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Protein

Tumor necrosis factor receptor superfamily member 1B

Gene

Tnfrsf1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-RNO-5668541 TNFR2 non-canonical NF-kB pathway
R-RNO-5669034 TNFs bind their physiological receptors
R-RNO-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 1B
Alternative name(s):
Tumor necrosis factor receptor 2
Short name:
TNF-R2
Tumor necrosis factor receptor type II
Short name:
TNF-RII
Short name:
TNFR-II
p75
p80 TNF-alpha receptor
CD_antigen: CD120b
Gene namesi
Name:Tnfrsf1b
Synonyms:Tnfr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621238 Tnfrsf1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 258ExtracellularSequence analysisAdd BLAST236
Transmembranei259 – 288HelicalSequence analysisAdd BLAST30
Topological domaini289 – 474CytoplasmicSequence analysisAdd BLAST186

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000003455123 – 474Tumor necrosis factor receptor superfamily member 1BAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30O-linked (GalNAc...) threonineBy similarity1
Disulfide bondi40 ↔ 54PROSITE-ProRule annotation
Disulfide bondi55 ↔ 68PROSITE-ProRule annotation
Disulfide bondi58 ↔ 76PROSITE-ProRule annotation
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi79 ↔ 94PROSITE-ProRule annotation
Disulfide bondi97 ↔ 111PROSITE-ProRule annotation
Disulfide bondi101 ↔ 119PROSITE-ProRule annotation
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi121 ↔ 127PROSITE-ProRule annotation
Disulfide bondi136 ↔ 145PROSITE-ProRule annotation
Disulfide bondi139 ↔ 163PROSITE-ProRule annotation
Disulfide bondi166 ↔ 181PROSITE-ProRule annotation
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi208O-linked (GalNAc...) threonineBy similarity1
Glycosylationi224O-linked (GalNAc...) threonineBy similarity1
Modified residuei331PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ80WY6
PRIDEiQ80WY6

Expressioni

Gene expression databases

BgeeiENSRNOG00000016575
GenevisibleiQ80WY6 RN

Interactioni

Subunit structurei

Binds to TRAF2. Interacts with BMX. Interacts (activated form) with XPNPEP3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ80WY6, 1 interactor
STRINGi10116.ENSRNOP00000022478

Structurei

3D structure databases

ProteinModelPortaliQ80WY6
SMRiQ80WY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati39 – 77TNFR-Cys 1Add BLAST39
Repeati78 – 119TNFR-Cys 2Add BLAST42
Repeati120 – 164TNFR-Cys 3Add BLAST45
Repeati165 – 203TNFR-Cys 4Add BLAST39

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ06 Eukaryota
ENOG410YPQW LUCA
GeneTreeiENSGT00760000119204
HOGENOMiHOG000132845
HOVERGENiHBG054237
InParanoidiQ80WY6
KOiK05141
OMAiNCVIMTQ
OrthoDBiEOG091G03XW
PhylomeDBiQ80WY6
TreeFamiTF331157

Family and domain databases

CDDicd10577 TNFRSF1B, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020411 TNFR_1B
IPR033996 TNFRSF1B_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 2 hits
PRINTSiPR01919 TNFACTORR1B
SMARTiView protein in SMART
SM00208 TNFR, 4 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80WY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAALWVAL VVELQLWATG HTVPAKVVLT PYKPEPGNQC QISQEYYDKK
60 70 80 90 100
AQMCCAKCPP GQYAKHFCNK TSDTVCADCA AGMFTQVWNH LHTCLSCSSS
110 120 130 140 150
CSDDQVETHN CTKKQNRVCA CNADSYCALK LHSGNCRQCM KLSKCGPGFG
160 170 180 190 200
VARSRTSNGN VICSACAPGT FSDTTSSTDV CRPHRICSIL AIPGNASTDA
210 220 230 240 250
VCASESPTPS AVPRTIYVSQ PEPTRSQPMD QEPGPSQTPH IPVSLGSTPI
260 270 280 290 300
IEPSITGGIS LPIGLIVGLT TLGLLMLGLA NCFILVQRKK KPSCLQRETM
310 320 330 340 350
VPHLPDDKSQ DAIGLEQQHL LTTAPSSSSS SLESSASAGD RRAPPGGHPQ
360 370 380 390 400
ARVTAEAQGS QEACAGSRSS DSSHGSHGTH VNVTCIVNVC SSSDHSSQCS
410 420 430 440 450
SQASTTVGDP DANPSGSPKD EQVPFSQEEC PSQSQWETTE TLQNHDKPFP
460 470
LGVPDVGMKP NQPGWYDQIA VKVP
Length:474
Mass (Da):50,148
Last modified:June 1, 2003 - v1
Checksum:i298C6AB9E8C8D714
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF498039 mRNA Translation: AAP33151.1
AY191268 mRNA Translation: AAO61402.1
AY191269 mRNA Translation: AAO61403.1
RefSeqiNP_569110.1, NM_130426.4
UniGeneiRn.83633

Genome annotation databases

EnsembliENSRNOT00000022478; ENSRNOP00000022478; ENSRNOG00000016575
GeneIDi156767
KEGGirno:156767

Similar proteinsi

Entry informationi

Entry nameiTNR1B_RAT
AccessioniPrimary (citable) accession number: Q80WY6
Secondary accession number(s): Q5YLP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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