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Protein
Submitted name:

Tumor necrosis factor receptor superfamily member 14

Gene

Tnfrsf14

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • apoptotic signaling pathway Source: GO_Central
  • defense response to Gram-negative bacterium Source: MGI
  • defense response to Gram-positive bacterium Source: MGI
  • inflammatory response Source: GO_Central
  • multicellular organism development Source: GO_Central
  • negative regulation of alpha-beta T cell proliferation Source: MGI
  • positive regulation of cytokine secretion involved in immune response Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of T cell migration Source: MGI
  • regulation of apoptotic process Source: GO_Central
  • response to lipopolysaccharide Source: GO_Central

Keywordsi

Molecular functionReceptorImported

Enzyme and pathway databases

ReactomeiR-MMU-388841 Costimulation by the CD28 family
R-MMU-5669034 TNFs bind their physiological receptors

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor receptor superfamily member 14Imported
Submitted name:
Tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)Imported
Gene namesi
Name:Tnfrsf14Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2675303 Tnfrsf14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei207 – 230HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_501410712339 – 275Sequence analysisAdd BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 67PROSITE-ProRule annotation
Disulfide bondi57 ↔ 75PROSITE-ProRule annotation
Disulfide bondi78 ↔ 93PROSITE-ProRule annotation
Disulfide bondi144 ↔ 162PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

MaxQBiQ80WM9

Expressioni

Gene expression databases

BgeeiENSMUSG00000042333

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ80WM9, 2 interactors
STRINGi10090.ENSMUSP00000045240

Structurei

3D structure databases

SMRiQ80WM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 75TNFR-CysInterPro annotationAdd BLAST35
Repeati41 – 75TNFR-CysPROSITE-ProRule annotationAdd BLAST35
Domaini77 – 119TNFR-CysInterPro annotationAdd BLAST43
Repeati77 – 119TNFR-CysPROSITE-ProRule annotationAdd BLAST43
Domaini120 – 162TNFR-CysInterPro annotationAdd BLAST43
Repeati120 – 162TNFR-CysPROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IX15 Eukaryota
ENOG410ZEC2 LUCA
GeneTreeiENSGT00760000119204
HOVERGENiHBG072084
KOiK05152
OMAiCRVCDPA
OrthoDBiEOG091G03XW
TreeFamiTF331157

Family and domain databases

CDDicd10582 TNFRSF14, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022332 TNFR_14
IPR034031 TNFRSF14/UL144_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 3 hits
PRINTSiPR01965 TNFACTORR14
SMARTiView protein in SMART
SM00208 TNFR, 4 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q80WM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLPGWGSA PWSQAPTDNT FRLVPCVFLL NLLQRISAQP SCRQEEFLVG
60 70 80 90 100
DECCPMCNPG YHVKQVCSEH TGTVCAPCPP QTYTAHANGL SKCLPCGVCD
110 120 130 140 150
PDMGLLTWQE CSSWKDTVCR CIPGYFCENQ DGSHCSTCLQ HTTCPPGQRV
160 170 180 190 200
EKRGTHDQDT VCADCLTGTF SLGGTQEECL PWTNCSAFQQ EVRRGTNSTD
210 220 230 240 250
TTCSSQVVYY VVSILLPLVI VGAGIAGFLI CTRRHLHTSS VAKELEPFQE
260 270
QQENTIRFPV TEVGFAETEE ETASN
Length:275
Mass (Da):30,171
Last modified:June 1, 2003 - v1
Checksum:iC4A7EAD8EFC0521D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX004788 Genomic DNA No translation available.
AY264405 mRNA Translation: AAO89081.1
RefSeqiNP_849262.1, NM_178931.2
XP_006538894.1, XM_006538831.3
UniGeneiMm.215147

Genome annotation databases

EnsembliENSMUST00000123514; ENSMUSP00000116757; ENSMUSG00000042333
GeneIDi230979
KEGGimmu:230979
UCSCiuc008wcj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ80WM9_MOUSE
AccessioniPrimary (citable) accession number: Q80WM9
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health