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Protein

Kinesin-like protein KIF20B

Gene

Kif20b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plus-end-directed motor enzyme that is required for completion of cytokinesis (By similarity). Required for proper midbody organization and abscission in polarized cortical stem cells (PubMed:24173802). Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner (PubMed:23864681). In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex (PubMed:23864681). Involved in cerebral cortex growth (PubMed:24173802). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi152 – 1598ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • microtubule-based movement Source: InterPro
  • mitotic nuclear division Source: UniProtKB-KW
  • neural tube closure Source: MGI
  • neuron projection morphogenesis Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of cytokinesis Source: UniProtKB
  • positive regulation of intracellular protein transport Source: UniProtKB
  • positive regulation of mitotic cytokinetic process Source: UniProtKB
  • positive regulation of neuron migration Source: UniProtKB
  • protein localization to microtubule Source: UniProtKB
  • regulation of establishment of cell polarity Source: UniProtKB
  • regulation of establishment of protein localization Source: MGI
  • regulation of mitotic nuclear division Source: InterPro
  • regulation of neuron migration Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF20BCurated
Alternative name(s):
Kinesin family member 20BImported
Kinesin-related motor interacting with PIN1By similarity
M-phase phosphoprotein 1By similarity
Short name:
MPP1By similarity
Gene namesi
Name:Kif20bImported
Synonyms:Mphosph1By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2444576. Kif20b.

Subcellular locationi

GO - Cellular componenti

  • axon Source: UniProtKB-SubCell
  • centrosome Source: UniProtKB
  • contractile ring Source: UniProtKB
  • cytoplasm Source: MGI
  • growth cone Source: UniProtKB-SubCell
  • microtubule Source: UniProtKB-KW
  • microtubule cytoskeleton Source: UniProtKB
  • midbody Source: UniProtKB
  • mitotic spindle midzone Source: UniProtKB
  • mitotic spindle pole Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • spindle midzone Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1047 – 10471Y → F: Reduces interaction with SHTN1; when associated with A-1048. 1 Publication
Mutagenesisi1048 – 10481R → A: Reduces interaction with SHTN1; when associated with F-1047. 1 Publication

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17741774Kinesin-like protein KIF20BPRO_0000274054Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei486 – 4861PhosphoserineBy similarity
Modified residuei950 – 9501PhosphoserineCombined sources
Modified residuei1107 – 11071PhosphoserineCombined sources
Modified residuei1598 – 15981Phosphothreonine; by CDK1By similarity
Modified residuei1612 – 16121PhosphoserineBy similarity
Modified residuei1694 – 16941PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated during mitosis by CDK1.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ80WE4.
MaxQBiQ80WE4.
PaxDbiQ80WE4.
PRIDEiQ80WE4.

PTM databases

iPTMnetiQ80WE4.
PhosphoSiteiQ80WE4.

Expressioni

Tissue specificityi

Expressed in the brain (at protein level) (PubMed:24173802).1 Publication

Developmental stagei

Expressed in the developing brain (PubMed:23864681). Expressed in the apical aspect of the ventricular zone, in the marginal zone, in a narrow stripe between the intermediate zone and the cortical plate at 14.5 dpc (PubMed:23864681). Expressed in multipolar cells at 14 dpc (at protein level) (PubMed:23864681). Expressed in neuronal stem/progenitor cells at 14.5 dpc (PubMed:24173802).2 Publications

Gene expression databases

BgeeiQ80WE4.
CleanExiMM_KIF20B.
GenevisibleiQ80WE4. MM.

Interactioni

Subunit structurei

Oligomerizes (via kinesin motor domain). Associates with microtubules. Interacts (via C-terminal globular tail region) with PIN1 (via WW domain). Interacts with PRC1 (By similarity). Interacts with SHTN1 (via N-terminus); the interaction is direct and promotes the association of SHTN1 to microtubules in primary neurons (PubMed:23864681). Associates with microtubules (PubMed:23864681).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi232217. 15 interactions.
IntActiQ80WE4. 14 interactions.
STRINGi10090.ENSMUSP00000084599.

