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Reviewed, UniProtKB/Swiss-Prot Q80WG7 (TRI36_MOUSE)

Last modified June 16, 2009. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Tripartite motif-containing protein 36
Alternative name(s):
    Haprin
    Acrosome RBCC protein
Gene names
Name: Trim36
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length729 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

May play a role in the acrosome reaction and fertilization. Ref.1

Subcellular location

Cytoplasm. Acrosome. Note: Found in the acrosomal region of elongated spermatids and mature sperm. Ref.1

Tissue specificity

Expressed only in testis. Ref.1

Developmental stage

Expressed only in testicular germ cells after meiotic division. Expression was first detected at the age of 4 weeks. Ref.1

Sequence similarities

Belongs to the TRIM/RBCC family.

Contains 2 B box-type zinc fingers.

Contains 1 B30.2/SPRY domain.

Contains 1 COS domain.

Contains 1 fibronectin type-III domain.

Contains 1 RING-type zinc finger.

Sequence caution

The sequence BAC76066.1 differs from that shown. Reason: Frameshift at positions 356 and 369.

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Ontologies

Keywords
   Cellular componentCytoplasm
   DomainCoiled coil
Repeat
Zinc-finger
   LigandMetal-binding
Zinc
Gene Ontology (GO)
   Biological processacrosome reaction Ref.1

Inferred from mutant phenotype. Source: MGI

   Cellular componentacrosomal vesicle Ref.1

Inferred from direct assay. Source: MGI

   Molecular functionprotein binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 729729Tripartite motif-containing protein 36
PRO_0000056253

Regions

Domain356 – 41358COS
Domain414 – 50895Fibronectin type-III
Domain509 – 723215B30.2/SPRY
Zinc finger33 – 8452RING-type; degenerate
Zinc finger154 – 19239B box-type 1
Zinc finger207 – 24943B box-type 2
Coiled coil271 – 30232 Potential

Experimental info

Sequence conflict2921G → V in BAC76066. Ref.1
Sequence conflict5321N → D in BAC76066. Ref.1
Sequence conflict601 – 6022WL → CV in BAC76066. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q80WG7-1 [UniParc].

Last modified December 7, 2004. Version 2.
Checksum: E13CC617EFD47F58

FASTA72982,791
        10         20         30         40         50         60 
MSESEEISEF GYIMELLAKG KVTIKNIEKE LICPACKELF THPLILPCQH SVCHKCVKEL 

        70         80         90        100        110        120 
LLSLDDSFND VASDSSNQSS PRLRLTSPSM DKIDKINRPG WKRNSLTPRP TTFPCPGCEH 

       130        140        150        160        170        180 
DVDLGERGVS GLFRNFTLET IVERYRQAAR AATAIMCDLC KPPPQESTKS CMDCSASYCN 

       190        200        210        220        230        240 
ECFKIYHPWG TVKAQHEYVG PTTNFRPKVL MCPEHETERI NMYCELCRRP VCHLCKLGGN 

       250        260        270        280        290        300 
HSNHRVTTMS SAYKTLKEKL SKDIDFLIGK ESQVKSQISE LNLLMKETEC NGERAKEEAL 

       310        320        330        340        350        360 
AHFEKLFEIL EDRKSSVLKA IDASKKLRLD KFHTQMEEYQ GLLENNGLVG YAQEVLKETD 

       370        380        390        400        410        420 
QSCFVQTAKQ LHLRIQKATE SLKSFRPAAQ ASFEDYVVNI SKQTEVLGEL SFFSSGIDIP 

       430        440        450        460        470        480 
EINEEQSKVY NNALIDWHHP EKDKADSYVL EYRKINRDEE MISWNEIEVH GTSKVVSNLE 

       490        500        510        520        530        540 
SNSPYAFRVR AYRGSICSPC SRELILHTPP APVFSFLFDE KCGYNTEHLL LNLKRDRVES 

       550        560        570        580        590        600 
RAGFNVLLAA ERIQVGHYTS LDYIIGDVGV TKGKHFWACR VEPYSYLVKV GVASSDKLQE 

       610        620        630        640        650        660 
WLRSPRDAAS PRYEQDSGHD SGSEDACFDS SQPFTLVTIG MKKFFIPKSP TSSNEPENRV 

       670        680        690        700        710        720 
LPMPTSIGIF LDCDKGKVSF YDMDHMKCLY ERQVDCSHTM YPAFALMGSG GIQLEEAITA 


KYLEYEEDV

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References

« Hide 'large scale' references
[1]"Haprin, a novel haploid germ cell-specific RING finger protein involved in the acrosome reaction."
Kitamura K., Tanaka H., Nishimune Y.
J. Biol. Chem. 278:44417-44423(2003) [PubMed: 12917430] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Testis.
[2]"Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding."
Short K.M., Cox T.C.
J. Biol. Chem. 281:8970-8980(2006) [PubMed: 16434393] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AB103063 mRNA. Translation: BAC76066.1. Frameshift.
AY251389 mRNA. Translation: AAP51209.1.
BC058106 mRNA. Translation: AAH58106.1.
IPIIPI00396799.
RefSeqNP_849203.2.
UniGeneMm.277382

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSMUSG00000033949. Mus musculus. [Contig view]
GeneID28105.
KEGGmmu:28105.

Organism-specific databases

MGIMGI:106264. Trim36.

Phylogenomic databases

HOGENOMQ80WG7.
HOVERGENQ80WG7.
OMAQ80WG7. FPCPGCE.

Gene expression databases

ArrayExpressQ80WG7.
BgeeQ80WG7.
CleanExMM_TRIM36.
GermOnlineENSMUSG00000033949. Mus musculus.

Family and domain databases

InterProIPR001870. B302.
IPR017903. COS_domain.
IPR003961. FN_III.
IPR000315. Znf_B-box.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF00041. fn3. 1 hit.
PF00643. zf-B_box. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTSM00336. BBOX. 1 hit.
SM00060. FN3. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEPS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio306656.
SOURCESearch...

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Entry information

Entry nameTRI36_MOUSE
AccessionPrimary (citable) accession number: Q80WG7
Secondary accession number(s): Q7TNM1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: June 16, 2009
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents