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Q80WQ8

- M18BP_MOUSE

UniProt

Q80WQ8 - M18BP_MOUSE

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Protein

Mis18-binding protein 1

Gene

Mis18bp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.By similarity

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.

Names & Taxonomyi

Protein namesi
Recommended name:
Mis18-binding protein 1
Alternative name(s):
Kinetochore-associated protein KNL-2 homolog
Gene namesi
Name:Mis18bp1
Synonyms:Kiaa1903, Knl2, M18bp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:2145099. Mis18bp1.

Subcellular locationi

Nucleus By similarity. Chromosomecentromere By similarity
Note: Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin By similarity.By similarity

GO - Cellular componenti

  1. chromosome, centromeric region Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 998998Mis18-binding protein 1PRO_0000379895Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei109 – 1091PhosphoserineBy similarity
Modified residuei134 – 1341PhosphoserineBy similarity
Modified residuei169 – 1691PhosphoserineBy similarity
Modified residuei258 – 2581PhosphoserineBy similarity
Modified residuei516 – 5161PhosphothreonineBy similarity
Modified residuei638 – 6381PhosphoserineBy similarity
Modified residuei639 – 6391PhosphoserineBy similarity
Modified residuei688 – 6881PhosphothreonineBy similarity
Modified residuei726 – 7261PhosphoserineBy similarity
Modified residuei872 – 8721PhosphoserineBy similarity
Modified residuei955 – 9551PhosphoserineBy similarity
Modified residuei985 – 9851PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80WQ8.
PRIDEiQ80WQ8.

PTM databases

PhosphoSiteiQ80WQ8.

Expressioni

Gene expression databases

BgeeiQ80WQ8.
ExpressionAtlasiQ80WQ8. baseline and differential.
GenevestigatoriQ80WQ8.

Interactioni

Subunit structurei

Interacts with SP1 Probable. Interacts with MIS18A. Identified in a complex containing MIS18A, MIS18B, MIS18BP1, RBBP7 and RBBP4 By similarity. Interacts (via N-terminus) with FLNA (via N-terminus).By similarity1 PublicationCurated

Structurei

3D structure databases

ProteinModelPortaliQ80WQ8.
SMRiQ80WQ8. Positions 739-800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini741 – 79656SANTAdd
BLAST

Sequence similaritiesi

Contains 1 SANT domain.Curated

Phylogenomic databases

eggNOGiNOG73415.
GeneTreeiENSGT00390000007395.
InParanoidiQ80WQ8.
OMAiNDCDKYV.
OrthoDBiEOG77M8R3.
TreeFamiTF106401.

Family and domain databases

InterProiIPR009057. Homeodomain-like.
IPR017877. Myb-like_dom.
IPR001005. SANT/Myb.
IPR015216. SANTA.
[Graphical view]
PfamiPF09133. SANTA. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q80WQ8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIVTPLKHSG IHLSSGTLQR RNMPLDAVFI DSIPSGTLTP LKDLVKYQKS
60 70 80 90 100
SLKVNGHKKN QLLEIRTSNN KDLFQSTMLS EATLPNSSLD ISVIKPSMDR
110 120 130 140 150
LRNEMIYESP GKIFQRMKAK VQRDKQEQLT RSSSMLGSPQ GEHTKDFPPN
160 170 180 190 200
TDKKAQLQQT YICEEKQTSV QSNDPSLGDP PILNQEQKNV SASCISKKAL
210 220 230 240 250
TRAQFGGQVL HSKESPVRIT VSKKNTFVLG GIDCTYEKFE NTDVNTISSL
260 270 280 290 300
CVPIKNHSQS ITSDNDVTTE RTAKEDITEP NEEMMSRRTI LQDPIKNTSK
310 320 330 340 350
IKRSSPRPNL TLSGRSQRKC TKLETVVKEV KKYQAVHLQE WMIKVINNNT
360 370 380 390 400
AICVEGKLVD MTDVYWHSNV IIERIKHNEL RTLSGNIYIL KGLIDSVSMK
410 420 430 440 450
EAGYPCYLTR KFMFGFPHNW KEHIDKFLEQ LRAEKKNKTR QETARVQEKQ
460 470 480 490 500
KSKKKDAEDK ETYVLQKASI TYDLNDNSLE RTEVPTDPLN SLEQPTSGKE
510 520 530 540 550
RRHPLLSQKR AYVLITPLRN KKLIEQRCID YSLSIEGISD FFKAKHQEES
560 570 580 590 600
DSDIHGTPSS TSKSQETFEH RVGFEGNTKE DCNECDIITA RHIQIPCPKS
610 620 630 640 650
KQMLTNDFMK KNKLPSKLQK TENQIGVSQY CRSSSHLSSE ENEVEIKSRT
660 670 680 690 700
RARNTKERLN RERENTNHIT KDILLISETE GERACYITPK RPRSCYITPK
710 720 730 740 750
RPRSSAKESH YKSAVSKDFL TEGKASDRTS RQLLDHLPGL TDDEEWSEQE
760 770 780 790 800
LQKLHCAFTS LPKHKPGFWS DVAMAVGSRT ADECQKKYTE EPQGQGSRKH
810 820 830 840 850
GSKKKQANKV QNGEKDSADA KTIKITAKVG TLKRKRQMRD CLEHLAKDNH
860 870 880 890 900
DDFFTATPLQ KQRIQLPSFQ YSQDDDFLLD MDRDPASPSS IITSPLRSTT
910 920 930 940 950
PQCQHFSPSM LAAIERNNCD RYVYQMQKNA KKYGKSNGGL VWGNIRKKTV
960 970 980 990
KTDLSSPPPT RKALFNKDLG KNTDISKYFI DDTESDEEEK DYYFSNSD
Length:998
Mass (Da):113,956
Last modified:June 1, 2003 - v1
Checksum:iE0194CC994543C8F
GO
Isoform 2 (identifier: Q80WQ8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     433-434: AE → EN
     435-998: Missing.

