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Protein

Leucine-rich repeat-containing protein 15

Gene

Lrrc15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 15
Gene namesi
Name:Lrrc15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1921738. Lrrc15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 536ExtracellularSequence analysisAdd BLAST515
Transmembranei537 – 557HelicalSequence analysisAdd BLAST21
Topological domaini558 – 579CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002160622 – 579Leucine-rich repeat-containing protein 15Add BLAST558

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Glycosylationi369N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ80X72.
PaxDbiQ80X72.
PeptideAtlasiQ80X72.
PRIDEiQ80X72.

PTM databases

PhosphoSitePlusiQ80X72.

Expressioni

Gene expression databases

BgeeiENSMUSG00000052316.
CleanExiMM_LRRC15.
GenevisibleiQ80X72. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066777.

Structurei

3D structure databases

ProteinModelPortaliQ80X72.
SMRiQ80X72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 53LRRNTAdd BLAST32
Repeati54 – 75LRR 1Add BLAST22
Repeati78 – 99LRR 2Add BLAST22
Repeati102 – 123LRR 3Add BLAST22
Repeati126 – 147LRR 4Add BLAST22
Repeati150 – 171LRR 5Add BLAST22
Repeati174 – 195LRR 6Add BLAST22
Repeati198 – 219LRR 7Add BLAST22
Repeati222 – 243LRR 8Add BLAST22
Repeati246 – 267LRR 9Add BLAST22
Repeati270 – 291LRR 10Add BLAST22
Repeati294 – 315LRR 11Add BLAST22
Repeati318 – 339LRR 12Add BLAST22
Repeati342 – 363LRR 13Add BLAST22
Repeati366 – 387LRR 14Add BLAST22
Repeati390 – 411LRR 15Add BLAST22
Domaini423 – 473LRRCTAdd BLAST51

Sequence similaritiesi

Contains 15 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000040004.
HOVERGENiHBG052343.
InParanoidiQ80X72.
OMAiHGNHLEY.
OrthoDBiEOG091G057B.
PhylomeDBiQ80X72.
TreeFamiTF351124.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 5 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 14 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80X72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLKHYLLLL VSCQAWAAGL AYYGCPSECT CSRASQVECT GAQIVAMPSP
60 70 80 90 100
LPWNAMSLQI LNTHITELPE DKFLNISALI ALKMEKNELA NIMPGAFRNL
110 120 130 140 150
GSLRHLSLAN NKLKNLPVRL FQDVNNLETL LLSNNQLVQI QPAQFSQFSN
160 170 180 190 200
LKELQLYGNN LEYIPEGVFD HLVGLTKLNL GNNGFTHLSP RVFQHLGNLQ
210 220 230 240 250
VLRLYENRLS DIPMGTFDAL GNLQELALQE NQIGTLSPGL FHNNRNLQRL
260 270 280 290 300
YLSNNHISHL PPGIFMQLPH LNKLTLFGNS LKELSPGVFG PMPNLRELWL
310 320 330 340 350
YNNHITSLPD NAFSHLNQLQ VLILSHNQLS YISPGAFNGL TNLRELSLHT
360 370 380 390 400
NALQDLDGNV FRSLANLRNV SLQNNRLRQL PGSIFANVNG LMTIQLQNNN
410 420 430 440 450
LENLPLGIFD HLGNLCELRL YDNPWRCDSN ILPLHDWLIL NRARLGTDTL
460 470 480 490 500
PVCSSPASVR GQSLVIINVN FPGPSVQGPE TPEVSSYPDT SSYPDSTSIS
510 520 530 540 550
STTEITRSTD DDYTDLNTIE PIDDRNTWGM TDAQSGLAIA AIVIGIIALA
560 570
CSLAACICCC CCKKRSQAVL MQMKAPNEC
Length:579
Mass (Da):64,177
Last modified:June 1, 2003 - v1
Checksum:i7841957F6FB643D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC050245 mRNA. Translation: AAH50245.1.
CCDSiCCDS28099.1.
RefSeqiNP_083249.1. NM_028973.2.
UniGeneiMm.290677.

Genome annotation databases

EnsembliENSMUST00000064606; ENSMUSP00000066777; ENSMUSG00000052316.
GeneIDi74488.
KEGGimmu:74488.
UCSCiuc007ywn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC050245 mRNA. Translation: AAH50245.1.
CCDSiCCDS28099.1.
RefSeqiNP_083249.1. NM_028973.2.
UniGeneiMm.290677.

3D structure databases

ProteinModelPortaliQ80X72.
SMRiQ80X72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066777.

PTM databases

PhosphoSitePlusiQ80X72.

Proteomic databases

MaxQBiQ80X72.
PaxDbiQ80X72.
PeptideAtlasiQ80X72.
PRIDEiQ80X72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064606; ENSMUSP00000066777; ENSMUSG00000052316.
GeneIDi74488.
KEGGimmu:74488.
UCSCiuc007ywn.2. mouse.

Organism-specific databases

CTDi131578.
MGIiMGI:1921738. Lrrc15.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000040004.
HOVERGENiHBG052343.
InParanoidiQ80X72.
OMAiHGNHLEY.
OrthoDBiEOG091G057B.
PhylomeDBiQ80X72.
TreeFamiTF351124.

Miscellaneous databases

PROiQ80X72.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052316.
CleanExiMM_LRRC15.
GenevisibleiQ80X72. MM.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 5 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 14 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 14 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRC15_MOUSE
AccessioniPrimary (citable) accession number: Q80X72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.