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Q80WQ8

- M18BP_MOUSE

UniProt

Q80WQ8 - M18BP_MOUSE

Protein

Mis18-binding protein 1

Gene

Mis18bp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.By similarity

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. DNA binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mis18-binding protein 1
    Alternative name(s):
    Kinetochore-associated protein KNL-2 homolog
    Gene namesi
    Name:Mis18bp1
    Synonyms:Kiaa1903, Knl2, M18bp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:2145099. Mis18bp1.

    Subcellular locationi

    Nucleus By similarity. Chromosomecentromere By similarity
    Note: Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin By similarity.By similarity

    GO - Cellular componenti

    1. chromosome, centromeric region Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Centromere, Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 998998Mis18-binding protein 1PRO_0000379895Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei109 – 1091PhosphoserineBy similarity
    Modified residuei134 – 1341PhosphoserineBy similarity
    Modified residuei169 – 1691PhosphoserineBy similarity
    Modified residuei258 – 2581PhosphoserineBy similarity
    Modified residuei516 – 5161PhosphothreonineBy similarity
    Modified residuei638 – 6381PhosphoserineBy similarity
    Modified residuei639 – 6391PhosphoserineBy similarity
    Modified residuei688 – 6881PhosphothreonineBy similarity
    Modified residuei726 – 7261PhosphoserineBy similarity
    Modified residuei872 – 8721PhosphoserineBy similarity
    Modified residuei955 – 9551PhosphoserineBy similarity
    Modified residuei985 – 9851PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ80WQ8.

    PTM databases

    PhosphoSiteiQ80WQ8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ80WQ8.
    BgeeiQ80WQ8.
    GenevestigatoriQ80WQ8.

    Interactioni

    Subunit structurei

    Interacts with SP1 Probable. Interacts with MIS18A. Identified in a complex containing MIS18A, MIS18B, MIS18BP1, RBBP7 and RBBP4 By similarity. Interacts (via N-terminus) with FLNA (via N-terminus).By similarity1 PublicationCurated

    Structurei

    3D structure databases

    ProteinModelPortaliQ80WQ8.
    SMRiQ80WQ8. Positions 739-800.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini741 – 79656SANTAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SANT domain.Curated

    Phylogenomic databases

    eggNOGiNOG73415.
    GeneTreeiENSGT00390000007395.
    InParanoidiQ571G6.
    OMAiNDCDKYV.
    OrthoDBiEOG77M8R3.
    TreeFamiTF106401.

    Family and domain databases

    InterProiIPR009057. Homeodomain-like.
    IPR017877. Myb-like_dom.
    IPR001005. SANT/Myb.
    IPR015216. SANTA.
    [Graphical view]
    PfamiPF09133. SANTA. 1 hit.
    [Graphical view]
    SMARTiSM00717. SANT. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q80WQ8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIVTPLKHSG IHLSSGTLQR RNMPLDAVFI DSIPSGTLTP LKDLVKYQKS    50
    SLKVNGHKKN QLLEIRTSNN KDLFQSTMLS EATLPNSSLD ISVIKPSMDR 100
    LRNEMIYESP GKIFQRMKAK VQRDKQEQLT RSSSMLGSPQ GEHTKDFPPN 150
    TDKKAQLQQT YICEEKQTSV QSNDPSLGDP PILNQEQKNV SASCISKKAL 200
    TRAQFGGQVL HSKESPVRIT VSKKNTFVLG GIDCTYEKFE NTDVNTISSL 250
    CVPIKNHSQS ITSDNDVTTE RTAKEDITEP NEEMMSRRTI LQDPIKNTSK 300
    IKRSSPRPNL TLSGRSQRKC TKLETVVKEV KKYQAVHLQE WMIKVINNNT 350
    AICVEGKLVD MTDVYWHSNV IIERIKHNEL RTLSGNIYIL KGLIDSVSMK 400
    EAGYPCYLTR KFMFGFPHNW KEHIDKFLEQ LRAEKKNKTR QETARVQEKQ 450
    KSKKKDAEDK ETYVLQKASI TYDLNDNSLE RTEVPTDPLN SLEQPTSGKE 500
    RRHPLLSQKR AYVLITPLRN KKLIEQRCID YSLSIEGISD FFKAKHQEES 550
    DSDIHGTPSS TSKSQETFEH RVGFEGNTKE DCNECDIITA RHIQIPCPKS 600
    KQMLTNDFMK KNKLPSKLQK TENQIGVSQY CRSSSHLSSE ENEVEIKSRT 650
    RARNTKERLN RERENTNHIT KDILLISETE GERACYITPK RPRSCYITPK 700
    RPRSSAKESH YKSAVSKDFL TEGKASDRTS RQLLDHLPGL TDDEEWSEQE 750
    LQKLHCAFTS LPKHKPGFWS DVAMAVGSRT ADECQKKYTE EPQGQGSRKH 800
    GSKKKQANKV QNGEKDSADA KTIKITAKVG TLKRKRQMRD CLEHLAKDNH 850
    DDFFTATPLQ KQRIQLPSFQ YSQDDDFLLD MDRDPASPSS IITSPLRSTT 900
    PQCQHFSPSM LAAIERNNCD RYVYQMQKNA KKYGKSNGGL VWGNIRKKTV 950
    KTDLSSPPPT RKALFNKDLG KNTDISKYFI DDTESDEEEK DYYFSNSD 998
    Length:998
    Mass (Da):113,956
    Last modified:June 1, 2003 - v1
    Checksum:iE0194CC994543C8F
    GO
    Isoform 2 (identifier: Q80WQ8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         433-434: AE → EN
         435-998: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:434
    Mass (Da):49,324
    Checksum:i40C837625C8B81CA
    GO
    Isoform 3 (identifier: Q80WQ8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         433-998: Missing.