Structurei

3D structure databases

ProteinModelPortaliQ80WE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 477420Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1002 – 105958Necessary and sufficient for interaction with SHTN11 PublicationAdd
BLAST
Regioni1514 – 1774261Interaction with PIN1By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili525 – 60177Sequence analysisAdd
BLAST
Coiled coili705 – 74743Sequence analysisAdd
BLAST
Coiled coili824 – 946123Sequence analysisAdd
BLAST
Coiled coili1021 – 1507487Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0247. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00830000128294.
HOGENOMiHOG000168226.
InParanoidiQ80WE4.
KOiK10402.
OMAiWAQREAD.
OrthoDBiEOG7TTQ73.
TreeFamiTF105232.

Family and domain databases

Gene3Di3.40.850.10. 2 hits.
InterProiIPR028828. KIF20B.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PTHR24115:SF534. PTHR24115:SF534. 3 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q80WE4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESHLNPDGV PRPSYVFSAD PIARPLEINF DGVKLDLSHE FSLVASNPAA
60 70 80 90 100
NSLGSKNYLQ VCLRIRPFTQ SEKEHEAEGC VQVLDSQSVL LKDPQSILGH
110 120 130 140 150
LSEKSSGQVA QKFSFSKVFG PETSQKEFFL GCIMQPVKDL LEGHSRLIFT
160 170 180 190 200
YGLTNSGKTY TFQGTEENIG ILPRTLNVLF DSLQERLYTK MSFKPHRCRE
210 220 230 240 250
YLKLSSDQEK EESANKNTLL RQIKEVTIHN DSYDVLCGHL TNSLTIPEFE
260 270 280 290 300
ESVNSCDQSS LNVDNIKYSV WVSFFEIYNE SIYDLFVPVS SKFQKRKMLR
310 320 330 340 350
LSQDIKGYSF IKDLQWVQVS DSKEAYRLLK LGVKHQSVAF TKLNNASSRS
360 370 380 390 400
HSIFTIRILQ IEDSEIPRVT RVSELSLCDL AGSERSMKTQ NEGERLREAG
410 420 430 440 450
NINTSLLTLG KCINVLKNSE KSKVQHVPFR ESKLTHYFQS FFTGKGKICM
460 470 480 490 500
IINISQSCSA YDETLNVLKF STTAQRVYVP DTLSSSQEKS FASNKSLQDV
510 520 530 540 550
SLDSNLDNKI LNVKRKTVSW ENSLEDVLEN EDLVEDLEEN EETQNMETEL
560 570 580 590 600
TDEDSDKSLE ECRVSTCHKK NKELLDLIEK LNKRLINENK EKLTLELKIR
610 620 630 640 650
EEVTQEFTQY WSQREADFKE TLLHEREILE ENAERRLAIF KDLVGKCDSQ
660 670 680 690 700
DEPTNRICDI ELETEEAHNY VGVEDIFHSL QDDVTDIKKQ AELAHLYITS
710 720 730 740 750
LVDPQEAIAC LQLKFNQVKA ELAETKEELI KAQEELKNRE SNSLVQALKT
760 770 780 790 800
SSKVDTSLTS NKSTCNETSE MPKNSRAQTH SERKRLNEDG LQLGEPPAKK
810 820 830 840 850
GLILVSPPIT EEQNKMGEMQ QSVSEVVEGN RVLKEKNEEL KRLLTIGENE
860 870 880 890 900
LRNEKEEKAE LNKQVVSLQQ QLRFFEEKNS SLRADVEQIQ ASYNSAVAEL
910 920 930 940 950
QTQKAVNQEQ RDRILKLSQE METAARSIES NVSQIKQMQT KIDELRSLDS
960 970 980 990 1000
PSHISKIDLL NLQDLSSGAK GDNCLNTSQQ LPGGDFSSTW VKEYHTQEIS
1010 1020 1030 1040 1050
RENSFHASIE AIWEECKEIV KASSKKSHQI QGLEEQIEKL QVEVKGYREE
1060 1070 1080 1090 1100
NSDLRAQESQ GKNRDHQLKE KESLIQQLRE ELQEKSVSLR VQVQLVAERE
1110 1120 1130 1140 1150
QALSELSQDV TCYKAKIKDL EVIVETQKDE CKRLVELEQS ILEKESAILK
1160 1170 1180 1190 1200
LEANLKECEA KHQDHIRTND LSAKEVKFRE EVTRLANNLH DTKQLLQSKE
1210 1220 1230 1240 1250
EENEISRQET EKLKEELAAN SILTQNLKAD LQKKEEDCAE LKEKFIDAKK
1260 1270 1280 1290 1300
QIEQVQREVS VMRDEEKLLR IKINELEKKK NQYSQDLDMK QRTIQQLKEQ
1310 1320 1330 1340 1350
LSNQKMEEAV QQYEKVCKDL SVKEKLVEDM RLTLVEQEQT QAEQDRVLEA
1360 1370 1380 1390 1400
KSEEADWLAT ELDKWKEKFK DLETRSNQRL NTGTMDDLDV LTRKFSKLQD
1410 1420 1430 1440 1450
ELQESEEKYK ADRKKWLEEK AVLTTQAKEA ENVRNREMRK YADDRERCLK
1460 1470 1480 1490 1500
LQNEVETLTA QLAEKNSELQ KWREERDQLV TAVETQMKAL LSSCKHKDEE
1510 1520 1530 1540 1550
IQELRKAAAK STGTENQTMN PKPEYNDSVD LGGVETEPQS TSLEISRNTA
1560 1570 1580 1590 1600
EDGSVVLDSC EVSTENVQST RFPKPELEIQ FTPLQPNKMA VKHPGCPTPV
1610 1620 1630 1640 1650
TIKIPKARKR KSGEVEEDLV KCENKKNSTP RSNVKFPVSE HRNSPVKKEQ
1660 1670 1680 1690 1700
KVSVGPSSKK TYSLRSQAST VSANIASKKR EGTLQKFGDF LQHSPTILQS
1710 1720 1730 1740 1750
KAKKIIETMS SPKLSTVEVS KENVSQPKKA KRKLYRNEIS SPINISGQVI
1760 1770
LMEQKVKETD HQILKRRLRT RTAK
Note: No experimental confirmation available.
Length:1,774
Mass (Da):203,514
Last modified:July 27, 2011 - v3
Checksum:i3EBB3D6553E79DA1
GO
Isoform 2 (identifier: Q80WE4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-386: Missing.
     666-705: Missing.

