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Protein

Protein LYRIC

Gene

Mtdh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance (By similarity).By similarity

Caution

Was originally thought to be a type II membrane protein but this is inconsistent with the results of multiple phosphorylation studies because this topology would locate the phosphorylation sites in the lumen or extracellularly rather than in the cytoplasm.1 Publication

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LYRIC
Alternative name(s):
3D3/LYRIC
Lysine-rich CEACAM1 co-isolated protein
Metadherin
Metastasis adhesion protein
Gene namesi
Name:Mtdh
Synonyms:Lyric
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1914404 Mtdh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48LumenalSequence analysisAdd BLAST48
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 579CytoplasmicSequence analysisAdd BLAST510

Keywords - Cellular componenti

Cell junction, Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000845341 – 579Protein LYRICAdd BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei179PhosphoserineBy similarity1
Modified residuei215PhosphoserineBy similarity1
Modified residuei250PhosphoserineBy similarity1
Modified residuei263N6-acetyllysineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei303PhosphoserineBy similarity1
Modified residuei308PhosphoserineBy similarity1
Modified residuei341PhosphoserineBy similarity1
Modified residuei366PhosphoserineBy similarity1
Modified residuei412PhosphoserineBy similarity1
Modified residuei423PhosphoserineBy similarity1
Modified residuei454PhosphoserineBy similarity1
Modified residuei475PhosphoserineBy similarity1
Modified residuei491PhosphoserineBy similarity1
Modified residuei493PhosphoserineBy similarity1
Modified residuei565PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ80WJ7
MaxQBiQ80WJ7
PaxDbiQ80WJ7
PeptideAtlasiQ80WJ7
PRIDEiQ80WJ7
TopDownProteomicsiQ80WJ7

PTM databases

iPTMnetiQ80WJ7
PhosphoSitePlusiQ80WJ7
SwissPalmiQ80WJ7

Expressioni

Tissue specificityi

In the mammary gland, expressed at the apical surface of epithelial cells lining ducts, as well as in the mammary fat pad. Not detected in the spleen, kidney, lung, or skin; minute amounts seen in the liver. Expressed in Purkinje neurons in the early postnatal and adult cerebellum. Overexpressed in mammary tumors (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000022255
CleanExiMM_MTDH
ExpressionAtlasiQ80WJ7 baseline and differential
GenevisibleiQ80WJ7 MM

Interactioni

Subunit structurei

Interacts with BCCIP, CREBBP/CBP and RELA/p65.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Snd1Q78PY74EBI-774530,EBI-529864

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211981, 1 interactor
IntActiQ80WJ7, 7 interactors
MINTiQ80WJ7
STRINGi10090.ENSMUSP00000022865

Structurei

3D structure databases

ProteinModelPortaliQ80WJ7
SMRiQ80WJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 71Activation of NF-kappa-BBy similarityAdd BLAST71
Regioni72 – 168Interaction with BCCIPBy similarityAdd BLAST97
Regioni100 – 204Interaction with RELABy similarityAdd BLAST105
Regioni378 – 440Lung-homing for mammary tumorsAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi59 – 67Poly-Leu9
Compositional biasi438 – 448Poly-LysAdd BLAST11
Compositional biasi570 – 574Poly-Lys5

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIV9 Eukaryota
ENOG410YF4D LUCA
GeneTreeiENSGT00390000004343
HOVERGENiHBG052379
InParanoidiQ80WJ7
OMAiDEGAWET
OrthoDBiEOG091G0889
PhylomeDBiQ80WJ7
TreeFamiTF331350

Family and domain databases

InterProiView protein in InterPro
IPR031402 LYRIC
PfamiView protein in Pfam
PF15686 LYRIC, 1 hit

Sequencei

Sequence statusi: Complete.

Q80WJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARSWQDEL AQQAEEGSAR LRELLSVGLG FLRTELGLDL GLEPKRYPGW
60 70 80 90 100
VILVGTGALG LLLLFLLGYG WAAACAGARK KRRSPPRKRE EAAPPTPAPD
110 120 130 140 150
DLAQLKNLRS EEQKKKNRKK LPEKPKPNGR TVEVPEDEVV RNPRSITAKQ
160 170 180 190 200
APETDKKNEK SKKNKKKSKS DAKAVQNSSR HDGKEVDEGA WETKISHREK
210 220 230 240 250
RQQRKRDKVL TDSGSLDSTI PGIENIITVT TEQLTTASFP VGSKKNKGDS
260 270 280 290 300
HLNVQVSNFK SGKGDSTLQV SSRLNENLTV NGGGWSEKSV KLSSQLSEEK
310 320 330 340 350
WNSVPPASAG KRKTEPSAWT QDTGDTNANG KDWGRNWSDR SIFSGIGSTA
360 370 380 390 400
EPVSQSTTSD YQWDVSRNQP YIDDEWSGLN GLSSADPSSD WNAPAEEWGN
410 420 430 440 450
WVDEDRASLL KSQEPISNDQ KVSDDDKEKG EGALPTGKSK KKKKKKKKQG
460 470 480 490 500
EDNSHTQDTE DLEKDTREEL PVNTSKARPK QEKACSLKTM STSDPAEVLI
510 520 530 540 550
KNSQPVKTLP PAISAEPSIT LSKGDSDNSS SQVPPMLQDT DKPKSNAKQN
560 570
SVPPSQTKSE TNWESPKQIK KKKKARRET
Length:579
Mass (Da):63,846
Last modified:June 1, 2003 - v1
Checksum:iE47E98303F588126
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190A → I in BAB27854 (PubMed:16141072).Curated1
Sequence conflicti264G → R in BAE30709 (PubMed:16141072).Curated1
Sequence conflicti271S → T in BAC26673 (PubMed:16141072).Curated1
Sequence conflicti296L → F in BAE30709 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY553638 mRNA Translation: AAS68097.1
AF501309 mRNA Translation: AAP30790.1
AK011808 mRNA Translation: BAB27854.1
AK029915 mRNA Translation: BAC26673.1
AK035302 mRNA Translation: BAC29022.1
AK151269 mRNA Translation: BAE30256.1
AK151810 mRNA Translation: BAE30709.1
BC023115 mRNA Translation: AAH23115.1
BC036994 mRNA Translation: AAH36994.1
BC138858 mRNA Translation: AAI38859.1
BC138859 mRNA Translation: AAI38860.1
CCDSiCCDS27415.1
RefSeqiNP_080278.3, NM_026002.4
UniGeneiMm.130883

Genome annotation databases

EnsembliENSMUST00000022865; ENSMUSP00000022865; ENSMUSG00000022255
GeneIDi67154
KEGGimmu:67154
UCSCiuc007vlh.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLYRIC_MOUSE
AccessioniPrimary (citable) accession number: Q80WJ7
Secondary accession number(s): B2RSG8
, Q05CM0, Q3U9F8, Q3UAQ8, Q8BN67, Q8CBT9, Q8CDL0, Q8CGI7, Q9D052
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health