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Q80WQ6

- RHDF2_MOUSE

UniProt

Q80WQ6 - RHDF2_MOUSE

Protein

Inactive rhomboid protein 2

Gene

Rhbdf2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration.1 Publication

    GO - Biological processi

    1. negative regulation of protein secretion Source: UniProtKB
    2. protein transport Source: UniProtKB-KW
    3. proteolysis Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Protein family/group databases

    MEROPSiS54.953.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive rhomboid protein 2
    Short name:
    iRhom2
    Alternative name(s):
    Rhomboid family member 2
    Rhomboid veinlet-like protein 6
    Rhomboid-related protein
    Gene namesi
    Name:Rhbdf2
    Synonyms:Irhom2, Rhbdl6, Rhor
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2442473. Rhbdf2.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 827827Inactive rhomboid protein 2PRO_0000341939Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei60 – 601Phosphoserine1 Publication
    Modified residuei83 – 831Phosphoserine1 Publication
    Modified residuei87 – 871Phosphoserine1 Publication
    Modified residuei293 – 2931Phosphoserine1 Publication
    Modified residuei295 – 2951Phosphoserine1 Publication
    Modified residuei298 – 2981Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ80WQ6.
    PRIDEiQ80WQ6.

    PTM databases

    PhosphoSiteiQ80WQ6.

    Expressioni

    Gene expression databases

    BgeeiQ80WQ6.
    GenevestigatoriQ80WQ6.

    Interactioni

    Subunit structurei

    Interacts with EGF.1 Publication

    Protein-protein interaction databases

    IntActiQ80WQ6. 3 interactions.
    MINTiMINT-8177177.

    Structurei

    3D structure databases

    ProteinModelPortaliQ80WQ6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 381381CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini403 – 627225LumenalSequence AnalysisAdd
    BLAST
    Topological domaini649 – 66315CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini685 – 6862LumenalSequence Analysis
    Topological domaini708 – 71811CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini740 – 7445LumenalSequence Analysis
    Topological domaini766 – 7738CytoplasmicSequence Analysis
    Topological domaini795 – 82733LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei382 – 40221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei628 – 64821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei664 – 68421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei687 – 70721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei719 – 73921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei745 – 76521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei774 – 79421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S54 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0705.
    GeneTreeiENSGT00390000012532.
    HOGENOMiHOG000154118.
    HOVERGENiHBG059673.
    InParanoidiQ80WQ6.
    OMAiRGIPHSA.
    OrthoDBiEOG7288QH.
    PhylomeDBiQ80WQ6.
    TreeFamiTF312988.

    Family and domain databases

    Gene3Di1.20.1540.10. 2 hits.
    InterProiIPR002610. Peptidase_S54_rhomboid.
    IPR022764. Peptidase_S54_rhomboid_dom.
    IPR022241. Rhomboid_SP.
    [Graphical view]
    PANTHERiPTHR22936. PTHR22936. 1 hit.
    PfamiPF01694. Rhomboid. 1 hit.
    PF12595. Rhomboid_SP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q80WQ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASADKNGSN LPSVSGSRLQ SRKPPNLSIT IPPPESQAPG EQDSMLPERR    50
    KNPAYLKSVS LQEPRGRWQE GAEKRPGFRR QASLSQSIRK STAQWFGVSG 100
    DWEGKRQNWH RRSLHHCSVH YGRLKASCQR ELELPSQEVP SFQGTESPKP 150
    CKMPKIVDPL ARGRAFRHPD EVDRPHAAHP PLTPGVLSLT SFTSVRSGYS 200
    HLPRRKRISV AHMSFQAAAA LLKGRSVLDA TGQRCRHVKR SFAYPSFLEE 250
    DAVDGADTFD SSFFSKEEMS SMPDDVFESP PLSASYFRGV PHSASPVSPD 300
    GVHIPLKEYS GGRALGPGTQ RGKRIASKVK HFAFDRKKRH YGLGVVGNWL 350
    NRSYRRSISS TVQRQLESFD SHRPYFTYWL TFVHIIITLL VICTYGIAPV 400
    GFAQHVTTQL VLKNRGVYES VKYIQQENFW IGPSSIDLIH LGAKFSPCIR 450
    KDQQIEQLVR RERDIERTSG CCVQNDRSGC IQTLKKDCSE TLATFVKWQN 500
    DTGPSDKSDL SQKQPSAVVC HQDPRTCEEP ASSGAHIWPD DITKWPICTE 550
    QAQSNHTGLL HIDCKIKGRP CCIGTKGSCE ITTREYCEFM HGYFHEDATL 600
    CSQVHCLDKV CGLLPFLNPE VPDQFYRIWL SLFLHAGIVH CLVSVVFQMT 650
    ILRDLEKLAG WHRISIIFIL SGITGNLASA IFLPYRAEVG PAGSQFGLLA 700
    CLFVELFQSW QLLERPWKAF FNLSAIVLFL FICGLLPWID NIAHIFGFLS 750
    GMLLAFAFLP YITFGTSDKY RKRALILVSL LVFAGLFASL VLWLYIYPIN 800
    WPWIEYLTCF PFTSRFCEKY ELDQVLH 827
    Length:827
    Mass (Da):93,434
    Last modified:June 1, 2003 - v1
    Checksum:i650052E5A4BD9CA5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti728 – 7281L → P in BAC26163. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY167043 mRNA. Translation: AAO34122.1.
    AK028872 mRNA. Translation: BAC26163.1.
    AK171085 mRNA. Translation: BAE42238.1.
    AL607039 Genomic DNA. Translation: CAM20511.1.
    BC031398 mRNA. Translation: AAH31398.1.
    BC052182 mRNA. Translation: AAH52182.1.
    CCDSiCCDS25672.1.
    RefSeqiNP_001161152.1. NM_001167680.1.
    NP_766160.2. NM_172572.3.
    UniGeneiMm.89695.

