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Q80WQ6

- RHDF2_MOUSE

UniProt

Q80WQ6 - RHDF2_MOUSE

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Protein

Inactive rhomboid protein 2

Gene

Rhbdf2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration.1 Publication

GO - Biological processi

  1. negative regulation of protein secretion Source: UniProtKB
  2. protein transport Source: UniProtKB-KW
  3. proteolysis Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Protein family/group databases

MEROPSiS54.953.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive rhomboid protein 2
Short name:
iRhom2
Alternative name(s):
Rhomboid family member 2
Rhomboid veinlet-like protein 6
Rhomboid-related protein
Gene namesi
Name:Rhbdf2
Synonyms:Irhom2, Rhbdl6, Rhor
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2442473. Rhbdf2.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 381381CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei382 – 40221HelicalSequence AnalysisAdd
BLAST
Topological domaini403 – 627225LumenalSequence AnalysisAdd
BLAST
Transmembranei628 – 64821HelicalSequence AnalysisAdd
BLAST
Topological domaini649 – 66315CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei664 – 68421HelicalSequence AnalysisAdd
BLAST
Topological domaini685 – 6862LumenalSequence Analysis
Transmembranei687 – 70721HelicalSequence AnalysisAdd
BLAST
Topological domaini708 – 71811CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei719 – 73921HelicalSequence AnalysisAdd
BLAST
Topological domaini740 – 7445LumenalSequence Analysis
Transmembranei745 – 76521HelicalSequence AnalysisAdd
BLAST
Topological domaini766 – 7738CytoplasmicSequence Analysis
Transmembranei774 – 79421HelicalSequence AnalysisAdd
BLAST
Topological domaini795 – 82733LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 827827Inactive rhomboid protein 2PRO_0000341939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei60 – 601Phosphoserine1 Publication
Modified residuei83 – 831Phosphoserine1 Publication
Modified residuei87 – 871Phosphoserine1 Publication
Modified residuei293 – 2931Phosphoserine1 Publication
Modified residuei295 – 2951Phosphoserine1 Publication
Modified residuei298 – 2981Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ80WQ6.
PaxDbiQ80WQ6.
PRIDEiQ80WQ6.

PTM databases

PhosphoSiteiQ80WQ6.

Expressioni

Gene expression databases

BgeeiQ80WQ6.
GenevestigatoriQ80WQ6.

Interactioni

Subunit structurei

Interacts with EGF.1 Publication

Protein-protein interaction databases

IntActiQ80WQ6. 3 interactions.
MINTiMINT-8177177.

Structurei

3D structure databases

ProteinModelPortaliQ80WQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S54 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0705.
GeneTreeiENSGT00390000012532.
HOGENOMiHOG000154118.
HOVERGENiHBG059673.
InParanoidiQ80WQ6.
OMAiRGIPHSA.
OrthoDBiEOG7288QH.
PhylomeDBiQ80WQ6.
TreeFamiTF312988.

Family and domain databases

Gene3Di1.20.1540.10. 2 hits.
InterProiIPR002610. Peptidase_S54_rhomboid.
IPR022764. Peptidase_S54_rhomboid_dom.
IPR022241. Rhomboid_SP.
[Graphical view]
PANTHERiPTHR22936. PTHR22936. 1 hit.
PfamiPF01694. Rhomboid. 1 hit.
PF12595. Rhomboid_SP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80WQ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASADKNGSN LPSVSGSRLQ SRKPPNLSIT IPPPESQAPG EQDSMLPERR
60 70 80 90 100
KNPAYLKSVS LQEPRGRWQE GAEKRPGFRR QASLSQSIRK STAQWFGVSG
110 120 130 140 150
DWEGKRQNWH RRSLHHCSVH YGRLKASCQR ELELPSQEVP SFQGTESPKP
160 170 180 190 200
CKMPKIVDPL ARGRAFRHPD EVDRPHAAHP PLTPGVLSLT SFTSVRSGYS
210 220 230 240 250
HLPRRKRISV AHMSFQAAAA LLKGRSVLDA TGQRCRHVKR SFAYPSFLEE
260 270 280 290 300
DAVDGADTFD SSFFSKEEMS SMPDDVFESP PLSASYFRGV PHSASPVSPD
310 320 330 340 350
GVHIPLKEYS GGRALGPGTQ RGKRIASKVK HFAFDRKKRH YGLGVVGNWL
360 370 380 390 400
NRSYRRSISS TVQRQLESFD SHRPYFTYWL TFVHIIITLL VICTYGIAPV
410 420 430 440 450
GFAQHVTTQL VLKNRGVYES VKYIQQENFW IGPSSIDLIH LGAKFSPCIR
460 470 480 490 500
KDQQIEQLVR RERDIERTSG CCVQNDRSGC IQTLKKDCSE TLATFVKWQN
510 520 530 540 550
DTGPSDKSDL SQKQPSAVVC HQDPRTCEEP ASSGAHIWPD DITKWPICTE
560 570 580 590 600
QAQSNHTGLL HIDCKIKGRP CCIGTKGSCE ITTREYCEFM HGYFHEDATL
610 620 630 640 650
CSQVHCLDKV CGLLPFLNPE VPDQFYRIWL SLFLHAGIVH CLVSVVFQMT
660 670 680 690 700
ILRDLEKLAG WHRISIIFIL SGITGNLASA IFLPYRAEVG PAGSQFGLLA
710 720 730 740 750
CLFVELFQSW QLLERPWKAF FNLSAIVLFL FICGLLPWID NIAHIFGFLS
760 770 780 790 800
GMLLAFAFLP YITFGTSDKY RKRALILVSL LVFAGLFASL VLWLYIYPIN
810 820
WPWIEYLTCF PFTSRFCEKY ELDQVLH
Length:827
Mass (Da):93,434
Last modified:June 1, 2003 - v1
Checksum:i650052E5A4BD9CA5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti728 – 7281L → P in BAC26163. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY167043 mRNA. Translation: AAO34122.1.
AK028872 mRNA. Translation: BAC26163.1.
AK171085 mRNA. Translation: BAE42238.1.
AL607039 Genomic DNA. Translation: CAM20511.1.
BC031398 mRNA. Translation: AAH31398.1.
BC052182 mRNA. Translation: AAH52182.1.
CCDSiCCDS25672.1.
RefSeqiNP_001161152.1. NM_001167680.1.
NP_766160.2. NM_172572.3.
UniGeneiMm.89695.

