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Q80WD1

- R4RL2_RAT

UniProt

Q80WD1 - R4RL2_RAT

Protein

Reticulon-4 receptor-like 2

Gene

Rtn4rl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.By similarity

    GO - Molecular functioni

    1. receptor activity Source: UniProtKB

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: RGD

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Reticulon-4 receptor-like 2
    Alternative name(s):
    Nogo receptor-like 3
    Nogo-66 receptor homolog 1
    Nogo-66 receptor-related protein 2
    Short name:
    NgR2
    Gene namesi
    Name:Rtn4rl2Imported
    Synonyms:Ngrh1Imported
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi727797. Rtn4rl2.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchorGPI-anchor Curated
    Note: Localized to the surface of neurons, including axons.1 Publication

    GO - Cellular componenti

    1. anchored component of plasma membrane Source: UniProtKB
    2. external side of plasma membrane Source: RGD
    3. membrane raft Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 390360Reticulon-4 receptor-like 2PRO_0000046052Add
    BLAST
    Propeptidei391 – 42030Removed in mature formSequence AnalysisPRO_0000046053Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Lipidationi390 – 3901GPI-anchor amidated cysteineSequence Analysis

    Post-translational modificationi

    Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein.By similarity

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PRIDEiQ80WD1.

    Expressioni

    Tissue specificityi

    In brain, detected in cerebral cortex and hippocampus. Weak or no expression detected in the cerebellum, thalamus or striatum.1 Publication

    Gene expression databases

    GenevestigatoriQ80WD1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000032922.

    Structurei

    Secondary structure

    1
    420
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi36 – 383
    Turni39 – 424
    Beta strandi43 – 453
    Beta strandi64 – 663
    Beta strandi85 – 884
    Turni99 – 1046
    Beta strandi110 – 1123
    Turni124 – 1296
    Beta strandi135 – 1373
    Turni148 – 1536
    Beta strandi159 – 1613
    Turni172 – 1776
    Beta strandi183 – 1853
    Turni196 – 2016
    Beta strandi207 – 2093
    Turni220 – 2256
    Beta strandi231 – 2333
    Helixi244 – 2485
    Beta strandi255 – 2573
    Helixi267 – 2693
    Helixi270 – 2789
    Beta strandi287 – 2915
    Helixi292 – 2943
    Helixi299 – 3013
    Helixi304 – 3074

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4P8SX-ray1.80A29-310[»]
    4P91X-ray2.10A29-330[»]
    ProteinModelPortaliQ80WD1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 6030LRRNTAdd
    BLAST
    Repeati61 – 8222LRR 1Add
    BLAST
    Repeati83 – 10422LRR 2Add
    BLAST
    Repeati107 – 12923LRR 3Add
    BLAST
    Repeati132 – 15322LRR 4Add
    BLAST
    Repeati156 – 17722LRR 5Add
    BLAST
    Repeati180 – 20122LRR 6Add
    BLAST
    Repeati204 – 22522LRR 7Add
    BLAST
    Repeati228 – 24922LRR 8Add
    BLAST
    Domaini261 – 31252LRRCTAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Nogo receptor family.Curated
    Contains 8 LRR (leucine-rich) repeats.Sequence Analysis
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4886.
    GeneTreeiENSGT00750000117338.
    HOGENOMiHOG000116109.
    HOVERGENiHBG063707.
    InParanoidiQ80WD1.
    KOiK16661.
    OMAiQDDIFSD.
    OrthoDBiEOG7CZK5N.
    PhylomeDBiQ80WD1.
    TreeFamiTF330080.

    Family and domain databases

    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF13855. LRR_8. 2 hits.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 4 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q80WD1-1 [UniParc]FASTAAdd to Basket

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    MLPGLRRLLQ GPASACLLLT LLALPPVTPS CPMLCTCYSS PPTVSCQANN    50
    FSSVPLSLPP STQRLFLQNN LIRSLRPGTF GPNLLTLWLF SNNLSTIYPG 100
    TFRHLQALEE LDLGDNRHLR SLEPDTFQGL ERLQSLHLYR CQLSSLPGNI 150
    FRGLVSLQYL YLQENSLLHL QDDLFADLAN LSHLFLHGNR LRLLTEHVFR 200
    GLGSLDRLLL HGNRLQGVHR AAFHGLSRLT ILYLFNNSLA SLPGEALADL 250
    PALEFLRLNA NPWACDCRAR PLWAWFQRAR VSSSDVTCAT PPERQGRDLR 300
    TLRDTDFQAC PPPTPTRPGS RARGNSSSNH LYGVAEAGAP PADPSTLYRD 350
    LPAEDSRGRQ GGDAPTEDDY WGGYGGEDQR GEQTCPGAAC QAPADSRGPV 400
    LSAGLRTPLL CLLLLAPHHL 420
    Length:420
    Mass (Da):46,184
    Last modified:June 1, 2003 - v1
    Checksum:i27536A80B4E34EF1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF532860 mRNA. Translation: AAP21837.1.
    RefSeqiNP_852045.1. NM_181380.2.
    UniGeneiRn.162683.

    Genome annotation databases

    EnsembliENSRNOT00000038250; ENSRNOP00000032922; ENSRNOG00000021513.
    GeneIDi311169.
    KEGGirno:311169.
    UCSCiRGD:727797. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF532860 mRNA. Translation: AAP21837.1 .
    RefSeqi NP_852045.1. NM_181380.2.
    UniGenei Rn.162683.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4P8S X-ray 1.80 A 29-310 [» ]
    4P91 X-ray 2.10 A 29-330 [» ]
    ProteinModelPortali Q80WD1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000032922.

    Proteomic databases

    PRIDEi Q80WD1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000038250 ; ENSRNOP00000032922 ; ENSRNOG00000021513 .
    GeneIDi 311169.
    KEGGi rno:311169.
    UCSCi RGD:727797. rat.

    Organism-specific databases

    CTDi 349667.
    RGDi 727797. Rtn4rl2.

    Phylogenomic databases

    eggNOGi COG4886.
    GeneTreei ENSGT00750000117338.
    HOGENOMi HOG000116109.
    HOVERGENi HBG063707.
    InParanoidi Q80WD1.
    KOi K16661.
    OMAi QDDIFSD.
    OrthoDBi EOG7CZK5N.
    PhylomeDBi Q80WD1.
    TreeFami TF330080.

    Miscellaneous databases

    NextBioi 663102.
    PROi Q80WD1.

    Gene expression databases

    Genevestigatori Q80WD1.

    Family and domain databases

    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF13855. LRR_8. 2 hits.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 4 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor."
      Pignot V., Hein A.E., Barske C., Wiessner C., Walmsley A.R., Kaupmann K., Mayeur H., Sommer B., Mir A.K., Frentzel S.
      J. Neurochem. 85:717-728(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: Sprague-DawleyImported.

    Entry informationi

    Entry nameiR4RL2_RAT
    AccessioniPrimary (citable) accession number: Q80WD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3