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Protein

G-protein coupled receptor 176

Gene

Gpr176

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Orphan receptor involved in normal circadian rhythm behavior (PubMed:26882873). Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production (PubMed:26882873).1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB

GO - Biological processi

  • circadian behavior Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • negative regulation of cAMP biosynthetic process Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBiological rhythms

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 176
Alternative name(s):
G-protein coupled receptor AGR9
Gene namesi
Name:Gpr176
Synonyms:Agr9, Gm1012
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2685858. Gpr176.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 64Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini65 – 77CytoplasmicCuratedAdd BLAST13
Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini99 – 108ExtracellularCurated10
Transmembranei109 – 129Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini130 – 157CytoplasmicCuratedAdd BLAST28
Transmembranei158 – 177Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini178 – 204ExtracellularCuratedAdd BLAST27
Transmembranei205 – 225Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini226 – 264CytoplasmicCuratedAdd BLAST39
Transmembranei265 – 285Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini286 – 301ExtracellularCuratedAdd BLAST16
Transmembranei302 – 322Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini323 – 515CytoplasmicCuratedAdd BLAST193

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Deficient mice exhibit a significantly shorter circadian period.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi140 – 141DR → RD: Decreases expression; No reduction of cAMP upon induction. 1 Publication2
Mutagenesisi145V → R: No reduction of cAMP upon induction. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696571 – 515G-protein coupled receptor 176Add BLAST515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi11N-linked (GlcNAc...)Sequence analysis1
Glycosylationi17N-linked (GlcNAc...)Sequence analysis1
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ80WT4.
PaxDbiQ80WT4.
PRIDEiQ80WT4.

PTM databases

iPTMnetiQ80WT4.
PhosphoSitePlusiQ80WT4.

Expressioni

Tissue specificityi

Expressed mainly in the brain, with prominent expression in the SCN (at protein level) (PubMed:26882873).1 Publication

Developmental stagei

Fluctuates in a circadian fashion, with highest level in night and lowest in the morning (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000040133.
CleanExiMM_GPR176.
GenevisibleiQ80WT4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037586.

Structurei

3D structure databases

ProteinModelPortaliQ80WT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123027.
HOGENOMiHOG000231854.
HOVERGENiHBG080463.
InParanoidiQ80WT4.
KOiK08442.
OMAiIWAHAVV.
OrthoDBiEOG091G032V.
PhylomeDBiQ80WT4.
TreeFamiTF331506.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80WT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHNSSWVSP NTSHPRNTSG AEAGANLSAF GELSEAQLYR QFTTTVQVVI
60 70 80 90 100
FIGSLLGNFM VLWSTCRTTV FKSVTNRFIK NLACSGICAS VVCVPFDIIL
110 120 130 140 150
SSSPHCCWWI YTMLFCKVLK FLHKVFCSVT VLSFPAIALD RYYSVLYPLE
160 170 180 190 200
RKISDAKSRE LVMYIWAHAV VASVPVFAVT NVADIYAMST CTEVWSNSLG
210 220 230 240 250
HLVYVLIYNV TTVIVPVAVV FLFLILIRRA LSASQKKKVI IAALRTPQNT
260 270 280 290 300
ISIPYASQRE AELHATLLSM VTVFILCSVP YATLVVYQTV LNVPNTSVFL
310 320 330 340 350
LLTAIWLPKV SLLANPVLFL TVNKSVRKCL VGTLVQLHHR YSRRNVVSTG
360 370 380 390 400
SGVAEPSLEP SMRSGSQLLE MFHIGQQQIF KPSEDEEESE AKYLGSADFQ
410 420 430 440 450
AKEVLTSCPE GEQEPPQLAP SVPPPGTVDS EPRVSPVAPM ESGIFPDKYS
460 470 480 490 500
LQFGFGPFEL PPQWLSETRN SKKRLLPPLG NTPEELIQTK VPRVNRVERK
510
MSRNNKVSIF PKVDS
Length:515
Mass (Da):57,143
Last modified:June 1, 2003 - v1
Checksum:i81D9B48CE5C4BB70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052037 mRNA. Translation: AAH52037.1.
AY255554 mRNA. Translation: AAO85066.1.
CCDSiCCDS16575.1.
RefSeqiNP_958755.1. NM_201367.3.
UniGeneiMm.70979.

Genome annotation databases

EnsembliENSMUST00000039160; ENSMUSP00000037586; ENSMUSG00000040133.
GeneIDi381413.
KEGGimmu:381413.
UCSCiuc008lru.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052037 mRNA. Translation: AAH52037.1.
AY255554 mRNA. Translation: AAO85066.1.
CCDSiCCDS16575.1.
RefSeqiNP_958755.1. NM_201367.3.
UniGeneiMm.70979.

3D structure databases

ProteinModelPortaliQ80WT4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037586.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ80WT4.
PhosphoSitePlusiQ80WT4.

Proteomic databases

MaxQBiQ80WT4.
PaxDbiQ80WT4.
PRIDEiQ80WT4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039160; ENSMUSP00000037586; ENSMUSG00000040133.
GeneIDi381413.
KEGGimmu:381413.
UCSCiuc008lru.2. mouse.

Organism-specific databases

CTDi11245.
MGIiMGI:2685858. Gpr176.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123027.
HOGENOMiHOG000231854.
HOVERGENiHBG080463.
InParanoidiQ80WT4.
KOiK08442.
OMAiIWAHAVV.
OrthoDBiEOG091G032V.
PhylomeDBiQ80WT4.
TreeFamiTF331506.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.

Miscellaneous databases

PROiPR:Q80WT4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040133.
CleanExiMM_GPR176.
GenevisibleiQ80WT4. MM.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGP176_MOUSE
AccessioniPrimary (citable) accession number: Q80WT4
Secondary accession number(s): Q80UC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 1, 2003
Last modified: April 12, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.