Genome annotation databases

EnsembliENSMUST00000103028; ENSMUSP00000099317; ENSMUSG00000020806.
ENSMUST00000103029; ENSMUSP00000099318; ENSMUSG00000020806.
GeneIDi217344.
KEGGimmu:217344.
UCSCiuc007mls.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY167043 mRNA. Translation: AAO34122.1 .
AK028872 mRNA. Translation: BAC26163.1 .
AK171085 mRNA. Translation: BAE42238.1 .
AL607039 Genomic DNA. Translation: CAM20511.1 .
BC031398 mRNA. Translation: AAH31398.1 .
BC052182 mRNA. Translation: AAH52182.1 .
CCDSi CCDS25672.1.
RefSeqi NP_001161152.1. NM_001167680.1.
NP_766160.2. NM_172572.3.
UniGenei Mm.89695.

3D structure databases

ProteinModelPortali Q80WQ6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q80WQ6. 3 interactions.
MINTi MINT-8177177.

Protein family/group databases

MEROPSi S54.953.

PTM databases

PhosphoSitei Q80WQ6.

Proteomic databases

MaxQBi Q80WQ6.
PaxDbi Q80WQ6.
PRIDEi Q80WQ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000103028 ; ENSMUSP00000099317 ; ENSMUSG00000020806 .
ENSMUST00000103029 ; ENSMUSP00000099318 ; ENSMUSG00000020806 .
GeneIDi 217344.
KEGGi mmu:217344.
UCSCi uc007mls.3. mouse.

Organism-specific databases

CTDi 79651.
MGIi MGI:2442473. Rhbdf2.

Phylogenomic databases

eggNOGi COG0705.
GeneTreei ENSGT00390000012532.
HOGENOMi HOG000154118.
HOVERGENi HBG059673.
InParanoidi Q80WQ6.
OMAi RGIPHSA.
OrthoDBi EOG7288QH.
PhylomeDBi Q80WQ6.
TreeFami TF312988.

Miscellaneous databases

NextBioi 375793.
PROi Q80WQ6.
SOURCEi Search...

Gene expression databases

Bgeei Q80WQ6.
Genevestigatori Q80WQ6.

Family and domain databases

Gene3Di 1.20.1540.10. 2 hits.
InterProi IPR002610. Peptidase_S54_rhomboid.
IPR022764. Peptidase_S54_rhomboid_dom.
IPR022241. Rhomboid_SP.
[Graphical view ]
PANTHERi PTHR22936. PTHR22936. 1 hit.
Pfami PF01694. Rhomboid. 1 hit.
PF12595. Rhomboid_SP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a mouse rhomboid-related gene."
    Kong X., Li S., Shi Y., Teng X., Hu L., Zhu Y.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Skin.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Dendritic cell and Skin.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Embryo and Mammary tumor.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; SER-83; SER-87; SER-293; SER-295 AND SER-298, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling."
    Zettl M., Adrain C., Strisovsky K., Lastun V., Freeman M.
    Cell 145:79-91(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH EGF.

Entry informationi

Entry nameiRHDF2_MOUSE
AccessioniPrimary (citable) accession number: Q80WQ6
Secondary accession number(s): Q3TBR9, Q8BJ70, Q8K2I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3