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Q80WQ6

- RHDF2_MOUSE

UniProt

Q80WQ6 - RHDF2_MOUSE

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Protein

Inactive rhomboid protein 2

Gene
Rhbdf2, Irhom2, Rhbdl6, Rhor
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration.1 Publication

GO - Biological processi

  1. negative regulation of protein secretion Source: UniProtKB
  2. protein transport Source: UniProtKB-KW
  3. proteolysis Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Protein family/group databases

MEROPSiS54.953.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive rhomboid protein 2
Short name:
iRhom2
Alternative name(s):
Rhomboid family member 2
Rhomboid veinlet-like protein 6
Rhomboid-related protein
Gene namesi
Name:Rhbdf2
Synonyms:Irhom2, Rhbdl6, Rhor
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2442473. Rhbdf2.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 381381Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei382 – 40221Helical; Reviewed predictionAdd
BLAST
Topological domaini403 – 627225Lumenal Reviewed predictionAdd
BLAST
Transmembranei628 – 64821Helical; Reviewed predictionAdd
BLAST
Topological domaini649 – 66315Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei664 – 68421Helical; Reviewed predictionAdd
BLAST
Topological domaini685 – 6862Lumenal Reviewed prediction
Transmembranei687 – 70721Helical; Reviewed predictionAdd
BLAST
Topological domaini708 – 71811Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei719 – 73921Helical; Reviewed predictionAdd
BLAST
Topological domaini740 – 7445Lumenal Reviewed prediction
Transmembranei745 – 76521Helical; Reviewed predictionAdd
BLAST
Topological domaini766 – 7738Cytoplasmic Reviewed prediction
Transmembranei774 – 79421Helical; Reviewed predictionAdd
BLAST
Topological domaini795 – 82733Lumenal Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 827827Inactive rhomboid protein 2PRO_0000341939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei60 – 601Phosphoserine1 Publication
Modified residuei83 – 831Phosphoserine1 Publication
Modified residuei87 – 871Phosphoserine1 Publication
Modified residuei293 – 2931Phosphoserine1 Publication
Modified residuei295 – 2951Phosphoserine1 Publication
Modified residuei298 – 2981Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80WQ6.
PRIDEiQ80WQ6.

PTM databases

PhosphoSiteiQ80WQ6.

Expressioni

Gene expression databases

BgeeiQ80WQ6.
GenevestigatoriQ80WQ6.

Interactioni

Subunit structurei

Interacts with EGF.1 Publication

Protein-protein interaction databases

IntActiQ80WQ6. 3 interactions.
MINTiMINT-8177177.

Structurei

3D structure databases

ProteinModelPortaliQ80WQ6.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S54 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0705.
GeneTreeiENSGT00390000012532.
HOGENOMiHOG000154118.
HOVERGENiHBG059673.
InParanoidiQ80WQ6.
OMAiRGIPHSA.
OrthoDBiEOG7288QH.
PhylomeDBiQ80WQ6.
TreeFamiTF312988.

Family and domain databases

Gene3Di1.20.1540.10. 2 hits.
InterProiIPR002610. Peptidase_S54_rhomboid.
IPR022764. Peptidase_S54_rhomboid_dom.
IPR022241. Rhomboid_SP.
[Graphical view]
PANTHERiPTHR22936. PTHR22936. 1 hit.
PfamiPF01694. Rhomboid. 1 hit.
PF12595. Rhomboid_SP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80WQ6-1 [UniParc]FASTAAdd to Basket

