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Protein
Submitted name:

2',5'-oligoisoadenylate synthetase-dependent ribonuclease L

Gene

Rnasel

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: InterPro
  • protein kinase activity Source: InterPro
  • ribonuclease activity Source: RGD
  • rRNA binding Source: RGD

GO - Biological processi

  • mRNA processing Source: InterPro
  • rRNA processing Source: RGD

Names & Taxonomyi

Protein namesi
Submitted name:
2',5'-oligoisoadenylate synthetase-dependent ribonuclease LImported
Gene namesi
Name:RnaselImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi727933. Rnasel.

Subcellular locationi

GO - Cellular componenti

  • nuclear matrix Source: RGD

PTM / Processingi

Proteomic databases

PaxDbiQ80WM6.

Expressioni

Gene expression databases

GenevisibleiQ80WM6. RN.

Structurei

3D structure databases

ProteinModelPortaliQ80WM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 308ANK_REP_REGIONInterPro annotationAdd BLAST285
Repeati58 – 90ANKPROSITE-ProRule annotationAdd BLAST33
Repeati91 – 123ANKPROSITE-ProRule annotationAdd BLAST33
Repeati124 – 156ANKPROSITE-ProRule annotationAdd BLAST33
Repeati167 – 189ANKPROSITE-ProRule annotationAdd BLAST23
Repeati276 – 308ANKPROSITE-ProRule annotationAdd BLAST33
Domaini369 – 589Protein kinaseInterPro annotationAdd BLAST221
Domaini592 – 725KENInterPro annotationAdd BLAST134

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1027. Eukaryota.
KOG4177. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000276879.
HOVERGENiHBG012673.
KOiK01165.
PhylomeDBiQ80WM6.

Family and domain databases

CDDicd00204. ANK. 2 hits.
Gene3Di1.25.40.20. 4 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR010513. KEN_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR018997. PUB_domain.
PfamiView protein in Pfam
PF12796. Ank_2. 2 hits.
PF00069. Pkinase. 1 hit.
PF06479. Ribonuc_2-5A. 1 hit.
PRINTSiPR01415. ANKYRIN.
SMARTiView protein in SMART
SM00248. ANK. 8 hits.
SM00580. PUG. 1 hit.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS51392. KEN. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q80WM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METTDHSTPQ CGSASAGGQK TVGKDDYLLI EAVNKGDADR VQQLLEQGAD
60 70 80 90 100
ANVCEESGGW TPLHNAVQSG RVDIVNLLLR YGADPHRRKK NGATPFIVAG
110 120 130 140 150
ICGDVSLLQI FLSRGANINE RDMYGFTAFM EAAEYGNVEA LKFLFAEGAD
160 170 180 190 200
VNLRRETTED RRRLKQGGAT ALMSAAENGH PEVVRILLDE MKAEADARDN
210 220 230 240 250
MGRNALIRSL LNRDCENVEI HVEEITSVLI QYGADINVRG EGEKTPLISA
260 270 280 290 300
VKRKHTGLVQ MLLSQEGIKV NDRDSEGKTA LQIAVELKLK EIVRLLLEKG
310 320 330 340 350
ADTKCGDLVW IAKRNYDHGL VKLLLSYEAN HDTNPPAKDW LPHSARWGEA
360 370 380 390 400
LERLHSVSRP MTGKLKIFMN DDYKIASTSE GGIYLGIYDN REVAVKVFCE
410 420 430 440 450
NSSRGRKEVS CLRDCGDHSN LLTFYGSEEH KGSLYVCVSL CESTLEKFLN
460 470 480 490 500
VPREEPMEKG EDKFALSVLL SIFKGVQKLH MHGYSHQNLQ PPNILIDSEK
510 520 530 540 550
AVRLADFDES IQWMRESQTV QRDLEDLGRL VLYVVNKGEI PFETLKGQND
560 570 580 590 600
EELLTIAPNE ETKDLVHCLF SPGENVKNCL MDLLGHPFFW TWENRYRTLR
610 620 630 640 650
DVGNESDIKV RNNKSKLLKL LQPQTHAPSR SFDRWTSKID KRVMSDMNGF
660 670 680 690 700
YKSRKGYRDT VGDLLKFIRN IGEHINEEKN RQMKEILGDP SRYFQETFPD
710 720 730
LVIYIYKKLK ETEFRKHFPQ PPPSLSVPEA AGPGGVQS
Length:738
Mass (Da):83,210
Last modified:June 1, 2003 - v1
Checksum:i2A288A114C5FE633
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262823 mRNA. Translation: AAP22025.1.
RefSeqiNP_872614.1. NM_182673.2.
UniGeneiRn.107928.
Rn.228575.

Genome annotation databases

GeneIDi359726.
KEGGirno:359726.
UCSCiRGD:727933. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ80WM6_RAT
AccessioniPrimary (citable) accession number: Q80WM6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: July 5, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)