Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q80WT2

- DMRT3_MOUSE

UniProt

Q80WT2 - DMRT3_MOUSE

Protein

Doublesex- and mab-3-related transcription factor 3

Gene

Dmrt3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (01 Mar 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi29 – 7648DMPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein heterodimerization activity Source: MGI
    3. sequence-specific DNA binding Source: MGI
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. adult walking behavior Source: MGI
    2. male sex differentiation Source: MGI
    3. regulation of odontogenesis of dentin-containing tooth Source: MGI
    4. transcription, DNA-templated Source: UniProtKB-KW
    5. transmission of nerve impulse Source: MGI
    6. ventral spinal cord interneuron specification Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Sexual differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Doublesex- and mab-3-related transcription factor 3
    Gene namesi
    Name:Dmrt3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:2449470. Dmrt3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Significantly increase of stride length and extension movements in all limbs. Mice have major difficulties running at higher velocities. In water, mice spend less time swimming and showed frequent twitching limb movements.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 476476Doublesex- and mab-3-related transcription factor 3PRO_0000277795Add
    BLAST

    Proteomic databases

    PRIDEiQ80WT2.

    PTM databases

    PhosphoSiteiQ80WT2.

    Expressioni

    Tissue specificityi

    Expressed in the ventral spinal cord, in a restrical population of neurons migrating ventrically in the developing spinal cord at E11.5.1 Publication

    Developmental stagei

    Expressed at E14.5 in testis, kidney and bladder. Expression drops at E13.5 in female gonads and is not detected at E15.5 while it is expressed by Sertoli cells in testis.1 Publication

    Gene expression databases

    BgeeiQ80WT2.
    GenevestigatoriQ80WT2.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000046812.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80WT2.
    SMRiQ80WT2. Positions 16-71.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DMRT family.Curated
    Contains 1 DM DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG245377.
    GeneTreeiENSGT00550000074486.
    HOGENOMiHOG000112230.
    HOVERGENiHBG080568.
    InParanoidiQ80WT2.
    OMAiSKSCFTP.
    OrthoDBiEOG7TXKGH.
    PhylomeDBiQ80WT2.
    TreeFamiTF317837.

    Family and domain databases

    Gene3Di4.10.1040.10. 1 hit.
    InterProiIPR001275. DM_DNA-bd.
    IPR005173. DMA.
    IPR026607. DMRT/dsx/mab-3.
    IPR009060. UBA-like.
    [Graphical view]
    PANTHERiPTHR12322. PTHR12322. 1 hit.
    PfamiPF00751. DM. 1 hit.
    PF03474. DMA. 1 hit.
    [Graphical view]
    SMARTiSM00301. DM. 1 hit.
    [Graphical view]
    SUPFAMiSSF46934. SSF46934. 1 hit.
    SSF82927. SSF82927. 1 hit.
    PROSITEiPS40000. DM_1. 1 hit.
    PS50809. DM_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q80WT2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNGYGSPYLY MGGPVSQPPR APLQRTPKCA RCRNHGVLSW LKGHKRYCRF    50
    KDCTCEKCIL IIERQRVMAA QVALRRQQAN ESLESLIPDS LRALPGPPPP 100
    GDAAATAATA SQSSPASQAS QPPAPPRPTA ELAAAAALRW VAEPQPGTLP 150
    AQLAKPDLTE ERVGDSSSTD NTAEAFSDKD TDQRSSPDVV KSKNCFTPES 200
    PEIVSVDEGG YAVQKNGGNP ESCPDSPKYH AEQSHLLIEG PSGTVSLPFS 250
    LKANRPPLEV LKKIFPNQKP TVLELILKGC GGDLVSAVEV LLSSRSSAAG 300
    AERTAEESLV LPSSGHIFEH TLGSYPISSS KWSVGSAFRV PDTLRFSADS 350
    SNVVPNPLAV PLQHPFPQPP RYPLMLRNTL ARNQSSPFLP NDVTLWNTMT 400
    LQQQYQLRSQ YVSPFPSNST SVFRSSPVLS SRTTEDPRIS IPDDGCPIVT 450
    KQSIYTEDDY DERSDSSDSR ILNTSS 476
    Length:476
    Mass (Da):51,518
    Last modified:March 1, 2004 - v2
    Checksum:i7FC6A4ED5DAE62A1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti93 – 931A → D in AAN77230. (PubMed:16141072)Curated
    Sequence conflicti301 – 3011A → T in AAN77230. (PubMed:16141072)Curated
    Sequence conflicti361 – 3611P → H in AAN77230. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF541936 mRNA. Translation: AAN77230.1.
    BC052041 mRNA. Translation: AAH52041.2.
    CCDSiCCDS29718.1.
    RefSeqiNP_796334.2. NM_177360.3.
    XP_006527129.1. XM_006527066.1.
    UniGeneiMm.62785.

    Genome annotation databases

    EnsembliENSMUST00000048935; ENSMUSP00000046812; ENSMUSG00000042372.
    GeneIDi240590.
    KEGGimmu:240590.
    UCSCiuc008hbk.2. mouse.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    A gait on the wildside - Issue 154 of November 2013

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF541936 mRNA. Translation: AAN77230.1 .
    BC052041 mRNA. Translation: AAH52041.2 .
    CCDSi CCDS29718.1.
    RefSeqi NP_796334.2. NM_177360.3.
    XP_006527129.1. XM_006527066.1.
    UniGenei Mm.62785.

    3D structure databases

    ProteinModelPortali Q80WT2.
    SMRi Q80WT2. Positions 16-71.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000046812.

    PTM databases

    PhosphoSitei Q80WT2.

    Proteomic databases

    PRIDEi Q80WT2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048935 ; ENSMUSP00000046812 ; ENSMUSG00000042372 .
    GeneIDi 240590.
    KEGGi mmu:240590.
    UCSCi uc008hbk.2. mouse.

    Organism-specific databases

    CTDi 58524.
    MGIi MGI:2449470. Dmrt3.

    Phylogenomic databases

    eggNOGi NOG245377.
    GeneTreei ENSGT00550000074486.
    HOGENOMi HOG000112230.
    HOVERGENi HBG080568.
    InParanoidi Q80WT2.
    OMAi SKSCFTP.
    OrthoDBi EOG7TXKGH.
    PhylomeDBi Q80WT2.
    TreeFami TF317837.

    Miscellaneous databases

    NextBioi 384629.
    PROi Q80WT2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q80WT2.
    Genevestigatori Q80WT2.

    Family and domain databases

    Gene3Di 4.10.1040.10. 1 hit.
    InterProi IPR001275. DM_DNA-bd.
    IPR005173. DMA.
    IPR026607. DMRT/dsx/mab-3.
    IPR009060. UBA-like.
    [Graphical view ]
    PANTHERi PTHR12322. PTHR12322. 1 hit.
    Pfami PF00751. DM. 1 hit.
    PF03474. DMA. 1 hit.
    [Graphical view ]
    SMARTi SM00301. DM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46934. SSF46934. 1 hit.
    SSF82927. SSF82927. 1 hit.
    PROSITEi PS40000. DM_1. 1 hit.
    PS50809. DM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "Sexually dimorphic expression of multiple doublesex-related genes in the embryonic mouse gonad."
      Kim S., Kettlewell J.R., Anderson R.C., Bardwell V.J., Zarkower D.
      Gene Expr. Patterns 3:77-82(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    4. Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiDMRT3_MOUSE
    AccessioniPrimary (citable) accession number: Q80WT2
    Secondary accession number(s): Q8CGX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    DMRT3 is a marker for a subset of spinal cord neurons (dI6).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3