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Protein

Multidrug resistance-associated protein 9

Gene

Abcc12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transporter.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi514 – 5218ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1161 – 11688ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 9
Alternative name(s):
ATP-binding cassette sub-family C member 12
Gene namesi
Name:Abcc12
Synonyms:Mrp9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2441679. Abcc12.

Subcellular locationi

  • Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei125 – 14521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei152 – 17221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei235 – 25521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei257 – 27721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei349 – 36921HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei377 – 39721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei788 – 80821HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei850 – 87021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei931 – 95121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei1038 – 105821HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13661366Multidrug resistance-associated protein 9PRO_0000253579Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence analysis
Glycosylationi978 – 9781N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ80WJ6.
PRIDEiQ80WJ6.

PTM databases

iPTMnetiQ80WJ6.
PhosphoSiteiQ80WJ6.

Expressioni

Tissue specificityi

Widely expressed at low level. Highly expressed in testis by Sertoli cells and Leydig cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000036872.
ExpressionAtlasiQ80WJ6. baseline and differential.
GenevisibleiQ80WJ6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079014.

Structurei

3D structure databases

ProteinModelPortaliQ80WJ6.
SMRiQ80WJ6. Positions 160-716, 881-1356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini123 – 404282ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini459 – 702244ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini792 – 1089298ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1127 – 1361235ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00840000129721.
HOGENOMiHOG000169755.
HOVERGENiHBG108314.
InParanoidiQ80WJ6.
KOiK05672.
OMAiGEKYNHQ.
OrthoDBiEOG091G01TC.
PhylomeDBiQ80WJ6.
TreeFamiTF105202.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030250. MRP9.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF10. PTHR24223:SF10. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80WJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVGEGPYLIS DLDRRGHRRS FAERYDPSLK TMIPVRPRAR LAPNPVDDAG
60 70 80 90 100
LLSFATFSWL TPVMIRSYKH TLTVDTLPPL SPYDSSDINA KRFQILWEEE
110 120 130 140 150
IKRVGPEKAS LGRVVWKFQR TRVLMDVVAN ILCIVMAALG PTVLIHQILQ
160 170 180 190 200
HITSISSGHI GIGICLCLAL FTTEFTKVLF WALAWAINYR TAIRLKVALS
210 220 230 240 250
TLIFENLLSF KTLTHISAGE VLNILSSDSY SLFEAALFCP LPATIPILMV
260 270 280 290 300
VCAVYAFFIL GSTALVGISV YLIFIPIQMF MAKLNSTFRR SAISVTDKRV
310 320 330 340 350
QTMNEFLTCI KLIKMYAWEE SFINTIHDIR KREKKLLEKA GYVQSGNSAL
360 370 380 390 400
APIVSTIAIV STFTCHIFLK RKLTAPVAFS VIAMFNVMKF SIAILPFSVK
410 420 430 440 450
AVAEASVSLR RMKKILIAKS PPSYITQPED PDTILLLANA TLTWEQEINR
460 470 480 490 500
KSDPPKAQIQ KRHVFKKQRP ELYSEQSRSD QGVASPEWQS GSPKSVLHNI
510 520 530 540 550
SFVVRKGKVL GICGNVGSGK SSLISALLGQ MQLQKGVVAV NGPLAYVSQQ
560 570 580 590 600
AWIFHGNVRE NILFGEKYNH QRYQHTVHVC GLQKDLNSLP YGDLTEIGER
610 620 630 640 650
GVNLSGGQRQ RISLARAVYA NRQLYLLDDP LSAVDAHVGK HVFEECIKKT
660 670 680 690 700
LKGKTVVLVT HQLQFLESCD EVILLEDGEI CEKGTHKELM EERGRYAKLI
710 720 730 740 750
HNLRGLQFKD PEHIYNVAMV ETLKESPAQR DEDAVLASGD EKDEGKEPET
760 770 780 790 800
EEFVDTNAPA HQLIQTESPQ EGIVTWKTYH TYIKASGGYL VSFLVLCLFF
810 820 830 840 850
LMMGSSAFST WWLGIWLDRG SQVVCASQNN KTACNVDQTL QDTKHHMYQL
860 870 880 890 900
VYIASMVSVL MFGIIKGFTF TNTTLMASSS LHNRVFNKIV RSPMSFFDTT
910 920 930 940 950
PTGRLMNRFS KDMDELDVRL PFHAENFLQQ FFMVVFILVI MAAVFPVVLV
960 970 980 990 1000
VLAGLAVIFL ILLRIFHRGV QELKQVENIS RSPWFSHITS SIQGLGVIHA
1010 1020 1030 1040 1050
YDKKDDCISK FKTLNDENSS HLLYFNCALR WFALRMDILM NIVTFVVALL
1060 1070 1080 1090 1100
VTLSFSSISA SSKGLSLSYI IQLSGLLQVC VRTGTETQAK FTSAELLREY
1110 1120 1130 1140 1150
ILTCVPEHTH PFKVGTCPKD WPSRGEITFK DYRMRYRDNT PLVLDGLNLN
1160 1170 1180 1190 1200
IQSGQTVGIV GRTGSGKSSL GMALFRLVEP ASGTIIIDEV DICTVGLEDL
1210 1220 1230 1240 1250
RTKLTMIPQD PVLFVGTVRY NLDPLGSHTD EMLWHVLERT FMRDTIMKLP
1260 1270 1280 1290 1300
EKLQAEVTEN GENFSVGERQ LLCMARALLR NSKIILLDEA TASMDSKTDT
1310 1320 1330 1340 1350
LVQSTIKEAF KSCTVLTIAH RLNTVLNCDL VLVMENGKVI EFDKPEVLAE
1360
KPDSAFAMLL AAEVGL
Length:1,366
Mass (Da):153,060
Last modified:June 1, 2003 - v1
Checksum:iFAE080A60BB4B6C0
GO
Isoform 2 (identifier: Q80WJ6-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     665-686: FLESCDEVILLEDGEICEKGTH → KVALPEQGIEMVGDTDESCSHS
     687-1366: Missing.

