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Protein

Tumor necrosis factor receptor superfamily member 1B

Gene

Tnfrsf1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity).By similarity

GO - Molecular functioni

  • tumor necrosis factor-activated receptor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-RNO-5668541. TNFR2 non-canonical NF-kB pathway.
R-RNO-5669034. TNFs bind their physiological receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 1B
Alternative name(s):
Tumor necrosis factor receptor 2
Short name:
TNF-R2
Tumor necrosis factor receptor type II
Short name:
TNF-RII
Short name:
TNFR-II
p75
p80 TNF-alpha receptor
CD_antigen: CD120b
Gene namesi
Name:Tnfrsf1b
Synonyms:Tnfr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621238. Tnfrsf1b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 258236ExtracellularSequence analysisAdd
BLAST
Transmembranei259 – 28830HelicalSequence analysisAdd
BLAST
Topological domaini289 – 474186CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon Source: RGD
  • integral component of plasma membrane Source: GO_Central
  • membrane Source: RGD
  • membrane raft Source: Ensembl
  • neuronal cell body Source: RGD
  • nucleus Source: RGD
  • perinuclear region of cytoplasm Source: RGD
  • varicosity Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 474452Tumor necrosis factor receptor superfamily member 1BPRO_0000034551Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301O-linked (GalNAc...)By similarity
Disulfide bondi40 ↔ 54PROSITE-ProRule annotation
Disulfide bondi55 ↔ 68PROSITE-ProRule annotation
Disulfide bondi58 ↔ 76PROSITE-ProRule annotation
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence analysis
Disulfide bondi79 ↔ 94PROSITE-ProRule annotation
Disulfide bondi97 ↔ 111PROSITE-ProRule annotation
Disulfide bondi101 ↔ 119PROSITE-ProRule annotation
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence analysis
Disulfide bondi121 ↔ 127PROSITE-ProRule annotation
Disulfide bondi136 ↔ 145PROSITE-ProRule annotation
Disulfide bondi139 ↔ 163PROSITE-ProRule annotation
Disulfide bondi166 ↔ 181PROSITE-ProRule annotation
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence analysis
Glycosylationi208 – 2081O-linked (GalNAc...)By similarity
Glycosylationi224 – 2241O-linked (GalNAc...)By similarity
Modified residuei331 – 3311PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ80WY6.
PRIDEiQ80WY6.

Expressioni

Gene expression databases

GenevisibleiQ80WY6. RN.

Interactioni

Subunit structurei

Binds to TRAF2. Interacts with BMX.By similarity

Protein-protein interaction databases

IntActiQ80WY6. 1 interaction.
STRINGi10116.ENSRNOP00000022478.

Structurei

3D structure databases

ProteinModelPortaliQ80WY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati39 – 7739TNFR-Cys 1Add
BLAST
Repeati78 – 11942TNFR-Cys 2Add
BLAST
Repeati120 – 16445TNFR-Cys 3Add
BLAST
Repeati165 – 20339TNFR-Cys 4Add
BLAST

Sequence similaritiesi

Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ06. Eukaryota.
ENOG410YPQW. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000132845.
HOVERGENiHBG054237.
InParanoidiQ80WY6.
KOiK05141.
OMAiNCVIMTQ.
OrthoDBiEOG786H2Q.
PhylomeDBiQ80WY6.
TreeFamiTF331157.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020411. TNFR_1B.
[Graphical view]
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01919. TNFACTORR1B.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80WY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAALWVAL VVELQLWATG HTVPAKVVLT PYKPEPGNQC QISQEYYDKK
60 70 80 90 100
AQMCCAKCPP GQYAKHFCNK TSDTVCADCA AGMFTQVWNH LHTCLSCSSS
110 120 130 140 150
CSDDQVETHN CTKKQNRVCA CNADSYCALK LHSGNCRQCM KLSKCGPGFG
160 170 180 190 200
VARSRTSNGN VICSACAPGT FSDTTSSTDV CRPHRICSIL AIPGNASTDA
210 220 230 240 250
VCASESPTPS AVPRTIYVSQ PEPTRSQPMD QEPGPSQTPH IPVSLGSTPI
260 270 280 290 300
IEPSITGGIS LPIGLIVGLT TLGLLMLGLA NCFILVQRKK KPSCLQRETM
310 320 330 340 350
VPHLPDDKSQ DAIGLEQQHL LTTAPSSSSS SLESSASAGD RRAPPGGHPQ
360 370 380 390 400
ARVTAEAQGS QEACAGSRSS DSSHGSHGTH VNVTCIVNVC SSSDHSSQCS
410 420 430 440 450
SQASTTVGDP DANPSGSPKD EQVPFSQEEC PSQSQWETTE TLQNHDKPFP
460 470
LGVPDVGMKP NQPGWYDQIA VKVP
Length:474
Mass (Da):50,148
Last modified:June 1, 2003 - v1
Checksum:i298C6AB9E8C8D714
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498039 mRNA. Translation: AAP33151.1.
AY191268 mRNA. Translation: AAO61402.1.
AY191269 mRNA. Translation: AAO61403.1.
RefSeqiNP_569110.1. NM_130426.4.
UniGeneiRn.83633.

Genome annotation databases

EnsembliENSRNOT00000022478; ENSRNOP00000022478; ENSRNOG00000016575.
GeneIDi156767.
KEGGirno:156767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498039 mRNA. Translation: AAP33151.1.
AY191268 mRNA. Translation: AAO61402.1.
AY191269 mRNA. Translation: AAO61403.1.
RefSeqiNP_569110.1. NM_130426.4.
UniGeneiRn.83633.

3D structure databases

ProteinModelPortaliQ80WY6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80WY6. 1 interaction.
STRINGi10116.ENSRNOP00000022478.

Proteomic databases

PaxDbiQ80WY6.
PRIDEiQ80WY6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022478; ENSRNOP00000022478; ENSRNOG00000016575.
GeneIDi156767.
KEGGirno:156767.

Organism-specific databases

CTDi7133.
RGDi621238. Tnfrsf1b.

Phylogenomic databases

eggNOGiENOG410IJ06. Eukaryota.
ENOG410YPQW. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000132845.
HOVERGENiHBG054237.
InParanoidiQ80WY6.
KOiK05141.
OMAiNCVIMTQ.
OrthoDBiEOG786H2Q.
PhylomeDBiQ80WY6.
TreeFamiTF331157.

Enzyme and pathway databases

ReactomeiR-RNO-5668541. TNFR2 non-canonical NF-kB pathway.
R-RNO-5669034. TNFs bind their physiological receptors.

Miscellaneous databases

PROiQ80WY6.

Gene expression databases

GenevisibleiQ80WY6. RN.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020411. TNFR_1B.
[Graphical view]
PfamiPF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01919. TNFACTORR1B.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and cellular expression of TNFR2 in rat dorsal root ganglion."
    Li Y., Ji A., Schafer M.K.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Spleen.

Entry informationi

Entry nameiTNR1B_RAT
AccessioniPrimary (citable) accession number: Q80WY6
Secondary accession number(s): Q5YLP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: June 1, 2003
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.