AK170635 mRNA. Translation: BAE41926.1.
BC050209 mRNA. Translation: AAH50209.1.
BC057160 mRNA. Translation: AAH57160.1.
CCDSiCCDS26788.1.
RefSeqiNP_598819.2. NM_134058.3.
UniGeneiMm.486295.

Genome annotation databases

EnsembliENSMUST00000109226; ENSMUSP00000104849; ENSMUSG00000042275.
GeneIDi105083.
KEGGimmu:105083.
UCSCiuc007ryb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148638 mRNA. Translation: AAK58116.1.
AF148639 Genomic DNA. Translation: AAK58117.1.
AK170635 mRNA. Translation: BAE41926.1.
BC050209 mRNA. Translation: AAH50209.1.
BC057160 mRNA. Translation: AAH57160.1.
CCDSiCCDS26788.1.
RefSeqiNP_598819.2. NM_134058.3.
UniGeneiMm.486295.

3D structure databases

ProteinModelPortaliQ80X73.
SMRiQ80X73. Positions 8-383.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222760. 1 interaction.
DIPiDIP-61683N.
STRINGi10090.ENSMUSP00000104849.

PTM databases

iPTMnetiQ80X73.
PhosphoSiteiQ80X73.

Proteomic databases

EPDiQ80X73.
MaxQBiQ80X73.
PaxDbiQ80X73.
PRIDEiQ80X73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109226; ENSMUSP00000104849; ENSMUSG00000042275.
GeneIDi105083.
KEGGimmu:105083.
UCSCiuc007ryb.2. mouse.

Organism-specific databases

CTDi53918.
MGIiMGI:2145154. Pelo.

Phylogenomic databases

eggNOGiKOG2869. Eukaryota.
COG1537. LUCA.
GeneTreeiENSGT00390000016326.
HOGENOMiHOG000184162.
HOVERGENiHBG053560.
InParanoidiQ80X73.
KOiK06965.
OMAiAFYGKKH.
OrthoDBiEOG091G0AVP.
TreeFamiTF105733.

Miscellaneous databases

PROiQ80X73.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042275.
CleanExiMM_PELO.
GenevisibleiQ80X73. MM.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR005140. eRF1_1_Pelota.
IPR005141. eRF1_2.
IPR005142. eRF1_3.
IPR029064. L30e-like.
IPR004405. Transl-rel_pelota.
[Graphical view]
PANTHERiPTHR10853. PTHR10853. 1 hit.
PfamiPF03463. eRF1_1. 1 hit.
PF03464. eRF1_2. 1 hit.
PF03465. eRF1_3. 1 hit.
[Graphical view]
SMARTiSM01194. eRF1_1. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
TIGRFAMsiTIGR00111. pelota. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPELO_MOUSE
AccessioniPrimary (citable) accession number: Q80X73
Secondary accession number(s): Q3TCN0, Q6PG91, Q91UZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.