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Protein

Equilibrative nucleoside transporter 3

Gene

Slc29a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine (By similarity).By similarity

GO - Molecular functioni

  • nucleoside transmembrane transporter activity Source: RGD

GO - Biological processi

  • nucleoside transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-83936. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Equilibrative nucleoside transporter 3
Alternative name(s):
Solute carrier family 29 member 3
Gene namesi
Name:Slc29a3
Synonyms:Ent3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi727811. Slc29a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51CytoplasmicSequence analysisAdd BLAST51
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Topological domaini73 – 105ExtracellularSequence analysisAdd BLAST33
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 132CytoplasmicSequence analysis6
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 162ExtracellularSequence analysis9
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 199CytoplasmicSequence analysisAdd BLAST16
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Topological domaini221 – 230ExtracellularSequence analysis10
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Topological domaini252 – 305CytoplasmicSequence analysisAdd BLAST54
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 340ExtracellularSequence analysisAdd BLAST14
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Topological domaini362 – 377CytoplasmicSequence analysisAdd BLAST16
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Topological domaini399 – 414ExtracellularSequence analysisAdd BLAST16
Transmembranei415 – 437HelicalSequence analysisAdd BLAST23
Topological domaini438 – 450CytoplasmicSequence analysisAdd BLAST13
Transmembranei451 – 471HelicalSequence analysisAdd BLAST21
Topological domaini472 – 475ExtracellularSequence analysis4

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002093451 – 475Equilibrative nucleoside transporter 3Add BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineBy similarity1
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ80WK7.
PRIDEiQ80WK7.

PTM databases

iPTMnetiQ80WK7.
PhosphoSitePlusiQ80WK7.

Expressioni

Tissue specificityi

Widely expressed. Highest levels in heart and liver (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000000568.
ExpressionAtlasiQ80WK7. baseline and differential.
GenevisibleiQ80WK7. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000689.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1479. Eukaryota.
ENOG410Y3MT. LUCA.
GeneTreeiENSGT00390000002232.
HOGENOMiHOG000007684.
HOVERGENiHBG108444.
InParanoidiQ80WK7.
KOiK15014.
OMAiAISTNIQ.
OrthoDBiEOG091G09WB.
PhylomeDBiQ80WK7.

Family and domain databases

InterProiIPR030193. ENT3.
IPR002259. Eqnu_transpt.
[Graphical view]
PANTHERiPTHR10332. PTHR10332. 1 hit.
PTHR10332:SF17. PTHR10332:SF17. 1 hit.
PfamiPF01733. Nucleoside_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF016379. ENT. 1 hit.
PRINTSiPR01130. DERENTRNSPRT.

Sequencei

Sequence statusi: Complete.

Q80WK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFASEDIAY HSSNAVYRVP SNRHEADQEA LLGKPLDYPA PGLQRPEDRF
60 70 80 90 100
NGAYIIFFCL GIGGLLPWNF FVTAKEYWAF KLRNCSSPAS GKDPEDADIL
110 120 130 140 150
NYFESYLAVA STVPSLLFLV ANFLLVNRIR VHVRVLASLS VSLAIFVVMA
160 170 180 190 200
VLVRVDTSSW TRGFFSIAMA CMAIISSSST IFNSSVYGLT GSFPMRNAQA
210 220 230 240 250
LISGGAMGGT VSAVASLVDL AASSDVRDSA LAFFLTAAVF LGLCVGLYLL
260 270 280 290 300
LPQLEYARYY MRPVVPIHVF SSEDSPPRDA PSTSSVAPAS RAVHTPPLGP
310 320 330 340 350
ILKKTAGLGF CAVFLYFITA LIFPAISTNI QPMHKGTGSP WTSKFYVPLT
360 370 380 390 400
VFLLFNFADL CGRQVTAWIQ VPGPRSKLLP ILAVSRVCLV PLFLLCNYQP
410 420 430 440 450
RSHLTLVLFQ SDIYPILFTC LLGLSNGYLS TLVLMYGPKI VPRELAEATS
460 470
VVMLFYMSLG LMLGSACAAL LEHFI
Length:475
Mass (Da):51,677
Last modified:June 16, 2009 - v2
Checksum:i014B34E12CCA6303
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142S → P in AAP23232 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY273196 mRNA. Translation: AAP23232.1.
BC078678 mRNA. Translation: AAH78678.1.
RefSeqiNP_853670.2. NM_181639.3.
UniGeneiRn.15870.

Genome annotation databases

EnsembliENSRNOT00000000689; ENSRNOP00000000689; ENSRNOG00000000568.
GeneIDi353307.
KEGGirno:353307.
UCSCiRGD:727811. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY273196 mRNA. Translation: AAP23232.1.
BC078678 mRNA. Translation: AAH78678.1.
RefSeqiNP_853670.2. NM_181639.3.
UniGeneiRn.15870.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000689.

PTM databases

iPTMnetiQ80WK7.
PhosphoSitePlusiQ80WK7.

Proteomic databases

PaxDbiQ80WK7.
PRIDEiQ80WK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000689; ENSRNOP00000000689; ENSRNOG00000000568.
GeneIDi353307.
KEGGirno:353307.
UCSCiRGD:727811. rat.

Organism-specific databases

CTDi55315.
RGDi727811. Slc29a3.

Phylogenomic databases

eggNOGiKOG1479. Eukaryota.
ENOG410Y3MT. LUCA.
GeneTreeiENSGT00390000002232.
HOGENOMiHOG000007684.
HOVERGENiHBG108444.
InParanoidiQ80WK7.
KOiK15014.
OMAiAISTNIQ.
OrthoDBiEOG091G09WB.
PhylomeDBiQ80WK7.

Enzyme and pathway databases

ReactomeiR-RNO-83936. Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.

Miscellaneous databases

PROiQ80WK7.

Gene expression databases

BgeeiENSRNOG00000000568.
ExpressionAtlasiQ80WK7. baseline and differential.
GenevisibleiQ80WK7. RN.

Family and domain databases

InterProiIPR030193. ENT3.
IPR002259. Eqnu_transpt.
[Graphical view]
PANTHERiPTHR10332. PTHR10332. 1 hit.
PTHR10332:SF17. PTHR10332:SF17. 1 hit.
PfamiPF01733. Nucleoside_tran. 1 hit.
[Graphical view]
PIRSFiPIRSF016379. ENT. 1 hit.
PRINTSiPR01130. DERENTRNSPRT.
ProtoNetiSearch...

Entry informationi

Entry nameiS29A3_RAT
AccessioniPrimary (citable) accession number: Q80WK7
Secondary accession number(s): Q6AZ86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 16, 2009
Last modified: November 2, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.