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Protein

Reticulon-4 receptor-like 1

Gene

Rtn4rl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in regulating axonal regeneration and plasticity in the adult central nervous system.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-4 receptor-like 1
Alternative name(s):
Nogo receptor-like 2
Nogo-66 receptor homolog 2
Nogo-66 receptor-related protein 3
Short name:
NgR3
Gene namesi
Name:Rtn4rl1Imported
Synonyms:Ngrh2Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi727812. Rtn4rl1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei424 – 44421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • anchored component of plasma membrane Source: UniProtKB
  • external side of plasma membrane Source: RGD
  • extracellular exosome Source: Ensembl
  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 424400Reticulon-4 receptor-like 1PRO_0000046046Add
BLAST
Propeptidei425 – 44521Removed in mature formSequence analysisPRO_0000046047Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi424 – 4241GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ80WD0.

Expressioni

Tissue specificityi

Expressed in various regions of the brain, including the cerebral cortex, hippocampus, striatum, thalamus and cerebellum.1 Publication

Gene expression databases

GenevisibleiQ80WD0. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058866.

Structurei

3D structure databases

ProteinModelPortaliQ80WD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 5430LRRNTAdd
BLAST
Repeati55 – 7622LRR 1Add
BLAST
Repeati77 – 9822LRR 2Add
BLAST
Repeati101 – 12323LRR 3Add
BLAST
Repeati126 – 14722LRR 4Add
BLAST
Repeati150 – 17122LRR 5Add
BLAST
Repeati174 – 19522LRR 6Add
BLAST
Repeati198 – 21922LRR 7Add
BLAST
Repeati222 – 24322LRR 8Add
BLAST
Domaini255 – 30652LRRCTAdd
BLAST

Sequence similaritiesi

Belongs to the Nogo receptor family.Curated
Contains 8 LRR (leucine-rich) repeats.Sequence analysis
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129720.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiQ80WD0.
KOiK16660.
OMAiNCTSHRN.
OrthoDBiEOG7CZK5N.
PhylomeDBiQ80WD0.
TreeFamiTF330080.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q80WD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRKGCCVEL LLLLLAGELP LSGGCPRDCV CYPSPMTVSC QAHNFAAIPE
60 70 80 90 100
GIPEDSERIF LQNNHITFLQ QGHFSPAMVT LWIYSNNITF IAPNTFEGFV
110 120 130 140 150
HLEELDLGDN RQLRTLAPET FQGLVKLHAL YLYKCGLSSL PAGIFGGLHS
160 170 180 190 200
LQYLYLQDNH IEYLQDDIFV DLVNLSHLFL HGNKLWSLGQ GIFRGLVNLD
210 220 230 240 250
RLLLHENQLQ WVHHKAFHDL HRLTTLFLFN NSLTELQGDC LAPLVALEFL
260 270 280 290 300
RLNGNAWDCG CRARSLWEWL RRFRGSSSVV PCATPELRQG QDLKSLRVED
310 320 330 340 350
FRNCTGPASP HQIKSHTLST SDRAARKEHH PSHGASRDKG HPHGHLPGSR
360 370 380 390 400
SGSKKPGKNC TSHRNRNQIS KGSAGKELPE LQDYAPDYQH KFSFDIMPTA
410 420 430 440
RPKRKGKCAR RTPIRAPSGV QQASSGTALG VSLLAWILGL VVSLR
Length:445
Mass (Da):49,775
Last modified:June 1, 2003 - v1
Checksum:i013FA4F1CE24A87C
GO
Isoform 21 Publication (identifier: Q80WD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: Missing.
     8-8: V → M

Show »
Length:438
Mass (Da):49,015
Checksum:i6A4255CA033B70E4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 77Missing in isoform 2. 1 PublicationVSP_051945
Alternative sequencei8 – 81V → M in isoform 2. 1 PublicationVSP_051946

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF532861 mRNA. Translation: AAP21838.1.
AY311478 mRNA. Translation: AAP74960.1.
BC129084 mRNA. Translation: AAI29085.1.
RefSeqiNP_852042.1. NM_181377.3. [Q80WD0-1]
UniGeneiRn.22361.

Genome annotation databases

EnsembliENSRNOT00000067414; ENSRNOP00000058866; ENSRNOG00000003121. [Q80WD0-1]
GeneIDi303311.
KEGGirno:303311.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF532861 mRNA. Translation: AAP21838.1.
AY311478 mRNA. Translation: AAP74960.1.
BC129084 mRNA. Translation: AAI29085.1.
RefSeqiNP_852042.1. NM_181377.3. [Q80WD0-1]
UniGeneiRn.22361.

3D structure databases

ProteinModelPortaliQ80WD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058866.

Proteomic databases

PaxDbiQ80WD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067414; ENSRNOP00000058866; ENSRNOG00000003121. [Q80WD0-1]
GeneIDi303311.
KEGGirno:303311.

Organism-specific databases

CTDi146760.
RGDi727812. Rtn4rl1.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129720.
HOGENOMiHOG000116109.
HOVERGENiHBG063707.
InParanoidiQ80WD0.
KOiK16660.
OMAiNCTSHRN.
OrthoDBiEOG7CZK5N.
PhylomeDBiQ80WD0.
TreeFamiTF330080.

Miscellaneous databases

PROiQ80WD0.

Gene expression databases

GenevisibleiQ80WD0. RN.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor."
    Pignot V., Hein A.E., Barske C., Wiessner C., Walmsley A.R., Kaupmann K., Mayeur H., Sommer B., Mir A.K., Frentzel S.
    J. Neurochem. 85:717-728(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Sprague-DawleyImported.
  2. "Cloning and expression of rat NGRH1 and NGRH2."
    Jin W.-L., Long M., Ju G.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: Sprague-DawleyImported.
    Tissue: BrainImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiR4RL1_RAT
AccessioniPrimary (citable) accession number: Q80WD0
Secondary accession number(s): A1L1I9, Q7TQ96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2003
Last modified: June 8, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.