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Protein

Inactive rhomboid protein 2

Gene

Rhbdf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Protein family/group databases

MEROPSiS54.953.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive rhomboid protein 2
Short name:
iRhom2
Alternative name(s):
Rhomboid family member 2
Rhomboid veinlet-like protein 6
Rhomboid-related protein
Gene namesi
Name:Rhbdf2
Synonyms:Irhom2, Rhbdl6, Rhor
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2442473. Rhbdf2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 381CytoplasmicSequence analysisAdd BLAST381
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Topological domaini403 – 627LumenalSequence analysisAdd BLAST225
Transmembranei628 – 648HelicalSequence analysisAdd BLAST21
Topological domaini649 – 663CytoplasmicSequence analysisAdd BLAST15
Transmembranei664 – 684HelicalSequence analysisAdd BLAST21
Topological domaini685 – 686LumenalSequence analysis2
Transmembranei687 – 707HelicalSequence analysisAdd BLAST21
Topological domaini708 – 718CytoplasmicSequence analysisAdd BLAST11
Transmembranei719 – 739HelicalSequence analysisAdd BLAST21
Topological domaini740 – 744LumenalSequence analysis5
Transmembranei745 – 765HelicalSequence analysisAdd BLAST21
Topological domaini766 – 773CytoplasmicSequence analysis8
Transmembranei774 – 794HelicalSequence analysisAdd BLAST21
Topological domaini795 – 827LumenalSequence analysisAdd BLAST33

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003419391 – 827Inactive rhomboid protein 2Add BLAST827

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei293PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei298PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80WQ6.
MaxQBiQ80WQ6.
PaxDbiQ80WQ6.
PeptideAtlasiQ80WQ6.
PRIDEiQ80WQ6.

PTM databases

iPTMnetiQ80WQ6.
PhosphoSitePlusiQ80WQ6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020806.
GenevisibleiQ80WQ6. MM.

Interactioni

Subunit structurei

Interacts with EGF.1 Publication

Protein-protein interaction databases

DIPiDIP-49675N.
IntActiQ80WQ6. 3 interactors.
MINTiMINT-8177177.
STRINGi10090.ENSMUSP00000099317.

Structurei

3D structure databases

ProteinModelPortaliQ80WQ6.
SMRiQ80WQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S54 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2290. Eukaryota.
COG0705. LUCA.
GeneTreeiENSGT00390000012532.
HOGENOMiHOG000154118.
HOVERGENiHBG059673.
InParanoidiQ80WQ6.
OMAiRGRWQEG.
OrthoDBiEOG091G021G.
PhylomeDBiQ80WQ6.
TreeFamiTF312988.

Family and domain databases

Gene3Di1.20.1540.10. 2 hits.
InterProiIPR002610. Peptidase_S54_rhomboid.
IPR022764. Peptidase_S54_rhomboid_dom.
IPR022241. Rhomboid_SP.
[Graphical view]
PANTHERiPTHR22936. PTHR22936. 2 hits.
PfamiPF01694. Rhomboid. 1 hit.
PF12595. Rhomboid_SP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80WQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASADKNGSN LPSVSGSRLQ SRKPPNLSIT IPPPESQAPG EQDSMLPERR
60 70 80 90 100
KNPAYLKSVS LQEPRGRWQE GAEKRPGFRR QASLSQSIRK STAQWFGVSG
110 120 130 140 150
DWEGKRQNWH RRSLHHCSVH YGRLKASCQR ELELPSQEVP SFQGTESPKP
160 170 180 190 200
CKMPKIVDPL ARGRAFRHPD EVDRPHAAHP PLTPGVLSLT SFTSVRSGYS
210 220 230 240 250
HLPRRKRISV AHMSFQAAAA LLKGRSVLDA TGQRCRHVKR SFAYPSFLEE
260 270 280 290 300
DAVDGADTFD SSFFSKEEMS SMPDDVFESP PLSASYFRGV PHSASPVSPD
310 320 330 340 350
GVHIPLKEYS GGRALGPGTQ RGKRIASKVK HFAFDRKKRH YGLGVVGNWL
360 370 380 390 400
NRSYRRSISS TVQRQLESFD SHRPYFTYWL TFVHIIITLL VICTYGIAPV
410 420 430 440 450
GFAQHVTTQL VLKNRGVYES VKYIQQENFW IGPSSIDLIH LGAKFSPCIR
460 470 480 490 500
KDQQIEQLVR RERDIERTSG CCVQNDRSGC IQTLKKDCSE TLATFVKWQN
510 520 530 540 550
DTGPSDKSDL SQKQPSAVVC HQDPRTCEEP ASSGAHIWPD DITKWPICTE
560 570 580 590 600
QAQSNHTGLL HIDCKIKGRP CCIGTKGSCE ITTREYCEFM HGYFHEDATL
610 620 630 640 650
CSQVHCLDKV CGLLPFLNPE VPDQFYRIWL SLFLHAGIVH CLVSVVFQMT
660 670 680 690 700
ILRDLEKLAG WHRISIIFIL SGITGNLASA IFLPYRAEVG PAGSQFGLLA
710 720 730 740 750
CLFVELFQSW QLLERPWKAF FNLSAIVLFL FICGLLPWID NIAHIFGFLS
760 770 780 790 800
GMLLAFAFLP YITFGTSDKY RKRALILVSL LVFAGLFASL VLWLYIYPIN
810 820
WPWIEYLTCF PFTSRFCEKY ELDQVLH
Length:827
Mass (Da):93,434
Last modified:June 1, 2003 - v1
Checksum:i650052E5A4BD9CA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti728L → P in BAC26163 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY167043 mRNA. Translation: AAO34122.1.
AK028872 mRNA. Translation: BAC26163.1.
AK171085 mRNA. Translation: BAE42238.1.
AL607039 Genomic DNA. Translation: CAM20511.1.
BC031398 mRNA. Translation: AAH31398.1.
BC052182 mRNA. Translation: AAH52182.1.
CCDSiCCDS25672.1.
RefSeqiNP_001161152.1. NM_001167680.1.
NP_766160.2. NM_172572.3.
UniGeneiMm.89695.

