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Protein

Probable G-protein coupled receptor 176

Gene

Gpr176

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 176
Alternative name(s):
G-protein coupled receptor AGR9
Gene namesi
Name:Gpr176
Synonyms:Agr9, Gm1012
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2685858. Gpr176.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence analysisAdd
BLAST
Transmembranei42 – 6423Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini65 – 7713CytoplasmicSequence analysisAdd
BLAST
Transmembranei78 – 9821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini99 – 10810ExtracellularSequence analysis
Transmembranei109 – 12921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini130 – 15728CytoplasmicSequence analysisAdd
BLAST
Transmembranei158 – 17720Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini178 – 20427ExtracellularSequence analysisAdd
BLAST
Transmembranei205 – 22521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini226 – 26439CytoplasmicSequence analysisAdd
BLAST
Transmembranei265 – 28521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini286 – 30116ExtracellularSequence analysisAdd
BLAST
Transmembranei302 – 32221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini323 – 515193CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Probable G-protein coupled receptor 176PRO_0000069657Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ80WT4.
PaxDbiQ80WT4.
PRIDEiQ80WT4.

PTM databases

iPTMnetiQ80WT4.
PhosphoSiteiQ80WT4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040133.
CleanExiMM_GPR176.
GenevisibleiQ80WT4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037586.

Structurei

3D structure databases

ProteinModelPortaliQ80WT4.
SMRiQ80WT4. Positions 45-319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123027.
HOGENOMiHOG000231854.
HOVERGENiHBG080463.
InParanoidiQ80WT4.
KOiK08442.
OMAiIWAHAVV.
OrthoDBiEOG091G032V.
PhylomeDBiQ80WT4.
TreeFamiTF331506.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80WT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHNSSWVSP NTSHPRNTSG AEAGANLSAF GELSEAQLYR QFTTTVQVVI
60 70 80 90 100
FIGSLLGNFM VLWSTCRTTV FKSVTNRFIK NLACSGICAS VVCVPFDIIL
110 120 130 140 150
SSSPHCCWWI YTMLFCKVLK FLHKVFCSVT VLSFPAIALD RYYSVLYPLE
160 170 180 190 200
RKISDAKSRE LVMYIWAHAV VASVPVFAVT NVADIYAMST CTEVWSNSLG
210 220 230 240 250
HLVYVLIYNV TTVIVPVAVV FLFLILIRRA LSASQKKKVI IAALRTPQNT
260 270 280 290 300
ISIPYASQRE AELHATLLSM VTVFILCSVP YATLVVYQTV LNVPNTSVFL
310 320 330 340 350
LLTAIWLPKV SLLANPVLFL TVNKSVRKCL VGTLVQLHHR YSRRNVVSTG
360 370 380 390 400
SGVAEPSLEP SMRSGSQLLE MFHIGQQQIF KPSEDEEESE AKYLGSADFQ
410 420 430 440 450
AKEVLTSCPE GEQEPPQLAP SVPPPGTVDS EPRVSPVAPM ESGIFPDKYS
460 470 480 490 500
LQFGFGPFEL PPQWLSETRN SKKRLLPPLG NTPEELIQTK VPRVNRVERK
510
MSRNNKVSIF PKVDS
Length:515
Mass (Da):57,143
Last modified:June 1, 2003 - v1
Checksum:i81D9B48CE5C4BB70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052037 mRNA. Translation: AAH52037.1.
AY255554 mRNA. Translation: AAO85066.1.
CCDSiCCDS16575.1.
RefSeqiNP_958755.1. NM_201367.3.
UniGeneiMm.70979.

Genome annotation databases

EnsembliENSMUST00000039160; ENSMUSP00000037586; ENSMUSG00000040133.
GeneIDi381413.
KEGGimmu:381413.
UCSCiuc008lru.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052037 mRNA. Translation: AAH52037.1.
AY255554 mRNA. Translation: AAO85066.1.
CCDSiCCDS16575.1.
RefSeqiNP_958755.1. NM_201367.3.
UniGeneiMm.70979.

3D structure databases

ProteinModelPortaliQ80WT4.
SMRiQ80WT4. Positions 45-319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037586.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ80WT4.
PhosphoSiteiQ80WT4.

Proteomic databases

MaxQBiQ80WT4.
PaxDbiQ80WT4.
PRIDEiQ80WT4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039160; ENSMUSP00000037586; ENSMUSG00000040133.
GeneIDi381413.
KEGGimmu:381413.
UCSCiuc008lru.2. mouse.

Organism-specific databases

CTDi11245.
MGIiMGI:2685858. Gpr176.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123027.
HOGENOMiHOG000231854.
HOVERGENiHBG080463.
InParanoidiQ80WT4.
KOiK08442.
OMAiIWAHAVV.
OrthoDBiEOG091G032V.
PhylomeDBiQ80WT4.
TreeFamiTF331506.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiQ80WT4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040133.
CleanExiMM_GPR176.
GenevisibleiQ80WT4. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP176_MOUSE
AccessioniPrimary (citable) accession number: Q80WT4
Secondary accession number(s): Q80UC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.