Note: No experimental confirmation available.

Show »
Length:434
Mass (Da):49,324
Checksum:i40C837625C8B81CA
GO
Isoform 3 (identifier: Q80WQ8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     433-998: Missing.

Show »
Length:432
Mass (Da):49,080
Checksum:i67625C8B81CA3F1E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti226 – 2261T → I in BAD90148. 1 PublicationCurated
Sequence conflicti321 – 3211T → A in BAC29410. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei433 – 998566Missing in isoform 3. 1 PublicationVSP_037731Add
BLAST
Alternative sequencei433 – 4342AE → EN in isoform 2. 1 PublicationVSP_037732
Alternative sequencei435 – 998564Missing in isoform 2. 1 PublicationVSP_037733Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK036395 mRNA. Translation: BAC29410.1.
AK053496 mRNA. Translation: BAC35403.1.
AK162657 mRNA. Translation: BAE37008.1.
BC042728 mRNA. Translation: AAH42728.1.
BC052175 mRNA. Translation: AAH52175.1.
AK220223 mRNA. Translation: BAD90148.1.
CCDSiCCDS25942.1. [Q80WQ8-1]
RefSeqiNP_766166.2. NM_172578.2. [Q80WQ8-1]
UniGeneiMm.21144.

Genome annotation databases

EnsembliENSMUST00000052201; ENSMUSP00000052109; ENSMUSG00000047534. [Q80WQ8-1]
GeneIDi217653.
KEGGimmu:217653.
UCSCiuc007nrg.2. mouse. [Q80WQ8-1]
uc007nri.1. mouse. [Q80WQ8-3]
uc011ymg.1. mouse. [Q80WQ8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK036395 mRNA. Translation: BAC29410.1 .
AK053496 mRNA. Translation: BAC35403.1 .
AK162657 mRNA. Translation: BAE37008.1 .
BC042728 mRNA. Translation: AAH42728.1 .
BC052175 mRNA. Translation: AAH52175.1 .
AK220223 mRNA. Translation: BAD90148.1 .
CCDSi CCDS25942.1. [Q80WQ8-1 ]
RefSeqi NP_766166.2. NM_172578.2. [Q80WQ8-1 ]
UniGenei Mm.21144.

3D structure databases

ProteinModelPortali Q80WQ8.
SMRi Q80WQ8. Positions 739-800.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q80WQ8.

Proteomic databases

MaxQBi Q80WQ8.
PRIDEi Q80WQ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000052201 ; ENSMUSP00000052109 ; ENSMUSG00000047534 . [Q80WQ8-1 ]
GeneIDi 217653.
KEGGi mmu:217653.
UCSCi uc007nrg.2. mouse. [Q80WQ8-1 ]
uc007nri.1. mouse. [Q80WQ8-3 ]
uc011ymg.1. mouse. [Q80WQ8-2 ]

Organism-specific databases

CTDi 55320.
MGIi MGI:2145099. Mis18bp1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG73415.
GeneTreei ENSGT00390000007395.
InParanoidi Q80WQ8.
OMAi NDCDKYV.
OrthoDBi EOG77M8R3.
TreeFami TF106401.

Enzyme and pathway databases

Reactomei REACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.

Miscellaneous databases

NextBioi 375934.
PROi Q80WQ8.
SOURCEi Search...

Gene expression databases

Bgeei Q80WQ8.
ExpressionAtlasi Q80WQ8. baseline and differential.
Genevestigatori Q80WQ8.

Family and domain databases

InterProi IPR009057. Homeodomain-like.
IPR017877. Myb-like_dom.
IPR001005. SANT/Myb.
IPR015216. SANTA.
[Graphical view ]
Pfami PF09133. SANTA. 1 hit.
[Graphical view ]
SMARTi SM00717. SANT. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6J.
    Tissue: Bone and Eye.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: FVB/N.
    Tissue: Embryo and Mammary tumor.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 172-998 (ISOFORM 1).
  4. "Identification of novel nuclear protein interactions with the N-terminal part of filamin A."
    Qiu H., Nomiyama R., Moriguchi K., Fukada T., Sugimoto K.
    Biosci. Biotechnol. Biochem. 75:145-147(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FLNA.

Entry informationi

Entry nameiM18BP_MOUSE
AccessioniPrimary (citable) accession number: Q80WQ8
Secondary accession number(s): Q571G6
, Q8BPR7, Q8CBB5, Q8CG92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3