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Q80WD1

- R4RL2_RAT

UniProt

Q80WD1 - R4RL2_RAT

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Protein

Reticulon-4 receptor-like 2

Gene

Rtn4rl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.By similarity

GO - Molecular functioni

  1. receptor activity Source: UniProtKB

GO - Biological processi

  1. cell surface receptor signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-4 receptor-like 2
Alternative name(s):
Nogo receptor-like 3
Nogo-66 receptor homolog 1
Nogo-66 receptor-related protein 2
Short name:
NgR2
Gene namesi
Name:Rtn4rl2Imported
Synonyms:Ngrh1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi727797. Rtn4rl2.

Subcellular locationi

Cell membrane Curated; Lipid-anchorGPI-anchor Curated
Note: Localized to the surface of neurons, including axons.1 Publication

GO - Cellular componenti

  1. anchored component of plasma membrane Source: UniProtKB
  2. external side of plasma membrane Source: RGD
  3. extracellular vesicular exosome Source: Ensembl
  4. membrane raft Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 390360Reticulon-4 receptor-like 2PRO_0000046052Add
BLAST
Propeptidei391 – 42030Removed in mature formSequence AnalysisPRO_0000046053Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Lipidationi390 – 3901GPI-anchor amidated cysteineSequence Analysis

Post-translational modificationi

Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein.By similarity

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRIDEiQ80WD1.

Expressioni

Tissue specificityi

In brain, detected in cerebral cortex and hippocampus. Weak or no expression detected in the cerebellum, thalamus or striatum.1 Publication

Gene expression databases

GenevestigatoriQ80WD1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032922.

Structurei

Secondary structure

1
420
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi36 – 383
Turni39 – 424
Beta strandi43 – 453
Beta strandi64 – 663
Beta strandi85 – 884
Turni99 – 1046
Beta strandi110 – 1123
Turni124 – 1296
Beta strandi135 – 1373
Turni148 – 1536
Beta strandi159 – 1613
Turni172 – 1776
Beta strandi183 – 1853
Turni196 – 2016
Beta strandi207 – 2093
Turni220 – 2256
Beta strandi231 – 2333
Helixi244 – 2485
Beta strandi255 – 2573
Helixi267 – 2693
Helixi270 – 2789
Beta strandi287 – 2915
Helixi292 – 2943
Helixi299 – 3013
Helixi304 – 3074

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4P8SX-ray1.80A29-310[»]
4P91X-ray2.10A29-330[»]
ProteinModelPortaliQ80WD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 6030LRRNTAdd
BLAST
Repeati61 – 8222LRR 1Add
BLAST
Repeati83 – 10422LRR 2Add
BLAST
Repeati107 – 12923LRR 3Add
BLAST
Repeati132 – 15322LRR 4Add
BLAST
Repeati156 – 17722LRR 5Add
BLAST
Repeati180 – 20122LRR 6Add
BLAST
Repeati204 – 22522LRR 7Add
BLAST
Repeati228 – 24922LRR 8Add
BLAST
Domaini261 – 31252LRRCTAdd
BLAST

Sequence similaritiesi

Belongs to the Nogo receptor family.Curated
Contains 8 LRR (leucine-rich) repeats.Sequence Analysis
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiQ80WD1.
KOiK16661.
OMAiQDDIFSD.
OrthoDBiEOG7CZK5N.
PhylomeDBiQ80WD1.
TreeFamiTF330080.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q80WD1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPGLRRLLQ GPASACLLLT LLALPPVTPS CPMLCTCYSS PPTVSCQANN
60 70 80 90 100
FSSVPLSLPP STQRLFLQNN LIRSLRPGTF GPNLLTLWLF SNNLSTIYPG
110 120 130 140 150
TFRHLQALEE LDLGDNRHLR SLEPDTFQGL ERLQSLHLYR CQLSSLPGNI
160 170 180 190 200
FRGLVSLQYL YLQENSLLHL QDDLFADLAN LSHLFLHGNR LRLLTEHVFR
210 220 230 240 250
GLGSLDRLLL HGNRLQGVHR AAFHGLSRLT ILYLFNNSLA SLPGEALADL
260 270 280 290 300
PALEFLRLNA NPWACDCRAR PLWAWFQRAR VSSSDVTCAT PPERQGRDLR
310 320 330 340 350
TLRDTDFQAC PPPTPTRPGS RARGNSSSNH LYGVAEAGAP PADPSTLYRD
360 370 380 390 400
LPAEDSRGRQ GGDAPTEDDY WGGYGGEDQR GEQTCPGAAC QAPADSRGPV
410 420
LSAGLRTPLL CLLLLAPHHL
Length:420
Mass (Da):46,184
Last modified:June 1, 2003 - v1
Checksum:i27536A80B4E34EF1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF532860 mRNA. Translation: AAP21837.1.
RefSeqiNP_852045.1. NM_181380.2.
UniGeneiRn.162683.

Genome annotation databases

EnsembliENSRNOT00000038250; ENSRNOP00000032922; ENSRNOG00000021513.
GeneIDi311169.
KEGGirno:311169.
UCSCiRGD:727797. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF532860 mRNA. Translation: AAP21837.1 .
RefSeqi NP_852045.1. NM_181380.2.
UniGenei Rn.162683.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4P8S X-ray 1.80 A 29-310 [» ]
4P91 X-ray 2.10 A 29-330 [» ]
ProteinModelPortali Q80WD1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000032922.

Proteomic databases

PRIDEi Q80WD1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000038250 ; ENSRNOP00000032922 ; ENSRNOG00000021513 .
GeneIDi 311169.
KEGGi rno:311169.
UCSCi RGD:727797. rat.

Organism-specific databases

CTDi 349667.
RGDi 727797. Rtn4rl2.

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00760000118777.
HOGENOMi HOG000116109.
HOVERGENi HBG063707.
InParanoidi Q80WD1.
KOi K16661.
OMAi QDDIFSD.
OrthoDBi EOG7CZK5N.
PhylomeDBi Q80WD1.
TreeFami TF330080.

Miscellaneous databases

NextBioi 663102.
PROi Q80WD1.

Gene expression databases

Genevestigatori Q80WD1.

Family and domain databases

InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF13855. LRR_8. 2 hits.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor."
    Pignot V., Hein A.E., Barske C., Wiessner C., Walmsley A.R., Kaupmann K., Mayeur H., Sommer B., Mir A.K., Frentzel S.
    J. Neurochem. 85:717-728(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Sprague-DawleyImported.

Entry informationi

Entry nameiR4RL2_RAT
AccessioniPrimary (citable) accession number: Q80WD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3