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Q80WG5 (LRC8A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine-rich repeat-containing protein 8A
Gene names
Name:Lrrc8a
Synonyms:Lrrc8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length810 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in B-cell development. Required for the pro-B cell to pre-B cell transition. Ref.4

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

High levels detected in the bone marrow; lower levels found in peripheral blood cells. Ref.4

Sequence similarities

Contains 17 LRR (leucine-rich) repeats.

Ontologies

Keywords
   Biological processDifferentiation
   Cellular componentMembrane
   DomainLeucine-rich repeat
Repeat
Transmembrane
Transmembrane helix
   PTMAcetylation
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpre-B cell differentiation

Inferred from mutant phenotype Ref.4. Source: UniProtKB

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 810810Leucine-rich repeat-containing protein 8A
PRO_0000084500

Regions

Transmembrane26 – 4520Helical; Potential
Transmembrane124 – 14623Helical; Potential
Transmembrane263 – 28523Helical; Potential
Transmembrane320 – 34223Helical; Potential
Repeat373 – 40129LRR 1
Repeat402 – 42423LRR 2
Repeat425 – 44723LRR 3
Repeat448 – 47023LRR 4
Repeat471 – 49424LRR 5
Repeat495 – 51824LRR 6
Repeat519 – 54527LRR 7
Repeat546 – 56823LRR 8
Repeat569 – 59224LRR 9
Repeat593 – 61523LRR 10
Repeat616 – 64025LRR 11
Repeat641 – 66323LRR 12
Repeat664 – 68623LRR 13
Repeat687 – 70620LRR 14
Repeat707 – 73226LRR 15
Repeat733 – 75523LRR 16
Repeat756 – 77722LRR 17

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue2171Phosphoserine Ref.5
Glycosylation831N-linked (GlcNAc...) Potential
Glycosylation1911N-linked (GlcNAc...) Potential
Glycosylation5261N-linked (GlcNAc...) Potential
Glycosylation5541N-linked (GlcNAc...) Potential
Glycosylation5921N-linked (GlcNAc...) Potential
Glycosylation6601N-linked (GlcNAc...) Potential
Glycosylation6961N-linked (GlcNAc...) Potential
Glycosylation7551N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q80WG5 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: E3B125BC9977DBB0

FASTA81094,120
        10         20         30         40         50         60 
MIPVTELRYF ADTQPAYRIL KPWWDVFTDY ISIVMLMIAV FGGTLQVTQD KMICLPCKWV 

        70         80         90        100        110        120 
TKDSCNDSFR GWAASSPEPT YPNSTVLPTP DTGPTGIKYD LDRHQYNYVD AVCYENRLHW 

       130        140        150        160        170        180 
FAKYFPYLVL LHTLIFLACS NFWFKFPRTS SKLEHFVSIL LKCFDSPWTT RALSETVVEE 

       190        200        210        220        230        240 
SDPKPAFSKM NGSMDKKSST VSEDVEATVP MLQRTKSRIE QGIVDRSETG VLDKKEGEQA 

       250        260        270        280        290        300 
KALFEKVKKF RTHVEEGDIV YRLYMRQTII KVIKFALIIC YTVYYVHNIK FDVDCTVDIE 

       310        320        330        340        350        360 
SLTGYRTYRC AHPLATLFKI LASFYISLVI FYGLICMYTL WWMLRRSLKK YSFESIREES 

       370        380        390        400        410        420 
SYSDIPDVKN DFAFMLHLID QYDPLYSKRF AVFLSEVSEN KLRQLNLNNE WTLDKLRQRL 

       430        440        450        460        470        480 
TKNAQDKLEL HLFMLSGIPD TVFDLVELEV LKLELIPDVT IPPSIAQLTG LKELWLYHTA 

       490        500        510        520        530        540 
AKIEAPALAF LRENLRALHI KFTDIKEIPL WIYSLKTLEE LHLTGNLSAE NNRYIVIDGL 

       550        560        570        580        590        600 
RELKRLKVLR LKSNLSKLPQ VVTDVGVHLQ KLSINNEGTK LIVLNSLKKM VNLTELELIR 

       610        620        630        640        650        660 
CDLERIPHSI FSLHNLQEID LKDNNLKTIE EIISFQHLHR LTCLKLWYNH IAYIPIQIGN 

       670        680        690        700        710        720 
LTNLERLYLN RNKIEKIPTQ LFYCRKLRYL DLSHNNLTFL PADIGLLQNL QNLAVTANRI 

       730        740        750        760        770        780 
EALPPELFQC RKLRALHLGN NVLQSLPSRV GELTNLTQIE LRGNRLECLP VELGECPLLK 

       790        800        810 
RSGLVVEEDL FSTLPPEVKE RLWRADKEQA

« Hide

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[4]"A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans."
Sawada A., Takihara Y., Kim J.Y., Matsuda-Hashii Y., Tokimasa S., Fujisaki H., Kubota K., Endo H., Onodera T., Ohta H., Ozono K., Hara J.
J. Clin. Invest. 112:1707-1713(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[5]"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry."
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M.
J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-217, MASS SPECTROMETRY.
Tissue: Melanoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL845258 Genomic DNA. Translation: CAM20568.1.
CH466542 Genomic DNA. Translation: EDL08450.1.
BC048152 mRNA. No translation available.
IPIIPI00126759.
RefSeqNP_808393.1. NM_177725.4.
UniGeneMm.389232.
Mm.475219.

3D structure databases

ProteinModelPortalQ80WG5.
SMRQ80WG5. Positions 331-802.
ModBaseSearch...

PTM databases

PhosphoSiteQ80WG5.

Proteomic databases

PaxDbQ80WG5.
PRIDEQ80WG5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000095078; ENSMUSP00000092690; ENSMUSG00000007476.
ENSMUST00000113654; ENSMUSP00000109284; ENSMUSG00000007476.
GeneID241296.
KEGGmmu:241296.
UCSCuc008jbu.2. mouse.

Organism-specific databases

CTD56262.
MGIMGI:2652847. Lrrc8a.

Phylogenomic databases

eggNOGCOG4886.
GeneTreeENSGT00600000084236.
HOGENOMHOG000231806.
HOVERGENHBG052360.
InParanoidA2AQZ0.
OMAVDTQPAY.
OrthoDBEOG45B1DW.

Gene expression databases

BgeeQ80WG5.
GenevestigatorQ80WG5.
GermOnlineENSMUSG00000007476. Mus musculus.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR021040. LRR_protein-8_N.
[Graphical view]
PfamPF12534. DUF3733. 2 hits.
PF12799. LRR_4. 1 hit.
[Graphical view]
SMARTSM00369. LRR_TYP. 2 hits.
[Graphical view]
PROSITEPS51450. LRR. 11 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLRRC8A. mouse.
NextBio384965.
SOURCESearch...

Entry information

Entry nameLRC8A_MOUSE
AccessionPrimary (citable) accession number: Q80WG5
Secondary accession number(s): A2AQZ0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2003
Last modified: May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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