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Protein

Bystin

Gene

Bysl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.By similarity

GO - Biological processi

  • brain development Source: RGD
  • cellular response to growth factor stimulus Source: RGD
  • cellular response to interleukin-1 Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • cellular response to organic cyclic compound Source: RGD
  • ribosome biogenesis Source: UniProtKB-KW

Keywordsi

Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bystin
Gene namesi
Name:ByslImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727959 Bysl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002949341 – 436BystinAdd BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54PhosphoserineBy similarity1
Modified residuei97PhosphoserineCombined sources1
Modified residuei155PhosphothreonineBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei413PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80WL2
PRIDEiQ80WL2

PTM databases

iPTMnetiQ80WL2
PhosphoSitePlusiQ80WL2

Interactioni

Subunit structurei

Binds trophinin, tastin and cytokeratins.By similarity

Protein-protein interaction databases

IntActiQ80WL2, 1 interactor
MINTiQ80WL2
STRINGi10116.ENSRNOP00000067656

Structurei

3D structure databases

SMRiQ80WL2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bystin family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3871 Eukaryota
ENOG410XPH5 LUCA
HOVERGENiHBG024425
InParanoidiQ80WL2
KOiK14797
PhylomeDBiQ80WL2

Family and domain databases

InterProiView protein in InterPro
IPR007955 Bystin
PANTHERiPTHR12821 PTHR12821, 1 hit
PfamiView protein in Pfam
PF05291 Bystin, 1 hit

Sequencei

Sequence statusi: Complete.

Q80WL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKLKVTRGA RNQERHAPLA EQILAGDAVR AGTREKRRRH GVEEEEEYVG
60 70 80 90 100
PRLSRRILQQ ARQQQEELET EHATGDRPAK PRERATRLGP GVPQDGSDEE
110 120 130 140 150
DEEWPTLEKA AKMTVVNHQA EVVVDPEDER AIEMFMNKNP PVRRTLADII
160 170 180 190 200
MEKLTEKQTE VETVMSEVSG FPMPQLDPRV LEVYRGVREV LCKYRSGILP
210 220 230 240 250
KAFKIIPALS NWEQILYVTE PEAWTAAAMY QATRIFASNL KERMAQRFYN
260 270 280 290 300
LVLLPRVRDD IAEYKRLNFH LYMALKKALF KPGAWFKGIL IPLCESGTCT
310 320 330 340 350
LREAIIVGSI ISKCSIPVLH SSAAMLKIAE MEYSGASSIF LRLLLDKKYA
360 370 380 390 400
LPYRVLDALV FHFLAFRTEK RQLPVLWHQC LLTLAQRYKA DLATEQKEAL
410 420 430
LELLRLQPHP QLSPEIRREL QSAVPRDVED VVVTME
Length:436
Mass (Da):50,012
Last modified:July 10, 2007 - v3
Checksum:i6DE83191F5135D5F
GO

Sequence cautioni

The sequence AAH79030 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP22286 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112Missing in AAH79030 (PubMed:15489334).Curated1
Sequence conflicti198I → K in AAH79030 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY257675 mRNA Translation: AAP22286.4 Different initiation.
BC079030 mRNA Translation: AAH79030.1 Different initiation.
RefSeqiNP_872615.3, NM_182674.3
UniGeneiRn.185236

Genome annotation databases

GeneIDi359727
KEGGirno:359727

Similar proteinsi

Entry informationi

Entry nameiBYST_RAT
AccessioniPrimary (citable) accession number: Q80WL2
Secondary accession number(s): Q6AYI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 61 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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