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Protein

DDRGK domain-containing protein 1

Gene

Ddrgk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription. May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B (By similarity). May also play a role in the cellular response to endoplasmic reticulum stress (PubMed:21494687).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
DDRGK domain-containing protein 1Curated
Alternative name(s):
UFM1-binding and PCI domain-containing protein 11 Publication
Gene namesi
Name:Ddrgk1Imported
Synonyms:Ufbp11 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1924256 Ddrgk1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000002103429 – 315DDRGK domain-containing protein 1Add BLAST287

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73PhosphoserineBy similarity1
Cross-linki268Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)By similarity

Post-translational modificationi

Ufmylated. Conjugated to ubiquitin-like protein UFM1, probably at Lys-268.1 Publication
Ubiquitinated. Ubiquitination probably triggers proteasomal degradation and is negatively regulated by UFL1, the enzyme involved in the ufmylation of DDRGK1.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ80WW9
MaxQBiQ80WW9
PaxDbiQ80WW9
PeptideAtlasiQ80WW9
PRIDEiQ80WW9

PTM databases

iPTMnetiQ80WW9
PhosphoSitePlusiQ80WW9

Expressioni

Tissue specificityi

Ubiquitously expressed (PubMed:20228063). Higher expression in pancreatic islets, pancreatic acini and testis (at protein level) (PubMed:21494687).2 Publications

Gene expression databases

BgeeiENSMUSG00000068290
ExpressionAtlasiQ80WW9 baseline and differential
GenevisibleiQ80WW9 MM

Interactioni

Subunit structurei

Interacts with TRIP4; the interaction with TRIP4 is direct. Interacts with UFL1. Interacts with NFKBIA. Interacts with CDK5RAP3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218455, 1 interactor
STRINGi10090.ENSMUSP00000086988

Structurei

Secondary structure

1315
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi216 – 226Combined sources11
Beta strandi228 – 230Combined sources3
Helixi232 – 239Combined sources8
Helixi243 – 256Combined sources14
Beta strandi257 – 259Combined sources3
Beta strandi261 – 263Combined sources3
Beta strandi269 – 271Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WI9NMR-A216-274[»]
ProteinModelPortaliQ80WW9
SMRiQ80WW9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ80WW9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini230 – 274PCIAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 115Mediates interaction with CDK5RAP3By similarityAdd BLAST115
Regioni119 – 217Mediates interaction with TRIP4By similarityAdd BLAST99
Regioni217 – 315Mediates interaction with UFL1By similarityAdd BLAST99

Sequence similaritiesi

Belongs to the DDRGK1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3054 Eukaryota
ENOG4111IPW LUCA
GeneTreeiENSGT00390000017193
HOGENOMiHOG000005758
HOVERGENiHBG051191
InParanoidiQ80WW9
OMAiEERGAGM
OrthoDBiEOG091G0SU6
PhylomeDBiQ80WW9
TreeFamiTF314645

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR019153 DDRGK_dom-contain
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF09756 DDRGK, 1 hit
SMARTiView protein in SMART
SM01128 DDRGK, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80WW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGPWVYLVA AVLLIGLILF LTRSRGRAAA ADGEPLHNEE ERAGAGQVGR
60 70 80 90 100
SLPQESEEQR TGSRPRRRRD LGSRLQAQRR AQRVAWEDGD ENVGQTVIPA
110 120 130 140 150
QEEEGIEKPA EVHPTGKIGA KKLRKLEEKQ ARKAQREAEE AEREERKRLE
160 170 180 190 200
SQREAEWKKE EERLRLKEEQ KEEEERKAQE EQARREHEEY LKLKEAFVVE
210 220 230 240 250
EEGVSETMTE EQSHSFLTEF INYIKKSKVV LLEDLAFQMG LRTQDAINRI
260 270 280 290 300
QDLLTEGTLT GVIDDRGKFI YITPEELAAV ANFIRQRGRV SITELAQASN
310
SLISWGQDLP AQASA
Length:315
Mass (Da):35,977
Last modified:September 26, 2003 - v2
Checksum:iD973B9AFBE265562
GO

Sequence cautioni

The sequence AAH51541 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731707, AL772162 Genomic DNA Translation: CAM13264.1
AL772162, AL731707 Genomic DNA Translation: CAM16448.1
CH466519 Genomic DNA Translation: EDL28284.1
BC115616 mRNA Translation: AAI15617.1
BC115617 mRNA Translation: AAI15618.1
BC051541 mRNA Translation: AAH51541.1 Different initiation.
AK011170 mRNA Translation: BAB27444.1
CCDSiCCDS38243.1
RefSeqiNP_084108.1, NM_029832.2
UniGeneiMm.440063

Genome annotation databases

EnsembliENSMUST00000089559; ENSMUSP00000086988; ENSMUSG00000068290
GeneIDi77006
KEGGimmu:77006
UCSCiuc008mjs.1 mouse

Entry informationi

Entry nameiDDRGK_MOUSE
AccessioniPrimary (citable) accession number: Q80WW9
Secondary accession number(s): Q14BT4, Q9CT52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: September 26, 2003
Last modified: March 28, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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