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Protein

Protein LYRIC

Gene

Mtdh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LYRIC
Alternative name(s):
3D3/LYRIC
Lysine-rich CEACAM1 co-isolated protein
Metadherin
Metastasis adhesion protein
Gene namesi
Name:Mtdh
Synonyms:Lyric
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1914404. Mtdh.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4848LumenalSequence analysisAdd
BLAST
Transmembranei49 – 6921HelicalSequence analysisAdd
BLAST
Topological domaini70 – 579510CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: Ensembl
  • bicellular tight junction Source: UniProtKB-SubCell
  • cytoplasm Source: MGI
  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • intercellular canaliculus Source: Ensembl
  • nuclear body Source: MGI
  • nuclear membrane Source: UniProtKB-SubCell
  • nucleolus Source: UniProtKB
  • nucleus Source: MGI
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 579579Protein LYRICPRO_0000084534Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei179 – 1791PhosphoserineBy similarity
Modified residuei215 – 2151PhosphoserineBy similarity
Modified residuei250 – 2501PhosphoserineBy similarity
Modified residuei263 – 2631N6-acetyllysineCombined sources
Modified residuei297 – 2971PhosphoserineCombined sources
Modified residuei303 – 3031PhosphoserineBy similarity
Modified residuei308 – 3081PhosphoserineBy similarity
Modified residuei341 – 3411PhosphoserineBy similarity
Modified residuei366 – 3661PhosphoserineBy similarity
Modified residuei412 – 4121PhosphoserineBy similarity
Modified residuei423 – 4231PhosphoserineBy similarity
Modified residuei454 – 4541PhosphoserineBy similarity
Modified residuei475 – 4751PhosphoserineBy similarity
Modified residuei491 – 4911PhosphoserineBy similarity
Modified residuei493 – 4931PhosphoserineBy similarity
Modified residuei565 – 5651PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ80WJ7.
MaxQBiQ80WJ7.
PaxDbiQ80WJ7.
PeptideAtlasiQ80WJ7.
PRIDEiQ80WJ7.
TopDownProteomicsiQ80WJ7.

PTM databases

iPTMnetiQ80WJ7.
PhosphoSiteiQ80WJ7.
SwissPalmiQ80WJ7.

Expressioni

Tissue specificityi

In the mammary gland, expressed at the apical surface of epithelial cells lining ducts, as well as in the mammary fat pad. Not detected in the spleen, kidney, lung, or skin; minute amounts seen in the liver. Expressed in Purkinje neurons in the early postnatal and adult cerebellum. Overexpressed in mammary tumors (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000022255.
CleanExiMM_MTDH.
ExpressionAtlasiQ80WJ7. baseline and differential.
GenevisibleiQ80WJ7. MM.

Interactioni

Subunit structurei

Interacts with BCCIP, CREBBP/CBP and RELA/p65.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Snd1Q78PY74EBI-774530,EBI-529864

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211981. 1 interaction.
IntActiQ80WJ7. 6 interactions.
MINTiMINT-1867478.
STRINGi10090.ENSMUSP00000022865.

Structurei

3D structure databases

ProteinModelPortaliQ80WJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7171Activation of NF-kappa-BBy similarityAdd
BLAST
Regioni72 – 16897Interaction with BCCIPBy similarityAdd
BLAST
Regioni100 – 204105Interaction with RELABy similarityAdd
BLAST
Regioni378 – 44063Lung-homing for mammary tumorsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 679Poly-Leu
Compositional biasi438 – 44811Poly-LysAdd
BLAST
Compositional biasi570 – 5745Poly-Lys

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIV9. Eukaryota.
ENOG410YF4D. LUCA.
GeneTreeiENSGT00390000004343.
HOVERGENiHBG052379.
InParanoidiQ80WJ7.
OMAiDWGRSWS.
OrthoDBiEOG091G0889.
PhylomeDBiQ80WJ7.
TreeFamiTF331350.

