Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Inactive rhomboid protein 2

Gene

Rhbdf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration.1 Publication

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Protein family/group databases

MEROPSiS54.953

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive rhomboid protein 2
Short name:
iRhom2
Alternative name(s):
Rhomboid family member 2
Rhomboid veinlet-like protein 6
Rhomboid-related protein
Gene namesi
Name:Rhbdf2
Synonyms:Irhom2, Rhbdl6, Rhor
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2442473 Rhbdf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 381CytoplasmicSequence analysisAdd BLAST381
Transmembranei382 – 402HelicalSequence analysisAdd BLAST21
Topological domaini403 – 627LumenalSequence analysisAdd BLAST225
Transmembranei628 – 648HelicalSequence analysisAdd BLAST21
Topological domaini649 – 663CytoplasmicSequence analysisAdd BLAST15
Transmembranei664 – 684HelicalSequence analysisAdd BLAST21
Topological domaini685 – 686LumenalSequence analysis2
Transmembranei687 – 707HelicalSequence analysisAdd BLAST21
Topological domaini708 – 718CytoplasmicSequence analysisAdd BLAST11
Transmembranei719 – 739HelicalSequence analysisAdd BLAST21
Topological domaini740 – 744LumenalSequence analysis5
Transmembranei745 – 765HelicalSequence analysisAdd BLAST21
Topological domaini766 – 773CytoplasmicSequence analysis8
Transmembranei774 – 794HelicalSequence analysisAdd BLAST21
Topological domaini795 – 827LumenalSequence analysisAdd BLAST33

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003419391 – 827Inactive rhomboid protein 2Add BLAST827

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei87PhosphoserineCombined sources1
Modified residuei293PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei298PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80WQ6
MaxQBiQ80WQ6
PaxDbiQ80WQ6
PeptideAtlasiQ80WQ6
PRIDEiQ80WQ6

PTM databases

iPTMnetiQ80WQ6
PhosphoSitePlusiQ80WQ6

Expressioni

Gene expression databases

BgeeiENSMUSG00000020806
GenevisibleiQ80WQ6 MM

Interactioni

Subunit structurei

Interacts with EGF.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

DIPiDIP-49675N
IntActiQ80WQ6, 5 interactors
MINTiQ80WQ6
STRINGi10090.ENSMUSP00000099317

Structurei

3D structure databases

ProteinModelPortaliQ80WQ6
SMRiQ80WQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S54 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2290 Eukaryota
COG0705 LUCA
GeneTreeiENSGT00390000012532
HOGENOMiHOG000154118
HOVERGENiHBG059673
InParanoidiQ80WQ6
OMAiQEVPSFQ
OrthoDBiEOG091G021G
PhylomeDBiQ80WQ6
TreeFamiTF312988

Family and domain databases

Gene3Di1.20.1540.10, 1 hit
InterProiView protein in InterPro
IPR002610 Peptidase_S54_rhomboid
IPR022764 Peptidase_S54_rhomboid_dom
IPR035952 Rhomboid-like_sf
IPR022241 Rhomboid_SP
PANTHERiPTHR22936 PTHR22936, 1 hit
PfamiView protein in Pfam
PF01694 Rhomboid, 1 hit
PF12595 Rhomboid_SP, 1 hit

Sequencei

Sequence statusi: Complete.

Q80WQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASADKNGSN LPSVSGSRLQ SRKPPNLSIT IPPPESQAPG EQDSMLPERR
60 70 80 90 100
KNPAYLKSVS LQEPRGRWQE GAEKRPGFRR QASLSQSIRK STAQWFGVSG
110 120 130 140 150
DWEGKRQNWH RRSLHHCSVH YGRLKASCQR ELELPSQEVP SFQGTESPKP
160 170 180 190 200
CKMPKIVDPL ARGRAFRHPD EVDRPHAAHP PLTPGVLSLT SFTSVRSGYS
210 220 230 240 250
HLPRRKRISV AHMSFQAAAA LLKGRSVLDA TGQRCRHVKR SFAYPSFLEE
260 270 280 290 300
DAVDGADTFD SSFFSKEEMS SMPDDVFESP PLSASYFRGV PHSASPVSPD
310 320 330 340 350
GVHIPLKEYS GGRALGPGTQ RGKRIASKVK HFAFDRKKRH YGLGVVGNWL
360 370 380 390 400
NRSYRRSISS TVQRQLESFD SHRPYFTYWL TFVHIIITLL VICTYGIAPV
410 420 430 440 450
GFAQHVTTQL VLKNRGVYES VKYIQQENFW IGPSSIDLIH LGAKFSPCIR
460 470 480 490 500
KDQQIEQLVR RERDIERTSG CCVQNDRSGC IQTLKKDCSE TLATFVKWQN
510 520 530 540 550
DTGPSDKSDL SQKQPSAVVC HQDPRTCEEP ASSGAHIWPD DITKWPICTE
560 570 580 590 600
QAQSNHTGLL HIDCKIKGRP CCIGTKGSCE ITTREYCEFM HGYFHEDATL
610 620 630 640 650
CSQVHCLDKV CGLLPFLNPE VPDQFYRIWL SLFLHAGIVH CLVSVVFQMT
660 670 680 690 700
ILRDLEKLAG WHRISIIFIL SGITGNLASA IFLPYRAEVG PAGSQFGLLA
710 720 730 740 750
CLFVELFQSW QLLERPWKAF FNLSAIVLFL FICGLLPWID NIAHIFGFLS
760 770 780 790 800
GMLLAFAFLP YITFGTSDKY RKRALILVSL LVFAGLFASL VLWLYIYPIN
810 820
WPWIEYLTCF PFTSRFCEKY ELDQVLH
Length:827
Mass (Da):93,434
Last modified:June 1, 2003 - v1
Checksum:i650052E5A4BD9CA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti728L → P in BAC26163 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY167043 mRNA Translation: AAO34122.1
AK028872 mRNA Translation: BAC26163.1
AK171085 mRNA Translation: BAE42238.1
AL607039 Genomic DNA No translation available.
BC031398 mRNA Translation: AAH31398.1
BC052182 mRNA Translation: AAH52182.1
CCDSiCCDS25672.1
RefSeqiNP_001161152.1, NM_001167680.1
NP_766160.2, NM_172572.3
UniGeneiMm.89695

Genome annotation databases

EnsembliENSMUST00000103028; ENSMUSP00000099317; ENSMUSG00000020806
ENSMUST00000103029; ENSMUSP00000099318; ENSMUSG00000020806
GeneIDi217344
KEGGimmu:217344
UCSCiuc007mls.3 mouse

Similar proteinsi

Entry informationi

Entry nameiRHDF2_MOUSE
AccessioniPrimary (citable) accession number: Q80WQ6
Secondary accession number(s): Q3TBR9, Q8BJ70, Q8K2I7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health