Show »
Length:686
Mass (Da):76,467
Checksum:iC5104DEF9C957791
GO
Isoform 3 (identifier: Q80WJ6-3) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     758-774: APAHQLIQTESPQEGIV → VEGTSGSQNVKIWRRKS
     775-1366: Missing.

Show »
Length:774
Mass (Da):86,702
Checksum:iA040BDFD5A80E35B
GO
Isoform 4 (identifier: Q80WJ6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     735-738: VLAS → GTVR
     739-1366: Missing.

Note: No experimental confirmation available.
Show »
Length:738
Mass (Da):82,681
Checksum:i4A99733F7458BBE8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei665 – 68622FLESC…EKGTH → KVALPEQGIEMVGDTDESCS HS in isoform 2. 1 PublicationVSP_021093Add
BLAST
Alternative sequencei687 – 1366680Missing in isoform 2. 1 PublicationVSP_021094Add
BLAST
Alternative sequencei735 – 7384VLAS → GTVR in isoform 4. 1 PublicationVSP_021095
Alternative sequencei739 – 1366628Missing in isoform 4. 1 PublicationVSP_021096Add
BLAST
Alternative sequencei758 – 77417APAHQ…QEGIV → VEGTSGSQNVKIWRRKS in isoform 3. 1 PublicationVSP_021097Add
BLAST
Alternative sequencei775 – 1366592Missing in isoform 3. 1 PublicationVSP_021098Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF502146 mRNA. Translation: AAP30800.1.
AF514414 mRNA. Translation: AAP30871.1.
AF514415 mRNA. Translation: AAP30872.1.
AK030123 mRNA. Translation: BAC26794.1.
AK133175 mRNA. Translation: BAE21541.1.
BC138380 mRNA. Translation: AAI38381.1.
BC138381 mRNA. Translation: AAI38382.1.
BC171952 mRNA. Translation: AAI71952.1.
CCDSiCCDS22502.1. [Q80WJ6-1]
RefSeqiNP_766500.3. NM_172912.4. [Q80WJ6-1]
XP_006531047.1. XM_006530984.2. [Q80WJ6-1]
UniGeneiMm.67485.

Genome annotation databases

EnsembliENSMUST00000080115; ENSMUSP00000079014; ENSMUSG00000036872. [Q80WJ6-1]
ENSMUST00000129898; ENSMUSP00000122577; ENSMUSG00000036872. [Q80WJ6-4]
ENSMUST00000131423; ENSMUSP00000122402; ENSMUSG00000036872. [Q80WJ6-1]
ENSMUST00000152438; ENSMUSP00000114582; ENSMUSG00000036872. [Q80WJ6-4]
GeneIDi244562.
KEGGimmu:244562.
UCSCiuc009mqk.1. mouse. [Q80WJ6-1]
uc009mql.1. mouse. [Q80WJ6-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF502146 mRNA. Translation: AAP30800.1.
AF514414 mRNA. Translation: AAP30871.1.
AF514415 mRNA. Translation: AAP30872.1.
AK030123 mRNA. Translation: BAC26794.1.
AK133175 mRNA. Translation: BAE21541.1.
BC138380 mRNA. Translation: AAI38381.1.
BC138381 mRNA. Translation: AAI38382.1.
BC171952 mRNA. Translation: AAI71952.1.
CCDSiCCDS22502.1. [Q80WJ6-1]
RefSeqiNP_766500.3. NM_172912.4. [Q80WJ6-1]
XP_006531047.1. XM_006530984.2. [Q80WJ6-1]
UniGeneiMm.67485.

3D structure databases

ProteinModelPortaliQ80WJ6.
SMRiQ80WJ6. Positions 160-716, 881-1356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000079014.

PTM databases

iPTMnetiQ80WJ6.
PhosphoSiteiQ80WJ6.

Proteomic databases

PaxDbiQ80WJ6.
PRIDEiQ80WJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080115; ENSMUSP00000079014; ENSMUSG00000036872. [Q80WJ6-1]
ENSMUST00000129898; ENSMUSP00000122577; ENSMUSG00000036872. [Q80WJ6-4]
ENSMUST00000131423; ENSMUSP00000122402; ENSMUSG00000036872. [Q80WJ6-1]
ENSMUST00000152438; ENSMUSP00000114582; ENSMUSG00000036872. [Q80WJ6-4]
GeneIDi244562.
KEGGimmu:244562.
UCSCiuc009mqk.1. mouse. [Q80WJ6-1]
uc009mql.1. mouse. [Q80WJ6-4]

Organism-specific databases

CTDi94160.
MGIiMGI:2441679. Abcc12.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00840000129721.
HOGENOMiHOG000169755.
HOVERGENiHBG108314.
InParanoidiQ80WJ6.
KOiK05672.
OMAiGEKYNHQ.
OrthoDBiEOG091G01TC.
PhylomeDBiQ80WJ6.
TreeFamiTF105202.

Miscellaneous databases

PROiQ80WJ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036872.
ExpressionAtlasiQ80WJ6. baseline and differential.
GenevisibleiQ80WJ6. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030250. MRP9.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF10. PTHR24223:SF10. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRP9_MOUSE
AccessioniPrimary (citable) accession number: Q80WJ6
Secondary accession number(s): B2RRF4
, Q80WJ2, Q80WJ3, Q8C0P3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.