« Hide

MASADKNGSN LPSVSGSRLQ SRKPPNLSIT IPPPESQAPG EQDSMLPERR    50
KNPAYLKSVS LQEPRGRWQE GAEKRPGFRR QASLSQSIRK STAQWFGVSG 100
DWEGKRQNWH RRSLHHCSVH YGRLKASCQR ELELPSQEVP SFQGTESPKP 150
CKMPKIVDPL ARGRAFRHPD EVDRPHAAHP PLTPGVLSLT SFTSVRSGYS 200
HLPRRKRISV AHMSFQAAAA LLKGRSVLDA TGQRCRHVKR SFAYPSFLEE 250
DAVDGADTFD SSFFSKEEMS SMPDDVFESP PLSASYFRGV PHSASPVSPD 300
GVHIPLKEYS GGRALGPGTQ RGKRIASKVK HFAFDRKKRH YGLGVVGNWL 350
NRSYRRSISS TVQRQLESFD SHRPYFTYWL TFVHIIITLL VICTYGIAPV 400
GFAQHVTTQL VLKNRGVYES VKYIQQENFW IGPSSIDLIH LGAKFSPCIR 450
KDQQIEQLVR RERDIERTSG CCVQNDRSGC IQTLKKDCSE TLATFVKWQN 500
DTGPSDKSDL SQKQPSAVVC HQDPRTCEEP ASSGAHIWPD DITKWPICTE 550
QAQSNHTGLL HIDCKIKGRP CCIGTKGSCE ITTREYCEFM HGYFHEDATL 600
CSQVHCLDKV CGLLPFLNPE VPDQFYRIWL SLFLHAGIVH CLVSVVFQMT 650
ILRDLEKLAG WHRISIIFIL SGITGNLASA IFLPYRAEVG PAGSQFGLLA 700
CLFVELFQSW QLLERPWKAF FNLSAIVLFL FICGLLPWID NIAHIFGFLS 750
GMLLAFAFLP YITFGTSDKY RKRALILVSL LVFAGLFASL VLWLYIYPIN 800
WPWIEYLTCF PFTSRFCEKY ELDQVLH 827
Length:827
Mass (Da):93,434
Last modified:June 1, 2003 - v1
Checksum:i650052E5A4BD9CA5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti728 – 7281L → P in BAC26163. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY167043 mRNA. Translation: AAO34122.1.
AK028872 mRNA. Translation: BAC26163.1.
AK171085 mRNA. Translation: BAE42238.1.
AL607039 Genomic DNA. Translation: CAM20511.1.
BC031398 mRNA. Translation: AAH31398.1.
BC052182 mRNA. Translation: AAH52182.1.
CCDSiCCDS25672.1.
RefSeqiNP_001161152.1. NM_001167680.1.
NP_766160.2. NM_172572.3.
UniGeneiMm.89695.

Genome annotation databases

EnsembliENSMUST00000103028; ENSMUSP00000099317; ENSMUSG00000020806.
ENSMUST00000103029; ENSMUSP00000099318; ENSMUSG00000020806.
GeneIDi217344.
KEGGimmu:217344.
UCSCiuc007mls.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY167043 mRNA. Translation: AAO34122.1 .
AK028872 mRNA. Translation: BAC26163.1 .
AK171085 mRNA. Translation: BAE42238.1 .
AL607039 Genomic DNA. Translation: CAM20511.1 .
BC031398 mRNA. Translation: AAH31398.1 .
BC052182 mRNA. Translation: AAH52182.1 .
CCDSi CCDS25672.1.
RefSeqi NP_001161152.1. NM_001167680.1.
NP_766160.2. NM_172572.3.
UniGenei Mm.89695.

3D structure databases

ProteinModelPortali Q80WQ6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q80WQ6. 3 interactions.
MINTi MINT-8177177.

Protein family/group databases

MEROPSi S54.953.

PTM databases

PhosphoSitei Q80WQ6.

Proteomic databases

PaxDbi Q80WQ6.
PRIDEi Q80WQ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000103028 ; ENSMUSP00000099317 ; ENSMUSG00000020806 .
ENSMUST00000103029 ; ENSMUSP00000099318 ; ENSMUSG00000020806 .
GeneIDi 217344.
KEGGi mmu:217344.
UCSCi uc007mls.3. mouse.

Organism-specific databases

CTDi 79651.
MGIi MGI:2442473. Rhbdf2.

Phylogenomic databases

eggNOGi COG0705.
GeneTreei ENSGT00390000012532.
HOGENOMi HOG000154118.
HOVERGENi HBG059673.
InParanoidi Q80WQ6.
OMAi RGIPHSA.
OrthoDBi EOG7288QH.
PhylomeDBi Q80WQ6.
TreeFami TF312988.

Miscellaneous databases

NextBioi 375793.
PROi Q80WQ6.
SOURCEi Search...

Gene expression databases

Bgeei Q80WQ6.
Genevestigatori Q80WQ6.

Family and domain databases

Gene3Di 1.20.1540.10. 2 hits.
InterProi IPR002610. Peptidase_S54_rhomboid.
IPR022764. Peptidase_S54_rhomboid_dom.
IPR022241. Rhomboid_SP.
[Graphical view ]
PANTHERi PTHR22936. PTHR22936. 1 hit.
Pfami PF01694. Rhomboid. 1 hit.
PF12595. Rhomboid_SP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a mouse rhomboid-related gene."
    Kong X., Li S., Shi Y., Teng X., Hu L., Zhu Y.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Skin.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Dendritic cell and Skin.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Embryo and Mammary tumor.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; SER-83; SER-87; SER-293; SER-295 AND SER-298, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling."
    Zettl M., Adrain C., Strisovsky K., Lastun V., Freeman M.
    Cell 145:79-91(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH EGF.

Entry informationi

Entry nameiRHDF2_MOUSE
AccessioniPrimary (citable) accession number: Q80WQ6
Secondary accession number(s): Q3TBR9, Q8BJ70, Q8K2I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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