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Protein

Equilibrative nucleoside transporter 3

Gene

Slc29a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine (By similarity).By similarity

GO - Molecular functioni

  • nucleoside transmembrane transporter activity Source: RGD

GO - Biological processi

  • nucleoside transmembrane transport Source: GOC
  • nucleoside transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-83936. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Equilibrative nucleoside transporter 3
Alternative name(s):
Solute carrier family 29 member 3
Gene namesi
Name:Slc29a3
Synonyms:Ent3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi727811. Slc29a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151CytoplasmicSequence analysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence analysisAdd
BLAST
Topological domaini73 – 10533ExtracellularSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Topological domaini127 – 1326CytoplasmicSequence analysis
Transmembranei133 – 15321HelicalSequence analysisAdd
BLAST
Topological domaini154 – 1629ExtracellularSequence analysis
Transmembranei163 – 18321HelicalSequence analysisAdd
BLAST
Topological domaini184 – 19916CytoplasmicSequence analysisAdd
BLAST
Transmembranei200 – 22021HelicalSequence analysisAdd
BLAST
Topological domaini221 – 23010ExtracellularSequence analysis
Transmembranei231 – 25121HelicalSequence analysisAdd
BLAST
Topological domaini252 – 30554CytoplasmicSequence analysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence analysisAdd
BLAST
Topological domaini327 – 34014ExtracellularSequence analysisAdd
BLAST
Transmembranei341 – 36121HelicalSequence analysisAdd
BLAST
Topological domaini362 – 37716CytoplasmicSequence analysisAdd
BLAST
Transmembranei378 – 39821HelicalSequence analysisAdd
BLAST
Topological domaini399 – 41416ExtracellularSequence analysisAdd
BLAST
Transmembranei415 – 43723HelicalSequence analysisAdd
BLAST
Topological domaini438 – 45013CytoplasmicSequence analysisAdd
BLAST
Transmembranei451 – 47121HelicalSequence analysisAdd
BLAST
Topological domaini472 – 4754ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475Equilibrative nucleoside transporter 3PRO_0000209345Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211PhosphoserineBy similarity
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ80WK7.
PRIDEiQ80WK7.

PTM databases

iPTMnetiQ80WK7.

Expressioni

Tissue specificityi

Widely expressed. Highest levels in heart and liver (at protein level).1 Publication

Gene expression databases

ExpressionAtlasiQ80WK7. baseline and differential.
GenevisibleiQ80WK7. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000689.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1479. Eukaryota.
ENOG410Y3MT. LUCA.
GeneTreeiENSGT00390000002232.
HOGENOMiHOG000007684.
HOVERGENiHBG108444.
InParanoidiQ80WK7.
KOiK15014.
PhylomeDBiQ80WK7.

Family and domain databases

InterProiIPR030193. ENT3.
IPR002259. Eqnu_transpt.
[Graphical view]
PANTHERiPTHR10332. PTHR10332. 1 hit.
PTHR10332:SF17. PTHR10332:SF17. 1 hit.
PfamiPF01733. Nucleoside_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF016379. ENT. 1 hit.
PRINTSiPR01130. DERENTRNSPRT.

Sequencei

Sequence statusi: Complete.

Q80WK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFASEDIAY HSSNAVYRVP SNRHEADQEA LLGKPLDYPA PGLQRPEDRF
60 70 80 90 100
NGAYIIFFCL GIGGLLPWNF FVTAKEYWAF KLRNCSSPAS GKDPEDADIL
110 120 130 140 150
NYFESYLAVA STVPSLLFLV ANFLLVNRIR VHVRVLASLS VSLAIFVVMA
160 170 180 190 200
VLVRVDTSSW TRGFFSIAMA CMAIISSSST IFNSSVYGLT GSFPMRNAQA
210 220 230 240 250
LISGGAMGGT VSAVASLVDL AASSDVRDSA LAFFLTAAVF LGLCVGLYLL
260 270 280 290 300
LPQLEYARYY MRPVVPIHVF SSEDSPPRDA PSTSSVAPAS RAVHTPPLGP
310 320 330 340 350
ILKKTAGLGF CAVFLYFITA LIFPAISTNI QPMHKGTGSP WTSKFYVPLT
360 370 380 390 400
VFLLFNFADL CGRQVTAWIQ VPGPRSKLLP ILAVSRVCLV PLFLLCNYQP
410 420 430 440 450
RSHLTLVLFQ SDIYPILFTC LLGLSNGYLS TLVLMYGPKI VPRELAEATS
460 470
VVMLFYMSLG LMLGSACAAL LEHFI
Length:475
Mass (Da):51,677
Last modified:June 16, 2009 - v2
Checksum:i014B34E12CCA6303
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1421S → P in AAP23232 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY273196 mRNA. Translation: AAP23232.1.
BC078678 mRNA. Translation: AAH78678.1.
RefSeqiNP_853670.2. NM_181639.3.
UniGeneiRn.15870.

Genome annotation databases

EnsembliENSRNOT00000000689; ENSRNOP00000000689; ENSRNOG00000000568.
GeneIDi353307.
KEGGirno:353307.
UCSCiRGD:727811. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY273196 mRNA. Translation: AAP23232.1.
BC078678 mRNA. Translation: AAH78678.1.
RefSeqiNP_853670.2. NM_181639.3.
UniGeneiRn.15870.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000689.

PTM databases

iPTMnetiQ80WK7.

Proteomic databases

PaxDbiQ80WK7.
PRIDEiQ80WK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000689; ENSRNOP00000000689; ENSRNOG00000000568.
GeneIDi353307.
KEGGirno:353307.
UCSCiRGD:727811. rat.

Organism-specific databases

CTDi55315.
RGDi727811. Slc29a3.

Phylogenomic databases

eggNOGiKOG1479. Eukaryota.
ENOG410Y3MT. LUCA.
GeneTreeiENSGT00390000002232.
HOGENOMiHOG000007684.
HOVERGENiHBG108444.
InParanoidiQ80WK7.
KOiK15014.
PhylomeDBiQ80WK7.

Enzyme and pathway databases

ReactomeiR-RNO-83936. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Miscellaneous databases

PROiQ80WK7.

Gene expression databases

ExpressionAtlasiQ80WK7. baseline and differential.
GenevisibleiQ80WK7. RN.

Family and domain databases

InterProiIPR030193. ENT3.
IPR002259. Eqnu_transpt.
[Graphical view]
PANTHERiPTHR10332. PTHR10332. 1 hit.
PTHR10332:SF17. PTHR10332:SF17. 1 hit.
PfamiPF01733. Nucleoside_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF016379. ENT. 1 hit.
PRINTSiPR01130. DERENTRNSPRT.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of rat equilibrative nucleoside transporter type 3 isoform."
    Toan S.-V., Ward J.L., Tse C.-M.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Brown Norway.
    Tissue: Testis.
  3. "Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes."
    Baldwin S.A., Yao S.Y.M., Hyde R.J., Ng A.M.L., Foppolo S., Barnes K., Ritzel M.W.L., Cass C.E., Young J.D.
    J. Biol. Chem. 280:15880-15887(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS29A3_RAT
AccessioniPrimary (citable) accession number: Q80WK7
Secondary accession number(s): Q6AZ86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 16, 2009
Last modified: June 8, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.