    Show »
    Length:432
    Mass (Da):49,080
    Checksum:i67625C8B81CA3F1E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti226 – 2261T → I in BAD90148. 1 PublicationCurated
    Sequence conflicti321 – 3211T → A in BAC29410. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei433 – 998566Missing in isoform 3. 1 PublicationVSP_037731Add
    BLAST
    Alternative sequencei433 – 4342AE → EN in isoform 2. 1 PublicationVSP_037732
    Alternative sequencei435 – 998564Missing in isoform 2. 1 PublicationVSP_037733Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036395 mRNA. Translation: BAC29410.1.
    AK053496 mRNA. Translation: BAC35403.1.
    AK162657 mRNA. Translation: BAE37008.1.
    BC042728 mRNA. Translation: AAH42728.1.
    BC052175 mRNA. Translation: AAH52175.1.
    AK220223 mRNA. Translation: BAD90148.1.
    CCDSiCCDS25942.1. [Q80WQ8-1]
    RefSeqiNP_766166.2. NM_172578.2. [Q80WQ8-1]
    UniGeneiMm.21144.

    Genome annotation databases

    EnsembliENSMUST00000052201; ENSMUSP00000052109; ENSMUSG00000047534. [Q80WQ8-1]
    GeneIDi217653.
    KEGGimmu:217653.
    UCSCiuc007nrg.2. mouse. [Q80WQ8-1]
    uc007nri.1. mouse. [Q80WQ8-3]
    uc011ymg.1. mouse. [Q80WQ8-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK036395 mRNA. Translation: BAC29410.1 .
    AK053496 mRNA. Translation: BAC35403.1 .
    AK162657 mRNA. Translation: BAE37008.1 .
    BC042728 mRNA. Translation: AAH42728.1 .
    BC052175 mRNA. Translation: AAH52175.1 .
    AK220223 mRNA. Translation: BAD90148.1 .
    CCDSi CCDS25942.1. [Q80WQ8-1 ]
    RefSeqi NP_766166.2. NM_172578.2. [Q80WQ8-1 ]
    UniGenei Mm.21144.

    3D structure databases

    ProteinModelPortali Q80WQ8.
    SMRi Q80WQ8. Positions 739-800.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q80WQ8.

    Proteomic databases

    PRIDEi Q80WQ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000052201 ; ENSMUSP00000052109 ; ENSMUSG00000047534 . [Q80WQ8-1 ]
    GeneIDi 217653.
    KEGGi mmu:217653.
    UCSCi uc007nrg.2. mouse. [Q80WQ8-1 ]
    uc007nri.1. mouse. [Q80WQ8-3 ]
    uc011ymg.1. mouse. [Q80WQ8-2 ]

    Organism-specific databases

    CTDi 55320.
    MGIi MGI:2145099. Mis18bp1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG73415.
    GeneTreei ENSGT00390000007395.
    InParanoidi Q571G6.
    OMAi NDCDKYV.
    OrthoDBi EOG77M8R3.
    TreeFami TF106401.

    Enzyme and pathway databases

    Reactomei REACT_198597. Deposition of new CENPA-containing nucleosomes at the centromere.

    Miscellaneous databases

    NextBioi 375934.
    PROi Q80WQ8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q80WQ8.
    Bgeei Q80WQ8.
    Genevestigatori Q80WQ8.

    Family and domain databases

    InterProi IPR009057. Homeodomain-like.
    IPR017877. Myb-like_dom.
    IPR001005. SANT/Myb.
    IPR015216. SANTA.
    [Graphical view ]
    Pfami PF09133. SANTA. 1 hit.
    [Graphical view ]
    SMARTi SM00717. SANT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: C57BL/6J.
      Tissue: Bone and Eye.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: FVB/N.
      Tissue: Embryo and Mammary tumor.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 172-998 (ISOFORM 1).
    4. "Identification of novel nuclear protein interactions with the N-terminal part of filamin A."
      Qiu H., Nomiyama R., Moriguchi K., Fukada T., Sugimoto K.
      Biosci. Biotechnol. Biochem. 75:145-147(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FLNA.

    Entry informationi

    Entry nameiM18BP_MOUSE
    AccessioniPrimary (citable) accession number: Q80WQ8
    Secondary accession number(s): Q571G6
    , Q8BPR7, Q8CBB5, Q8CG92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3