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Protein

Hyaluronan and proteoglycan link protein 3

Gene

Hapln3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May function in hyaluronic acid binding.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Hyaluronic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan and proteoglycan link protein 3
Gene namesi
Name:Hapln3
Synonyms:Lpr3
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1914916. Hapln3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 359342Hyaluronan and proteoglycan link protein 3Sequence analysisPRO_0000013191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi70 ↔ 146By similarity
Disulfide bondi188 ↔ 259By similarity
Disulfide bondi212 ↔ 233By similarity
Disulfide bondi286 ↔ 355By similarity
Disulfide bondi311 ↔ 332By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ80WM5.
PaxDbiQ80WM5.
PRIDEiQ80WM5.

Expressioni

Gene expression databases

BgeeiQ80WM5.
CleanExiMM_HAPLN3.
GenevisibleiQ80WM5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032827.

Structurei

3D structure databases

ProteinModelPortaliQ80WM5.
SMRiQ80WM5. Positions 51-260, 276-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 164117Ig-like V-typeCuratedAdd
BLAST
Domaini166 – 26196Link 1PROSITE-ProRule annotationCuratedAdd
BLAST
Domaini266 – 35792Link 2PROSITE-ProRule annotationCuratedAdd
BLAST

Sequence similaritiesi

Belongs to the HAPLN family.Curated
Contains 2 Link domains.PROSITE-ProRule annotationCurated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IG4T. Eukaryota.
ENOG410Z8AC. LUCA.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000234353.
HOVERGENiHBG051922.
InParanoidiQ80WM5.
KOiK06852.
OMAiFGFPDPQ.
OrthoDBiEOG7ZWD1D.
TreeFamiTF332134.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link_dom.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF56436. SSF56436. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80WM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLFLVLLS PFPCVLGLPF YNGFYYSNDL SGRTLGNGYG EGLFNGVKLV
60 70 80 90 100
VETTEESLFS HQGASVTLPC HYHYEPALAS PRHVRVKWWK LSENGAPEQD
110 120 130 140 150
VLVVIGQRHR SFGDYQGRVQ LRQDKQQEVS LELRDLRLED SGRYRCEVID
160 170 180 190 200
GLEDESGLVE LELRGVVFPY QSREGRYQLN FHEAQQACQE QGAMVATFEQ
210 220 230 240 250
LFRAWEEGLD WCNAGWLQDA SVQYPIVLPR QPCGGLGLAP GVRSYGQRHH
260 270 280 290 300
RLHRYDVFCF AAALKGRVYY LENPKKLTLL EAREACQEDG AQISTVGQLF
310 320 330 340 350
AAWKFRGLDR CDAGWLADGS ARYPIVHPRL NCGPPEPGVR TFGFPDPHTR

YGVYCYVQH
Length:359
Mass (Da):40,740
Last modified:July 27, 2011 - v3
Checksum:i81E8F78DA76BB1E3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121F → L in AAP12624 (Ref. 2) Curated
Sequence conflicti29 – 313DLS → GLR in AAP12624 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262757 mRNA. Translation: AAP22049.1.
AY269788 mRNA. Translation: AAP12624.1.
AK136956 mRNA. Translation: BAE23187.1.
CH466543 Genomic DNA. Translation: EDL07078.1.
CCDSiCCDS21378.1.
RefSeqiNP_839986.2. NM_178255.3.
XP_006541190.1. XM_006541127.2.
XP_006541191.1. XM_006541128.2.
UniGeneiMm.178759.

Genome annotation databases

EnsembliENSMUST00000206092; ENSMUSP00000146090; ENSMUSG00000030606.
GeneIDi67666.
KEGGimmu:67666.
UCSCiuc009hxy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262757 mRNA. Translation: AAP22049.1.
AY269788 mRNA. Translation: AAP12624.1.
AK136956 mRNA. Translation: BAE23187.1.
CH466543 Genomic DNA. Translation: EDL07078.1.
CCDSiCCDS21378.1.
RefSeqiNP_839986.2. NM_178255.3.
XP_006541190.1. XM_006541127.2.
XP_006541191.1. XM_006541128.2.
UniGeneiMm.178759.

3D structure databases

ProteinModelPortaliQ80WM5.
SMRiQ80WM5. Positions 51-260, 276-359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032827.

Proteomic databases

MaxQBiQ80WM5.
PaxDbiQ80WM5.
PRIDEiQ80WM5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000206092; ENSMUSP00000146090; ENSMUSG00000030606.
GeneIDi67666.
KEGGimmu:67666.
UCSCiuc009hxy.1. mouse.

Organism-specific databases

CTDi145864.
MGIiMGI:1914916. Hapln3.

Phylogenomic databases

eggNOGiENOG410IG4T. Eukaryota.
ENOG410Z8AC. LUCA.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000234353.
HOVERGENiHBG051922.
InParanoidiQ80WM5.
KOiK06852.
OMAiFGFPDPQ.
OrthoDBiEOG7ZWD1D.
TreeFamiTF332134.

Miscellaneous databases

PROiQ80WM5.
SOURCEiSearch...

Gene expression databases

BgeeiQ80WM5.
CleanExiMM_HAPLN3.
GenevisibleiQ80WM5. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link_dom.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF56436. SSF56436. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links."
    Spicer A.P., Joo A., Bowling R.A. Jr.
    J. Biol. Chem. 278:21083-21091(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6JImported.
  2. "Discoordinate expression of link proteins and skeletal tissue proteoglycans (aggrecan and versican) in different organs from early embryonic to adult age of mice."
    Czipri M., Nesterovitch A.B., Glant T.T.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJImported.
    Tissue: BrainImported.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiHPLN3_MOUSE
AccessioniPrimary (citable) accession number: Q80WM5
Secondary accession number(s): Q3UVT2, Q80XX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.