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Protein
Submitted name:

2',5'-oligoisoadenylate synthetase-dependent ribonuclease L

Gene

Rnasel

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. protein kinase activity Source: InterPro
  3. ribonuclease activity Source: RGD
  4. rRNA binding Source: RGD

GO - Biological processi

  1. mRNA processing Source: InterPro
  2. RNA phosphodiester bond hydrolysis Source: GOC
  3. rRNA processing Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
2',5'-oligoisoadenylate synthetase-dependent ribonuclease LImported
Gene namesi
Name:RnaselImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi727933. Rnasel.

Subcellular locationi

GO - Cellular componenti

  1. nuclear matrix Source: RGD
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ80WM6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032975.

Structurei

3D structure databases

SMRiQ80WM6. Positions 24-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 8 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotation, RepeatUniRule annotation

Phylogenomic databases

eggNOGiCOG0666.
HOGENOMiHOG000276879.
HOVERGENiHBG012673.
KOiK01165.
PhylomeDBiQ80WM6.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR010513. KEN_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR006567. PUG-dom.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF00069. Pkinase. 1 hit.
PF06479. Ribonuc_2-5A. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 8 hits.
SM00580. PUG. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS51392. KEN. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80WM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METTDHSTPQ CGSASAGGQK TVGKDDYLLI EAVNKGDADR VQQLLEQGAD
60 70 80 90 100
ANVCEESGGW TPLHNAVQSG RVDIVNLLLR YGADPHRRKK NGATPFIVAG
110 120 130 140 150
ICGDVSLLQI FLSRGANINE RDMYGFTAFM EAAEYGNVEA LKFLFAEGAD
160 170 180 190 200
VNLRRETTED RRRLKQGGAT ALMSAAENGH PEVVRILLDE MKAEADARDN
210 220 230 240 250
MGRNALIRSL LNRDCENVEI HVEEITSVLI QYGADINVRG EGEKTPLISA
260 270 280 290 300
VKRKHTGLVQ MLLSQEGIKV NDRDSEGKTA LQIAVELKLK EIVRLLLEKG
310 320 330 340 350
ADTKCGDLVW IAKRNYDHGL VKLLLSYEAN HDTNPPAKDW LPHSARWGEA
360 370 380 390 400
LERLHSVSRP MTGKLKIFMN DDYKIASTSE GGIYLGIYDN REVAVKVFCE
410 420 430 440 450
NSSRGRKEVS CLRDCGDHSN LLTFYGSEEH KGSLYVCVSL CESTLEKFLN
460 470 480 490 500
VPREEPMEKG EDKFALSVLL SIFKGVQKLH MHGYSHQNLQ PPNILIDSEK
510 520 530 540 550
AVRLADFDES IQWMRESQTV QRDLEDLGRL VLYVVNKGEI PFETLKGQND
560 570 580 590 600
EELLTIAPNE ETKDLVHCLF SPGENVKNCL MDLLGHPFFW TWENRYRTLR
610 620 630 640 650
DVGNESDIKV RNNKSKLLKL LQPQTHAPSR SFDRWTSKID KRVMSDMNGF
660 670 680 690 700
YKSRKGYRDT VGDLLKFIRN IGEHINEEKN RQMKEILGDP SRYFQETFPD
710 720 730
LVIYIYKKLK ETEFRKHFPQ PPPSLSVPEA AGPGGVQS
Length:738
Mass (Da):83,210
Last modified:May 31, 2003 - v1
Checksum:i2A288A114C5FE633
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262823 mRNA. Translation: AAP22025.1.
RefSeqiNP_872614.1. NM_182673.2.
UniGeneiRn.107928.
Rn.228575.

Genome annotation databases

GeneIDi359726.
KEGGirno:359726.
UCSCiRGD:727933. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262823 mRNA. Translation: AAP22025.1.
RefSeqiNP_872614.1. NM_182673.2.
UniGeneiRn.107928.
Rn.228575.

3D structure databases

SMRiQ80WM6. Positions 24-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032975.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi359726.
KEGGirno:359726.
UCSCiRGD:727933. rat.

Organism-specific databases

CTDi6041.
RGDi727933. Rnasel.

Phylogenomic databases

eggNOGiCOG0666.
HOGENOMiHOG000276879.
HOVERGENiHBG012673.
KOiK01165.
PhylomeDBiQ80WM6.

Miscellaneous databases

NextBioi672697.

Gene expression databases

GenevestigatoriQ80WM6.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR010513. KEN_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR006567. PUG-dom.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF00069. Pkinase. 1 hit.
PF06479. Ribonuc_2-5A. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 8 hits.
SM00580. PUG. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS51392. KEN. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of the rat RNaseL gene."
    Hummer B.T., Hassel B.A.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ80WM6_RAT
AccessioniPrimary (citable) accession number: Q80WM6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2003
Last sequence update: May 31, 2003
Last modified: March 31, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.