Family and domain databases

InterProiIPR031402. LYRIC.
[Graphical view]
PfamiPF15686. LYRIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q80WJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARSWQDEL AQQAEEGSAR LRELLSVGLG FLRTELGLDL GLEPKRYPGW
60 70 80 90 100
VILVGTGALG LLLLFLLGYG WAAACAGARK KRRSPPRKRE EAAPPTPAPD
110 120 130 140 150
DLAQLKNLRS EEQKKKNRKK LPEKPKPNGR TVEVPEDEVV RNPRSITAKQ
160 170 180 190 200
APETDKKNEK SKKNKKKSKS DAKAVQNSSR HDGKEVDEGA WETKISHREK
210 220 230 240 250
RQQRKRDKVL TDSGSLDSTI PGIENIITVT TEQLTTASFP VGSKKNKGDS
260 270 280 290 300
HLNVQVSNFK SGKGDSTLQV SSRLNENLTV NGGGWSEKSV KLSSQLSEEK
310 320 330 340 350
WNSVPPASAG KRKTEPSAWT QDTGDTNANG KDWGRNWSDR SIFSGIGSTA
360 370 380 390 400
EPVSQSTTSD YQWDVSRNQP YIDDEWSGLN GLSSADPSSD WNAPAEEWGN
410 420 430 440 450
WVDEDRASLL KSQEPISNDQ KVSDDDKEKG EGALPTGKSK KKKKKKKKQG
460 470 480 490 500
EDNSHTQDTE DLEKDTREEL PVNTSKARPK QEKACSLKTM STSDPAEVLI
510 520 530 540 550
KNSQPVKTLP PAISAEPSIT LSKGDSDNSS SQVPPMLQDT DKPKSNAKQN
560 570
SVPPSQTKSE TNWESPKQIK KKKKARRET
Length:579
Mass (Da):63,846
Last modified:June 1, 2003 - v1
Checksum:iE47E98303F588126
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti190 – 1901A → I in BAB27854 (PubMed:16141072).Curated
Sequence conflicti264 – 2641G → R in BAE30709 (PubMed:16141072).Curated
Sequence conflicti271 – 2711S → T in BAC26673 (PubMed:16141072).Curated
Sequence conflicti296 – 2961L → F in BAE30709 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY553638 mRNA. Translation: AAS68097.1.
AF501309 mRNA. Translation: AAP30790.1.
AK011808 mRNA. Translation: BAB27854.1.
AK029915 mRNA. Translation: BAC26673.1.
AK035302 mRNA. Translation: BAC29022.1.
AK151269 mRNA. Translation: BAE30256.1.
AK151810 mRNA. Translation: BAE30709.1.
BC023115 mRNA. Translation: AAH23115.1.
BC036994 mRNA. Translation: AAH36994.1.
BC138858 mRNA. Translation: AAI38859.1.
BC138859 mRNA. Translation: AAI38860.1.
CCDSiCCDS27415.1.
RefSeqiNP_080278.3. NM_026002.4.
UniGeneiMm.130883.

Genome annotation databases

EnsembliENSMUST00000022865; ENSMUSP00000022865; ENSMUSG00000022255.
GeneIDi67154.
KEGGimmu:67154.
UCSCiuc007vlh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY553638 mRNA. Translation: AAS68097.1.
AF501309 mRNA. Translation: AAP30790.1.
AK011808 mRNA. Translation: BAB27854.1.
AK029915 mRNA. Translation: BAC26673.1.
AK035302 mRNA. Translation: BAC29022.1.
AK151269 mRNA. Translation: BAE30256.1.
AK151810 mRNA. Translation: BAE30709.1.
BC023115 mRNA. Translation: AAH23115.1.
BC036994 mRNA. Translation: AAH36994.1.
BC138858 mRNA. Translation: AAI38859.1.
BC138859 mRNA. Translation: AAI38860.1.
CCDSiCCDS27415.1.
RefSeqiNP_080278.3. NM_026002.4.
UniGeneiMm.130883.

3D structure databases

ProteinModelPortaliQ80WJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211981. 1 interaction.
IntActiQ80WJ7. 6 interactions.
MINTiMINT-1867478.
STRINGi10090.ENSMUSP00000022865.

PTM databases

iPTMnetiQ80WJ7.
PhosphoSiteiQ80WJ7.
SwissPalmiQ80WJ7.

Proteomic databases

EPDiQ80WJ7.
MaxQBiQ80WJ7.
PaxDbiQ80WJ7.
PeptideAtlasiQ80WJ7.
PRIDEiQ80WJ7.
TopDownProteomicsiQ80WJ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022865; ENSMUSP00000022865; ENSMUSG00000022255.
GeneIDi67154.
KEGGimmu:67154.
UCSCiuc007vlh.1. mouse.

Organism-specific databases

CTDi92140.
MGIiMGI:1914404. Mtdh.

Phylogenomic databases

eggNOGiENOG410IIV9. Eukaryota.
ENOG410YF4D. LUCA.
GeneTreeiENSGT00390000004343.
HOVERGENiHBG052379.
InParanoidiQ80WJ7.
OMAiDWGRSWS.
OrthoDBiEOG091G0889.
PhylomeDBiQ80WJ7.
TreeFamiTF331350.

Miscellaneous databases

ChiTaRSiMtdh. mouse.
PROiQ80WJ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022255.
CleanExiMM_MTDH.
ExpressionAtlasiQ80WJ7. baseline and differential.
GenevisibleiQ80WJ7. MM.

Family and domain databases

InterProiIPR031402. LYRIC.
[Graphical view]
PfamiPF15686. LYRIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYRIC_MOUSE
AccessioniPrimary (citable) accession number: Q80WJ7
Secondary accession number(s): B2RSG8
, Q05CM0, Q3U9F8, Q3UAQ8, Q8BN67, Q8CBT9, Q8CDL0, Q8CGI7, Q9D052
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be a type II membrane protein but this is inconsistent with the results of multiple phosphorylation studies because this topology would locate the phosphorylation sites in the lumen or extracellularly rather than in the cytoplasm.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.