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Protein
Submitted name:

Nrp1 protein

Gene

Nrp1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. growth factor binding Source: MGI
  2. semaphorin receptor activity Source: MGI
  3. vascular endothelial growth factor-activated receptor activity Source: InterPro
  4. vascular endothelial growth factor binding Source: MGI

GO - Biological processi

  1. angiogenesis Source: MGI
  2. axonal fasciculation Source: MGI
  3. axon guidance Source: MGI
  4. cell migration Source: MGI
  5. cellular response to hepatocyte growth factor stimulus Source: MGI
  6. dendrite development Source: MGI
  7. dichotomous subdivision of terminal units involved in salivary gland branching Source: MGI
  8. endothelial cell chemotaxis Source: MGI
  9. heart development Source: MGI
  10. hepatocyte growth factor receptor signaling pathway Source: MGI
  11. negative regulation of axon extension Source: MGI
  12. negative regulation of axon extension involved in axon guidance Source: MGI
  13. patterning of blood vessels Source: MGI
  14. platelet-derived growth factor receptor signaling pathway Source: MGI
  15. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  16. regulation of axon extension involved in axon guidance Source: MGI
  17. response to wounding Source: Ensembl
  18. semaphorin-plexin signaling pathway Source: MGI
  19. sympathetic nervous system development Source: MGI
  20. toxin transport Source: MGI
  21. trigeminal nerve morphogenesis Source: MGI
  22. vascular endothelial growth factor receptor signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Nrp1 proteinImported
Gene namesi
Name:Nrp1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:106206. Nrp1.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: MGI
  2. cell surface Source: Ensembl
  3. cytosol Source: MGI
  4. extracellular space Source: MGI
  5. focal adhesion Source: MGI
  6. growth cone Source: Ensembl
  7. neurofilament Source: MGI
  8. neuronal cell body Source: Ensembl
  9. plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ80X28.
ExpressionAtlasiQ80X28. baseline and differential.
GenevestigatoriQ80X28.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026917.

Structurei

3D structure databases

ProteinModelPortaliQ80X28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR027146. NRP1.
[Graphical view]
PANTHERiPTHR10127:SF616. PTHR10127:SF616. 1 hit.
PfamiPF00431. CUB. 1 hit.
[Graphical view]
SMARTiSM00042. CUB. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q80X28-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERGLPLLCA TLALALALAG AFRSDKCGGT IKIENPGYLT SPGYPHSYHP
60 70 80 90
SEKCEWLIQA PEPYQRIMIN FNPHFDLEDR DCKYDYVEVI DGENE
Length:95
Mass (Da):10,748
Last modified:June 1, 2003 - v1
Checksum:iF61167BD4910EADB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei95 – 951Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC051447 mRNA. Translation: AAH51447.1.
UniGeneiMm.271745.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC051447 mRNA. Translation: AAH51447.1.
UniGeneiMm.271745.

3D structure databases

ProteinModelPortaliQ80X28.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026917.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:106206. Nrp1.

Miscellaneous databases

ChiTaRSiNrp1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ80X28.
ExpressionAtlasiQ80X28. baseline and differential.
GenevestigatoriQ80X28.

Family and domain databases

Gene3Di2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR027146. NRP1.
[Graphical view]
PANTHERiPTHR10127:SF616. PTHR10127:SF616. 1 hit.
PfamiPF00431. CUB. 1 hit.
[Graphical view]
SMARTiSM00042. CUB. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C3H/HeImported.
    Tissue: OsteoblastImported.

Entry informationi

Entry nameiQ80X28_MOUSE
AccessioniPrimary (citable) accession number: Q80X28
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: February 4, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.