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Q80WT2 (DMRT3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Doublesex- and mab-3-related transcription factor 3
Gene names
Name:Dmrt3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length476 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development. Ref.4

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed in the ventral spinal cord, in a restrical population of neurons migrating ventrically in the developing spinal cord at E11.5. Ref.4

Developmental stage

Expressed at E14.5 in testis, kidney and bladder. Expression drops at E13.5 in female gonads and is not detected at E15.5 while it is expressed by Sertoli cells in testis. Ref.3

Disruption phenotype

Significantly increase of stride length and extension movements in all limbs. Mice have major difficulties running at higher velocities. In water, mice spend less time swimming and showed frequent twitching limb movements. Ref.4

Miscellaneous

DMRT3 is a marker for a subset of spinal cord neurons (dI6).

Sequence similarities

Belongs to the DMRT family.

Contains 1 DM DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 476476Doublesex- and mab-3-related transcription factor 3
PRO_0000277795

Regions

DNA binding29 – 7648DM

Experimental info

Sequence conflict931A → D in AAN77230. Ref.1
Sequence conflict3011A → T in AAN77230. Ref.1
Sequence conflict3611P → H in AAN77230. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q80WT2 [UniParc].

Last modified March 1, 2004. Version 2.
Checksum: 7FC6A4ED5DAE62A1

FASTA47651,518
        10         20         30         40         50         60 
MNGYGSPYLY MGGPVSQPPR APLQRTPKCA RCRNHGVLSW LKGHKRYCRF KDCTCEKCIL 

        70         80         90        100        110        120 
IIERQRVMAA QVALRRQQAN ESLESLIPDS LRALPGPPPP GDAAATAATA SQSSPASQAS 

       130        140        150        160        170        180 
QPPAPPRPTA ELAAAAALRW VAEPQPGTLP AQLAKPDLTE ERVGDSSSTD NTAEAFSDKD 

       190        200        210        220        230        240 
TDQRSSPDVV KSKNCFTPES PEIVSVDEGG YAVQKNGGNP ESCPDSPKYH AEQSHLLIEG 

       250        260        270        280        290        300 
PSGTVSLPFS LKANRPPLEV LKKIFPNQKP TVLELILKGC GGDLVSAVEV LLSSRSSAAG 

       310        320        330        340        350        360 
AERTAEESLV LPSSGHIFEH TLGSYPISSS KWSVGSAFRV PDTLRFSADS SNVVPNPLAV 

       370        380        390        400        410        420 
PLQHPFPQPP RYPLMLRNTL ARNQSSPFLP NDVTLWNTMT LQQQYQLRSQ YVSPFPSNST 

       430        440        450        460        470 
SVFRSSPVLS SRTTEDPRIS IPDDGCPIVT KQSIYTEDDY DERSDSSDSR ILNTSS 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[3]"Sexually dimorphic expression of multiple doublesex-related genes in the embryonic mouse gonad."
Kim S., Kettlewell J.R., Anderson R.C., Bardwell V.J., Zarkower D.
Gene Expr. Patterns 3:77-82(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
[4]"Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice."
Andersson L.S., Larhammar M., Memic F., Wootz H., Schwochow D., Rubin C.-J., Patra K., Arnason T., Wellbring L., Hjalm G., Imsland F., Petersen J.L., McCue M.E., Mickelson J.R., Cothran G., Ahituv N., Roepstorff L., Mikko S. expand/collapse author list , Vallstedt A., Lindgren G., Andersson L., Kullander K.
Nature 488:642-646(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Web resources

Protein Spotlight

A gait on the wildside - Issue 154 of November 2013

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF541936 mRNA. Translation: AAN77230.1.
BC052041 mRNA. Translation: AAH52041.2.
RefSeqNP_796334.2. NM_177360.3.
XP_006527129.1. XM_006527066.1.
UniGeneMm.62785.

3D structure databases

ProteinModelPortalQ80WT2.
SMRQ80WT2. Positions 16-71.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000046812.

PTM databases

PhosphoSiteQ80WT2.

Proteomic databases

PRIDEQ80WT2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000048935; ENSMUSP00000046812; ENSMUSG00000042372.
GeneID240590.
KEGGmmu:240590.
UCSCuc008hbk.2. mouse.

Organism-specific databases

CTD58524.
MGIMGI:2449470. Dmrt3.

Phylogenomic databases

eggNOGNOG245377.
GeneTreeENSGT00550000074486.
HOGENOMHOG000112230.
HOVERGENHBG080568.
InParanoidQ80WT2.
OMASKSCFTP.
OrthoDBEOG7TXKGH.
PhylomeDBQ80WT2.
TreeFamTF317837.

Gene expression databases

BgeeQ80WT2.
GenevestigatorQ80WT2.

Family and domain databases

Gene3D4.10.1040.10. 1 hit.
InterProIPR001275. DM_DNA-bd.
IPR005173. DMA.
IPR026607. DMRT/dsx/mab-3.
IPR009060. UBA-like.
[Graphical view]
PANTHERPTHR12322. PTHR12322. 1 hit.
PfamPF00751. DM. 1 hit.
PF03474. DMA. 1 hit.
[Graphical view]
SMARTSM00301. DM. 1 hit.
[Graphical view]
SUPFAMSSF46934. SSF46934. 1 hit.
SSF82927. SSF82927. 1 hit.
PROSITEPS40000. DM_1. 1 hit.
PS50809. DM_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio384629.
PROQ80WT2.
SOURCESearch...

Entry information

Entry nameDMRT3_MOUSE
AccessionPrimary (citable) accession number: Q80WT2
Secondary accession number(s): Q8CGX1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2004
Last modified: April 16, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot