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Protein

Doublesex- and mab-3-related transcription factor 3

Gene

Dmrt3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development.1 Publication

Miscellaneous

DMRT3 is a marker for a subset of spinal cord neurons (dI6).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi29 – 76DMPROSITE-ProRule annotationAdd BLAST48

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: MGI
  • sequence-specific DNA binding Source: MGI
  • transcription factor activity, sequence-specific DNA binding Source: InterPro

GO - Biological processi

  • adult walking behavior Source: MGI
  • male sex differentiation Source: MGI
  • regulation of odontogenesis of dentin-containing tooth Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • transmission of nerve impulse Source: MGI
  • ventral spinal cord interneuron specification Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Sexual differentiation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Doublesex- and mab-3-related transcription factor 3
Gene namesi
Name:Dmrt3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2449470. Dmrt3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: MGI

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Significantly increase of stride length and extension movements in all limbs. Mice have major difficulties running at higher velocities. In water, mice spend less time swimming and showed frequent twitching limb movements.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002777951 – 476Doublesex- and mab-3-related transcription factor 3Add BLAST476

Proteomic databases

PaxDbiQ80WT2.
PRIDEiQ80WT2.

PTM databases

iPTMnetiQ80WT2.
PhosphoSitePlusiQ80WT2.

Expressioni

Tissue specificityi

Expressed in the ventral spinal cord, in a restrical population of neurons migrating ventrically in the developing spinal cord at E11.5.1 Publication

Developmental stagei

Expressed at E14.5 in testis, kidney and bladder. Expression drops at E13.5 in female gonads and is not detected at E15.5 while it is expressed by Sertoli cells in testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000042372.
GenevisibleiQ80WT2. MM.

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI

Structurei

3D structure databases

ProteinModelPortaliQ80WT2.
SMRiQ80WT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DMRT family.Curated

Phylogenomic databases

eggNOGiKOG3815. Eukaryota.
ENOG410XSK9. LUCA.
GeneTreeiENSGT00550000074486.
HOGENOMiHOG000112230.
HOVERGENiHBG080568.
InParanoidiQ80WT2.
KOiK19490.
OMAiSNGHLFE.
OrthoDBiEOG091G08TD.
PhylomeDBiQ80WT2.
TreeFamiTF317837.

Family and domain databases

Gene3Di4.10.1040.10. 1 hit.
InterProiView protein in InterPro
IPR001275. DM_DNA-bd.
IPR005173. DMA.
IPR026607. DMRT/dsx/mab-3.
IPR009060. UBA-like.
PANTHERiPTHR12322. PTHR12322. 1 hit.
PfamiView protein in Pfam
PF00751. DM. 1 hit.
PF03474. DMA. 1 hit.
SMARTiView protein in SMART
SM00301. DM. 1 hit.
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF82927. SSF82927. 1 hit.
PROSITEiView protein in PROSITE
PS40000. DM_1. 1 hit.
PS50809. DM_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80WT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGYGSPYLY MGGPVSQPPR APLQRTPKCA RCRNHGVLSW LKGHKRYCRF
60 70 80 90 100
KDCTCEKCIL IIERQRVMAA QVALRRQQAN ESLESLIPDS LRALPGPPPP
110 120 130 140 150
GDAAATAATA SQSSPASQAS QPPAPPRPTA ELAAAAALRW VAEPQPGTLP
160 170 180 190 200
AQLAKPDLTE ERVGDSSSTD NTAEAFSDKD TDQRSSPDVV KSKNCFTPES
210 220 230 240 250
PEIVSVDEGG YAVQKNGGNP ESCPDSPKYH AEQSHLLIEG PSGTVSLPFS
260 270 280 290 300
LKANRPPLEV LKKIFPNQKP TVLELILKGC GGDLVSAVEV LLSSRSSAAG
310 320 330 340 350
AERTAEESLV LPSSGHIFEH TLGSYPISSS KWSVGSAFRV PDTLRFSADS
360 370 380 390 400
SNVVPNPLAV PLQHPFPQPP RYPLMLRNTL ARNQSSPFLP NDVTLWNTMT
410 420 430 440 450
LQQQYQLRSQ YVSPFPSNST SVFRSSPVLS SRTTEDPRIS IPDDGCPIVT
460 470
KQSIYTEDDY DERSDSSDSR ILNTSS
Length:476
Mass (Da):51,518
Last modified:March 1, 2004 - v2
Checksum:i7FC6A4ED5DAE62A1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93A → D in AAN77230 (PubMed:16141072).Curated1
Sequence conflicti301A → T in AAN77230 (PubMed:16141072).Curated1
Sequence conflicti361P → H in AAN77230 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF541936 mRNA. Translation: AAN77230.1.
BC052041 mRNA. Translation: AAH52041.2.
CCDSiCCDS29718.1.
RefSeqiNP_796334.2. NM_177360.3.
XP_006527129.1. XM_006527066.3.
UniGeneiMm.62785.

Genome annotation databases

EnsembliENSMUST00000048935; ENSMUSP00000046812; ENSMUSG00000042372.
GeneIDi240590.
KEGGimmu:240590.
UCSCiuc008hbk.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDMRT3_MOUSE
AccessioniPrimary (citable) accession number: Q80WT2
Secondary accession number(s): Q8CGX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2004
Last modified: July 5, 2017
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families