Show »
Length:1,348
Mass (Da):155,178
Checksum:iE681F753C33DD2A1
GO
Isoform 3 (identifier: Q80WE4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     666-705: Missing.

Show »
Length:1,734
Mass (Da):198,979
Checksum:iC00B5BE9B7A1EBC8
GO
Isoform 4 (identifier: Q80WE4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-237: Missing.
     375-375: Missing.

Show »
Length:1,762
Mass (Da):202,140
Checksum:iBB9BA9F2135F274B
GO

Sequence cautioni

The sequence AAH48954.1 differs from that shown. Reason: Frameshift at position 1680. Curated
The sequence AAP14646.1 differs from that shown. Reason: Frameshift at position 1699. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti675 – 6751D → E in BAE43340 (PubMed:16141072).Curated
Sequence conflicti763 – 7631S → P in BAE43340 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 386386Missing in isoform 2. 1 PublicationVSP_022623Add
BLAST
Alternative sequencei227 – 23711Missing in isoform 4. CuratedVSP_022624Add
BLAST
Alternative sequencei375 – 3751Missing in isoform 4. CuratedVSP_022625
Alternative sequencei666 – 70540Missing in isoform 2 and isoform 3. 2 PublicationsVSP_022626Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY259532 mRNA. Translation: AAP14646.1. Frameshift.
AC113244 Genomic DNA. No translation available.
AK045067 mRNA. Translation: BAC32207.1.
AK049225 mRNA. Translation: BAE43340.1.
AB054030 Genomic DNA. Translation: BAB32494.1.
BC048954 mRNA. Translation: AAH48954.1. Frameshift.
CCDSiCCDS37967.1. [Q80WE4-1]
RefSeqiNP_898867.1. NM_183046.1. [Q80WE4-1]
XP_006527143.1. XM_006527080.2. [Q80WE4-1]
XP_006527144.1. XM_006527081.2. [Q80WE4-1]
XP_006527149.1. XM_006527086.1. [Q80WE4-2]
UniGeneiMm.278471.

