Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q80WD1 (R4RL2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Reticulon-4 receptor-like 2
Alternative name(s):
Nogo receptor-like 3
Nogo-66 receptor homolog 1
Nogo-66 receptor-related protein 2
Short name=NgR2
Gene names
Name:Rtn4rl2
Synonyms:Ngrh1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in regulating axonal regeneration and plasticity in the adult central nervous system By similarity. UniProtKB Q86UN3

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor Potential. Note: Localized to the surface of neurons, including axons. Ref.1

Tissue specificity

In brain, detected in cerebral cortex and hippocampus. Weak or no expression detected in the cerebellum, thalamus or striatum. Ref.1

Post-translational modification

Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; where BRE is released as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein By similarity.

Sequence similarities

Belongs to the Nogo receptor family.

Contains 8 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 LRRNT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 390360Reticulon-4 receptor-like 2
PRO_0000046052
Propeptide391 – 42030Removed in mature form Potential
PRO_0000046053

Regions

Domain31 – 6030LRRNT
Repeat61 – 8222LRR 1
Repeat83 – 10422LRR 2
Repeat107 – 12923LRR 3
Repeat132 – 15322LRR 4
Repeat156 – 17722LRR 5
Repeat180 – 20122LRR 6
Repeat204 – 22522LRR 7
Repeat228 – 24922LRR 8
Domain261 – 31252LRRCT

Amino acid modifications

Lipidation3901GPI-anchor amidated cysteine Potential
Glycosylation501N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q80WD1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 27536A80B4E34EF1

FASTA42046,184
        10         20         30         40         50         60 
MLPGLRRLLQ GPASACLLLT LLALPPVTPS CPMLCTCYSS PPTVSCQANN FSSVPLSLPP 

        70         80         90        100        110        120 
STQRLFLQNN LIRSLRPGTF GPNLLTLWLF SNNLSTIYPG TFRHLQALEE LDLGDNRHLR 

       130        140        150        160        170        180 
SLEPDTFQGL ERLQSLHLYR CQLSSLPGNI FRGLVSLQYL YLQENSLLHL QDDLFADLAN 

       190        200        210        220        230        240 
LSHLFLHGNR LRLLTEHVFR GLGSLDRLLL HGNRLQGVHR AAFHGLSRLT ILYLFNNSLA 

       250        260        270        280        290        300 
SLPGEALADL PALEFLRLNA NPWACDCRAR PLWAWFQRAR VSSSDVTCAT PPERQGRDLR 

       310        320        330        340        350        360 
TLRDTDFQAC PPPTPTRPGS RARGNSSSNH LYGVAEAGAP PADPSTLYRD LPAEDSRGRQ 

       370        380        390        400        410        420 
GGDAPTEDDY WGGYGGEDQR GEQTCPGAAC QAPADSRGPV LSAGLRTPLL CLLLLAPHHL 

« Hide

References

[1]"Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor."
Pignot V., Hein A.E., Barske C., Wiessner C., Walmsley A.R., Kaupmann K., Mayeur H., Sommer B., Mir A.K., Frentzel S.
J. Neurochem. 85:717-728(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: Sprague-Dawley.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF532860 mRNA. Translation: AAP21837.1.
RefSeqNP_852045.1. NM_181380.2.
UniGeneRn.162683.

3D structure databases

ProteinModelPortalQ80WD1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000032922.

Proteomic databases

PRIDEQ80WD1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000038250; ENSRNOP00000032922; ENSRNOG00000021513.
GeneID311169.
KEGGrno:311169.
UCSCRGD:727797. rat.

Organism-specific databases

CTD349667.
RGD727797. Rtn4rl2.

Phylogenomic databases

eggNOGCOG4886.
GeneTreeENSGT00750000117338.
HOGENOMHOG000116109.
HOVERGENHBG063707.
InParanoidQ80WD1.
KOK16661.
OMAQDDIFSD.
OrthoDBEOG7CZK5N.
PhylomeDBQ80WD1.
TreeFamTF330080.

Gene expression databases

GenevestigatorQ80WD1.

Family and domain databases

InterProIPR000483. Cys-rich_flank_reg_C.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
SMARTSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio663102.
PROQ80WD1.

Entry information

Entry nameR4RL2_RAT
AccessionPrimary (citable) accession number: Q80WD1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families