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Protein

Bystin

Gene

Bysl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits.By similarity

GO - Biological processi

  • brain development Source: RGD
  • cellular response to growth factor stimulus Source: RGD
  • cellular response to interleukin-1 Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • cellular response to organic cyclic compound Source: RGD
  • ribosome biogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bystin
Gene namesi
Name:ByslImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727959. Bysl.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleusnucleolus By similarity

  • Note: Associated with 40S ribosomal subunits.By similarity

GO - Cellular componenti

  • cell projection Source: RGD
  • cytoplasm Source: RGD
  • cytoplasmic microtubule Source: RGD
  • nucleolus Source: UniProtKB-SubCell
  • perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436BystinPRO_0000294934Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei97 – 971PhosphoserineCombined sources
Modified residuei166 – 1661PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ80WL2.
PRIDEiQ80WL2.

PTM databases

iPTMnetiQ80WL2.
PhosphoSiteiQ80WL2.

Interactioni

Subunit structurei

Binds trophinin, tastin and cytokeratins.By similarity

Protein-protein interaction databases

IntActiQ80WL2. 1 interaction.
MINTiMINT-7138243.
STRINGi10116.ENSRNOP00000067656.

Family & Domainsi

Sequence similaritiesi

Belongs to the bystin family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3871. Eukaryota.
ENOG410XPH5. LUCA.
HOVERGENiHBG024425.
InParanoidiQ80WL2.
KOiK14797.
PhylomeDBiQ80WL2.

Family and domain databases

InterProiIPR007955. Bystin.
[Graphical view]
PANTHERiPTHR12821. PTHR12821. 1 hit.
PfamiPF05291. Bystin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80WL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKLKVTRGA RNQERHAPLA EQILAGDAVR AGTREKRRRH GVEEEEEYVG
60 70 80 90 100
PRLSRRILQQ ARQQQEELET EHATGDRPAK PRERATRLGP GVPQDGSDEE
110 120 130 140 150
DEEWPTLEKA AKMTVVNHQA EVVVDPEDER AIEMFMNKNP PVRRTLADII
160 170 180 190 200
MEKLTEKQTE VETVMSEVSG FPMPQLDPRV LEVYRGVREV LCKYRSGILP
210 220 230 240 250
KAFKIIPALS NWEQILYVTE PEAWTAAAMY QATRIFASNL KERMAQRFYN
260 270 280 290 300
LVLLPRVRDD IAEYKRLNFH LYMALKKALF KPGAWFKGIL IPLCESGTCT
310 320 330 340 350
LREAIIVGSI ISKCSIPVLH SSAAMLKIAE MEYSGASSIF LRLLLDKKYA
360 370 380 390 400
LPYRVLDALV FHFLAFRTEK RQLPVLWHQC LLTLAQRYKA DLATEQKEAL
410 420 430
LELLRLQPHP QLSPEIRREL QSAVPRDVED VVVTME
Length:436
Mass (Da):50,012
Last modified:July 10, 2007 - v3
Checksum:i6DE83191F5135D5F
GO

Sequence cautioni

The sequence AAH79030.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAP22286.4 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121Missing in AAH79030 (PubMed:15489334).Curated
Sequence conflicti198 – 1981I → K in AAH79030 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY257675 mRNA. Translation: AAP22286.4. Different initiation.
BC079030 mRNA. Translation: AAH79030.1. Different initiation.
RefSeqiNP_872615.3. NM_182674.3.
UniGeneiRn.185236.

Genome annotation databases

GeneIDi359727.
KEGGirno:359727.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY257675 mRNA. Translation: AAP22286.4. Different initiation.
BC079030 mRNA. Translation: AAH79030.1. Different initiation.
RefSeqiNP_872615.3. NM_182674.3.
UniGeneiRn.185236.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ80WL2. 1 interaction.
MINTiMINT-7138243.
STRINGi10116.ENSRNOP00000067656.

PTM databases

iPTMnetiQ80WL2.
PhosphoSiteiQ80WL2.

Proteomic databases

PaxDbiQ80WL2.
PRIDEiQ80WL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi359727.
KEGGirno:359727.

Organism-specific databases

CTDi705.
RGDi727959. Bysl.

Phylogenomic databases

eggNOGiKOG3871. Eukaryota.
ENOG410XPH5. LUCA.
HOVERGENiHBG024425.
InParanoidiQ80WL2.
KOiK14797.
PhylomeDBiQ80WL2.

Miscellaneous databases

PROiQ80WL2.

Family and domain databases

InterProiIPR007955. Bystin.
[Graphical view]
PANTHERiPTHR12821. PTHR12821. 1 hit.
PfamiPF05291. Bystin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of rat bystin gene."
    Yang S., Li Z., Xu L., Zhou J.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-DawleyImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TestisImported.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBYST_RAT
AccessioniPrimary (citable) accession number: Q80WL2
Secondary accession number(s): Q6AYI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: June 8, 2016
This is version 54 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.