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Q80WT2

- DMRT3_MOUSE

UniProt

Q80WT2 - DMRT3_MOUSE

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Protein

Doublesex- and mab-3-related transcription factor 3

Gene

Dmrt3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi29 – 7648DMPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein heterodimerization activity Source: MGI
  3. sequence-specific DNA binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. adult walking behavior Source: MGI
  2. male sex differentiation Source: MGI
  3. regulation of odontogenesis of dentin-containing tooth Source: MGI
  4. transcription, DNA-templated Source: UniProtKB-KW
  5. transmission of nerve impulse Source: MGI
  6. ventral spinal cord interneuron specification Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Sexual differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Doublesex- and mab-3-related transcription factor 3
Gene namesi
Name:Dmrt3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:2449470. Dmrt3.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Significantly increase of stride length and extension movements in all limbs. Mice have major difficulties running at higher velocities. In water, mice spend less time swimming and showed frequent twitching limb movements.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476Doublesex- and mab-3-related transcription factor 3PRO_0000277795Add
BLAST

Proteomic databases

PRIDEiQ80WT2.

PTM databases

PhosphoSiteiQ80WT2.

Expressioni

Tissue specificityi

Expressed in the ventral spinal cord, in a restrical population of neurons migrating ventrically in the developing spinal cord at E11.5.1 Publication

Developmental stagei

Expressed at E14.5 in testis, kidney and bladder. Expression drops at E13.5 in female gonads and is not detected at E15.5 while it is expressed by Sertoli cells in testis.1 Publication

Gene expression databases

BgeeiQ80WT2.
GenevestigatoriQ80WT2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046812.

Structurei

3D structure databases

ProteinModelPortaliQ80WT2.
SMRiQ80WT2. Positions 16-71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DMRT family.Curated
Contains 1 DM DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG245377.
GeneTreeiENSGT00550000074486.
HOGENOMiHOG000112230.
HOVERGENiHBG080568.
InParanoidiQ80WT2.
OMAiSKSCFTP.
OrthoDBiEOG7TXKGH.
PhylomeDBiQ80WT2.
TreeFamiTF317837.

Family and domain databases

Gene3Di4.10.1040.10. 1 hit.
InterProiIPR001275. DM_DNA-bd.
IPR005173. DMA.
IPR026607. DMRT/dsx/mab-3.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR12322. PTHR12322. 1 hit.
PfamiPF00751. DM. 1 hit.
PF03474. DMA. 1 hit.
[Graphical view]
SMARTiSM00301. DM. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF82927. SSF82927. 1 hit.
PROSITEiPS40000. DM_1. 1 hit.
PS50809. DM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80WT2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNGYGSPYLY MGGPVSQPPR APLQRTPKCA RCRNHGVLSW LKGHKRYCRF
60 70 80 90 100
KDCTCEKCIL IIERQRVMAA QVALRRQQAN ESLESLIPDS LRALPGPPPP
110 120 130 140 150
GDAAATAATA SQSSPASQAS QPPAPPRPTA ELAAAAALRW VAEPQPGTLP
160 170 180 190 200
AQLAKPDLTE ERVGDSSSTD NTAEAFSDKD TDQRSSPDVV KSKNCFTPES
210 220 230 240 250
PEIVSVDEGG YAVQKNGGNP ESCPDSPKYH AEQSHLLIEG PSGTVSLPFS
260 270 280 290 300
LKANRPPLEV LKKIFPNQKP TVLELILKGC GGDLVSAVEV LLSSRSSAAG
310 320 330 340 350
AERTAEESLV LPSSGHIFEH TLGSYPISSS KWSVGSAFRV PDTLRFSADS
360 370 380 390 400
SNVVPNPLAV PLQHPFPQPP RYPLMLRNTL ARNQSSPFLP NDVTLWNTMT
410 420 430 440 450
LQQQYQLRSQ YVSPFPSNST SVFRSSPVLS SRTTEDPRIS IPDDGCPIVT
460 470
KQSIYTEDDY DERSDSSDSR ILNTSS
Length:476
Mass (Da):51,518
Last modified:March 1, 2004 - v2
Checksum:i7FC6A4ED5DAE62A1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931A → D in AAN77230. (PubMed:16141072)Curated
Sequence conflicti301 – 3011A → T in AAN77230. (PubMed:16141072)Curated
Sequence conflicti361 – 3611P → H in AAN77230. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF541936 mRNA. Translation: AAN77230.1.
BC052041 mRNA. Translation: AAH52041.2.
CCDSiCCDS29718.1.
RefSeqiNP_796334.2. NM_177360.3.
XP_006527129.1. XM_006527066.1.
UniGeneiMm.62785.

Genome annotation databases

EnsembliENSMUST00000048935; ENSMUSP00000046812; ENSMUSG00000042372.
GeneIDi240590.
KEGGimmu:240590.
UCSCiuc008hbk.2. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

A gait on the wildside - Issue 154 of November 2013

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF541936 mRNA. Translation: AAN77230.1 .
BC052041 mRNA. Translation: AAH52041.2 .
CCDSi CCDS29718.1.
RefSeqi NP_796334.2. NM_177360.3.
XP_006527129.1. XM_006527066.1.
UniGenei Mm.62785.

3D structure databases

ProteinModelPortali Q80WT2.
SMRi Q80WT2. Positions 16-71.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000046812.

PTM databases

PhosphoSitei Q80WT2.

Proteomic databases

PRIDEi Q80WT2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048935 ; ENSMUSP00000046812 ; ENSMUSG00000042372 .
GeneIDi 240590.
KEGGi mmu:240590.
UCSCi uc008hbk.2. mouse.

Organism-specific databases

CTDi 58524.
MGIi MGI:2449470. Dmrt3.

Phylogenomic databases

eggNOGi NOG245377.
GeneTreei ENSGT00550000074486.
HOGENOMi HOG000112230.
HOVERGENi HBG080568.
InParanoidi Q80WT2.
OMAi SKSCFTP.
OrthoDBi EOG7TXKGH.
PhylomeDBi Q80WT2.
TreeFami TF317837.

Miscellaneous databases

NextBioi 384629.
PROi Q80WT2.
SOURCEi Search...

Gene expression databases

Bgeei Q80WT2.
Genevestigatori Q80WT2.

Family and domain databases

Gene3Di 4.10.1040.10. 1 hit.
InterProi IPR001275. DM_DNA-bd.
IPR005173. DMA.
IPR026607. DMRT/dsx/mab-3.
IPR009060. UBA-like.
[Graphical view ]
PANTHERi PTHR12322. PTHR12322. 1 hit.
Pfami PF00751. DM. 1 hit.
PF03474. DMA. 1 hit.
[Graphical view ]
SMARTi SM00301. DM. 1 hit.
[Graphical view ]
SUPFAMi SSF46934. SSF46934. 1 hit.
SSF82927. SSF82927. 1 hit.
PROSITEi PS40000. DM_1. 1 hit.
PS50809. DM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Sexually dimorphic expression of multiple doublesex-related genes in the embryonic mouse gonad."
    Kim S., Kettlewell J.R., Anderson R.C., Bardwell V.J., Zarkower D.
    Gene Expr. Patterns 3:77-82(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  4. Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiDMRT3_MOUSE
AccessioniPrimary (citable) accession number: Q80WT2
Secondary accession number(s): Q8CGX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2004
Last modified: October 1, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

DMRT3 is a marker for a subset of spinal cord neurons (dI6).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3