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Protein
Submitted name:

Protein Tnfrsf14

Gene

Tnfrsf14

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • apoptotic signaling pathway Source: GO_Central
  • defense response to Gram-negative bacterium Source: MGI
  • defense response to Gram-positive bacterium Source: MGI
  • immune response Source: GO_Central
  • inflammatory response Source: GO_Central
  • multicellular organismal development Source: GO_Central
  • negative regulation of alpha-beta T cell proliferation Source: MGI
  • positive regulation of cytokine secretion involved in immune response Source: MGI
  • positive regulation of MAPK cascade Source: GO_Central
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of T cell migration Source: MGI
  • regulation of apoptotic process Source: GO_Central
  • response to lipopolysaccharide Source: GO_Central
  • tumor necrosis factor-mediated signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiR-MMU-388841. Costimulation by the CD28 family.
R-MMU-5669034. TNFs bind their physiological receptors.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Tnfrsf14Imported
Submitted name:
Tumor necrosis factor receptor superfamily member 14Imported
Gene namesi
Name:Tnfrsf14Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2675303. Tnfrsf14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei207 – 23024HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838Sequence analysisAdd
BLAST
Chaini39 – 275237Sequence analysisPRO_5006748599Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiQ80WM9.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ80WM9. 2 interactions.
STRINGi10090.ENSMUSP00000045240.

Structurei

3D structure databases

SMRiQ80WM9. Positions 40-205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 7535TNFR-CysInterPro annotationAdd
BLAST
Domaini77 – 11943TNFR-CysInterPro annotationAdd
BLAST
Domaini120 – 16243TNFR-CysInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IX15. Eukaryota.
ENOG410ZEC2. LUCA.
GeneTreeiENSGT00760000119204.
HOVERGENiHBG072084.
KOiK05152.
OMAiIICVKRR.
PhylomeDBiQ80WM9.
TreeFamiTF331157.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022332. TNFR_14.
[Graphical view]
PfamiPF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01965. TNFACTORR14.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80WM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLPGWGSA PWSQAPTDNT FRLVPCVFLL NLLQRISAQP SCRQEEFLVG
60 70 80 90 100
DECCPMCNPG YHVKQVCSEH TGTVCAPCPP QTYTAHANGL SKCLPCGVCD
110 120 130 140 150
PDMGLLTWQE CSSWKDTVCR CIPGYFCENQ DGSHCSTCLQ HTTCPPGQRV
160 170 180 190 200
EKRGTHDQDT VCADCLTGTF SLGGTQEECL PWTNCSAFQQ EVRRGTNSTD
210 220 230 240 250
TTCSSQVVYY VVSILLPLVI VGAGIAGFLI CTRRHLHTSS VAKELEPFQE
260 270
QQENTIRFPV TEVGFAETEE ETASN
Length:275
Mass (Da):30,171
Last modified:June 1, 2003 - v1
Checksum:iC4A7EAD8EFC0521D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX004788 Genomic DNA. No translation available.
AY264405 mRNA. Translation: AAO89081.1.
RefSeqiNP_849262.1. NM_178931.2.
XP_006538894.1. XM_006538831.2.
UniGeneiMm.215147.

Genome annotation databases

EnsembliENSMUST00000045919; ENSMUSP00000045240; ENSMUSG00000042333.
ENSMUST00000123514; ENSMUSP00000116757; ENSMUSG00000042333.
GeneIDi230979.
KEGGimmu:230979.
UCSCiuc008wcj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX004788 Genomic DNA. No translation available.
AY264405 mRNA. Translation: AAO89081.1.
RefSeqiNP_849262.1. NM_178931.2.
XP_006538894.1. XM_006538831.2.
UniGeneiMm.215147.

3D structure databases

SMRiQ80WM9. Positions 40-205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80WM9. 2 interactions.
STRINGi10090.ENSMUSP00000045240.

Proteomic databases

MaxQBiQ80WM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045919; ENSMUSP00000045240; ENSMUSG00000042333.
ENSMUST00000123514; ENSMUSP00000116757; ENSMUSG00000042333.
GeneIDi230979.
KEGGimmu:230979.
UCSCiuc008wcj.1. mouse.

Organism-specific databases

CTDi8764.
MGIiMGI:2675303. Tnfrsf14.

Phylogenomic databases

eggNOGiENOG410IX15. Eukaryota.
ENOG410ZEC2. LUCA.
GeneTreeiENSGT00760000119204.
HOVERGENiHBG072084.
KOiK05152.
OMAiIICVKRR.
PhylomeDBiQ80WM9.
TreeFamiTF331157.

Enzyme and pathway databases

ReactomeiR-MMU-388841. Costimulation by the CD28 family.
R-MMU-5669034. TNFs bind their physiological receptors.

Miscellaneous databases

NextBioi380338.
SOURCEiSearch...

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022332. TNFR_14.
[Graphical view]
PfamiPF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01965. TNFACTORR14.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Light regulation in a murine model of ovarian carcinoma."
    Benencia F., Conejo-Garcia J.R., Courreges M.C., Coukos G.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
    Tissue: ThymusImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ80WM9_MOUSE
AccessioniPrimary (citable) accession number: Q80WM9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: April 13, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.