    Genome annotation databases

    EnsembliENSMUST00000103028; ENSMUSP00000099317; ENSMUSG00000020806.
    ENSMUST00000103029; ENSMUSP00000099318; ENSMUSG00000020806.
    GeneIDi217344.
    KEGGimmu:217344.
    UCSCiuc007mls.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY167043 mRNA. Translation: AAO34122.1 .
    AK028872 mRNA. Translation: BAC26163.1 .
    AK171085 mRNA. Translation: BAE42238.1 .
    AL607039 Genomic DNA. Translation: CAM20511.1 .
    BC031398 mRNA. Translation: AAH31398.1 .
    BC052182 mRNA. Translation: AAH52182.1 .
    CCDSi CCDS25672.1.
    RefSeqi NP_001161152.1. NM_001167680.1.
    NP_766160.2. NM_172572.3.
    UniGenei Mm.89695.

    3D structure databases

    ProteinModelPortali Q80WQ6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q80WQ6. 3 interactions.
    MINTi MINT-8177177.

    Protein family/group databases

    MEROPSi S54.953.

    PTM databases

    PhosphoSitei Q80WQ6.

    Proteomic databases

    PaxDbi Q80WQ6.
    PRIDEi Q80WQ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000103028 ; ENSMUSP00000099317 ; ENSMUSG00000020806 .
    ENSMUST00000103029 ; ENSMUSP00000099318 ; ENSMUSG00000020806 .
    GeneIDi 217344.
    KEGGi mmu:217344.
    UCSCi uc007mls.3. mouse.

    Organism-specific databases

    CTDi 79651.
    MGIi MGI:2442473. Rhbdf2.

    Phylogenomic databases

    eggNOGi COG0705.
    GeneTreei ENSGT00390000012532.
    HOGENOMi HOG000154118.
    HOVERGENi HBG059673.
    InParanoidi Q80WQ6.
    OMAi RGIPHSA.
    OrthoDBi EOG7288QH.
    PhylomeDBi Q80WQ6.
    TreeFami TF312988.

    Miscellaneous databases

    NextBioi 375793.
    PROi Q80WQ6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q80WQ6.
    Genevestigatori Q80WQ6.

    Family and domain databases

    Gene3Di 1.20.1540.10. 2 hits.
    InterProi IPR002610. Peptidase_S54_rhomboid.
    IPR022764. Peptidase_S54_rhomboid_dom.
    IPR022241. Rhomboid_SP.
    [Graphical view ]
    PANTHERi PTHR22936. PTHR22936. 1 hit.
    Pfami PF01694. Rhomboid. 1 hit.
    PF12595. Rhomboid_SP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a mouse rhomboid-related gene."
      Kong X., Li S., Shi Y., Teng X., Hu L., Zhu Y.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Skin.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Dendritic cell and Skin.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Embryo and Mammary tumor.
    5. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; SER-83; SER-87; SER-293; SER-295 AND SER-298, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling."
      Zettl M., Adrain C., Strisovsky K., Lastun V., Freeman M.
      Cell 145:79-91(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH EGF.

    Entry informationi

    Entry nameiRHDF2_MOUSE
    AccessioniPrimary (citable) accession number: Q80WQ6
    Secondary accession number(s): Q3TBR9, Q8BJ70, Q8K2I7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3