Genome annotation databases

EnsembliENSMUST00000103028; ENSMUSP00000099317; ENSMUSG00000020806.
ENSMUST00000103029; ENSMUSP00000099318; ENSMUSG00000020806.
GeneIDi217344.
KEGGimmu:217344.
UCSCiuc007mls.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY167043 mRNA. Translation: AAO34122.1.
AK028872 mRNA. Translation: BAC26163.1.
AK171085 mRNA. Translation: BAE42238.1.
AL607039 Genomic DNA. Translation: CAM20511.1.
BC031398 mRNA. Translation: AAH31398.1.
BC052182 mRNA. Translation: AAH52182.1.
CCDSiCCDS25672.1.
RefSeqiNP_001161152.1. NM_001167680.1.
NP_766160.2. NM_172572.3.
UniGeneiMm.89695.

3D structure databases

ProteinModelPortaliQ80WQ6.
SMRiQ80WQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-49675N.
IntActiQ80WQ6. 3 interactors.
MINTiMINT-8177177.
STRINGi10090.ENSMUSP00000099317.

Protein family/group databases

MEROPSiS54.953.

PTM databases

iPTMnetiQ80WQ6.
PhosphoSitePlusiQ80WQ6.

Proteomic databases

EPDiQ80WQ6.
MaxQBiQ80WQ6.
PaxDbiQ80WQ6.
PeptideAtlasiQ80WQ6.
PRIDEiQ80WQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103028; ENSMUSP00000099317; ENSMUSG00000020806.
ENSMUST00000103029; ENSMUSP00000099318; ENSMUSG00000020806.
GeneIDi217344.
KEGGimmu:217344.
UCSCiuc007mls.3. mouse.

Organism-specific databases

CTDi79651.
MGIiMGI:2442473. Rhbdf2.

Phylogenomic databases

eggNOGiKOG2290. Eukaryota.
COG0705. LUCA.
GeneTreeiENSGT00390000012532.
HOGENOMiHOG000154118.
HOVERGENiHBG059673.
InParanoidiQ80WQ6.
OMAiRGRWQEG.
OrthoDBiEOG091G021G.
PhylomeDBiQ80WQ6.
TreeFamiTF312988.

Miscellaneous databases

PROiQ80WQ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020806.
GenevisibleiQ80WQ6. MM.

Family and domain databases

Gene3Di1.20.1540.10. 2 hits.
InterProiIPR002610. Peptidase_S54_rhomboid.
IPR022764. Peptidase_S54_rhomboid_dom.
IPR022241. Rhomboid_SP.
[Graphical view]
PANTHERiPTHR22936. PTHR22936. 2 hits.
PfamiPF01694. Rhomboid. 1 hit.
PF12595. Rhomboid_SP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHDF2_MOUSE
AccessioniPrimary (citable) accession number: Q80WQ6
Secondary accession number(s): Q3TBR9, Q8BJ70, Q8K2I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.