Genome annotation databases

EnsembliENSMUST00000087341; ENSMUSP00000084599; ENSMUSG00000024795. [Q80WE4-1]
GeneIDi240641.
KEGGimmu:240641.
UCSCiuc008hgz.1. mouse. [Q80WE4-1]
uc008hha.1. mouse. [Q80WE4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY259532 mRNA. Translation: AAP14646.1. Frameshift.
AC113244 Genomic DNA. No translation available.
AK045067 mRNA. Translation: BAC32207.1.
AK049225 mRNA. Translation: BAE43340.1.
AB054030 Genomic DNA. Translation: BAB32494.1.
BC048954 mRNA. Translation: AAH48954.1. Frameshift.
CCDSiCCDS37967.1. [Q80WE4-1]
RefSeqiNP_898867.1. NM_183046.1. [Q80WE4-1]
XP_006527143.1. XM_006527080.2. [Q80WE4-1]
XP_006527144.1. XM_006527081.2. [Q80WE4-1]
XP_006527149.1. XM_006527086.1. [Q80WE4-2]
UniGeneiMm.278471.

3D structure databases

ProteinModelPortaliQ80WE4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232217. 15 interactions.
IntActiQ80WE4. 14 interactions.
STRINGi10090.ENSMUSP00000084599.

PTM databases

iPTMnetiQ80WE4.
PhosphoSiteiQ80WE4.

Proteomic databases

EPDiQ80WE4.
MaxQBiQ80WE4.
PaxDbiQ80WE4.
PRIDEiQ80WE4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087341; ENSMUSP00000084599; ENSMUSG00000024795. [Q80WE4-1]
GeneIDi240641.
KEGGimmu:240641.
UCSCiuc008hgz.1. mouse. [Q80WE4-1]
uc008hha.1. mouse. [Q80WE4-2]

Organism-specific databases

CTDi9585.
MGIiMGI:2444576. Kif20b.

Phylogenomic databases

eggNOGiKOG0247. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00830000128294.
HOGENOMiHOG000168226.
InParanoidiQ80WE4.
KOiK10402.
OMAiWAQREAD.
OrthoDBiEOG7TTQ73.
TreeFamiTF105232.

Miscellaneous databases

ChiTaRSiKif20b. mouse.
PROiQ80WE4.
SOURCEiSearch...

Gene expression databases

BgeeiQ80WE4.
CleanExiMM_KIF20B.
GenevisibleiQ80WE4. MM.

Family and domain databases

Gene3Di3.40.850.10. 2 hits.
InterProiIPR028828. KIF20B.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PTHR24115:SF534. PTHR24115:SF534. 3 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel mouse M-phase phosphoprotein gene."
    Shan Y.X., Yu L.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-781 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-732 (ISOFORM 3).
    Strain: C57BL/6J.
    Tissue: Embryo.
  4. "All kinesin superfamily protein, KIF, genes in mouse and human."
    Miki H., Setou M., Kaneshiro K.
    Proc. Natl. Acad. Sci. U.S.A. 98:7004-7011(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 148-384 (ISOFORM 4).
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1232-1774.
    Strain: FVB/N-3.
    Tissue: Mammary tumor.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1107, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  7. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-950, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1694, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.
  9. "The vertebrate-specific Kinesin-6, Kif20b, is required for normal cytokinesis of polarized cortical stem cells and cerebral cortex size."
    Janisch K.M., Vock V.M., Fleming M.S., Shrestha A., Grimsley-Myers C.M., Rasoul B.A., Neale S.A., Cupp T.D., Kinchen J.M., Liem K.F. Jr., Dwyer N.D.
    Development 140:4672-4682(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  10. "Shootin1 acts in concert with KIF20B to promote polarization of migrating neurons."
    Sapir T., Levy T., Sakakibara A., Rabinkov A., Miyata T., Reiner O.
    J. Neurosci. 33:11932-11948(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SHTN1, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, MUTAGENESIS OF TYR-1047 AND ARG-1048.

Entry informationi

Entry nameiKI20B_MOUSE
AccessioniPrimary (citable) accession number: Q80WE4
Secondary accession number(s): E9QPW5
, Q3V347, Q80VC0, Q8BLI2, Q99PT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.